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Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5723-5731页

作者： Akihiro Yoshihara Kota Nishihama Chisa Inoue Yuko Okano Kazuhito Eguchi Soichiro Tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka yano Department of Diabetes and Endocrinology Japan Community Health care Organization Yokkaichi Hazu Medical CenterYokkaichi 510-0016MieJapan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie UniversityTsu 514-8507MieJapan Department of Immunology Faculty and Graduate School of MedicineMie UniversityTsu 514-8507MieJapan Department of Immunology and Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan

BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare *** with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor *** and coagulopathies have been reported as the cause of ***,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been *** SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric *** analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol *** enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic *** cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine *** Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical *** patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular *** multiple organ infections and thromboses responded well to antimicrobial and anticoagulant *** studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly *** of surgery,antitumor chemotherapy was *** patient was transferred to another hospital to initiate ***,she died four months later due to the rapidly progressive *** ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor ***

关键词： Neuroendocrine tumors Cushing's syndrome Ectopic adrenocorticotropic hormone syndrome Pneumocystis pneumonia Pulmonary embolism Infections Case report

Parallel Tolerance Analysis of a Power Electronic Converter by the Genetic Algorithm with the Island Model

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Parallel Tolerance Analysis of a Power Electronic Converter ...

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

第4届国际电力电子及运动控制国际会议

作者： Toshiji Kato Kaoru Inoue Yuichi yano Shintaro Oshio Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN

＜正＞ It is necessary to consider variations of circuit element values for a power electronic converter design to satisfy a given specification. This analysis is so-called tolerance or worst-case analysis. The analysis is a sort of nonlinear minimum and maximum （min/max） problem with respect to circuit parameters. However its computation cost is large and practically the problem is converted to a simpler and easier one with various techniques. This paper proposes an approximate method which finds a quasi-min/max solution by applying the Genetic Algorithm （GA）. The GA models an evolution process of life forms for an engineering use and it is mainly applied to an optimization problem to utilize its selection process. This paper proposes the GA method which is based on the island model and suitable for the parallel tolerance analysis to find quasi-optimal solutions. Output voltage variations, for example, of a Cuk converter for element parameter variations are analyzed.

关键词： tolerance analysis power converters genetic algorithm parallel processing DGA

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Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

EXTRACELLULAR RELEASE OF β-LACTAMASE BY OSMOTIC SHOCK IN SYNECHOCOCCUS TRANSFORMANT

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Chinese Journal of Oceanology and Limnology 1998年第S1期16卷 105-108页

作者： Shin-ichi yano Yoshikazu Kawata Hiroyuki Kojima(Osaka National Research Institute, Agency of Industrial Science and Technology, Ikeda, Osaka 563, Japan ) 1. Agency of Industrial Science and Technology Osaka National Research Institute 563 Ikeda Osaka Japan

A unicellular cyanobacterium Synechococcus sp. strain PCC 7002 was transformedwith plasmid pQL1, on which β-lactamase gene (bla) and β-galactosidase gene (lacZ) were *** transformant cells released β-lactamase into medium by an abrupt drop of osmotic pressure. This re-sult indicates that this cyanobacterium recognizes and processes the signal sequence of β-lactamase, andaccumulates the enzyme in periplasm. Repeated release of β-lactamase was possible by repeated osmoticshocks without impairing cell viability. On the other hand, most of the β-galactosidase remained in cyto-plasm under the osmotic shock.

关键词： Synechococcus perienzyme β-lactamase osmotic shock

Surgical strategy in case with co-existence of malignant oligodendroglioma and arteriovenous malformation: A case report

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Case Reports in Clinical Medicine 2013年第8期2卷 473-478页

作者： Hirohito yano Noriyuki Nakayama Naoyuki Ohe Toshinori Takagi Jun Shinoda Toru Iwama Chubu Medical Center for Prolonged Traumatic Brain Dysfunction Department of Neurosurgery Kizawa Memorial Hospital Minokamo Japan Department of Neurosurgery Gifu University Graduate School of Medicine Gifu Japan Department of Neurosurgery Gifu University Graduate School of Medicine Gifu Japan

A brain tumor associated with an arteriovenous malformation (AVM) is very rare. A 42-year-old female presented with two separate lesions in her right frontal lobe on MRI. An angiogram diagnosed one of the lesions as an AVM. The second lesion appeared to be a tumor. Tumor removal was difficult due to bleeding from the nearby AVM, necessitating removal of the AVM and allowing complete excision of the tumor. Histopathological analysis revealed the tumor was an anaplastic oligodendroglioma. There was no recurrence of the tumor 5 year after completion of therapy. We discuss the operative strategy in case of synchronous diseases and provide a review of the literature.

关键词： Oligodendroglioma Arteriovenous Malformation Co-Existence

Cases of pediatric intra-abdominal solid organ injury induced by blunt trauma experienced over a 15-year period at two centers in Japan

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World Journal of Pediatric Surgery 2023年第3期6卷 168-174页

作者： Mayu Matsui Koshiro Sugita Takafumi Kawano Nanako Nishida Ayaka Nagano Masakazu Murakami Keisuke yano Toshio Harumatsu Shun Onishi Koji Yamada Waka Yamada Mitsuru Muto Tatsuru Kaji Satoshi Ieiri Department of Pediatric Surgery Kagoshima City HospitalKagoshimaJapan Department of Pediatric Surgery Research Field in Medical and Health SciencesMedical and Dental AreaResearch and Education AssemblyKagoshima UniversityKagoshimaJapan Department of Pediatric Surgery Kurume University School of MedicineKurumeJapan

Objective The present study attempts to clarify the clinical features of pediatric intra-abdominal solid organ injury at two *** The injured organ,patient age,sex,injury grade,imaging findings,intervention,length of hospital stay,and complications were retrospectively reviewed using medical records at two centers from 2007 to *** There were 25 cases of liver injury,9 of splenic injury,8 of pancreatic injury,and 5 of renal *** mean age of all patients was 8.6±3.8 years old,with no difference between organ injury *** intervention was performed in four cases of liver injury(16.0%)and one case of splenic injury(11.1%),and surgery was performed in two cases of liver injury(8.0%)and three cases of pancreatic injury(37.5%).All other cases were treated *** included adhesive ileus in one case of liver injury(4.0%),splenic atrophy in one case of splenic injury(11.1%),pseudocysts in three cases of pancreatic injury(37.5%),atrophy of the pancreatic parenchyma in one case of pancreatic injury(12.5%),and urinoma in one case of renal injury(20.0%).No mortalities were *** Pediatric patients with blunt trauma had favorable outcomes at two pediatric trauma centers covering a broad medical area,including remote islands.

关键词： pediatric trauma injury

Estimation of Three-Dimensional Volumetric Errors of Numerically Controlled Machine Tools by a Tracking Interferometer

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Journal of Mechanics Engineering and Automation 2011年第4期1卷 313-319页

作者： Soichi Ibaraki Kunitaka Takeuchi Tomoaki yano Toshiyuki Takatsuji Sonko Osawa Osamu Sato Department of Micro Engineering Graduate School of Engineering Kyoto University Yoshida-honmachi Sakyo-ku Kyoto606-8501 Japan Fine Manufacturing Systems Group Advanced Manufacturing Research Institute National Institute of Advanced IndustrialScience and Technology Japan National Metrology Institute of Japan National Institute of Advanced Industrial Science and Technology Japan

This paper presents the estimation of three-dimensional volumetric errors of a machining center by using a tracking interferometer. A tracking interferometer is a laser interferometer with the mechanism to steer the laser direction to follow a target retroreflector. Based on the triangulation principle, the three-dimensional position of the target can be estimated from measured laser displacements. Its capability to measure three-dimensional positioning errors for arbitrary trajectories is important for the indirect measurement of the machine＇s kinematic model. This paper presents experimental investigation of the estimation accuracy of the multilateration-based measurement by a tracking interferometer. A tracking interferometer developed by a part of the authors is used in experiments. In the present experiment, the measured volume of target positions was 100 mm × 100 mm × 100 mm. The estimation accuracy of targets within this volume was not sufficiently high compared to the positioning error of the measured machine tool. The results of the experiment and simulation show that the estimation uncertainty is dependent on tracking interferometer locations relative to target locations. Error sensitivity analysis shows that wider distribution of tracker positions in XY improves the estimation accuracy.

关键词： Tracking interferometer laser tracker volumetric errors multilateration machine tools estimation accuracy.

野生植物南山王粗提物对菜青虫的生物活性和光活化作用

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昆虫知识 2005年第2期42卷 196-198页

作者：姚安庆长江大学农学院湖北荆州434025

野生植物南山王 (Celastrussp .)的根茎叶用甲醇、氯仿和石油醚提取 ,并制备干粉。浓度为 0l. 0 1g mL的粗提物对菜青虫PierisrapaeL .的非选择性拒食率达到 61 . 73 %～ 93 . 5 5 % ;用浸渍法测得根的粗提物对菜青虫的光活化比达到 2 ... 详细信息

野生植物南山王 (Celastrussp .)的根茎叶用甲醇、氯仿和石油醚提取 ,并制备干粉。浓度为 0l. 0 1g mL的粗提物对菜青虫PierisrapaeL .的非选择性拒食率达到 61 . 73 %～ 93 . 5 5 % ;用浸渍法测得根的粗提物对菜青虫的光活化比达到 2 5 . 5～ 3 4. 1。南山王根的氯仿提取物活性最高。

关键词：野生植物菜青虫粗提物南山王光活化作用生物活性非选择性 sp. 石油醚拒食率浸渍法提取物氯仿

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湖滨房屋日本山梨

世界建筑导报 2019年第5期34卷 6-9页

作者： Toshiyuki yano Shinichi Ogawa & Associates

这间房屋是一间单层别墅,坐落于山梨县富士山山脚的海滨地区。该地区面朝美丽的湖泊,是个非常迷人的地方。湖泊在微风和阳光的抚摸下泛起丝丝涟漪。湖泊两旁种植了高大的榉树和日本枫树。

关键词：房屋湖滨海滨地区富士山湖泊别墅