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Palladium-Catalyzed Intramolecular Dehydrogenative Arylboration of Alkenes

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Chinese Journal of Chemistry 2022年第20期40卷 2437-2444页

作者： Chenchen zou Hongli Wu Yuqi Ji Penglin Zhang Huanhuan Cui Genping Huang Chun Zhang Institute of Molecular Plus Tianjin Key Laboratory of Molecular Optoelectronic ScienceDepartment of ChemistrySchool of ScienceTianjin UniversityTianjin300072 China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin300071 China

The palladium-catalyzed borylative cyclization via C—H activation has been *** this chemistry,the indole-fused dihydro-pyrrole motif,which is a kind of important unit in natural products and bio-active molecules,could be constructed and installed with a boric ester ***,the utilities of products have been illustrated by the study of further ***,by using chiral ligand,the enantioselectivity of this borylative cyclization reaction could be ***,the borylative mechanism,which should proceed through a Pd(II)/Pd(IV)catalytic cycle,has been proposed based on the DFT calculations.

关键词： Palladium Dehydrogenative coupling reaction Indole-fused dihydro-pyrrole Boron

Organic matter pore characteristics of over-mature marine black shale: a comparison of organic fractions with different densities

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Frontiers of Earth Science 2023年第1期17卷 310-321页

作者： Shitan NING Peng XIA Niuniu zou Yi ZHONG Yin YU Yuliang MOU Ke WANG College of Resources and Environmental Engineering Guizhou UniversityGuiyang 500025China Key Laboratory of Karst Georesources and Environment Ministry of Education Guizhou UniversityGuiyang 500025China School of Geosciences China University of PetroleumQingdao 266580China

Organic matter pores are considered to be the most important type of pore for preserving hydrocarbon gases in shale gas *** organic matter in each over-mature marine shale sample was separated into two organic fractions with densities of greater than and less than 1.25 g/cm^(3),and then their molecular compositions and pore characteristics were quantitatively evaluated using solid state 13C-nuclear magnetic resonance(NMR)and gas(N2 and CO_(2))adsorption analyses,*** results revealed that aromatic carbon is the dominant molecular composition of the over-mature organic matter in the Lower Cambrian Niutitang *** the over-mature stage,the organic fractions with densities of greater than and less than 1.25 g/cm^(3) have no significant differences in molecular *** organic fractions with densities of greater than and less than 1.25 g/cm^(3) do have significant differences in their organic pore *** contrast to the high density organic fraction,the low density fraction contained abundant micropores and lacked mesopores and *** organic pore structures of the different occurrence states of organic matter were significantly *** C/O of organic matter in different occurrence states are obviously different,which proves that the organic pore structure is closely related to both the occurrence state and density of the organic ***,these relationships are still unclear and require further study.

关键词： pore characteristics organic matter black shale Early Cambrian Yangtze Block

Estimation of Shallow Landslide Susceptibility Incorporating the Impacts of Vegetation on Slope Stability

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International Journal of Disaster Risk Science 2023年第4期14卷 618-635页

作者： Hu Jiang Qiang zou Bin Zhou Yao Jiang Junfang Cui Hongkun Yao Wentao Zhou Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and Environment(IMHE)Chinese Academy of Sciences(CAS)Chengdu 610041China China-Pakistan Joint Research Center on Earth Sciences Islamabad 45320Pakistan University of Chinese Academy of Sciences Beijing 100049China

This study aimed to develop a physical-based approach for predicting the spatial likelihood of shallow landslides at the regional scale in a transition zone with extreme *** landslide susceptibility study in an area with diverse vegetation types as well as distinctive geographic factors(such as steep terrain,fractured rocks,and joints)that dominate the occurrence of shallow landslides is *** article presents a novel methodology for comprehensively assessing shallow landslide susceptibility,taking into account both the positive and negative impacts of *** includes considering the positive efects of vegetation canopy interception and plant root reinforcement,as well as the negative efects of plant gravity loading and preferential fow of root *** approach was applied to simulate the regional-scale shallow landslide susceptibility in the Dadu River Basin,a transition zone with rapidly changing terrain,uplifting from the Sichuan Plain to the Qinghai–Tibet *** research fndings suggest that:(1)The proposed methodology is efective and capable of assessing shallow landslide susceptibility in the study area;(2)the proposed model performs better than the traditional pseudo-static analysis method(TPSA)model,with 9.93%higher accuracy and 5.59%higher area under the curve;and(3)when the ratio of vegetation weight loads to unstable soil mass weight is high,an increase in vegetation biomass tends to be advantageous for slope *** study also mapped the spatial distribution of shallow landslide susceptibility in the study area,which can be used in disaster prevention,mitigation,and risk management.

关键词： Physical-based model Qinghai-Tibet Plateau Shallow landslide Susceptibility analysis Vegetation effect

基于YOLOv7网络的废弃塑料瓶颜色智能分选系统研究

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林业机械与木工设备 2024年第3期52卷 43-49页

作者：倪瑞涛邹红艳倪超朱瑞林南京林业大学机械电子工程学院江苏南京210037

由于分拣环境中塑料瓶形状、颜色多样,人工提取的特征往往存在着主观性,可能丢失重要的信息或特征之间的复杂关系,从而导致塑料瓶分类效果差等问题,研究提出了一种基于卷积神经网络的废弃塑料瓶颜色分选系统。收集了市面上常见的塑料瓶... 详细信息

由于分拣环境中塑料瓶形状、颜色多样,人工提取的特征往往存在着主观性,可能丢失重要的信息或特征之间的复杂关系,从而导致塑料瓶分类效果差等问题,研究提出了一种基于卷积神经网络的废弃塑料瓶颜色分选系统。收集了市面上常见的塑料瓶,使用工业相机采集图像,使用labelimg进行人工标注制作数据集,通过数据增强来增扩数据集,提高训练模型的鲁棒性。利用YOLOv7卷积神经网络模型进行颜色分类的检测识别,使用喷阀筛选目标颜色的塑料瓶。实验表明,实时检测准确率高达95.7%,具有高度自动化和智能化水平,在回收行业中具有较高的应用价值。

关键词：颜色分类废弃塑料瓶 YOLOv7 智能分类

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Click chemistry-based enrichment strategy for tracing cellular fatty acid metabolism by LC-MS/MS

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1221-1231页

作者： Ru-Jie Yang Jian zou Jia-Yue Liu Jiang-Kun Dai Jian-Bo Wan State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR999078China

Fatty acids(FAs),which were initially recognized as energy sources and essential building blocks of biomembranes,serve as the precursors of important signaling *** FA metabolism is essential to understanding the biochemical activity and role of FAs in physiological and pathological *** by the advances in click chemistry for protein enrichment,we herein established a click chemistry-based enrichment(CCBE)strategy for tracing the cellular metabolism of eicosapentaenoic acid(EPA,20:5 n-3)in neural *** alkyne-labeled EPA(EPAA)used as a surrogate was incubated with N2a,mouse neuroblastoma cells,and alkyne-labeled metabolites(ALMs)were selectively captured by an azide-modified resin via a Cu(I)-catalyzed azide-alkyne cycloaddition reaction for *** removing unlabeled metabolites,ALMs containing a triazole moiety were cleaved from solid-phase resins and subjected to liquid chromatography mass spectrometry(LC-MS)*** proposed CCBE strategy is highly selective for capturing and enriching alkyne-labeled metabolites from the complicated *** addition,this method can overcome current detection limits by enhancing MS sensitivity of targets,improving the chromatographic separation of sn-position glycerophospholipid regioisomers,facilitating structural characterization of ALMs by a specific MS/MS fragmentation signature,and providing versatile fluorescence detection of ALMs for cellular *** CCBE strategy might be expanded to trace the metabolism of other FAs,small molecules,or drugs.

关键词： Click chemistry-based enrichment EPA metabolism Terminal alkyne-labeled EPA Azide-modified resin LC-MS/MS

超声改性甲壳素吸附水产品加工副产物中脂溶性维生素的作用效果研究

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食品安全质量检测学报 2024年第4期15卷 114-121页

作者：赵宝鼎杨约萍邹小雨宋茹浙江海洋大学食品与药学学院舟山316022

目的探讨超声改性甲壳素(ultrasonic modified chitin,UM-C-chitin)对水产品加工副产物中脂溶性维生素的吸附效果。方法商品甲壳素(commercial chitin,C-chitin)经超声法改性,采用扫描电镜观察甲壳素改性前后微观形貌,傅里叶变换红外光... 详细信息

目的探讨超声改性甲壳素(ultrasonic modified chitin,UM-C-chitin)对水产品加工副产物中脂溶性维生素的吸附效果。方法商品甲壳素(commercial chitin,C-chitin)经超声法改性,采用扫描电镜观察甲壳素改性前后微观形貌,傅里叶变换红外光谱和X射线衍射分析甲壳素改性前后的官能团和衍射峰变化,检测UM-C-chitin对水产品加工副产物中脂溶性维生素(维生素A、维生素D和维生素E)静态吸附效果。结果C-chitin经超声处理后微观结构由致密向疏松转变,并伴有无规则孔道及小孔形成,UM-C-chitin的酰胺I基团含有与α-型甲壳素相关的1665cm^(-1)特征峰,但是1624cm^(-1)处特征峰强度减弱接近消失,X射线衍射分析中UM-C-chitin在9.18°、12.68°、19.12°、23.04°和26.16°处有α-型甲壳素特征衍射峰,但各衍射峰强度较C-chitin的出现不同程度降低。与C-chitin相比较,UM-C-chitin对水产品加工副产物中维生素E的吸附效果较好(P<0.05),吸附量达到6.10μg/mg,较C-chitin的提高了84.8%。结论超声改性会降低C-chitin的结晶度,形成的无规则孔道及小孔结构有助于提高维生素E的负载量。本研究为快速富集水产品加工副产物中脂溶性维生素,特别是维生素E提供了技术依据。

关键词：甲壳素超声改性结构表征水产品加工副产物脂溶性维生素吸附

Potential role of long noncoding RNA RP5-881L22.5 as a novel biomarker and therapeutic target of colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2108-2121页

作者： Hua Zong Jian-Qiang zou Jian-Peng Huang Shi-Ting Huang Department of Gastrointestinal Surgery The Third People’s Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina

BACKGROUND The incidence of colorectal cancer in humans is high,and it is in the top five for cancer-related morbidity and *** is one of the main threats to human *** function of long noncoding RNAs in tumor occurrence and development has gradually gained attention in recent *** increasing numbers of studies,researchers have demonstrated that it plays an important role in the pathogenesis of colorectal *** To find out if long noncoding RNA RP5-881L22.5 played a role in the pathogenesis of colorectal cancer in relation to the tumor *** We analyzed the transcriptome data and clinical data in The Cancer Genome Atlas-colon *** CIRBERSORT algorithm was applied to evaluate these tumor-infiltrating immune cells in The Cancer Genome Atlas-colon adenocarcinoma cancer tissue *** the“estimate”package in R,we assessed the tumor immune *** expression level of RP5-881L22.5 in tumor tissue and adjacent normal tissue samples from 4 pairs of colorectal cancer patients was determined by quantitative reverse transcription *** cancer cells were tested for invasiveness using a transwell invasion assay after RP5-881L22.5 expression was knocked *** The expression of lncRNA RP5-881L22.5 was related to the clinical characteristics of the tumors,and it was negatively related to the infiltration level of immune cells in the tumor microenvironment and the expression of T cell inhibitory receptors.A major function of its coexpressed mRNA was to regulate tumor immunity,such as the immune *** quantitative reverse transcription PCR was performed on tumor tissues from 4 pairs of colorectal cancer patients,the results showed that RP5-881L22.5 was highly ***,knocking down the expression of RP5-881L22.5,the invasiveness of colorectal cancer cell lines was reduced,and the apoptosis rate was *** RP5-881L22.5 plays a crucial role in the microenvironm

关键词： Colorectal cancer Long noncoding RNA RP5-881L22.5 Tumor immune microenvironment Biomarker Therapeutic target

Development of the Self-doping Porous Carbon and Its Application in Supercapacitor Electrode

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Chemical Research in Chinese Universities 2022年第4期38卷 1065-1072页

作者： YANG Zhichen KANG Xiaoting zou Bo YUAN Xuna LI Yajie WU Qin GUO Yupeng College of Chemistry Jilin UniversityChangchun130012P.R.China

The massive discharge of biomass wastes not only causes waste of resources,but also pollutes the ***,converting biomass wastes into carbon materials is an effective way to solve the above ***,using biomass waste pig nails as raw materials and K_(2)CO_(3) as chemical activators,the N-doped porous carbon(KPNC)is prepared by direct *** an electrode for supercapacitors,the electrochemical tests of KPNCs showed that they exhibited good electrochemical performance and excellent cycling *** the current density is 0.2 A/g,the specific capacitance is up to 344.6 F/***,it still maintains 97.6%initial capacitance retention after 2000 cycles at a high current density of 5 A/*** exceptional electrochemical performances may be ascribed to an appropriate porous structure(Smicro/Stotal=80.31%,Vmicro/Vtotal=76.19%),high nitrogen contents(4.44%,atomic fraction),oxygen contents(9.13%,atomic fraction)as well as small internal *** above experimental results show that the conversion of pig nails to porous carbon can reduce the waste of resources and alleviate environmental pollution.

关键词： Supercapacitor Porous carbon Biomass waste Heteroatom doping Electrochemical performance

苦参碱对神经母细胞瘤细胞增殖、迁移和侵袭的影响

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中国临床药理学杂志 2024年第14期40卷 2048-2052页

作者：刘南京王冬娟刘方杰黄文霞邹琳何晓燕重庆医科大学附属儿童医院临床分子医学检测中心国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆400014 重庆大学附属肿瘤医院肿瘤转移与个体化诊治转化研究重庆市重点实验室重庆400030

目的观察苦参碱对人神经母细胞瘤细胞增殖、迁移和侵袭的影响,探讨其可能的分子机制。方法实验分为AS实验组(SK-N-AS细胞给予IC50浓度的苦参碱)、AS空白组(SK-N-AS细胞正常培养)、AS对照组(SK-N-AS细胞加入等量二甲基亚砜处理)和DZ实验... 详细信息

目的观察苦参碱对人神经母细胞瘤细胞增殖、迁移和侵袭的影响,探讨其可能的分子机制。方法实验分为AS实验组(SK-N-AS细胞给予IC50浓度的苦参碱)、AS空白组(SK-N-AS细胞正常培养)、AS对照组(SK-N-AS细胞加入等量二甲基亚砜处理)和DZ实验组(SK-N-DZ细胞给予IC50浓度的苦参碱)、DZ空白组(SK-N-DZ细胞正常培养)、DZ对照组(SK-N-DZ细胞加入等量二甲基亚砜处理)。用划痕实验和Transwell小室检测苦参碱对各组细胞迁移和侵袭能力的影响,用蛋白质印迹法检测苦参碱对各组细胞中E-钙黏蛋白(E-cadherin)、N-钙黏蛋白(N-cadherin)和波形蛋白(Vimentin)蛋白表达的影响。结果各实验组不同干预后,AS空白组、AS对照组、AS实验组、DZ空白组、DZ对照组和DZ实验组的迁移百分率分别为(66.32±3.12)%、(65.27±3.44)%、(23.73±0.79)%、(46.25±4.68)%、(44.15±5.60)%和(16.77±3.52)%,侵袭细胞数分别为(870.45±19.32)、(865.32±23.39)、(492.74±16.81)、(1198.10±43.71)、(1203.03±71.91)和(891.69±42.62)个,E-cadherin蛋白表达水平分别为(100.00±11.72)%、(105.65±13.11)%、(477.20±29.71)%、(100.00±12.54)%、(97.78±12.77)%和(240.53±12.23)%,N-cadherin蛋白表达水平分别为(100.00±15.44)%、(103.90±10.76)%、(43.52±9.96)%、(100.00±10.12)%、(104.95±10.49)%和(38.39±8.70)%,Vimentin蛋白表达水平分别为(100.00±9.51)%、(97.39±11.33)%、(59.13±10.25)%、(100.00±13.20)%、(96.27±11.01)%和(47.67±9.48)%。AS实验组的上述指标与AS空白组比较,在统计学上差异有统计学意义(P<0.01、P<0.001),DZ实验组的上述指标与DZ空白组比较,在统计学上差异有统计学意义(P<0.01、P<0.001)。结论苦参碱抑制人神经母细胞瘤SK-N-AS和SK-N-DZ细胞增殖、迁移和侵袭,其机制可能与抑制上皮间质转化有关。

关键词：苦参碱神经母细胞瘤迁移侵袭上皮间质转化