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The Role of Solvent in Tautomer Solvate Crystallization: A Case of 6-Amino-1,3-Dimethyl-5-Nitrosouracil

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Transactions of Tianjin University 2020年第6期26卷 458-469页

作者： Luguang Qi Yanhui Jin Huina Li yanpeng dong Chuang Xie School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Xinhua Pharmaceutical(Shouguang)Co. LtdWeifang 262700China National Collaborative Innovation Centre of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Tautomers are structural isomers that readily interconvert and may exhibit diff erent *** eff ect of solvent on tautomeric equilibria in solution has been a subject of some *** solvate is less common,and the role of solvent in the crystallization of tautomer solvate remains an interesting *** this work,we used 6-amino-1,3-dimethyl-5-nitrosouracil(NAU)as the tautomeric model material,which can present in nitrone–enamine form(Tautomer A)or oxime–imine form(Tautomer B).A solvate with NAU/DMSO ratio of 1:1 was discovered and characterized using single/powder X-ray diff raction and *** crystal structure of NAU·DMSO was determined for the fi rst time,where only Tautomer A was formed in the tautomeric *** chemical calculation and molecular dynamics simulation were conducted to determine the tautomeric form in DMSO *** potential analysis,radial distribution function analysis,and binding energy suggested possible DMSO–NAU interaction modes and stable tautomer complexes in *** A-containing complexes were found to dominate in solution,as verifi ed by comparing predicted and experimental 1 H NMR *** reveal that the hydrogen bonding between DMSO and NAU is similar in solution and in NAU–DMSO solvate crystal,which helps preserve the form of Tautomer A during solvate crystallization.

关键词： Tautomerization Solvate Molecular dynamics simulation Quantum chemical calculation

Semantic information processing for interoperability in the Industrial Internet of Things

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Fundamental Research 2024年第1期4卷 8-12页

作者： Shengshi Yao yanpeng Lu Kai Niu Jincheng Dai Chao dong Ping Zhang Key Laboratory of Universal Wireless Communications Ministry of EducationBeijing University of Posts and TelecommunicationsBeijing 100876China The State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

With the advent of the Internet of Everything(IoE),the concept of fully interconnected systems has become a reality,and the need for seamless communication and interoperability among different industrial systems has become more pressing than ever *** address the challenges posed by massive data traffic,we demonstrate the potentials of semantic information processing in industrial manufacturing processes and then propose a brief framework of semantic processing and communication system for industrial *** particular,the scheme is featured with task-orientation and collaborative *** illustrate its applicability,we provide examples of time series and images,as typical industrial data sources,for practical tasks,such as lifecycle estimation and surface defect *** results show that semantic information processing achieves a more efficient way of information processing and exchanging,compared to conventional methods,which is crucial for handling the demands of future interconnected industrial networks.

关键词： Semantic communication Intelligent manufacturing Signal processing Industrial Internet Task-oriented communication

Protective performance of shear stiffening gel-modified foam against ballistic impact:Experimental and numerical study

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Defence Technology（防务技术） 2024年第2期32卷 510-520页

作者： Huan Tu Haowei Yang Pengzhao Xu Zhe Yang Fan Tang Cheng dong Yuchao Chen Lei Ren Wenjian Cao Chenguang Huang Yacong Guo yanpeng Wei Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Xi'an Institute of Electromechanical Information Technology Xi'an 710065China Science and Technology on Transient Impact Laboratory Beijing 102202China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

As one of the most widely used personal protective equipment(PPE),body armors play an important role in protecting the human body from the high-velocity impact of bullets or *** body torso and critical organs of the wear may suffer severe behind-armor blunt trauma(BABT)even though the impactor is stopped by the body armor.A type of novel composite material through incorporating shear stiffening gel(STG)into ethylene-vinyl acetate(EVA)foam is developed and used as buffer layers to reduce *** this paper,the protective performance of body armors composed of fabric bulletproof layers and a buffer layer made of foam material is investigated both experimentally and *** effectiveness of STG-modified EVA in damage relief is verified by ballistic *** parallel with the experimental study,numerical simulations are conducted by LS-DYNA®to investigate the dynamic response of each component and capture the key mechanical parameters,which are hardly obtained from field *** fully describe the material behavior under the transient impact,the selected constitutive models take the failure and strain rate effect into consideration.A good agreement between the experimental observations and numerical results is achieved to prove the validity of the modelling *** tests and simulations show that the impact-induced deformation on the human body is significantly reduced by using STG-modified EVA as the buffering *** improvement of protective performance is attributed to better dynamic properties and more outstanding energy absorption capability of the composite foam.

关键词： Ballistic behavior Composite foam Shear stiffening gel Finite element analysis Protective mechanism

Genomic insights into the fast growth of paulownias and the formation of Paulownia witches' broom

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Molecular Plant 2021年第10期14卷 1668-1682页

作者： Yabing Cao Guiling Sun Xiaoqiao Zhai Pingluo Xu Liming Ma Minjie Deng Zhenli Zhao Haibo Yang yanpeng dong Zhonghai Shang Yujie Lv Lijun Yan Haifang Liu Xibing Cao Bingbing Li Zhe Wang Xiaogai Zhao Haiyan Yu Fan Wang Wen Ma Jinling Huang Guoqiang Fan Institute of Paulownia Henan Agricultural UniversityZhengzhouHenan 450002China College of Forestry Henan Agricultural UniversityZhengzhouHenan 450002China Key Laboratory of Plant Stress Biology State Key Laboratory of Crop Stress Adaptation and ImprovementState Key Laboratory of Cotton BiologySchool of Life SciencesHenan UniversityKaifengHenan 475004China Henan Academy of Forestry ZhengzhouHenan 450002China Biomarker Technologies Corporation Beijing 101399China Department of Biology East Carolina UniversityGreenvilleNC 27858USA

Paulownias are among the fastest growing trees in the world,but they often suffer tremendous loss of wood production due to infection by Paulownia witches'broom(PaWB)*** this study,we have sequenced and assembled a high-quality nuclear genome of Paulownia fortunei,a commonly cultivated paulownia *** assembled genome of *** is 511.6 Mb in size,with 93.2%of its sequences anchored to 20 pseudo-chromosomes,and it contains 31985 protein-coding *** analyses show that the family Paulowniaceae is sister to a clade composed of Phrymaceae and *** photosynthetic efficiency is achieved by integrating C3 photosynthesis and the crassulacean acid metabolism pathway,which may contribute to the extremely fast growth habit of paulownia *** transcriptome analyses reveal modules related to cambial growth and development,photosynthesis,and defense *** genome sequencing of PaWB phytoplasma,combined with functional analyses,indicates that the effector PaWB-SAP54 interacts directly with Paulownia PfSPLa,which in turn causes the degradation of PfSPLa by the ubiquitin-mediated pathway and leads to the formation of witches'*** together,these results provide significant insights into the biology of paulownias and the regulatory mechanism for the formation of PaWB.

关键词： Paulownia fortunei phytoplasma crassulacean acid metabolism Paulownia witches'broom PaWB photosynthesis

奥卡西平及丙戊酸钠治疗儿童癫痫部分性发作的效果比较

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中国民康医学 2019年第15期31卷 9-10页

作者：董艳鹏南阳市第一人民医院儿三科

目的:比较奥卡西平及丙戊酸钠治疗儿童癫痫部分性发作的效果。方法:选取74例癫痫部分性发作的患儿作为研究对象,按照随机数字表法将其分为对照组和观察组各37例。对照组给予丙戊酸钠口服液治疗,观察组给予奥卡西平片治疗。随访1年,比较... 详细信息

目的:比较奥卡西平及丙戊酸钠治疗儿童癫痫部分性发作的效果。方法:选取74例癫痫部分性发作的患儿作为研究对象,按照随机数字表法将其分为对照组和观察组各37例。对照组给予丙戊酸钠口服液治疗,观察组给予奥卡西平片治疗。随访1年,比较两组临床疗效及不良反应发生情况。结果:观察组的治疗有效率为94.59%(35/37),明显高于对照组的75.68%(28/37),差异有统计学意义(P<0.05)。结论:与丙戊酸钠相比,奥卡西平治疗儿童癫痫部分性发作的疗效更确切,且安全性好。

关键词：奥卡西平丙戊酸钠儿童癫痫部分性发作

吗啡与舒芬太尼交替用药对大鼠中脑导水管周围灰质μ受体表达的影响

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中华麻醉学杂志 2016年第6期36卷 697-700页

作者：刘晓艳董彦鹏孙莉中国医学科学院肿瘤医院麻醉科北京市100021

目的评价吗啡与舒芬太尼交替用药对大鼠中脑导水管周围灰质（PAG）μ受体表达的影响。方法40只健康雄性Wistar大鼠，体重250～290g，8周龄，采用随机数字表法，将其分为5组（n=8）：正常对照组（C组）、7d舒芬太尼组（S组）、7d吗啡组（... 详细信息

目的评价吗啡与舒芬太尼交替用药对大鼠中脑导水管周围灰质（PAG）μ受体表达的影响。方法40只健康雄性Wistar大鼠，体重250～290g，8周龄，采用随机数字表法，将其分为5组（n=8）：正常对照组（C组）、7d舒芬太尼组（S组）、7d吗啡组（M组）、14d吗啡组（MM组）和14d吗啡与舒芬太尼交替组（MS组）。C组、S组和M组分别颈部皮下注射生理盐水2ml／kg、舒芬太尼0．01mg／kg或吗啡10mg／kg，连续7d；MM组颈部皮下注射吗啡10mg／kg，连续14d，MS组第1—7天颈部皮下注射吗啡10mg／kg，第8-14天颈部皮下注射舒芬太尼0．01mg／kg；上述药物2次／d。分别于每天首次给药后15min或30min时测定热甩尾潜伏期（TFL），最后一次给药后处死大鼠，分离PAG，采用RT—PCR法和Western blot法测定μ受体及其mRNA表达。结果与C组比较，M组、MM组和MS组给药第1—6天TFL延长，S组给药第1—7天TFL延长，M组、MM组和MS组PAG区μ受体及其mRNA表达下调（P〈0．05）；与MM组比较，MS组给药第8—14天TFL延长，PAG区μ受体及其mRNA表达上调（P〈0．05）。结论吗啡与舒芬太尼交替用药减轻大鼠吗啡耐受的机制与增强PAG区μ受体活性有关。

关键词：吗啡舒芬太尼受体,阿片样,μ 脑导水管水管周灰质

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铬对母猪繁殖性能的影响及其作用机制

动物营养学报 2019年第5期31卷 2030-2037页

作者：董艳鹏吴小玲李自梅徐盛玉四川农业大学动物营养研究所成都611130

铬是动物机体所必需的微量元素之一。研究发现,铬能够通过调节胰岛素来改善糖类和脂类代谢、提高动物的免疫力和抗应激能力,进而对母猪的生长性能和繁殖性能产生影响。本文综述了铬对母猪繁殖性能的影响及其作用机制,为铬在母猪上的合... 详细信息

铬是动物机体所必需的微量元素之一。研究发现,铬能够通过调节胰岛素来改善糖类和脂类代谢、提高动物的免疫力和抗应激能力,进而对母猪的生长性能和繁殖性能产生影响。本文综述了铬对母猪繁殖性能的影响及其作用机制,为铬在母猪上的合理应用提供参考。

关键词：铬母猪繁殖性能作用机制

水下发射装置非线性冲击响应分析及减振器参数优化

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振动与冲击 2019年第3期38卷 164-169页

作者：张亚静苏金鹏董彦鹏彭雪明华宏星上海交通大学机械系统与振动国家重点实验室上海20240 高新船舶与深海开发装备协同创新中心上海20240 北京机械设备研究所北京100854

水下弹体连续发射时,会导致振动叠加问题,同时随着发射装置中剩余弹体数目减少和纵向减振器锁死,系统的质量、刚度发生突变,必需采用非线性方法进行冲击响应分析。将水下发射装置简化为多自由度非线性时变系统,根据牛顿第二定律建立了... 详细信息

水下弹体连续发射时,会导致振动叠加问题,同时随着发射装置中剩余弹体数目减少和纵向减振器锁死,系统的质量、刚度发生突变,必需采用非线性方法进行冲击响应分析。将水下发射装置简化为多自由度非线性时变系统,根据牛顿第二定律建立了系统运动方程,其中系统质量、阻尼、刚度及外载荷矩阵均随时间变化,随后基于NewMark直接积分法求解了系统非线性冲击响应。最后给出数值算例,通过比较该方法和有限元建模得到的动力学响应,验证了该方法的准确性,并对系统冲击响应特性进行分析。在此基础上,提出了系统纵向减振器刚度、阻尼参数的优化方法,研究结果为发射装置减振器设计和参数优化提供高效分析手段,具有重要工程意义。

关键词：连射非线性冲击响应直接积分法参数优化

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热毒宁注射液治疗小儿手足口病的疗效观察

中国继续医学教育 2016年第19期8卷 185-186页

作者：董艳鹏张晓河南省南阳市第一人民医院儿三科河南南阳473000

目的观察热毒宁注射液治疗小儿手足口病的临床效果。方法将156例患儿随即分为两组,对照组77例,观察组79例。对照组给予利巴韦林注射液治疗,观察组给予热毒宁注射液治疗。结果观察组治疗总有效率97.46%,高于对照组的77.62%(P<0.05);观察... 详细信息

目的观察热毒宁注射液治疗小儿手足口病的临床效果。方法将156例患儿随即分为两组,对照组77例,观察组79例。对照组给予利巴韦林注射液治疗,观察组给予热毒宁注射液治疗。结果观察组治疗总有效率97.46%,高于对照组的77.62%(P<0.05);观察组的退热时间、疱疹消退时间以及总病程均较对照组短(P<0.05)。结论静脉滴注热毒宁注射液治疗小儿手足口病有显著的临床效果。

关键词：热毒宁注射液小儿手足口病