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Crystallographic facet-dependent stress responses by polyhedral lead sulfide nanocrystals and the potential ＂safe-by-design＂ approach

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Nano Research 2016年第12期9卷 3812-3827页

作者： Yun Chang Kai Li yanlin feng Ning Liu Yan Cheng Xiujuan Sun Yuqing feng Xi Li Zhijian Wu Haiyuan Zhang Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China School of Chemistry and Life Science Changchun University of Technology Changchun 130012 China

The particular physicochemical properties of nanomaterials are able to elicit unique biological responses. The property activity relationship is usually established for in-depth understanding of toxicity mechanisms and designing safer nanomaterials. In this study, the toxic role of specific crystallographic facets of a series of polyhedral lead sulfide （PbS） nanocrystals, including truncated octahedrons, cuboctahedrons, truncated cubes, and cubes, was investigated in human bronchial epithelial cells （BEAS-2B） and murine alveolar macrophages （RAW 264.7） cells./100} facets were found capable of triggering facet-dependent cellular oxidative stress and heavy metal stress responses, such as glutathione depletion, lipid peroxidation, reactive oxygen species （ROS） production, heme oxygenase-1 （HO-1） and metallothionein （MT） expression, and mitochondrial dysfunction, while {111} facets remained inert under biological conditions. The {100}-facet-dependent toxicity was ascribed to {100}-facet-dependent lead dissolution, while the low lead dissolution of {111} facets was due to the strong protection afforded by poly（vinyl pyrrolidone） during synthesis. Based on this facet-toxicity relationship, a ＂safe-by-design＂ strategy was designed to prevent lead dissolution from {100} facets through the formation of atomically thin lead-chloride adlayers, resulting in safer polyhedral PbS nanocrystals.

关键词： nanomaterials facet metal dissolution safe-by-design toxicity

Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy

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Nano Research 2019年第12期12卷 2947-2953页

作者： Keqiang Xu Yan Cheng Jiao Yan yanlin feng Runxiao Zheng Xiaqhig Wu Yanjing Wang Panpan Song Haiyuan Zhang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology cf China Hefei 230026China

The development of effective nanoplatforms is extremely necessary for cancer ***,we prepared polydopamine(PDA)andammonium bicarbonate(NH4HCO3)coated and doxorubicin(Dox)loaded hollow cerium oxide(CeO2)NPs(PDAC NPs),which showedexcellent synergistic effect for photothermal therapy,chemotherapy and chemodynamic *** near infrared laser irradiation,PDA shell could absorb the incident light and convert it into heat,which could not only kill tumor cells with hyperthermia,but also trigger thedecomposition of NH4HCO3 into gaseous carbon dioxide and ammonia,leading to the destroy of PDA *** leakage of PDA furtheraccelerated Dox release and exposed CeO2 surface,in which Dox could enter into cell nucleus to induce chemotherapy,and CeO2 couldcatalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic *** fact,PDAC NPs showed an excellenttherapeutic efficacy both in vitro and in *** design provides a new strategy for synergistic tumor therapy.

关键词： photothermal therapy chemotherapy chemodynamic therapy polydopamine cerium oxide

BaTiO_(3)@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism

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Nano Research 2023年第2期16卷 2775-2785页

作者： yanlin feng Jianlin Wang Xin Ning Aiyun Li Qing You Wanzhen Su Deping Wang Jianyun Shi Lan Zhou Fangfang Cao Xiaoyuan Chen Jimin Cao Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Educationand the Department of PhysiologyShanxi Medical UniversityTaiyuan 030001China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and Faculty of EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore

Abnormal metabolism has become a potential target for highly malignant and invasive triple-negative breast cancer(TNBC)due to its relatively low response to traditional *** existing metabolic interventions demonstrated unsatisfactory therapeutic outcomes and potential systemic toxicity,resulting from the metabolic instability and limited targeting ability of inhibitors as well as complex tumor *** address these limitations,here we developed a robust pyroelectric BaTiO_(3)@Au core–shell nanostructure(BTO@Au)to selectively and persistently block energy generation of tumor *** by near-infrared(NIR)laser,the Au shell could generate heat to activate the BaTiO_(3)core to produce reactive oxygen species(ROS)regardless of the constrained microenvironment,thus prominently inhibits mitochondrial oxidative phosphorylation(OXPHOS)and reduces ATP production to induce TNBC cell *** therapeutic effects have been well demonstrated in vitro and in vivo,paving a new way for the development of metabolic interventions.

关键词： pyroelectric nanoheterostructure reactive oxidative species(ROS) metabolic interventions mitochondrial oxidative phosphorylation(OXPHOS) triple-negative breast cancer(TNBC)

Prognostic factors for pN2 non-small cell lung cancer:a comprehensive evidence from 73 studies involving 23,772 patients

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Oncology and Translational Medicine 2020年第2期6卷 57-63页

作者： Shuo Li yanlin feng Chunzi Liang Jiancheng Tu Department&Program of Clinical Laboratory Medicine Center for Gene DiagnosisZhongnan Hospital of Wuhan UniversityWuhan 430071China

Obojective Non-small-cell lung cancer(NSCLC)is a common ***2 NSCLC,with pathologically confirmed ipsilateral mediastinal/subcarinal nodes metastasis,has been known as a very heterogeneous subgroup in terms of its anatomical,biological and patient *** factors based on patient characteristics were not well determined yet in this subgroup,and there is currently no standard treatment recommendation for these heterogeneous pN2 *** disagreements and inconsistency exist in study reports concerning the prognostic significance of certain factors in pN2 NSCLC,especially regarding to the issue about whether skip N2 metastasis benefit from *** We therefore performed this comprehensive summary of the published literatures to draw a more precise and less uncertain *** a comprehensive literature search,a total of 73 studies involving 23,773 subjects were included according to eligibility *** As expected,most of the investigated factors,such as old age,male,advanced pathological T stage,advanced clinical N stage,multiple N2 stations,extended surgical resection(pneumonectomy),and incomplete resection,but not post-operation treatment(*** and radiotherapy)were significantly associated with poor ***,skip N2 metastasis was favourable prognostic factors in operable pN2 NSCLC *** factors(histological type and primary tumour side)were neutral in terms of association with overall *** highlighted a number of important prognostic factors for pN2 NSCLC ***,patients with skip N2 disease benefit from *** Our findings could be used as reference information for decision-making in clinical practice and future study design.

关键词： non-small cell lung cancer meta-analysis prognostic factors overall survival

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微腔辅助的自旋动力学特性和超辐射相变

光学学报 2024年第5期44卷 245-252页

作者：崔超冯彦林山东师范大学物理与电子科学学院光场调控及应用中心山东济南250358

将玻色爱因斯坦凝聚制备在随时间简谐振荡的势场中,并与光学微腔系统相耦合,建立新的模型。分析了该模型中原子受到的有效磁场和简谐势阱的振动强度等因素对超辐射量子相变的影响,并探究了其随时间振荡的自旋动力学特性。提出的新模型... 详细信息

将玻色爱因斯坦凝聚制备在随时间简谐振荡的势场中,并与光学微腔系统相耦合,建立新的模型。分析了该模型中原子受到的有效磁场和简谐势阱的振动强度等因素对超辐射量子相变的影响,并探究了其随时间振荡的自旋动力学特性。提出的新模型具有重要的研究意义,且为深入研究腔量子调控提供了可行方案。

关键词：量子光学光学微腔超辐射自旋动力学玻色爱因斯坦凝聚

Equivalent combined cycle modelling for three-heat-reservoir thermal Brownian heat pump with heat-transfer effect and its optimal performance

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Science China Technological Sciences 2025年

作者： Lingen CHEN Congzheng QI yanlin GE Huijun feng Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety Wuhan Institute of Technology Hubei Provincial Engineering Technology Research Center of Green Chemical Equipment Wuhan Institute of Technology Institute of Thermal Science and Power Engineering Wuhan Institute of Technology School of Mechanical & Electrical Engineering Wuhan Institute of Technology

Because of the important role of the absorption heat pump in low-grade thermal energy utilization, this paper extends it to micro domain and performs a finite-time thermodynamic modelling for a three-heat-reservoir (THR) thermal Brownian heat pump with heat transfer effect by using an equivalent combined cycle method, which was applied for macro endoreversible THR heat pumps. The working principle and energy transformation rule are studied, and the coefficient of performance (COP) and heating load are derived. With a fixed overall thermal conductance of three heat exchangers, the maximal heating load is determined by optimizing thermal conductance distributions among three heat exchangers and barrier height, and the optimal working temperatures are also obtained. The impact of external heat transfer is elucidated to show the difference between this model and a non-equilibrium thermodynamic one. Results indicate that external heat transfer determines the energy transformation directly, and performance characteristics are closer to reality when external heat transfer is considered. The heating load has a maximal value about thermal conductance allocation ratios. About half the overall heat exchanger inventory needs to be assigned to the heat exchanger of the heating space for maximal heating load. When the cycle is with only heat transfer effect, the net particle numbers are zero, and the cycle fails to pump heat. The research results are expected to offer an idea for thermodynamic optimization and design of micro THR thermal Brownian heat pump devices.

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The possible value of ~18F-FDG positron emission tomography/computerized tomography imaging in detection of atherosclerotic plaque

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Journal of Nanjing Medical University 2008年第1期22卷 61-65页

作者： Jianwei Yuan yanlin feng Lingxiao Fan Xiaohong He Departrnent of Nuclear Medicine Affiliated Foshan Hospital of Sun Yat-sen University Foshan 528000 Guangdong Province China Office of Scientific Research Management zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080

Objective：To evaluate the clinical value with positron emission tomography/computerized tomography（PET/CT） imaging for the detection of vulnerable plaque in atherosclerotic lesions. Methods：Sixty people with a age of over 60[mean age （69.2 ± 7.1）years] underwent three dimension（3D） whole-body fluorine-18-2-fluoro-2-deoxy-D-glucose（^18F-FDG） PET/CT imaging and were evaluated retrospectively, including 6 cases assessed as normal and 54 cases with active atherosclerotic plaque. Fifty-four cases with SUVs and CT values in the aortic wall of high-FDG-uptake were measured retrospectively. These high-FDG-uptake cases in the aortic wall were divided into three groups according their CT value. Cases in group 1 had high uptake in atherosclerotic lesions of the aortic wall with CT value of less than 60 Hu（soft plaque）. Cases in group 2 had high uptake with CT value between 60-100 Hu （intermediate plaque）, Cases in group 3 had high uptake with CT value more than 100 Hu（calcified plaque）, Group 4 was normal. Results： In group 1, there were 42 high-FDG-uptake sites （average SUV 1.553 ± 0.486）. In group 2, there were 30 high-FDG-uptake sites（average SUV 1.393 ± 0.296）. In group 3, there were 36 high-FDG-uptake sites（average SUV 1.354 ± 0.189）. In group 4, there were 33 normal-FDG-uptake sites （average SUV was 1.102 ± 0.141）, The SUVs showed significant difference among the four groups（F = 678.909, P = 0.000）. There were also significant difference found between the normal-FDG-uptake group and the high-FDG-uptake groups（P = 0.000, 0.000, 0.001, respectively）. Conclusion：Different degrees of ^18F-FDG uptake in active large atherosclerotic plaque were shown in different stages of atherosclerotic plaque formation. The soft plaque had the highest FDG uptake in this study. This suggested that ^18F- FDG PET/CT imaging may be of great potential value in early diagnosis and monitoring of vulnerable soft plaque in atherosclerotic lesions.

关键词： fluorine-18-2-fluoro-2-deoxy-D-glucose positron-emission tomography computerized, tomography atherosclerosis vulnerable plaque

Link between miR-19b and the mTOR signaling pathway in cancer prognosis

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Oncology and Translational Medicine 2020年第4期6卷 153-164页

作者： yanlin feng Souraka Tapara Dramani Maman Shuo Li Dingdong He Jiancheng Tu Department of Clinical Laboratory Medicine&Center for Gene Diagnosis Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Objective Previous studies have reported differing conclusions regarding the prognostic value of miR-19b in ***,miR-19b may affect tumor growth by different pathways,mainly targeting PTENPI3K-AKT,which activates the downstream mTOR ***,we performed data mining to explore the possible correlation between miR-19b and mTOR in cancer *** We conducted online search and collected a total of 943 *** to different authors cross check and our study including/excluding criteria we at end retained 21 articles with 25 studies in this *** TCGA data containing miR-19b level with cancer progression were obtained using ***,Trial Sequential Analysis(TSA)was performed to determine whether the results of our meta-analysis could be used in clinical *** that,articles regarding the mechanism of miR-19b in various cancers were analyzed and KEGG pathway database was used to find the main regulatory function of miR-19b in human *** Overall hazard ratio(HR)results showed that higher levels of miR-19b expression were correlated with shorter overall survival time[HR=1.54,95%confidence interval(CI)=1.20-1.98]by promoting distant metastasis,but had no correlation with disease-free survival(DFS)/progression-free survival(PFS;HR=0.61,95%CI=0.31–1.19).Data from The Cancer Genome Atlas also revealed the role of miR-19b in *** to trial sequential analysis results,more evidence is required to confirm that miR-19b is not correlated with DFS/*** of the mechanism revealed a possible link between miR-19b and the mTOR *** miR-19b may have a pro-carcinogenic role through the mTOR pathway and thus,it is likely to be a therapeutic target for cancers.

关键词： microRNA miR-19b prognosis mechanism mTOR cancers

SUV_(max)、Ki-67、p53、EGFR对三阴性乳腺癌新辅助化疗疗效的预测价值

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肿瘤防治研究 2016年第1期43卷 45-47页

作者：李雯冯彦林佛山市第一人民医院核医学科佛山528000

目的探讨^(18)F-FDG PET/CT化疗前SUV_(max)、Ki-67、p53、EGFR对三阴性乳腺癌(TNBC)及非三阴性乳腺癌(非TNBC)对新辅助化疗完全病理缓解(pathologic complete response,p CR)率的预测价值。方法初治TNBC患者27例,非TNBC患者184例,在新辅助化疗前行18F-FDG PET/CT显像并测量其SUV_(max),取化疗前乳腺肿瘤组织进行Ki-67、p53、EGFR免疫组织化学分析并计算化疗后完全p CR率。结果 TNBC新辅助化疗前的SUV_(max)明显高于非TNBC的SUV_(max)(P=0.045),TNBC新辅助化疗后p CR率明显高于非TNBC(P0.05)。Ki-67、p53、EGFR阳性表达组的p CR率与阴性表达组之间差异无统计学意义(P>0.05)。结论 TNBC对新辅助化疗的敏感度高于非TNBC,且TNBC化疗前SUV_(max)高于非TNBC,提示TNBC具有较高的能量代谢。化疗前SUV_(max)以及Ki-67、p53、EGFR不能预测TNBC及非TNBC新辅助化疗的p CR。

关键词： PET-CT 三阴性乳腺癌新辅助化疗最大标准摄取值 Ki-67 p53 EGFR 病理完全缓解(pCR)