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Food Science and Human Wellness 2024年第5期13卷 2718-2726页

作者： Xue Li Yiwen shao Limin Hao Qiaozhen Kang Xiaolong Wang Jiaqing Zhu Changcheng Zhao yanling Shi Jike Lu Juanjuan Yi School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Food Laboratory of Zhongyuan Zhengzhou UniversityLuohe 462300China Systems Engineering Institute Academy of Military Sciences(AMS)Beijing 100010China Henan Yinfeng Biological Engineering Technology Co. Ltd.Zhengzhou 450000China

Chinese yam(Dioscorea opposita Thunb.),as one of the medicinal and edible homologous plants,is rich in various nutrients and functional *** this study,Chinese yam fermented by Saccharomyces boulardii was performed to investigate its bioactive components and metabolic *** then,the main bioactive components and biological activities of fermented Chinese yam ethanol extract(FCYE)were *** showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese ***,corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcoholsoluble small molecular ***,the total polyphenol content and the total flavonoid content in FCYE were significantly increased,and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly *** study provided a new reference for the comprehensive utilization of Chinese yam and laid a theoretical foundation for the development and application of natural probiotic-fermented products.

关键词： Chinese yam Saccharomyces boulardii Metabolites Antioxidant Immunomodulation

Internet search data could Be used as novel indicator for assessing COVID-19 epidemic

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Infectious Disease Modelling 2020年第1期5卷 848-854页

作者： Kang Li yanling Liang Jianjun Li Meiliang Liu Yi Feng Yiming shao Key Laboratory of Molecular Microbiology and Technology Ministry of EducationCollege of Life SciencesNankai UniversityTianjinChina State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Guangxi Center for Disease Prevention and Control NanningGuangxiChina School of Public Health Guangxi Medical UniversityNanningGuangxiChina

The pandemic of the coronavirus disease(COVID-19)poses a huge challenge all countries,since no one is well prepared for *** be better prepared for future pandemics,we evaluated association between the internet search data with reported COVID-19 cases to verify whether it could become an early indicator for emerging *** the keyword filtering and Index composition,we found that there were close correlations between Composite Index and suspected cases for COVID-19(r?0.921,P<0.05).The Search Index was applied for the Autoregressive Integrated Moving Average with Exogenous Variables(ARIMAX)model to quantify the *** with the model based on surveillance data only,the ARIMAX model had smaller Akaike Information Criterion(AIC?403.51)and the most accurate predictive ***,the Internet search data could serve as a convenient indicator for predicting the epidemic and to monitor its trends.

关键词： COVID-19 Internet data ARIMAX Predict

Fauna characteristics and ecological distribution of Carnivora and Artiodactyla in Niubeiliang National Nature Reserve,China

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Frontiers in Biology 2007年第1期2卷 92-99页

作者： ZENG Zhigao SONG yanling MA Yingtai WANG Xifeng WU Xuntao XIE Zhenfeng shao Jianbin LI Chunning Institute of Zoology Chinese Academy of SciencesBeijing 100080China Niubeiliang National Nature Reserve Xi’an 710100China

Niubeiliang National Nature Reserve(NNR,108°45p-109°04p E,33°47p-33°56p N)is located on the east-ern range of the Qinling Mountains in Shaanxi Province,China and spans the southern and northern slopes of ***.A transect survey and investigation were carried out in NNR to determine the fauna characteristics and ecological distribution of carnivora and artiodactyla from May 2003 to August *** NNR has 18 mammals(carnivore and artiodactyl),two of which belong to the first class and seven to the second class of state key protected wildlife in *** results of this study indicated that ungulates were abun-dant in the NNR,as all ungulates that were distributed within *** could be found within the ***,only 45.5%of the carnivores distributed within *** were detected within the *** the mammals,there were 12 oriental species(66.7%),1 palearctic specie(5.5%)and 5 widely-distributed species(27.8%).The NNR is a crossing area of palearctic species and oriental species on the zoogeo-graphical regions,and it is a transitional area from the oriental realm to the palearctic *** results of the analysis on the ecological distribution of carnivore and artiodactyl in the area showed that their elevation ranges had large *** species whose elevation ranges above 1300 m,about 1000 m,and in 450-700 m occupied one third *** results also indicated that species richness for the mam-mals in the NNR peaked at a middle elevation(rising at first,then descending with the increase in elevation).Not only on the southern slope,but also on the northern slope of ***,the number of species distributed in the area at 1800-2200 m *** the largest(more than 80%),while the number of species distributed in the area above 2600 m *** the smallest(about 50%).Elevation gradients of species richness for the mammals in the NNR also embodied the mammal distributions among the vegetation *** number of species distribute

关键词： mammal fauna ecological distribution eleva-tion gradients species richness Niubeiliang National Nature Reserve

ICG荧光染色在肝癌腹腔镜解剖性肝切除术中的应用

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中华肝脏外科手术学电子杂志 2023年第5期12卷 557-561页

作者：孟令展李虎俞鹏于燕宾曹李翟伟高远邵艳玲严锦朱震宇解放军总医院第五医学中心肝病外科北京100039

目的探讨ICG荧光染色在原发性肝癌(肝癌)腹腔镜解剖性肝切除术中应用的可行性和安全性。方法回顾性分析2021年1月至2021年12月解放军总医院第五医学中心行腹腔镜解剖性肝切除术的52例肝癌患者临床资料。患者均签署知情同意书,符合医学... 详细信息

目的探讨ICG荧光染色在原发性肝癌(肝癌)腹腔镜解剖性肝切除术中应用的可行性和安全性。方法回顾性分析2021年1月至2021年12月解放军总医院第五医学中心行腹腔镜解剖性肝切除术的52例肝癌患者临床资料。患者均签署知情同意书,符合医学伦理学规定。其中男40例,女12例;平均年龄(56±9)岁。中国肝癌分期(CNLC)Ⅰa期34例,Ⅰb期13例,Ⅱa期5例;肿瘤直径中位数3.1(1.1~13.2)cm。术前行三维可视化重建评估,术中超声引导下行ICG荧光染色。观察术中ICG染色情况、手术和术后情况、随访情况。结果所有患者均顺利完成手术。52例患者中45例染色成功,7例失败;其中采用反染法32例,染色失败2例,成功率94%;采用正染法20例,染色失败5例,成功率75%。手术方式包括腹腔镜右半肝切除术5例,左半肝切除术4例,右前叶切除术7例,右后叶切除术2例,肝中叶切除术2例,Ⅴ段切除术11例,Ⅵ段切除术1例,Ⅶ段切除术11例,Ⅷ段切除术9例。手术时间279(88~447)min,术中出血量200(50~500)ml。术后住院时间(9.1±3.5)d。术后出现并发症3例,其中胆漏1例,经引流后痊愈;胸腔积液1例,经胸腔穿刺引流后痊愈;肺部感染1例,予抗感染治疗后痊愈。术后未发生出血等并发症,无术后死亡。术后随访期间2例肝内复发。结论ICG荧光染色应用于腹腔镜解剖性肝切除术中安全可行。反染法成功率高,正染法尤其适用于后、上肝段等困难部位的解剖性肝段切除。

关键词：肝肿瘤腹腔镜肝切除术解剖性吲哚氰绿荧光显象三维可视化

DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice

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Virologica Sinica 2024年第3期39卷 490-500页

作者： Xiuli Shen Shuhui Wang yanling Hao Yuyu Fu Li Ren Dan Li Wenqi Tang Jing Li Ran Chen Meiling Zhu Shuo Wang Ying Liu Yiming shao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Changping Laboratory Yard 28Science Park RoadChangping DistrictBeijing 102206China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

As of December 2022,2603 laboratory-identified Middle East respiratory syndrome coronavirus(MERS-CoV)infections and 935 associated deaths,with a mortality rate of 36%,had been reported to the World Health Organization(WHO).However,there are still no vaccines for MERS-CoV,which makes the prevention and control of MERS-CoV *** this study,we generated two DNA vaccine candidates by integrating MERS-CoV Spike(S)gene into a replicating Vaccinia Tian Tan(VTT)*** to homologous immunization with either vaccine,mice immunized with DNA vaccine prime and VTT vaccine boost exhibited much stronger and durable humoral and cellular immune *** immunized mice produced robust binding antibodies and broad neutralizing antibodies against the EMC2012,England1 and KNIH strains of ***-Boost immunization also induced strong MERS-S specific T cells responses,with high memory and poly-functional(CD107a-IFN-γ-TNF-α)effector CD8t T *** conclusion,the research demonstrated that DNA-Prime/VTT-Boost strategy could elicit robust and balanced humoral and cellular immune responses against *** study not only provides a promising set of MERS-CoV vaccine candidates,but also proposes a heterologous sequential immunization strategy worthy of further development.

关键词： MERS-CoV VTT vaccine DNA vaccine Humoral and cellular immune responses Prime/boost strategy

China CDC’s HIV/AIDS Vaccine Efforts, from Basic Research to Clinical Studies

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China CDC weekly 2020年第48期2卷 929-932页

作者： Yiming shao Ying Liu yanling Hao Jing Xu Taisheng Li Hao Wu Tong Zhang Lihua Wu Shuhui Wang Dan Li Li Ren Yingqi Wu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Vaccine and Serum Institute BeijingChina Peking Union Medical College Hospital BeijingChina Beijing Youan Hospital BeijingChina The First Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejiangChina

After nearly 40 years of research and control efforts,much progress has been made to accomplish the most significant achievements in antiviral drug development and cocktail therapy that has transformed the human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)treatment regiment from having the highest mortality into a manageable chronic disease like hypertension or diabetes.

关键词： HIV/AIDS immunodeficiency hypertension

Cerium-based nanoparticles for cancer photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第6期15卷 4-16页

作者： Hui Li Min Wei Xinyi Lv yanling Hu Jinjun shao Xuejiao Song Dongliang Yang Wenjun Wang Buhong Li Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM)School of Physical and Mathematical Sciences Nanjing Tech University(NanjingTech)NanjingJiangsu 211816P.R.China School of Physical Science and Information Technology Liaocheng University LiaochengShandong 252059P.R.China MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory of Photonics Technology Fujian Normal University FuzhouFujian 350117P.R.China School of Chemistry&Materials Science Jiangsu Normal University Xuzhou Jiangsu 221116P.R.China

Metal-and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy(PDT).Among these materials,cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties,especially the reversible transition between the valence states of Ce(Ⅲ)and Ce(Ⅳ).In this review,the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed,and the activation mechanisms for electron transfer to generate singlet oxygen are *** addition,the types of cerium-based nanoparticles used for PDT of cancer are ***,the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.

关键词： Photodynamic therapy photosensitizer cerium reactive oxygen species

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我国的陶瓷乐器

中国陶瓷 2007年第12期43卷 88-90页

作者：刘妍玲邵奇景德镇高等专科学校艺术系景德镇333000

中国被誉为"瓷之国",自古以来就有"礼仪之邦"的美誉,有着悠久的制瓷历史精湛的制瓷技艺,孕育出厚实丰富的陶瓷文化,而且传统音乐也相当发达,在世界音乐史有着很重要的地位。陶瓷乐器作为我国传统乐器的一种,源远流长由来已久,长久以来,... 详细信息

中国被誉为"瓷之国",自古以来就有"礼仪之邦"的美誉,有着悠久的制瓷历史精湛的制瓷技艺,孕育出厚实丰富的陶瓷文化,而且传统音乐也相当发达,在世界音乐史有着很重要的地位。陶瓷乐器作为我国传统乐器的一种,源远流长由来已久,长久以来,人们就用"声如磬"来形容陶瓷的特殊音色。随着人类文明的不断进步,科学技术的不断发展,陶瓷乐器也不断的推陈出新。

关键词：陶瓷乐器新石器时代陶哨唐宋时期近现代

Coralline-like Ni_(2)P decorated novel tetrapod-bundle Cd_(0.9)Zn_(0.1)S ZB/WZ homojunctions for highly efficient visible-light photocatalytic hydrogen evolution

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Chinese Journal of Catalysis 2021年第3期42卷 439-449页

作者： Zhuwang shao Xiao Meng Hong Lai Dafeng Zhang Xipeng Pu Changhua Su Hong Li Xiaozhen Ren yanling Geng School of Materials Science and Engineering Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina State Key Laboratory Base of Eco-chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042ShandongChina

In this study,Ni_(2)P-Cd_(0.9)Zn_(0.1)S(NPCZS)composites were synthesized by coupling tetrapod bundle Cd_(0.9)Zn_(0.1)S(CZS)and coralline-like Ni_(2)P(NP)via a simple calcination *** shows outstanding activity in photocatalytic hydrogen evolution(1.31 mmol h^(‒1)),owing to its unique morphology and heterophase homojunctions(ZB/WZ),which accelerate the separation and transfer of photogenerated *** coupling with NP,the photoactivity of NPCZS was enhanced,and the maximum hydrogen evolution rate of 1.88 mmol h^(‒1)was reached at a NP content of 12 wt%,which was 1.43 times higher than that of pure *** experimental results of the photocatalytic activity,*** spectra,surface photovoltage spectra,and electrochemical test showed that the enhanced photoactivity of NPCZS should be attributed to the synergistic effects of the novel tetrapod-bundle morphology,heterophase homojunctions,and decoration of the NP ***,the as-prepared NPCZS composites exhibited excellent photostability and ***,we propose a possible mechanism for the enhanced photocatalytic activity.

关键词： Photocatalytic hydrogen evolution Cd_(0.9)Zn_(0.1)S Ni_(2)P Homojunctions Noble-metal-free

In Situ Synthesis and Characterization of Nanosize Hydroxyapatite/Polyacrylonitrile Composite Bead

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In Situ Synthesis and Characterization of Nanosize Hydroxyap...