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The Journal of Biomedical Research 2021年第3期35卷 206-215页

作者： Wei Shu yanman zhang Chen zhang Qiang You Hong Zhou Shuang Wen Department of Immunology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Department of Stomatology Jiangsu Provincial Hospital of Traditional Chinese MedicineNanjingJiangsu 210029China Department of Biotherapeutics the Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China.

Periodontitis is a highly prevalent,chronic,non-specific,and immunologically devastating disease of periodontal tissues,caused by microbial *** study aims to examine the efficacy and protective mechanism of triclosan(TCS),a bisphenolic,non-cationic component of oral care products,against periodontal inflammation induced by lipopolysaccharide purified from Porphyromonas gingivalis(LPS-PG).TCS markedly downregulated interleukin-6(IL-6),IL-8,and IL-15 in human periodontal ligament fibroblasts(HPDLFs)treated with *** using a liquid chromatography-tandem mass spectrometry(LC-MS/MS)approach,318 differentially expressed proteins(161 upregulated and 157 downregulated)were identified in TCS-pretreated *** upregulated HSPA5 and HSP90B1 but downregulated ***,TCS upregulated miR-548i in HPDLFs,which downregulated *** results indicate that TCS attenuates the activation of HPDLFs and downregulates the inflammatory cytokines through various mechanisms,thus highlighting its protective role in periodontal inflammation.

关键词： human periodontal ligament fibroblasts lipopolysaccharide triclosan heat shock protein

Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

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Science China(Life Sciences) 2024年第8期67卷 1697-1714页

作者： Huan Wu yanman zhang Yuqian Li Shuya Sun Jintao zhang Qingsong Xie Yue Dong Shushu Zhou Xuan Sha Kuokuo Li Jinyi Chen Xin zhang Yang Gao Qunshan Shen Guanxiong Wang Xiaomin Zha Zongliu Duan Dongdong Tang Chuan Xu Hao Geng Mingrong Lv Yuping Xu Ping Zhou Zhaolian Wei Rong Hua Yunxia Cao Mingxi Liu Xiaojin He Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Reproductive Medicine and Offspring Health Clinical Center of Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China Anhui Province Key Laboratory of Reproductive Health and Genetics Hefei 230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei 230032China

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across *** shuttles,particularly adenylate kinase(AK)and creatine kinase(CK),are pivotal in the efficient transfer of intracellular ATP,showing distinct tissue-and ***,the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups,of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across *** AK8 and AK9 were found to be indispensable to male reproduction after analysis of an infertile male *** mouse models showed that AK8 and AK9 were central to promoting sperm *** combined with mass spectrometry revealed that AK8 and AK9 interact with the radial spoke(RS)of the *** of various human and mouse sperm samples with substructural damage,including the presence of multiple RS subunits,showed that the head of radial spoke 3 acts as an adapter for AK9 in the flagellar *** an ATP probe together with metabolomic analysis,it was found that AK8 and AK9 cooperatively regulated ATP transfer in the axoneme,and were concentrated at sites associated with energy consumption in the *** findings indicate a novel function for RS beyond its structural role,namely,the regulation of ATP *** conclusion,the results expand the functional spectrum of AK proteins and suggest a fresh model regarding ATP transfer within mammalian flagella.

关键词： adenylate kinase Subgroup III AKs AK8 AK9 male infertility ATP transfer radial spoke

实现伟大梦想必须进行伟大斗争--《1848年至1850年的法兰西阶级斗争》的新时代解读

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中共中央党校（国家行政学院）学报 2020年第2期24卷 35-42页

作者：韩喜平张延曼吉林大学马克思主义学院吉林长春130012

马克思通过对1848年至1850年的法兰西阶级斗争的物质经济根源的分析以及对法国内部各阶级之间错综复杂的牵制关系的梳理,指出阶级斗争是阶级社会发展的直接动力;通过对阶级斗争过程中历经各个阶段的详尽解析,得出"人民群众是历史的创造... 详细信息

马克思通过对1848年至1850年的法兰西阶级斗争的物质经济根源的分析以及对法国内部各阶级之间错综复杂的牵制关系的梳理,指出阶级斗争是阶级社会发展的直接动力;通过对阶级斗争过程中历经各个阶段的详尽解析,得出"人民群众是历史的创造者"这一历史唯物主义观点。《1848年至1850年的法兰西阶级斗争》所体现出来的将革命进行到底、坚定立场排除万难、敢于斗争善于斗争的勇气以及对革命必胜的信念等革命精神,对于我们在进行伟大斗争的征途中,坚定斗争意志、坚持正确的立场方向原则、提高斗争本领具有重要的现实意义。

关键词：《1848年至1850年的法兰西阶级斗争》阶级斗争人民群众革命精神伟大斗争

胰腺癌诊断中螺旋CT扫描的价值及临床意义探究

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影像研究与医学应用 2017年第2期1卷 145-146页

作者：张砚满南通大学附属医院放射科江苏南通226007

目的:探讨胰腺癌诊断中螺旋CT扫描的价值及临床意义。方法:对我院近两年收治的100例经术后病理诊断却真的额胰腺癌患者临床资料进行研究分析,患者均接受螺旋CT扫描诊断,观察患者CT表现及超声诊断结果,并将两种诊断结果与术后病理结果进... 详细信息

目的:探讨胰腺癌诊断中螺旋CT扫描的价值及临床意义。方法:对我院近两年收治的100例经术后病理诊断却真的额胰腺癌患者临床资料进行研究分析,患者均接受螺旋CT扫描诊断,观察患者CT表现及超声诊断结果,并将两种诊断结果与术后病理结果进行比较分析。结果:CT能够对患者肿瘤大小、密度、形态及肿瘤与临近脏器、组织的关系进行清晰显示;超声诊断结果与螺旋CT诊断和术后病理诊断结果比较有显著差异(P<0.05),螺旋CT与术后病理诊断结果比较无显著差异(P﹥0.05)。结论:螺旋CT诊断胰腺癌效果显著,能够清晰显示肿瘤与临近组织关系等,可作为胰腺癌术前诊断的影像学诊断方式推广使用。

关键词：胰腺癌螺旋CT 超声价值

跨线列车速度目标值及到发线有效长标准选择的研究

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铁道标准设计 2006年第1期26卷 19-20,26页

作者：张艳满铁道第三勘察设计院天津300142

根据国家铁路主要技术政策及铁路中长期发展规划中的客运专线定位,从宏观规划到工程、运营分析,论述了跨线列车速度匹配问题。

关键词：跨线列车速度目标值到发线有效长标准选择

肾透明细胞癌MSCT征象与Fuhrman分级相关性研究

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临床放射学杂志 2019年第6期38卷 1068-1070页

作者：张砚满田浩张青张思琦吴献华江苏省南通市南通大学附属医院放射科 226001 江苏省南通市南通大学附属医院病理科 226001

目的探讨肾透明细胞癌(CCRCC)的多层螺旋CT(MSCT)征象与Fuhrman分级的关系。方法回顾性分析经病理证实的CCRCC患者的MSCT征象,包括肿瘤位置、生长方式、边缘类型、肿瘤其他特征(包括包膜侵犯、同对侧肿瘤周围脂肪间隙CT值、肿瘤长径、... 详细信息

目的探讨肾透明细胞癌(CCRCC)的多层螺旋CT(MSCT)征象与Fuhrman分级的关系。方法回顾性分析经病理证实的CCRCC患者的MSCT征象,包括肿瘤位置、生长方式、边缘类型、肿瘤其他特征(包括包膜侵犯、同对侧肿瘤周围脂肪间隙CT值、肿瘤长径、有无钙化、肿瘤密度是否均匀、肾周脂肪间隙密度),并与病理Fuhrman分级进行统计学分析。结果高级别和低级别CCRCC之间肿瘤生长方式、边缘类型、肿瘤钙化及包膜侵犯的差异具有统计学意义,其他征象的差异无统计学意义;Logistic回归分析显示,肿瘤生长方式和边缘类型是预测低级别CCRCC的独立预测因素(OR=0.859182,P<0.05;OR=0.789602,P<0.05),肿瘤钙化和包膜侵犯是预测高级别CCRCC的独立预测因素(OR=0.899346,P<0.05;OR=0.896207,P<0.05)。结论 MSCT在一定程度上能够预测CCRCC的Fuhrman分级,肿瘤生长方式、肿瘤边缘类型、包膜侵犯及肿瘤钙化构成了CCRCC的Fuhrman分级的独立预测因素,MSCT有助于评估CCRCC的侵袭性评估,对临床决策具有重要的指导意义。

关键词：肾透明细胞癌 Fuhrman分级多层螺旋CT

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胸膜腔CT仿真内镜表现

临床放射学杂志 2019年第10期38卷 1842-1846页

作者：曹和涛王素娟张砚满刘婷婷万娟成月江苏省南通大学附属医院医学影像科 226001 江苏省盐城市大丰人民医院医学影像科 224100

目的观察不同类型气胸胸膜腔CT仿真内镜(CTVE)表现。方法搜集118例气胸患者MSCT资料,采用CTVE导航技术观察胸膜腔表面形态并与MPR对照,胸膜腔顶表面光滑度分光滑与粗糙两级。原发性自发性气胸(PSP)、继发性自发性气胸(SSP)和创伤性气胸(... 详细信息

目的观察不同类型气胸胸膜腔CT仿真内镜(CTVE)表现。方法搜集118例气胸患者MSCT资料,采用CTVE导航技术观察胸膜腔表面形态并与MPR对照,胸膜腔顶表面光滑度分光滑与粗糙两级。原发性自发性气胸(PSP)、继发性自发性气胸(SSP)和创伤性气胸(TP)组间等级资料采用单因素方差分析,计量资料采用χ~2检验。结果 118例气胸患者中PSP 45例、SSP 42例、TP 31例,PSP胸膜腔顶较SSP和TP粗糙(F=11.46,P0.05),MPR无法显示光滑度情况。62例中等量以上气胸患者CTVE清晰显示上纵隔面隆起大血管及肋膈胸膜面形态,胸骨两侧纵行细条状隆起结构MPR证实为胸廓内动静脉。6例跨胸膜腔条状或幕状影、21例壁层胸膜面类圆或椭圆形缺损、16例脏层胸膜面半球状隆起、28例心膈角胸膜面及11例其他胸膜面高低不平"面貌"CTVE均直观显示;MPR分别证实为粘连带、胸膜洞(真性缺损)20例,胸膜下局限性积气(假性缺损)1例,肺大泡、心包脂肪垫和结节状胸膜肥厚。27例发现33个胸膜洞,其中PSP 21例(26个),SSP 6例(7个),TP (0个)(F=15.76,P<0.05);58例CTVE心表面呈轮毂或车辙状表现,MPR证实心脏边缘运动伪影,呈"记波摄影"状改变;7例CTVE胸腔积液面呈现"沸水征",MPR证实为液面连续规则波纹状征象。结论 CTVE能清晰直观显示胸膜腔表面形态特征,胸膜顶粗糙和胸膜洞是PSP胸膜腔CTVE特殊表现。

关键词：胸膜气胸 CT仿真内镜多层螺旋CT

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关于提升用户数据一致性的方法讨论

现代信息科技 2021年第8期5卷 20-23页

作者：张彦满王兰王奇张力陈宝平中国移动通信集团甘肃有限公司甘肃兰州730070

文章针对业务支撑中心CRM中的用户数据和网络运营中心网元中的用户数据不一致或网元与网元间用户数据不一致的问题,介绍提升用户数据一致性的方法,重点讲解安全、精准、智能的用户数据一致性稽核、修复的系统流程:多源用户数据采集、根... 详细信息

文章针对业务支撑中心CRM中的用户数据和网络运营中心网元中的用户数据不一致或网元与网元间用户数据不一致的问题,介绍提升用户数据一致性的方法,重点讲解安全、精准、智能的用户数据一致性稽核、修复的系统流程:多源用户数据采集、根据配置解析入库、依据稽核规则开展批量稽核、差异数据进行二次实时稽核、按照实时稽核结果自动下发修复指令、修复后复测一致性结果、投诉关联智能化跟踪修复。

关键词：用户数据数据解析数据稽核数据修复投诉关联

Real-time Safety Helmet-wearing Detection Based on Improved YOLOv5

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Computer Systems Science & Engineering 2022年第12期43卷 1219-1230页

作者： yanman Li Jun zhang Yang Hu Yingnan Zhao Yi Cao NARI Nanjing Control System Ltd. Nanjing210032China School of Computer Nanjing University of Information Science&TechnologyNanjing210044China Department of Electrical and computer Engineering University of WindsorWindsorN9B 3P4Canada

Safety helmet-wearing detection is an essential part of the intelligentmonitoring system. To improve the speed and accuracy of detection, especiallysmall targets and occluded objects, it presents a novel and efficient detectormodel. The underlying core algorithm of this model adopts the YOLOv5 (YouOnly Look Once version 5) network with the best comprehensive detection performance. It is improved by adding an attention mechanism, a CIoU (CompleteIntersection Over Union) Loss function, and the Mish activation function. First,it applies the attention mechanism in the feature extraction. The network can learnthe weight of each channel independently and enhance the information dissemination between features. Second, it adopts CIoU loss function to achieve accuratebounding box regression. Third, it utilizes Mish activation function to improvedetection accuracy and generalization ability. It builds a safety helmet-wearingdetection data set containing more than 10,000 images collected from the Internetfor preprocessing. On the self-made helmet wearing test data set, the averageaccuracy of the helmet detection of the proposed algorithm is 96.7%, which is1.9% higher than that of the YOLOv5 algorithm. It meets the accuracy requirements of the helmet-wearing detection under construction scenarios.

关键词： Safety helmet wearing detection object detection deep learning YOLOv5 Attention Mechanism

Research on power control strategy of household-level electric power router based on hybrid energy storage droop control

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Protection and Control of Modern Power Systems 2021年第1期6卷 178-190页

作者： Kun Huang yanman Li Xiaoyan zhang Lei Liu Yanbin Zhu Xin Meng NARI Technology Development Co. LtdNo.19Chengxin AvenueJiangning DistrictNanjing CityJiangsu ProvinceChina Nari Group Corporation/State Grid Electric Power Research Institute No.19Chengxin AvenueJiangning DistrictNanjing CityJiangsu ProvinceChina School of Physics University of OxfordOxfordOX13RHUK Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin300072China

In the light of user-side energy power control requirements, a power control strategy for a household-level EPR based on HES droop control is proposed, focusing on the on-grid, off-grid and seamless switching process. The system operating states are divided based on the DC bus voltage information with one converter used as a slack terminal to stabilize the DC bus voltage and the other converters as power terminals. In the on-grid mode, the GCC and the HES are used as the main control unit to achieve on-grid stable operation, whereas in the off-grid mode, the PV, HES and LC are used as the main control unit at different voltages to achieve stable operation of the island network. Finally, a DC MG system based on a household-level EPR is developed using the PSCAD / EMTDC simulation platform and the results show that the control strategy can effectively adjust the output of each subunit and maintain the stability of the DC bus voltage.

关键词： Household-level electric power router Hybrid energy storage Droop control On-grid mode Off-grid mode