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Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes

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Cellular & Molecular Immunology 2022年第8期19卷 944-956页

作者： Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu yanme wenyue zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu Department of Pediatrics and Adolescent Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARPR China The First Affliated Hospital Faculty of Medical ScienceJinan UniversityGuangzhou 510632 GuangdongPR China Zhuhai Precision Medical Center Zhuhai People's Hospital(Zhuhai Hospital Affliated with Jinan University)Jinan UniversityZhuhai 519000 GuangdongPR China The Biomedical Translational Research Institute Jinan UniversityGuangzhou 510632 GuangdongPR China GuangDong 999 Brain Hospital Guangzhou CityGuangdong ProvincePR China Department of Endocrinology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180PR China Computational and Systems Biology Interdepartmental Program University of CaliforniaLos AngelesLos AngelesCA 90095USA

Patients with type 2 diabetes mellitus(T2DM)have an increased risk of *** effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain ***,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in ***,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T *** results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance.

关键词： γδT cells Glucose metabolism Tumor surveillance Lactate AMPK T2DM

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基于GAN-DCNN的树叶识别

林业科学 2024年第4期60卷 40-51页

作者：徐竞怡张志闫飞张雯悦北京林业大学精准林业北京市重点实验室北京100083 中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 中国科学院大学北京101408 商汤科技研究院北京100039

【目的】利用深度学习进行树叶识别时需要大量训练样本,当样本量不足、图像风格单一会导致识别准确率不稳定。研究利用少量的样本进行树叶图像增殖和风格转换,可极大减轻数据采集的负担,为提升林业调查信息化、智能化提供有效的技术手... 详细信息

【目的】利用深度学习进行树叶识别时需要大量训练样本,当样本量不足、图像风格单一会导致识别准确率不稳定。研究利用少量的样本进行树叶图像增殖和风格转换,可极大减轻数据采集的负担,为提升林业调查信息化、智能化提供有效的技术手段和理论支撑。【方法】采集6种树种的树叶图像建立数据集,引入light-weight GAN对图像进行增殖和风格转换,扩充人工拍摄的树叶数据集,通过在该数据集与原数据集上分别应用AlexNet、GoogLeNet、ResNet34和ShuffleNetV2四种深度卷积神经网络进行训练,分析生成对抗网络的图像增殖技术在树叶识别中的作用。综合模型准确率和训练时间等性能指标选择最优模型,同时对模型的学习率进行调整。使用测试样本对参数优化后的模型进行验证,分析该方法在实践中的可行性和意义。【结果】基于生成对抗网络生成的样本具有高清晰度,高保真性,能够有效地辅助神经网络模型的训练工作,同时也丰富了样本类别,使之获得包含更多不同季节、形状、健康状况的树叶图像。与原始数据集相比,AlexNet、GoogLeNet、ResNet34和ShuffleNetV2四种网络在新数据集的训练上均表现出训练误差更小、验证精度更高的特点,其中学习率为0.01的ShuffleNetV2模型对该数据集的训练效果最好,训练时最高验证精度为99.7%。使用未参与训练的测试样本对该模型进行验证,模型对各树叶的识别效果较好,模型的总体识别准确率高达99.8%。与未使用GAN技术的普通深度卷积神经网络相比,本文提出的模型对树叶识别准确率明显提升。【结论】生成对抗网络可以有效地扩充图像数量,对图像进行风格转换,与深度卷积神经网络相结合,可以显著提高树叶识别准确率,适合应用于林业树叶识别领域。

关键词：树叶识别生成对抗网络深度卷积神经网络

Half-precessional cycle revealed by environment magnetism of stalagmite in Shizhu Cave from southwestern China during the Last Glacial

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Journal of Earth Science 2024年

作者： Huihui Yang Yu-Min Chou Xiuyang Jiang wenyue Xia Hai Li Yi Zhong Jingyu zhang Yaoqi He Tsai-Luen Yu Qingsong Liu Chuan-Chou Shen College of Tourism and Air Service， Guizhou Minzu University Research Center for Future Earth， Taiwan University Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) School of Environment， Harbin Institute of Technology High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC)， Department of Geosciences， Taiwan University Key Laboratory of Humid Subtropical Eco-Geographical Processes， College of Geography Science， Fujian Normal University Center for Marine Magnetism (CM2)， Department of Ocean Science and Engineering， Southern University of Science and Technology

The environmental magnetic proxies of stalagmites hold significant potential for reconstructing regional hydroclimate changes by revealing the content and grain size of magnetic particles within stalagmites. In this study， we present the contents and grain sizes of magnetic particles within a stalagmite SZ-1， from Shizhu Cave in southwestern China from 70.4 to 22.3 thousand years ago (ka) during the last glacial period. Specifically， the parameters IRMsoft， soil-derived magnetic minerals， and ARM/SIRM (anhysteretic remanent magnetization/saturation isothermal remanent magnetization)， the ratio of fine magnetic particles to total ferrimagnetic particles preserved in stalagmite SZ-1， indicate the fluctuation of regional precipitation. Obvious half-precessional cycles are evident in these two proxies， indicating that hydroclimatic variations in southwestern China may predominantly arise from the heat and moisture transported from tropical oceans. These variations are likely influenced by shifts in the Intertropical Convergence Zone and fluctuations in the Asian summer monsoon.

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基于视觉吸引的森林景观色彩要素识别及影响因素研究——以云南轿子山自然保护区为例

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西部林业科学 2024年第2期53卷 133-141页

作者：林文月王锦张喆西南林业大学园林园艺学院云南昆明650224

为探究影响森林景观视觉吸引力的色彩要素以及提升森林景观视觉质量的色彩营造途径,采用视觉行为实验对云南轿子山四季森林色彩景观视觉吸引力进行评估,从色彩组成与空间构成两方面进行森林色彩特征分析,基于色彩特征要素与公众视觉行... 详细信息

为探究影响森林景观视觉吸引力的色彩要素以及提升森林景观视觉质量的色彩营造途径,采用视觉行为实验对云南轿子山四季森林色彩景观视觉吸引力进行评估,从色彩组成与空间构成两方面进行森林色彩特征分析,基于色彩特征要素与公众视觉行为构建视觉吸引力评价模型,并分析影响景观视觉吸引力的色彩要素最佳阈值。结果表明:(1)轿子山森林四季色彩呈多样化特点,色相在红色、黄色、绿色、蓝色和蓝紫色中均有涉及。景观色谱集中在选择性色谱与点缀性色谱。(2)公众视觉注意力和焦点随着森林景观的色彩变化而改变。春、夏、秋三季森林景观更能引起公众视觉关注。(3)春季的红色、蓝紫色等彩色相是影响色彩景观视觉吸引力的主要因素;秋季的色彩要素组成与斑块空间构成共同影响色彩景观视觉吸引力;冬季的森林色彩景观,视觉吸引力与绿色相密切相关。研究结论可为森林景观高品质视景营造提供理论依据。

关键词：景观视觉吸引森林色彩眼动色彩阈值轿子山自然保护区

Diatomic Pd catalyst with conjugated backbone for synergistic electrochemical CO_(2)reduction

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Nano Research 2024年第6期17卷 4850-4855页

作者： Wenxuan zhang Mengran zhang Hongjuan Wang Wen zhang Min zhang MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China

Double-site catalysts have attracted widespread attention in the field of electrocatalysis due to their high metal loading,adjustable active centres,and electronic valence ***,the development of bimetallic sites catalysts that coordinate with definite atoms is still in the exploratory ***,we designed and synthesized a bimetallic palladium complex(BPB-Pd_(2))with conjugated *** supported BPB-Pd_(2)was applied to electrochemical CO_(2)reduction reaction(CO_(2)RR)for the first *** as-obtained BPB-Pd_(2)gives an exceptional Faradaic efficiency of CO(FECO)of 94.4%at−0.80 V *** hydrogen electrode(RHE),which is significantly superior to monoatomic palladium catalyst(BPB-Pd1).The density functional theory(DFT)calculations revealed that the essential reason for the outstanding activity of BPB-Pd_(2)toward CO_(2)RR was that the electronic effect between diatomic palladium reduces the free energy change for CO_(2)RR ***,BPB-Pd_(2)exhibits moderate free energy change to form COOH*intermediate,which was beneficial for the generation of CO in CO_(2)RR.

关键词： synthesis electrocatalysis CO_(2)reduction bimetallic palladium complex synergistic catalysis

N-doped graphene quantum dot-decorated N-TiO2/P-doped porous hollow g-C_(3)N_(4) nanotube composite photocatalysts for antibiotic photodegradation and H2 production

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 165-178页

作者： Jingshu Yuan Yao zhang Xiaoyan zhang Junjie zhang Shen’gen zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Xi’an Fanyi University Xi’an 710105China Shunde Graduate School of University of Science and Technology Beijing Foshan 528399China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao SAR 820000China

Exclusive responsiveness to ultraviolet light (~3.2 eV) and high photogenerated charge recombination rate are the two primary drawbacks of pure TiO_(2). We combined N-doped graphene quantum dots (N-GQDs), morphology regulation, and heterojunction construction strategies to synthesize N-GQD/N-doped TiO_(2)/P-doped porous hollow g-C_(3)N_(4) nanotube (PCN) composite photocatalysts (denoted as G-TPCN). The optimal sample (G-TPCN doped with 0.1wt% N-GQD, denoted as 0.1% G-TPCN) exhibits significantly enhanced photoabsorption, which is attributed to the change in bandgap caused by elemental doping (P and N), the improved light-harvesting resulting from the tube structure, and the upconversion effect of N-GQDs. In addition, the internal charge separation and transfer capability of0.1% G-TPCN are dramatically boosted, and its carrier concentration is 3.7, 2.3, and 1.9 times that of N-TiO_(2), PCN, and N-TiO_(2)/PCN(TPCN-1), respectively. This phenomenon is attributed to the formation of Z-scheme heterojunction between N-TiO_(2) and PCNs, the excellent electron conduction ability of N-GQDs, and the short transfer distance caused by the porous nanotube structure. Compared with those of N-TiO_(2), PCNs, and TPCN-1, the H2 production activity of 0.1%G-TPCN under visible light is enhanced by 12.4, 2.3, and 1.4times, respectively, and its ciprofloxacin (CIP) degradation rate is increased by 7.9, 5.7, and 2.9 times, respectively. The optimized performance benefits from excellent photoresponsiveness and improved carrier separation and migration efficiencies. Finally, the photocatalytic mechanism of 0.1% G-TPCN and five possible degradation pathways of CIP are proposed. This study clarifies the mechanism of multiple modification strategies to synergistically improve the photocatalytic performance of 0.1% G-TPCN and provides a potential strategy for rationally designing novel photocatalysts for environmental remediation and solar energy conversion.

关键词： N-doped TiO_(2) N-doped graphene quantum dots P-doped g-C_(3)N_(4) porous hollow nanotube heterojunction photocatalysis

Reversing free-electron transfer of sulfide cocatalyst for exceptional photocatalytic H_(2)evolution

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Journal of Materials Science & Technology 2024年第4期171卷 147-149页

作者： Yanfeng zhang Zhenyi zhang National Experimental Chemistry Teaching Center Hebei Key Laboratory of Inorganic Nano-materialsCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission Key Laboratory of Photosensitive Materials and Devices of Liaoning ProvinceSchool of Physics and Materials EngineeringDalian Minzu UniversityDalian 116600China

Recently,Yu and co-workers deeply explore the potential impact of free electron transfer between co-catalysts and photocatalyst carriers on H_(2)evolution efficiency of active sites over MoS_(2+x).They pro-pose an electron-reversal tactics to evade the unexpected electron transfer and synchronously regulate the above transfer in a beneficial orientation for weakening hydrogen adsorption on S ***,this highlight not only discusses and summarizes the essences of electron reversal and the optimized H ad-sorption/desorption mechanism,but also emphasizes the significance of femtosecond transient absorp-tion spectroscopy(fs-TAS)and in-situ irradiated X-ray photoelectron spectroscopy(ISI-XPS)for revealing charge transfer dynamics and *** anticipate that this highlight can disseminate a new per-spective on the roles of photocatalyst carriers in improving cocatalytic H_(2)-production kinetics.

关键词： Photocatalysis Cocatalyst Electron reversal Antibonding-orbital occupancy S–H bonds

刷碗少的人请买花:夫妻贡献不均与家庭享乐性消费

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心理科学进展 2024年第8期32卷 1250-1264页

作者：李世豪张文悦符国群对外经济贸易大学国际商学院北京100029 北京大学光华管理学院北京100871

面对着家庭中各式各样的联合任务,夫妻贡献度不均的情况普遍存在。然而,鲜有研究关注其对消费行为的影响。由此,本研究系统研究:第一,基于动态公平视角和夫-妻二元互依模型,验证夫妻在家庭任务中的贡献不均对家庭享乐性消费的影响,同时... 详细信息

面对着家庭中各式各样的联合任务,夫妻贡献度不均的情况普遍存在。然而,鲜有研究关注其对消费行为的影响。由此,本研究系统研究:第一,基于动态公平视角和夫-妻二元互依模型,验证夫妻在家庭任务中的贡献不均对家庭享乐性消费的影响,同时验证感知公平的中介作用,以及内疚和自我奖赏的二重中介作用,深入理解感知公平这一心理机制;第二,基于性别角色理念、伴侣情绪支持、性别平等文化的调节作用,识别不同公平理论起作用的方式和条件。本研究将有助于丰富夫妻联合消费研究,加深对公平相关理论的理解,并为面向家庭用户的企业提供有效的营销决策指导。

关键词：享乐性消费家庭分工家庭消费决策感知公平

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Inter-well internal resonance analysis of rectangular asymmetric cross-ply bistable composite laminated cantilever shell under transverse foundation excitation

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1353-1370页

作者： Lele REN Wei zhang Yufei zhang State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Department of Mechanics Guangxi UniversityNanning 530004China Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures College of Mechanical EngineeringBeijing University of TechnologyBeijing 100124China

The chaotic dynamic snap-through and complex nonlinear vibrations are investigated in a rectangular asymmetric cross-ply bistable composite laminated cantilever shell,in cases of 1:2 inter-well internal resonance and primary *** transverse foundation excitation is applied to the fixed end of the structure,and the other end is in a free *** first-order approximate multiple scales method is employed to perform the perturbation analysis on the dimensionless two-degree-of-freedom ordinary differential motion control *** four-dimensional averaged equations are derived in both polar and rectangular coordinate *** from the obtained frequency-amplitude and force-amplitude response curves,a detailed analysis is conducted to examine the impacts of excitation amplitude,damping coefficient,and tuning parameter on the nonlinear internal resonance characteristics of the *** nonlinear softening characteristic is exhibited in the upper stable-state,while the lower stable-state demonstrates the softening and linearity *** simulation is carried out using the fourth-order Runge-Kutta method,and a series of nonlinear response curves are *** the excitation amplitude further elucidates the global bifurcation and chaotic dynamic snap-through characteristics of the bistable cantilever shell.

关键词： bistable composite laminated cantilever shell inter-well internal resonance primary resonance chaotic dynamic snap-through complex nonlinear vibration