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Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation

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Animal Models and Experimental Medicine 2022年第1期5卷 61-71页

作者： Xian Zhou Zhichao Sun Mengdi Zhang Xiaoyu Qu Shuhui Yang Lianmei Wang yanling jing Li Li Weiwei Deng Fangming Liu Jin Di Jie Chen Jian Wu Hongbing Zhang State Key Laboratory of Medical Molecular Biology Department of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Institute of Cancer Stem Cell Dalian Medical UniversityDalianChina Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina MyGenostics Inc. BeijingChina

Background:Largely due to incidental detection,asymptomatic pancreatic cystic le-sions(PCLs)have become prevalent in recent *** them,intraductal papillary mucinous neoplasm(IPMN)infrequently advances to pancreatic ductal adenocarcinoma(PDAC).Conservative surveillance versus surgical intervention is a difficult clinical decision for both caregivers and PCL *** RNF43 loss-of-function mutations and KRAS gain-of-function mutations concur in a subset of IPMN and PDAC,their biological significance and therapeutic potential should be ***:Pancreatic Rnf43 knockout and Kras activated mice(Rnf43^(−/−);Kras^(G12D))were generated to evaluate their clinical significance in pancreatic pre-neoplastic initiation and malignant ***:Loss of Rnf43 potentiated the occurrence and severity of IPMN and PDAC in oncogenic Kras *** Wnt/β-catenin signaling pathway was activated in pan-creatic Kras^(G12D)and Rnf43 knockout mice and the PORCN inhibitor LGK974 blocked pancreatic IPMN initiation and progression to PDAC ***:Rnf43 is a tumor suppressor in the prevention of pancreatic malignant *** genetically reconstituted autochthonous pancreatic Rnf43^(−/−);Kras^(G12D)preclinical cancer model recapitulates the pathological process from pancreatic cyst to cancer in humans and can be treated with inhibitors of Wnt/β-catenin *** the presence of RNF43 and KRAS mutations in IPMNs predicts future development of advanced neoplasia from PCLs,patients with these genetic anomalies warrant surveillance,surgery,and/or targeted therapeutics such as Wnt/β-catenin inhibitors.

关键词： intraductal papillary mucinous neoplasms KRAS pancreatic ductal adenocarcinoma RNF43 Wnt

哌拉西林钠他唑巴坦钠治疗支气管扩张急性感染的效果观察

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中外医药研究 2024年第19期3卷 21-23页

作者：井艳玲莱西市市立医院药剂科山东青岛266600

目的:观察哌拉西林钠他唑巴坦钠治疗支气管扩张急性感染的效果。方法:选取2021年2月—2023年2月莱西市市立医院收治的支气管扩张急性感染患者88例为研究对象,按照随机数字表法分为对照组和观察组,各44例。对照组采用阿莫西林钠克拉维酸... 详细信息

目的:观察哌拉西林钠他唑巴坦钠治疗支气管扩张急性感染的效果。方法:选取2021年2月—2023年2月莱西市市立医院收治的支气管扩张急性感染患者88例为研究对象,按照随机数字表法分为对照组和观察组,各44例。对照组采用阿莫西林钠克拉维酸钾治疗,观察组采用哌拉西林钠他唑巴坦钠治疗。比较两组细菌清除率、炎性指标水平以及不良反应发生率。结果:观察组细菌清除率高于对照组,差异有统计学意义(P=0.015)。治疗前,两组白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)水平比较,差异无统计学意义(P>0.05);治疗后,两组WBC、CRP、PCT水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.020)。结论:哌拉西林钠他唑巴坦钠治疗支气管扩张急性感染的效果良好,病原菌清除率较高,可降低炎性指标水平,且不良反应发生率较低。

关键词：支气管扩张急性感染哌拉西林钠他唑巴坦钠阿莫西林钠克拉维酸钾

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精神分裂症心理社会危险因素研究

四川精神卫生 2012年第1期25卷 6-9页

作者：景艳玲王东明段妮山东省青岛市精神卫生中心 266034

目的探讨精神分裂症患者的心理社会危险因素。方法采用生活事件量表(LES)、社会支持评定量表(SSRS)及防御方式问卷(DSQ)对120例精神分裂症患者(病例组)以及121例正常志愿者(对照组)进行测查,并分析精神分裂症患者的心理社会危险因素。... 详细信息

目的探讨精神分裂症患者的心理社会危险因素。方法采用生活事件量表(LES)、社会支持评定量表(SSRS)及防御方式问卷(DSQ)对120例精神分裂症患者(病例组)以及121例正常志愿者(对照组)进行测查,并分析精神分裂症患者的心理社会危险因素。结果精神分裂症患者生活事件总频度和分值以及负性生活事件频度和分值均高于对照组(P<0.01),社会支持总分、主观社会支持因子分、客观支持因子分及社会支持利用度因子分均低于对照组(P<0.01),更多采用不成熟和中间型防御方式(P<0.01)。Logistic回归分析显示负性事件总分、社会支持利用度、不成熟防御机制和中间型防御机制是影响精神分裂症发病的重要因素。结论负性生活事件、社会支持利用度、不成熟防御机制及中间型防御方式与精神分裂症的发病密切相关。

关键词：精神分裂症生活事件社会支持防御方式

帕利哌酮缓释剂治疗首发与复发精神分裂症的临床疗效比较

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四川精神卫生 2011年第1期24卷 15-17页

作者：景艳玲王东明段妮山东省青岛市精神卫生中心 266034

目的比较帕利哌酮缓释剂治疗首发、复发精神分裂症患者的临床疗效。方法以28例首发精神分裂症患者(首发组)和32例复发再次住院的精神分裂症患者(复发组)为研究对象,分别给予帕利哌酮缓释剂治疗,于入院时、治疗2、4及8周末,采用阳性与阴... 详细信息

目的比较帕利哌酮缓释剂治疗首发、复发精神分裂症患者的临床疗效。方法以28例首发精神分裂症患者(首发组)和32例复发再次住院的精神分裂症患者(复发组)为研究对象,分别给予帕利哌酮缓释剂治疗,于入院时、治疗2、4及8周末,采用阳性与阴性症状量表(PANSS)评定疗效。结果治疗前首发组与复发组PANSS总分、阳性症状量表分、阴性症状量表分及一般病理量表分差异均无统计学意义(P>0.05)。治疗后第2、4和第8周末,首发组PANSS总分、阳性症状分量表分、阴性症状分量表分及一般病理量表分逐渐降低,差异有统计学意义(P0.05)。结论帕利哌酮缓释剂治疗首发、复发精神分裂症患者阴阳性症状均具有良好的疗效,且安全性、依从性好,可在临床进一步推广应用。

关键词：首发精神分裂症复发精神分裂症帕利哌酮缓释剂疗效

西酞普兰合并小剂量喹硫平治疗老年抑郁症的对照研究

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四川精神卫生 2011年第4期24卷 215-217页

作者：王东明刘琳琳景艳玲山东省青岛市精神卫生中心 266034

目的探讨西酞普兰合并喹硫平治疗老年抑郁症的疗效及安全性。方法将92例符合CCMD-3诊断标准的老年抑郁症患者分为研究组(西酞普兰合并喹硫平组)和对照组(单用西酞普兰组)治疗12周,采用四级临床疗效及汉密尔顿抑郁量表(HAMD)评定疗效,治... 详细信息

目的探讨西酞普兰合并喹硫平治疗老年抑郁症的疗效及安全性。方法将92例符合CCMD-3诊断标准的老年抑郁症患者分为研究组(西酞普兰合并喹硫平组)和对照组(单用西酞普兰组)治疗12周,采用四级临床疗效及汉密尔顿抑郁量表(HAMD)评定疗效,治疗时出现的症状量表(TESS)评定不良反应。结果两组8周末HAMD总分分别为(8.13±4.87),(11.72±3.89),两组12周末HAMD总分分别为(6.99±3.05)、(10.12±3.11),两组间差异均具有显著性意义(P0.05)。结论西酞普兰合并喹硫平治疗老年抑郁症的疗效更好,且不良反应无明显增加。

关键词：老年抑郁症西酞普兰喹硫平

Estimating PM_(2.5) concentrations in a central region of China usinga three-stage model

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International Journal of Digital Earth 2023年第1期16卷 578-592页

作者： Yue jing Long Pan yanling Sun Xi’an Institute for Innovative Earth Environment Research Xi’anPeople’s Republic of China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouPeople’s Republic of China School of Geographic and Environmental Sciences Tianjin Normal UniversityTianjinPeople’s Republic of China

Owing to uneven environmental monitoring site distribution,there are significant spatial data gaps for concentrations of ambientfine particles with diameters≤2.5µm(PM_(2.5))obtained using traditional monitoring *** products are an alternative data source for locations where monitoring sites are *** Moderate Resolution Imaging Spectroradiometer(MODIS)aerosol optical depth(AOD)product has been widely used in PM_(2.5) assessment for years;however,it has obvious data gaps in ***,the Visible Infrared Imaging Radiometer Suite(VIIRS)AOD was applied to supplement MODIS AOD data to obtain a fused AOD dataset.A three-stage model consisting of a corrected AOD model,mixed effects model,and geographically weighted regression model was developed and used with meteorological and vegetation factors to estimate PM_(2.5).Results showed overall modelfitting by cross-validation(CV)with an R^(2) of 0.92,mean absolute error of 5.72μg/m^(3),and root mean square error of 7.15μg/m^(3).The combination of MODIS AOD and VIIRS AOD was a suitable method for enhancing AOD *** CV R^(2) value of the three-stage model(0.92)was higher than that of the two-stage model(0.9).Hence,the three-stage model could achieve a betterfit in estimating PM_(2.5) on a regional scale.

关键词： VIIRS AOD MODISAOD PM_(2.5)concentrations combined model

Boosting energy storage performance of low-temperature sputtered CaBi_(2)Nb_(2)O_(9) thin film capacitors via rapid thermal annealing

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Journal of Advanced Ceramics 2021年第3期10卷 627-635页

作者： jing YAN yanling WANG Chun-Ming WANG Jun OUYANG Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Advanced Energy Materials and Chemistry School of Chemistry and Chemical EngineeringShandong Provincial Key Laboratory of Molecular EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China College of Physics and Electronic Engineering Qilu Normal UniversityJinan 250013China Amperex Technology Limited Ningde 352100China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

CaBi_(2)Nb_(2)O_(9) thin film capacitors were fabricated on SrRuO_(3)-buffered Pt(111)/Ti/Si(100)substrates by adopting a two-step fabrication *** process combines a low-temperature sputtering deposition with a rapid thermal annealing(RTA)to inhibit the grain growth,for the purposes of delaying the polarization saturation and reducing the ferroelectric *** using this method,CaBi_(2)Nb_(2)O_(9) thin films with uniformly distributed nanograins were obtained,which display a large recyclable energy density Wrec≈69 J/cm^(3) and a high energy efficiencyη≈82.4%.A superior fatigue-resistance(negligible energy performance degradation after 10^(9) charge-discharge cycles)and a good thermal stability(from-170 to 150℃)have also been *** two-step method can be used to prepare other bismuth layer-structured ferroelectric film capacitors with enhanced energy storage performances.

关键词： bismuth layer-structured ferroelectrics(BLSFs) calcium bismuth niobate(CaBi_(2)Nb_(2)O_(9)) nanograin films rapid thermal annealing(RTA) energy storage fatigue-resistance

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汉字实验室仪器设备计算机管理系统

甘肃工业大学学报 1987年第2期 91-98页

作者：陈逸军荆延令马晓安郁夫强

本文论述了运用数据库管理方法进行汉字实验室仪器设备计算机管理系统的设计思想,着重讨论了系统的结构、数据结构和检索等主要内容。

关键词：数据库数据结构索引文件

The Study on the Anti-corrosion Performance of NiTi Alloy in Human Body Solution with the Fabricating Processes of Laser Irradiation and PDMS Modification

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Journal of Bionic Engineering 2021年第1期18卷 77-91页

作者： Chengjuan Yang weiran Cao Zhen Yang Meng Wang Xiubing jing yanling Tian School of Mechanical Engineering Tianjin UniversityTianjin 300054China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin 300072China School of Engineering University of WarwickCoventry CV47ALUK

This paper presents a new and safe method of fabricating super-hydrophobic surface on NiTi Shape Memory Alloy(SMA),which aims to further improve the corrosion resistance performance and biocompatibility of NiTi *** super-hydrophobic surfaces with Water Contact Angle(WCA)of 155.4°±0.9°and Water Sliding Angle(WSA)of 4.4°±1.1°were obtained by the hybrid of laser irradiation and polydimethylsiloxane(PDMS)*** forming mechanism was systematically revealed via Scanming Electron Microscopy(SEM)and X-ray Photoelectron Spectroscopy(XPS).The ant-corrosion of samples was investigated in Simulated Body Fluid(SBF)via the potentiodynamie polarization(PDP)and Electrochemical Impedance Spectroscopy(EIS)*** super-hydrophobic coatings showed superior anti-corrosion *** Ni ions release experiment was also conducted and the corresponding result demonstrated that the super-hydrophobic samplcs effectively inhibited the rclease of Ni ions both in clctrolyte and SBF Besides,biocompaibility was further analyzed,indicating that the prepared super-hydrophobic surfaces present a huge potential advantage in biocompatibility.

关键词： wettability lascr tcxturing corrosion resistance mechanism human body liquid Ni ions release