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Journal of Rare Earths 2023年第11期41卷 1819-1826,I0006页

作者： yanlin pan Yue Xu Di Zhang Jishan Zhang Guxin Zhou Yujing Lang China Academy of Ordnance Science Ningbo Branch Ningbo315103China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China

Nowadays,it is a challenge to improve the strength of 5xxx aluminium alloy while maintaining its distinctive properties.To address this,the Zn and Sc modified high strength 5xxx aluminium alloys with good intergranular corrosion resistance were prepared through chill casting,and the effects of minor Sc on mechanical properties,corrosion behavior and microstructure evolution of Al-5.0Mg-3.0Zn alloys were systematically investigated.The results show that the Sc containing alloy has high number density and small size of intragranular precipitates,combined with the solid solution strengthening of Sc and the Al_(3)(Sc_(1-x),Zr_(x))second phase strengthening,the strength of Al-5.0Mg-3.0Zn-0.1Sc alloy is obviously enhanced.Meanwhile,the intergranular corrosion resistance of the Sc containing alloy is also improved due to the formation of a large number of low angle grain boundaries and the weakening of the continuity of precipitated phases along the grain boundaries.

关键词： Al-Mg-Zn Scandium Mechanical properties Intergranular corrosion Transmission electron microscopy(TEM) Rare earths

Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement

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Protein & Cell 2024年第1期15卷 52-68页

作者： Yiyao Chen Bingxin Yang Xiaoyu Merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng Huang Jinglan Zhang Chenming Xu Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China bstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Intermational Peace Matermity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Rice Biology the Key Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of BiotechnologyZhejiang UniversityHangzhou 310058China Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of MedicineHoustonTX 77030USA Children's hospital of Fudan University Shanghai 201102China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024ZhejiangChina Research Units of Embryo Original Diseases Chinese Academy of Medical Sciences(No.2019RU056)Shanghai 200011China

Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 gene.The patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial features.Familial whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein family.The p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in vivo.Additionally,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index patient.The human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by E13.5.RNA-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development.

关键词： RBM42 gene RNA-binding protein neurodevelopmental disorder Au-Kline syndrome alternative splicing

Effects of Y2O3 on the microstructure and mechanical properties ofspark plasma sintered fine-grained W-Ni-Mn alloy

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Journal of Rare Earths 2017年第11期35卷 1149-1155页

作者： yanlin pan Lei Ding Hui Li Daoping Xiang State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University Haikou 570228 China Key Laboratory for Advanced Materials in Tropical Island Resources Ministry of Education Hainan University Haikou 570228 China

Fine-grained W-Ni-Mn-YOalloys were fabricated by mechanical alloying-assisted spark plasma sintering(SPS), and the effects of YOcontent on the microstructure and mechanical properties of the alloys were studied. Fine-grained 90 W-6 Ni-4 Mn-YOalloys with uniform microstructure and excellent properties were prepared by SPS at 1150 ℃. The addition of trace YOinhibited the sintering densification process and refined the W grain size. The average W grain size decreased from 5.5 μm to 2.1 μm.The fracture mode changed from W grain transgranular fracture and W-W interface fracture to W-W and W-Matrix phase interface fracture. The Rockwell hardness and bending strength of alloys initially increased and then decreased with increasing YOcontent. The optimum comprehensive mechanical properties(Rockwell hardness and bending strength) of the alloys were obtained at the same time when the mass fraction of YOwas 0.4%.

关键词： 90W-6Ni-4Mn alloys Y_2O_3 Spark plasma sintering Bending strength Fracture morphology

A new gain-of-function OsGS2/GRF4 allele generated by CRISPR/Cas9 genome editing increases rice grain size and yield

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The Crop Journal 2022年第4期10卷 1207-1212页

作者： Wenshu Wang Weipeng Wang yanlin pan Chao Tan Hongjing Li Ya Chen Xingdan Liu Jing Wei Nian Xu Yu Han Han Gu Rongjian Ye Qi Ding Chonglie Ma Life Science and Technology Center China National Seed Group Co.Ltd.Wuhan 430000HubeiChina State Key Laboratory of Crop Breeding Technology Innovation and Integration China National Seed Group Co.Ltd.Wuhan 430000HubeiChina

Grain size is one of the most important factors affecting rice grain quality and yield,and attracts great attention from molecular biologists and breeders.In this study,we engineered a CRISPR/Cas9 system targeting the miR396 recognition site of the rice GS2 gene,which encodes growth-regulating factor 4(OsGRF4)and regulates multiple agronomic traits including grain size,grain quality,nitrogen use efficiency,abiotic stress response,and seed shattering.In contrast to most previous genome editing efforts in which indel mutations were chosen to obtain null mutants,a mutant named GS2^(E) carrying an in-frame 6-bp deletion and 1-bp substitution within the miR396-targeted sequence was identified.GS2^(E) plants showed increased expression of GS2 in consistent with impaired repression by miR396.As expected,the gain-of-function GS2^(E) mutant exhibited multiple beneficial traits including increased grain size and yield and bigger grain length/width ratio.Thousand grain weight and grain yield per plant of GS2^(E) plants were increased by 23.5%and 10.4%,respectively.These improved traits were passed to hybrids in a semidominant way,suggesting that the new GS2^(E) allele has great potential in rice improvement.Taken together,we report new GS2 germplasm and describe a novel gene-editing strategy that can be widely employed to improve grain size and yield in rice.This trait-improvement strategy could be applied to other genes containing miRNA target sites,in particular the conserved miR396-GRF/GIF module that governs plant growth,development and environmental response.

关键词： Genome editing GS2/GRF4 Grain size Yield Rice

Current-driving intergranular corrosion performance regeneration below the precipitates solvus temperature in Al–Mg alloy

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Journal of Materials Science & Technology 2020年第18期52卷 132-139页

作者： Di Zhang Zhen Zhang yanlin pan Yanbin Jiang Linzhong Zhuang Jishan Zhang Xinfang Zhang State Key Laboratory of Advanced Metals and Materials University of Science and Technology Beijing.Beijing 100083China School of Materials Science and Engineering.Central South University Changsha 410083China School of Metallurgical and Ecological Engineering.University of Science and Technology Beijing Beijing 100083China

Heat treatment is an effective method to improve the intergranular corrosion resistance of the sensitized Al–Mg alloy due to dissolution of the grain boundary precipitates above the solvus temperature ofβ-phase.The grain boundary precipitates will grow and coarsening below the solvus temperature.In this study,the in-situ intergranular corrosion performance regeneration of the sensitized Al–Mg alloy can be realized by low-density electro-pulsing treatment below the solvus temperature ofβ-phase.Our findings show that the dissolution of grain boundary precipitates by electro-pulsing treatment is accelerated at relatively low temperature in comparison to traditional heat treatment.The athermal effect produced by the interaction between atoms and electrons on the dissolution of grain boundary precipitates is the main reason for the improved corrosion resistance below the solvus temperature ofβ-phase.

关键词： Aluminium alloys Phase transformation kinetics Electro-pulsing treatment Intergranular corrosion

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改进变值逻辑与线性预测在心音分类中的应用

云南大学学报（自然科学版） 2024年第3期46卷 432-442页

作者：王彦麟孙静杨宏波郭涛潘家华王威廉云南大学信息学院云南昆明650500 云南省阜外心血管病医院云南昆明650102

心音对于评价心脏健康状况具有重要作用.文章介绍了一种新的基于变值逻辑与线性预测倒谱系数融合特征的先心病分类算法,有助于提取心音中的深度病理特征.算法首先对心音进行降噪、包络提取;然后进行变值逻辑运算、标记并转换为可分析的... 详细信息

心音对于评价心脏健康状况具有重要作用.文章介绍了一种新的基于变值逻辑与线性预测倒谱系数融合特征的先心病分类算法,有助于提取心音中的深度病理特征.算法首先对心音进行降噪、包络提取;然后进行变值逻辑运算、标记并转换为可分析的测度数据,并计算信号的线性预测倒谱系数进行特征融合;最后使用随机森林,XGBOOST和LIGHTGBM机器学习分类器进行先心病二分类.研究所用心音样本共4000例,测试结果对正常和异常心音分类的平均准确率为0.9138.算法无需对心音进行心动周期分割,大大简化了分析流程,可望用于先心病的筛查.

关键词：心音先心病 3比特编码变值逻辑线性预测倒谱系数特征融合

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基于时频融合特征的肺动脉高压心音分类模型

计算机科学 2024年第S1期51卷 375-381页

作者：王彦麟孙静杨宏波郭涛潘家华王威廉云南大学信息学院昆明650500 昆明医科大学附属心血管病医院昆明650102

先心病相关肺动脉高压是一种严重的心血管疾病,致死率高,对其进行早期筛查与识别对于治愈尤为重要。目前临床是通过右心导管术确诊,此为有创检查,不便于在大规模筛查中采用,研究一种无创便捷的识别方法迫在眉睫。文中建立了一种时频融... 详细信息

先心病相关肺动脉高压是一种严重的心血管疾病,致死率高,对其进行早期筛查与识别对于治愈尤为重要。目前临床是通过右心导管术确诊,此为有创检查,不便于在大规模筛查中采用,研究一种无创便捷的识别方法迫在眉睫。文中建立了一种时频融合的心音分类模型。首先对心音信号进行预处理,然后使用融合滤波器组对信号进行转换并求取动态时频特征,最后将得到的融合特征参数输入表格式先验数据拟合网络(TabPFN)中进行分类识别。实验结果表明,该算法在正常、CHD-PAH和CHD中的平均准确率、精确率、灵敏度、特异度和F1分别为92.21%,92.15%,92.15%,96.11%,92.14%。对于先心病相关肺动脉高压的早期筛查与识别具有重要意义。

关键词：心音先心病相关肺动脉高压动态特征提取时频特征融合表格式先验数据拟合网络

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二语词汇及语言技能损耗研究

外语与翻译 2024年第2期31卷 63-68,I0001页

作者：潘克菊杨连瑞赵艳琳中国海洋大学山东省青岛市266100

本研究探讨中国非英语专业大学生二语词汇及语言技能损耗的表现特征与影响因素,发现如下:(1)研究支持二语词汇损耗中存在“起始平台”的观点,且时间的节点大概为外语减少或停止使用的6到12个月。(2)语言技能判定方法下被试对其损耗程度... 详细信息

本研究探讨中国非英语专业大学生二语词汇及语言技能损耗的表现特征与影响因素,发现如下:(1)研究支持二语词汇损耗中存在“起始平台”的观点,且时间的节点大概为外语减少或停止使用的6到12个月。(2)语言技能判定方法下被试对其损耗程度过度认知,且在产出性技能方面尤为明显,词汇判断的结果更加接近于被试的真实损耗状态。(3)影响词汇和语言技能保持因素中学习者动机最为显著,二语使用次之,二语接触对其影响较弱。

关键词：词汇损耗语言技能损耗动机语言使用

体外膜肺氧合患者早期急性胃肠损伤及影响因素分析

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中华急诊医学杂志 2024年第2期33卷 210-214页

作者：姜文学潘春熹韦燕琳韦巧王驰裴明毓吕立文右江民族医学院研究生学院百色533000 广西壮族自治区人民医院急诊科南宁530000

目的探讨体外膜肺氧合(ECMO)患者上机早期的急性胃肠损伤(AGI)及影响因素。方法回顾分析2020年9月至2021年12月于广西壮族自治区人民医院急诊监护病房住院治疗的ECMO患者共70例,按照2012年欧洲重症医学会关于重症患者急性胃肠损伤分级... 详细信息

目的探讨体外膜肺氧合(ECMO)患者上机早期的急性胃肠损伤(AGI)及影响因素。方法回顾分析2020年9月至2021年12月于广西壮族自治区人民医院急诊监护病房住院治疗的ECMO患者共70例,按照2012年欧洲重症医学会关于重症患者急性胃肠损伤分级指导意见,将患者分为AGI组与非AGI组,统计其早期急性胃肠损伤的发生率,并对其ECMO上机时血气分析结果及ECMO转机后ECMO参数、血流动力学指标及生化指标进行统计分析,探讨其早期发生AGI的影响因素及独立危险因素。另外将70例患者按照是否撤机成功分为撤机成功组与未撤机成功组,比较两组间急性胃肠损伤的发生情况,分析急性胃肠损伤的发生对ECMO患者撤机的影响。结果70例ECMO患者中,早期AGI的发生率为71.43%(50例),其中AGIⅠ、Ⅱ、Ⅲ、Ⅳ级的构成依次为18.57%(13例)、41.43%(29例)、11.43%(8例)、0%(0例);①单因素分析显示:AGI组与非AGI组相比较,ECMO上机时收缩压、舒张压、平均动脉压(MAP)、血管活性药物指数(VIS)、pH、乳酸、BMI差异有统计学意义(P<0.05);②Logistic二元回归分析显示:BMI是ECMO患者早期发生AGI的独立危险因素(ROC曲线下面积为0.657,95%可信区间为0.522~0.791(P<0.05),约登指数为0.15);③撤机成功组与未成功撤机组比较,未成功撤机组AGI的构成比更高,差异有统计学意义(P<0.05)。结论ECMO患者早期有较高的AGI发生率,主要发生Ⅰ、Ⅱ级,ECMO上机时收缩压、舒张压、MAP、VIS、pH、乳酸、BMI是ECMO患者早期发生AGI的影响因素,其中,BMI是ECMO患者早期发生AGI的独立危险因素。AGI的发生降低了ECMO患者的成功撤机率。

关键词：体外膜肺氧合急性胃肠损伤血流灌注 BMI 血管活性药物指数乳酸影响因素预后

Poly(lactic acid)-aspirin microspheres prepared via the traditional and improved solvent evaporation methods and its application performances

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中国化学工程学报:英文版 2023年第8期60卷 194-204页

作者： Xiaolin pan Mengyuan Gao Yun Wang Yanping He Tian Si yanlin Sun School of Chemical Engineering Kunming University of Science and TechnologyKunming 650504China

Drug-loaded microspheres are significant for the development of modern pharmaceutical products. It is well known that the taken of aspirin for long-term increases the risk of serious gastrointestinal complications, therefore a controllable delivery of aspirin is of importance to lighten those side effects. In this work, poly(lactic acid)(PLA) was chosen as the carrier to prepare PLA-aspirin microspheres by using the traditional and the improved solvent evaporation methods. It was found that no matter which experimental condition was, the encapsulation efficiency of aspirin was higher by using the improved method than that of the traditional method. Specifically, when the concentration of polyvinyl alcohol = 1%(mass),the polymer concentration = 1:20, the oil/water rate = 1:2.5, PLA-aspirin microspheres were obtained via the improved method with a high yield of 82.83%(mass) and an encapsulation efficiency of 44.09%. PLAaspirin microspheres were then prepared continuously using the improved method, which further enhanced the encapsulation efficiency to 54.56%. Approximate 85% aspirin released from microspheres within 7 days. Obvious degradation which was represented by reduction on hardness was observed by soaking microspheres in PBS for 60 days. This work is of interest because it provides a continuous route to prepare PLA-aspirin microspheres continuously with a high drug encapsulation efficiency.

关键词： Aspirin Degradation Foam-transfer Microspheres Poly(lactic acid) Slow-release