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An Assisted Diagnosis of Alzheimer’s Disease Incorporating Attention Mechanisms Med-3D Transfer Modeling

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Computers, Materials & Continua 2024年第1期78卷 713-733页

作者： yanmei Li Jinghong Tang Weiwu Ding Jian luo Naveed Ahmad Rajesh Kumar School of Artificial Intelligence Chongqing University of TechnologyChongqing400054China Computer School China West Normal UniversityNanchong637009China Department of Computer Science Prince Sultan UniversityRiyadh11586Saudi Arabia Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China

Alzheimer’s disease(AD)is a complex,progressive neurodegenerative *** subtle and insidious onset of its pathogenesis makes early detection of a formidable challenge in both contemporary neuroscience and clinical *** this study,we introduce an advanced diagnostic methodology rooted in theMed-3D transfermodel and enhanced with an attention *** aim to improve the precision of AD diagnosis and facilitate its early ***,we employ a spatial normalization technique to address challenges like clarity degradation and unsaturation,which are commonly observed in imaging ***,an attention mechanism is incorporated to selectively focus on the salient features within the imaging *** upon this foundation,we present the novelMed-3D transfermodel,designed to further elucidate and amplify the intricate features associated *** proposedmodel has demonstrated promising results,achieving a classification accuracy of 92%.To emphasize the robustness and practicality of our approach,we introduce an adaptive‘hot-updating’auxiliary diagnostic *** system not only enables continuous model training and optimization but also provides a dynamic platform to meet the real-time diagnostic and therapeutic demands of AD.

关键词： Alzheimer’s disease channel attention Med-3D hot update

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耐高温有机硅树脂示温涂层的制备

空天防御 2024年第3期7卷 79-85页

作者：罗艳梅刘江峰窦怡彬王文芳刘陆广许斌钟正祥哈尔滨工业大学化工与化学学院黑龙江哈尔滨150001 上海机电工程研究所上海201109

近年来,我国的航空航天事业发展迅猛,由此对发动机涡轮机、燃烧室等高温部件的温度及分布测试提出了更高要求,其中示温漆受到广泛关注。为了解决我国航空发动机等高热部件温度测量问题,需要进一步提高示温漆的变色温度上限和显色性能。... 详细信息

近年来,我国的航空航天事业发展迅猛,由此对发动机涡轮机、燃烧室等高温部件的温度及分布测试提出了更高要求,其中示温漆受到广泛关注。为了解决我国航空发动机等高热部件温度测量问题,需要进一步提高示温漆的变色温度上限和显色性能。本文选用正硅酸乙酯(TEOS)、二苯基二甲氧基硅烷(DMDPS)、三甲基氧基苯基硅烷(TMPS)为原料制备TEOS杂化甲基苯基硅树脂(SR),通过调节TEOS与DMDPS比例提高树脂的柔韧性;采用七异丁基三硅羟基多面体低聚倍半硅氧烷(POSS)对所制备的增韧SR进行改性,制备出一种兼具韧性和耐高温性且可室温固化的杂化有机硅树脂,其在500℃残重达82%。选择新胭脂红、三氧化钨、三氧化二铬、氧化铁、硅酸铝等为颜料,锆英粉和三氧化硼为耐高温填料,无水乙醇为溶剂,与制备的耐高温有机硅树脂混合研磨制备耐高温示温漆,分别研究其在400、500、800、900、1000、1150及1300℃时的显色效果及显色机制。研究表明,所制备的示温漆工艺、耐高温、显色等性能较为优异,具有高温部件测温的潜能。

关键词：不可逆高温示温漆正硅酸乙酯(TEOS)杂化甲基苯基有机硅树脂多面体低聚倍半硅氧烷(POSS)改性热致变色

Genome-wide detection of additional fetal chromosomal abnormalities by cell-free DNA testing of 15,626 consecutive pregnant women

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Science China(Life Sciences) 2019年第2期62卷 215-224页

作者： Hong Yao Ya Gao Jia Zhao Rong Zhang Huixin Xu Huamei Hu yanmei luo Yuying Yuan Meili Fu Hongyun Zhang Hui Jiang Wei Wang Huanming Yang Jian Wang Zhiqing Liang Fang Chen Department of Gynecology & Obstetrics Southwest Hospital the Third Military Medical University BGI-Shenzhen China National GeneBank BGI-Shenzhen Birth Defect Screening Project Lab BGI-Shenzhen Clinical laboratories of BGI Health BGI-Shenzhen James D.Watson Institute of Genome Sciences Laboratory of Genomics and Molecular Biomedicine Department of Biology University of Copenhagen

Cell-free DNA(cfDNA) testing for common fetal trisomies(T21, T18, T13) is highly effective. However, the usefulness of cfDNA testing in detecting other chromosomal abnormalities is unclear. We evaluated the performance of cfDNA testing for genome-wide abnormalities, and analyzed the incremental yield by reporting extra abnormalities. We performed genome-wide cfDNA testing in 15,626 consecutive pregnancies prospectively enrolled in this study. cfDNA testing results were reported and counseling was given depending on the presence of extra chromosomal abnormalities. cfDNA testing identified 190 cases(1.2%)of chromosomal abnormalities including 100 common trisomies and 90 additional abnormalities. By expanding the cfDNA reporting range to genome-wide abnormalities, the false positive rate increased to 0.39%(P<0.001) and positive predictive value(PPV) was reduced to 65.58%(P=0.42). However, the detection yield increased from 0.44% to 0.65%(P=0.014), and cfDNA testing detected 38.61%(39/101) additional abnormalities with no ultrasound and biochemical screening findings. cfDNA testing outperformed biochemical screening by showing 60 times higher true positive rate and fewer false negative ***-wide cfDNA testing significantly increased the diagnostic yield by detecting extra abnormalities, especially those without diagnostic indications. Genome-wide cfDNA testing has fewer false positive and false negative results compared with biochemical screening.

关键词： cell-free DNA genome-wide chromosomal abnormalities sensitivity specificity PPV

员工薪酬激励、知识能力与内部控制质量——来自中国制造业上市公司的经验证据

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南京审计大学学报 2020年第5期17卷 51-60页

作者：罗艳梅黑龙江大学经济与工商管理学院黑龙江哈尔滨150080

在“中国制造2025”国家战略政策指引下,以提升制造业高质量发展为目标,选取2012-2018年中国制造业A股上市公司为样本,基于员工视角实证检验员工薪酬激励、知识能力特征对内部控制质量的影响。结果表明:员工薪酬激励水平越高,内部控制... 详细信息

在“中国制造2025”国家战略政策指引下,以提升制造业高质量发展为目标,选取2012-2018年中国制造业A股上市公司为样本,基于员工视角实证检验员工薪酬激励、知识能力特征对内部控制质量的影响。结果表明:员工薪酬激励水平越高,内部控制质量越好,与东部经济发达地区相比,中西部地区的效果更为明显;员工知识能力越高,内部控制质量越好。从内部控制五要素来看,员工薪酬激励及知识能力特征在提升控制环境和信息与沟通方面发挥重要作用。相对于劳动密集型制造企业,资本密集型与技术密集型制造企业员工的知识能力在内部控制中发挥的积极作用更为显著。

关键词：员工薪酬激励员工知识能力内部控制质量制造业上市公司地区差异知识经济人力资本

Fetal Seroperitoneum associated with Kabuki syndrome: a case report

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Fetal Seroperitoneum associated with Kabuki syndrome: a case...

Submicroscopic familial duplication at 18q22.3 without phenotypic effect

第十一届全国遗传病诊断与产前诊断学术交流会暨第二届海峡两岸医药卫生交流协会遗传与生殖专业委员会年会

作者： Pan Yan Ma Yongyi Xu Gang Hu Huamei luo yanmei Yao Hong The First Affiliated Hospital of Army Medical University

Background: Kabuki syndrome(KS) is a rare multiple congenital anomaly *** are a few reports of fetal ultrasonography indicating seroperitoneum, Here we report a case with Seroperitoneum in the womb. Whole exome sequencing(WES) of the fetu was proved to be Kabuki syndrome with heterozygous mutations in KMT2 D *** presentation: A pregnant woman after in-vitro fertilization(IVF), At the 26 weeks gestation age the fetus was found multiple congenital anomaly by ultrasonography including seroperitoneum. She was offered an amniocentesis *** chromosome karyotyping and single nucleotide polymorphims(SNP) were proved to be normal, but whole exome sequencing(WES) found heterozygous mutations of KMT2 D gene. The case was diagnosed to be Kabuki ***: From this case, we can learn that fetal seroperitoneum can be revealed to Kabuki syndrome, and the whole exome sequencing(WES) has good value in prenatal diagnosis.

关键词： Kabuki syndrome KMT2D Whole exome sequencing(WES) Retroperitoneum

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Submicroscopic familial duplication at 18q22.3 without pheno...

Switching Behavior of Cascode GaN Under Influence of Gate Driver

第十一届全国遗传病诊断与产前诊断学术交流会暨第二届海峡两岸医药卫生交流协会遗传与生殖专业委员会年会

作者： Huamei Hu Yongyi Ma yanmei luo Rong Zhang Juchun Xu Hong Yao Department of Gynecology and Obstetrics Southwest Hospital

Background: Recent development of single nucleotide polymorphism array(SNP array) technology allows detection of a wide range of new submicroscopic abnormalities. Publishing new cases and case reviews associated with both clinical abnormalities and a normal phenotype is of great ***/results: We report two phenotypically normal families with microduplication of 18 q22. One was maternal origin and the other was patrilinealorigin. Both abnormalities were found by SNP *** 1: In 2013, the pregnant women choosed the non-invasive prenatal screening tests(NIPTs), when 14 weeks it revealed that a suspicious 2.7-Mb duplication in18 q22.3. Using high-resolution SNP array analysis, we identified the fetus have a2.36-Mb microduplication in 18 q22.3(chr18: 70,476,039-72,845,315) on uncultured amniocytes. Its mother was confirmed to have the same abnormalities by SNP *** fetus were born and was healthy with normal intellectuality and phenotype at two-year-old follow-up. The woman was pregnant again, and the amniotic fluid puncture prenatal diagnosis was due to an abnormal NT value,in 2016. Her second child also inherited the 2.41-Mb microduplication in 18 q22.3(chr18:70,463,682-72,869,656) with normal phenotype at one-year-old *** 2: Because of the age ≥35 years old, the pregnant women choose *** fetus carried a patrilineal-inherited 1.76-Mb microduplication of chromosome18 q22.3(chr18:70,348,272-72,103,197).We used the HumanCytoSNP-12 array of Illumina to visualize the CNVs and map the ***: We suggest that a CNV at 18 q22.3 microduplication may represent a new benign euchromatic variant.

关键词： 18q22.3 genomic SNP array CNV prenatal diagnosis

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1816-1833页

作者： Bin luo Guangzhao luo Sihai Li School of Automation Northwestern Polytechnical UniversityXi’an 710072China

With high-frequency,low power dissipation and high-efficiency characteristics,Gallium nitride(GaN)power devices are of significant benefit in designing high-speed motor drives,as they improve performance and reduce ***,due to the cascode structure,coupling with the parasitics in gate driver and power circuits,power converters based on cascode GaN are prone to overshoot and oscillate on switching waveforms,which may lead to serious EMC problems,or even device *** complicated structure of cascode GaN device makes the gate driver design comparatively *** analytical model of the switching process considering gate driver parameters is proposed in this *** influence of gate driver parameters on switching behavior is investigated from the perspective of switching speed,waveform overshoot,and power ***-offs among overshoot,switching speed,and power loss are discussed;guidelines to design gate driver parameters are given.

关键词： Gallium nitride(GaN) gate driver oscillation and overshoot switching characteristics

双重委托代理关系下的内部审计实验研究——角色冲突、权力配置与内部审计行为

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管理评论 2014年第11期26卷 201-208页

作者：罗艳梅程新生黑龙江大学经济与工商管理学院南开大学中国公司治理研究院南开大学商学院

内部审计服务于不同主体承担多种任务所产生的角色冲突是影响内部审计行为的重要因素。本文以内部审计双重委托代理关系为背景,借鉴角色冲突理论,构建角色冲突的实验环境,模拟董事长、总经理与内审经理之间的关系,揭示不同权力配置下,... 详细信息

内部审计服务于不同主体承担多种任务所产生的角色冲突是影响内部审计行为的重要因素。本文以内部审计双重委托代理关系为背景,借鉴角色冲突理论,构建角色冲突的实验环境,模拟董事长、总经理与内审经理之间的关系,揭示不同权力配置下,角色冲突对内部审计治理和管理两种活动的影响。研究发现内部审计治理功能和管理功能的实现受到角色冲突与两种任务领导人权力配置交互作用的制约。

关键词：内部审计角色间冲突角色内冲突权力配置

Large language model and domain-specific model collaboration for smart education

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 333-341页

作者： Yawei luo Yi YANG School of Software Technology Zhejiang UniversityNingbo 315048China College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China

In this paper,we introduce the large language model and domain-specific model collaboration(LDMC)framework designed to enhance smart *** LDMC framework leverages the comprehensive and versatile knowledge of large domain-general models,combines it with the specialized and disciplinary knowledge from small domainspecific models(DSMs),and incorporates pedagogy knowledge from learning theory *** integration yields multiple knowledge representations,fostering personalized and adaptive educational *** explore various applications of the LDMC framework in the context of smart education.

关键词： smart language knowledge