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China CDC weekly 2024年第27期6卷 658-664,I0001-I0004页

作者： Jing Han Jian Li Yuhua Shi Chunpeng Zang Zhimin Yang Yu Han yanling Ma Qiongli Duan Yuhua Hu Zikuang bai Cuiyun Yang Gabriella Bulloch Yurong Mao Houlin Tang Zunyou Wu Yufen Liu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Yunnan Provincial Center for Disease Control and Prevention Kunming CityYunnan ProvinceChina Honghe Prefectural Center for Disease Control and Prevention Honghe CityYunnan ProvinceChina Wenshan Prefectural Center for Disease Control and Prevention Wenshan CityYunnan ProvinceChina Zhaotong Prefectural Center for Disease Control and Prevention Zhaotong CityYunnan ProvinceChina Lincang Prefectural Center for Disease Control and Prevention Lincang CityYunnan ProvinceChina Faculty of Medicine Dentistry and Health SciencesUniversity of MelbourneMelbourneVICAustralia

Summary What is already known about this topic?HIV transmission among serodiscordant couples remains a persistent issue in ***,the practice of combining counseling with antiretroviral therapies(ART)to enhance ART adhe... 详细信息

关键词： China ant discord

基于信息化的多重耐药菌感染防控管理与效果分析

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中国数字医学 2023年第4期18卷 18-23页

作者：杜明梅姚宏武刘伯伟白艳玲杨姗姗谢丽君闫中强周玉叶丽艳索继江赵烁刘运喜中国人民解放军总医院第一医学中心疾病预防控制科北京100853 中国人民解放军总医院第一医学中心临床检验科北京100853 中国人民解放军总医院第二医学中心疾病预防控制科中国人民解放军总医院第二医学中心临床检验科国家卫生健康委医院管理研究所医疗服务与安全研究部

目的:探讨信息化在多重耐药菌(MDROs)感染防控管理中的应用和管理效果。方法:自2022年1月开始实施基于信息化的多学科协作耐药菌防控新模式,对住院患者中检出的3类(耐碳青霉烯类肠杆菌目细菌、耐碳青霉烯类鲍曼不动杆菌、耐甲氧西林金... 详细信息

目的:探讨信息化在多重耐药菌(MDROs)感染防控管理中的应用和管理效果。方法:自2022年1月开始实施基于信息化的多学科协作耐药菌防控新模式,对住院患者中检出的3类(耐碳青霉烯类肠杆菌目细菌、耐碳青霉烯类鲍曼不动杆菌、耐甲氧西林金黄色葡萄球菌)MDROs进行信息化实时监测和干预防控,并分析MDROs防控措施执行率、MDROs检出率的变化。结果:与2021年对照组相比,2022年干预组隔离医嘱下达率由45.0%提高至87.5%(P<0.001),转科告知填写率提升5.1倍(P<0.001),医务人员手卫生依从性、环境清洁合格率、特殊类抗菌药物使用前送检率均有显著提高(P<0.001)。CRE、CRAB和MRSA新发感染率由对照组的0.4%下降至干预组的0.3%,千日感染率由0.7‰下降至0.4‰(P<0.001)。结论:基于信息化的耐药菌防控新模式的实施,提高了医务人员MDROs防控措施的执行力,并有效降低了MDROs的新发感染,值得推广应用。

关键词：信息化多重耐药菌预防与控制

Gene expression signatures for phlegm-dampness constitution of Chinese Medicine

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Science China(Life Sciences) 2017年第1期60卷 105-107页

作者： Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun yanling Wu Tongtong bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang Center for studies in Constitution Research of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Medical Systems Biology Research Center School of MedicineTsinghua UniversityBeijing 100084China Nutrition Department China-Japan Friendship HospitalBeijing 100029China Preventive Treatment of Disease Department Zhengzhou Hospital of Traditional Chinese MedicineZhengzhou 450002China

Dear Editor, The term ＂individualized medicine＂ was first used in Bio- chemistry Individuality in 1956 by Williams （Williams et al., 1956）. With the emergence of the post-genome era in the 21 st century, individualized precision medicine has attracted increasing attention. In traditional Chinese medicine （TCM）, there is also concept of individualized medicine, which is known as the Chinese constitutional theory, proposed in the 1970s （Wang, 2012）. According to this theory, the human population is divided into nine constitutions, including one balanced constitution （Normality） and eight unbalanced constitutions （Yang-deficient, Yin-deficient, Qi-deficient,

关键词：中医学体质基因表达特征后基因组时代构成要件不平衡 Bio

Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,Polygonum multiflorum

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Frontiers of Medicine 2021年第2期15卷 330-332页

作者： Chunyu Li Ming Niu Zhaofang bai Congen Zhang yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang China Military Institute of Chinese Medicine 302 Military HospitalBeijing 100039China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Integrative Medical Center 302 Military HospitalBeijing 100039China Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China Diagnosis and Treatment Center for Non-infectious Diseases 302 Military HospitalBeijing 100039China Beijing Union University Beijing 100101China Shanxi University of Traditional Chinese Medicine Taiyuan 030619China

Erratum to Frontiers of Medicine 201711(2):253–265 https://***/10.1007/s11684-017-0508-9 The original version of this article unfortunately contained some *** panel of“LPS–/drug–”in Fig.3B(Page 259),the panels of“LPS–/EtoAc+”and“LPS–/Residue+”in Supplementary Fig.3(Page 7 in the online supplementary materials)should be *** authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.

关键词： Medicine hepato corrected

Rare inherited missense variants of POGZ associate with autism risk and disrupt neuronal development

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Journal of Genetics and Genomics 2019年第5期46卷 247-257页

作者： Wenjing Zhao Jieqiong Tan Tengfei Zhu Jianjun Ou Ying Li Lu Shen Huidan Wu Lin Han yanling Liu Xiangbin Jia Ting bai Honghui Li Xiaoyan Ke Jingping Zhao Xiaobing Zou Zhengmao Hu Hui Guo Kun Xia Center of Medical Genetics & Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha410078China Mental Health Institute of the Second Xiangya Hospital Central South UniversityChangsha410011China Key Laboratory of Developmental Disorders in Children Liuzhou Maternity and Child Healthcare HospitalLiuzhou545001China Child Mental Health Research Center Nanjing Brain Hospital Affiliated of Nanjing Medical UniversityNanjing210029China Children Development Behavior Center of the Third Affiliated Hospital of Sun Yat-sen University Guangzhou510630China School of Life Sciences and Technology Xinjiang UniversityUrumqi830046China CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT) Chinese Academy of SciencesShanghai200030China

Excess de novo likely gene-disruptive and missense variants within dozens of genes have been identified in autism spectrum disorder(ASD)and other neurodevelopmental ***,many rare inherited missense variants of these high-risk genes have not been thoroughly *** this study,we analyzed the rare missense variant burden of POGZ in a large cohort of ASD patients from the Autism Clinical and Genetic Resources in China(ACGC)and further dissected the functional effect of diseaseassociated missense variants on neuronal *** results showed a significant burden of rare missense variants in ASD patients compared to the control population(P=4.6×10-5,OR=3.96),and missense variants in ASD patients showed more severe predicted functional outcomes than those in ***,by leveraging published large-scale sequencing data of neurodevelopmental disorders(NDDs)and sporadic case reports,we identified 8 de novo missense variants of POGZ in NDD *** analysis revealed that two inherited,but not de novo,missense variants influenced the cellular localization of POGZ and failed to rescue the defects in neurite and dendritic spine development caused by Pogz knockdown in cultured mouse primary cortical ***,L1CAM,an autism candidate risk gene,is differentially expressed in POGZ deficient cell *** expression of L1cam was able to partially rescue the neurite length defects caused by Pogz *** study showed the important roles of rare inherited missense variants of POGZ in ASD risk and neuronal development and identified the potential downstream targets of POGZ,which are important for further molecular mechanism studies.

关键词： Autism POGZ Neuronal development Missense variants

数字生态系统多主体协同创新超网络模型及治理路径研究

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中国科技论坛 2024年第10期 53-62页

作者：胡艳玲白世贞哈尔滨商业大学工商管理博士后科研流动站黑龙江哈尔滨150028 哈尔滨理工大学经济与管理学院黑龙江哈尔滨150040

在数字生态系统中,多主体协同创新是基于场景化的需求,以跨界创新项目为载体,将资源按需整合配置,以共同培育孵化数字创新产品的行为。本文结合超网络工具,将不同数字主体间技术水平、市场关系嵌入数字业务合作网络,构建数字生态系统多... 详细信息

在数字生态系统中,多主体协同创新是基于场景化的需求,以跨界创新项目为载体,将资源按需整合配置,以共同培育孵化数字创新产品的行为。本文结合超网络工具,将不同数字主体间技术水平、市场关系嵌入数字业务合作网络,构建数字生态系统多主体协同创新超网络模型,运用变分不等式对其求解,分析不同层级的网络流之间相互作用关系。在此基础上,以内容治理、关系治理和价值治理为核心,提出促进创新超网络实现均衡的框架和治理路径,以期为数字生态系统可持续发展提供参考借鉴。

关键词：数字生态系统协同创新超网络治理路径

Evidence chain-based causality identification in herb-induced liver injury： exemplification of a well-known liver-restorative herb Polygonum multiflorum

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Frontiers of Medicine 2015年第4期9卷 457-467页

作者： Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang yanling Zhao Jingyuan Song Zhaofang bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao China Military Institute of Chinese Medicine 302 Military Hospital Beijing 100039 China Beijing Friendship Hospital Capital Medical University Beijing 100050 China Diagnosis and Treatment Center for Non-infectious Diseases 302 Military Hospital Beijing 100039 China Institate of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China Integrative Medical Center 302 Military Hospital Beijing 100039 China Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China Diagnosis and Treatment Center of Western and Chinese Medicine for Liver Diseases 302 Military Hospital Beijing 100039 China Institute of Clinical Pharmacology Central South University Changsha 410008 China

Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury （DILI） in the United States. However, reliable methods to identify the DILl causality of some herbs, such as Heshouwu （dried root ofPolygonum multiflorum）, remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% （9/40） and 30.6% （45/147） of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% （19/20） of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence. Toxin （heavy metals, pesticides, and mycotoxins） contamination was also excluded from Heshouwu DILI causality. The objectivity of these screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements.

关键词： Polygonum multiflorum Chinese herbal medicine drug-induced liver injury pharmacognosy metabolomics stilbene

Hyperammonemia Influences Nonsense-mediated mRNA Decay(NMD) By Change The Quantity Of UPF1,UPF2 and SMG1

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Hyperammonemia Influences Nonsense-mediated mRNA Decay(NMD) ...

Prokaryotic Expression and Preparation of Polyclonal Antibody of HtrA Protein from Escherichia coli Causing Pneumonia in Fox

中华医学会第十三次全国感染病学术会议

作者： Fulei Li Jingjing Li Qiongye Wang Shasha Li yanling Chen Lu bai Zujiang Yu The First Affiliated Hospital of Zhengzhou University

Backround Chronic severe hepatitis is a critical disease with high ***,effective drugs and therapy still *** observed many patients with severe hepatitis always had hyperammonemia and with using medicine or therapy by Lowering blood ammonia the mortality was also ***’s more,a lot of patients got liver cancer after suffering severe *** nonsense-mediated RNA decay(NMD)was viewed as an important constitutive mechanism to rapidly eliminate mutated *** recently,it has been apprecia-

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Animal Husbandry and Feed Science 2018年第1期10卷 58-61页

作者： Zhang Zhiqiang Wu Tonglei Wu Qingmin Yan Xijun bai Xue Zhang yanling He Hongxuan Zhang Hongxue Liu Changhao Shi Qiumei Key Laboratory of Preventive Veterinary Medicine College of Animal Science and Technology Hebei Normal University of Science and TechnologyChangli 066600China China Agricultural University Beijing 100193China Key Laboratory of Economic Animal Diseases of Ministry of Agriculture Institute of Special Wild Economic Animals and Plants Chinese Academy of Agricultural SciencesChangchun 130112China Institute of Zoology Chinese Academy of SciencesBeijing 100101China Qilu Animal Health Products Co. Ltd.Jinan 250100China

To investigate the roles of HtrA protein in bacterial adaption to stresses, htra gene was cloned from an Escherichia coli strain isolated from silver fox, double digested, and ligated into the prokaryotic expression vector pET32a. Then, the recombinant plasmid pET32a-htra was transformed into E. coli BL21 competent cells. The over-expression of His-HtrA protein was induced by the addition of IPTG at a final concentration of 1 mmol/L, and verified by SDA-PAGE and Western blot. In addition, the protein was purified with Ni-NTA agarose, and used to immunize mice,and the polyclonal antibody specifically bound to E. coli HtrA protein. The results will provide a theoretical basis for studying the roles of HtrA protein and developing vaccines for fur-bearing animals against E. coli.

关键词： Silver fox Escherichia coli Pneumonia HtrA Prokaryotic expression

Network analysis of primary active compounds in Danqi analogous formulas for treating cardiovascular disease

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Journal of Traditional Chinese Medical Sciences 2016年第2期3卷 116-123页

作者： Shichao Zheng yanling Zhang Yanjiang Qiao Research Center of Traditional Chinese Medicine Information Engineering School of Chinese PharmacyBeijing University of Chinese MedicineBeijing 100102China

Objective:Used extensively to treat cardiovascular disease,Danqi analogous formulas(DQAF)include prescriptions for Danqi(DQ),Fufang Danshen(FFDS)and Qishen Yiqi(QSYQ).Differences in prescription compatibility result in varying emphases of DQAF in clinical *** and results:Based on network analysis in this study,common and distinct mechanisms of DQAF actions on cardiovascular disease were analyzed at a systemic *** etargetsepathways models were developed by Cytoscape(http://***/);whereby,target information for active compounds was obtained based on the PharmMapper database(http://59.***.96.61/pharmmapper/),which was further used to search pathways using the Kyoto Encyclopedia of Genes and Genomes database(http://***/kegg/).Based on target and network analyses,we discovered RBP4 is a potential common target of DQAF,while mitogen-activated protein kinase 1(MAPK1)and glutathione S-transferase P were potential targets of FFDS and QSYQ,***,the potential of DQAF to treat cardiovascular disease occurs through effects on the endocrine,immune,and digestive systems,in addition to lipid,sugar and amino acid metabolic *** FFDS exhibits effects on Toll-like receptor,transforming growth factor beta and MAPK signaling pathways;QSYQ exerts effects on cyclic adenosine monophosphate signaling,as well as metabolism of glutathione and arachidonic acid.

关键词： Network Danqi analogous formulas Docking Cardiovascular diseases