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MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer

World Journal of Gastroenterology 2014年第32期20卷 11199-11209页

作者： Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier Cancer Research Center of Toulouse Team 10 UMR INSERM U1037Université Paul Sabatier P?le Digestif Centre Hospitalier Universitaire Toulouse

Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC.

关键词： MicroRNAs Biomarkers Pancreatic cancer Therapeutic targets Precancerous lesions

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Floristic diversity and carbon stocks in the periphery of Deng–Deng National Park,Eastern Cameroon

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Journal of Forestry Research 2020年第3期31卷 989-1003页

作者： Louis Paul Roger Kabelong Banoho Louis Zapfack Robert Bertrand Weladji Cedric Chimi Djomo Melanie Chichi Nyako yannick Enock Bocko Damien Marie Essono Julliete Mancho Nasang Nade`ge Madountsap Tagnang Charles Innocent Memvi Abessolo Kenneth Roger Mvondo Sakouma Farikou Mamadou Souahibou Florence Jeanne Sarah Palla Tonga Ketchatang Peguy Remi Jiagho Thierry Loic Kenmou Ulrich Arnaud Choumele Kana Jumo Boris Armel Anyam Yi Andjik Roger Bruno Tabue Mbobda Department of Plant Biology Faculty of ScienceUniversity of Yaounde IBP 812 YaoundeCameroon IUCN World Commission On Protected Areas Co-Vice Chair Commission Mondiale des Aires Protegees-Afrique Centrale(CMAP-UICN)GlandSwitzerland Organisation pour la Conservation et le Developpement(OCD) BP 33323 YaoundeCameroun Department of Biology Concordia University7141 Sherbrooke St.W.MontrealMontrealQC H4B 1R6Canada Institute of Agricultural Research for Development(IRAD) PO.BOX 2123YaoundeCameroon Laboratoire de Botanique et Ecologie Facultedes Sciences et TechniquesUniversiteMarien NgouabiBrazzavilleCongo Ministry of Forestry and Wildlife BP 34430 YaoundeCameroon Programme National de Developpement Participatif(PNDP) YaoundeCameroun Observatoire des Forets du Bassin du Congo(OFAC) BP 20818 YaoundeCameroun Fokabs International PO BOX 14097YaoundeCameroon International Union for Conservation of Nature Programme CamerounBP:5506 YaoundeCameroun Secretariat Technique REDD BP 320 YaoundeCameroun

Carbon is continuously being removed from the atmosphere by photosynthesis and stored in carbon pools(live,dead,and soil carbon)of forest ***,carbon stock in dead wood and of trees with diameters at breast height(dbh)between 5 and 10 cm is often not considered in many studies carried out in the Congo Basin *** relationship between tree diversity,life-forms and carbon stocks has received little *** study was carried out on the outskirts of Deng Deng National Park(DDNP)to determine tree diversity(dominant families,species richness and Shannon index),assess carbon stocks in the five carbon compartments(living tree,understory,fine roots,dead wood and litter)as well as to analyze the relationship between(1)carbon stocks and tree diversity;and,(2)between carbon stock and *** Shannon index of trees≥10 cm dbh ranged from 2.6 in riparian forest to 4.3 in secondary forest;and for the tree between 5 and 10 cm,it ranged to 1.56 in riparian forest to 3.68 in the secondary *** study site housed 16 species,7 genera and 3 families which are only found in trees of dbh between 5 and 10 *** average total carbon stock of the five compartments varied from 200.1 t ha-1 in forest residues to 439.1 t ha-1 in secondary *** wood carbon stock varied from 1.2 t ha-1 in riparian forests to 12.51t ha-1 in *** above ground carbon stocks for trees with diameter between 5 and 10 cm varied from 0.7 t ha-1 in young fallow fields to 5.02 t ha-1 in old secondary *** study reveals a low but positive correlation between species richness and total carbon stocks,as well as a significant positive relationship between life-forms and total carbon *** findings highlight the need for more data concerning carbon content of dead wood,carbon of trees≥5 cm<10 cm dbh and the relationship between carbon stocks and tree diversity from other areas of the Congo Basin for a good understanding of the contribution of tropical forests

关键词： Deng Deng national park Carbon stocks Land cover types Species diversity Dead wood

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