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Open Journal of Applied Sciences 2024年第2期14卷 320-329页

作者： Shuli Gao yanli guo College of Arts and Sciences Beijing Union University Beijing China

With the arrival of the big data era, the modern higher education model has undergone radical changes, and higher requirements have been put forward for the data literacy of college teachers. The paper first analyzes the connotation of teacher data literacy, and then combs through the status quo and dilemmas of teachers’ data literacy ability in applied universities. The paper proposes to enhance the data literacy ability of teachers from the perspective of organizational learning. Through building a digital culture, building a data-driven teaching environment, and constructing an interdisciplinary learning community to further promote the application of the theory and practice of datafication inside and outside the organization, and ultimately improve the quality of teaching.

关键词： Organizational Learning Teachers’ Data Literacy Lifting Paths

Cationic Conjugated Oligomers for Efficient and Rapid Antibacterial Photodynamic Therapy via Both Type Ⅰ and Type Ⅱ Pathways

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Chinese Journal of Chemistry 2024年第1期42卷 61-66页

作者： Huan Wang Shuwen guo Qiong Yuan Meiqi Li yanli Tang Country Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'anShaanxi 710119China

Recently,photodynamic therapy(PDT)has attracted wide attention due to its less susceptibility to drug resistance,broad-spectrum biocidal activity and biosafety in normal tissues.However,the traditional photosensitizers(Ps)face the disadvantage of poor therapeutic efficacy due to the requirement of an aerobic environment to generate ^(1)O_(2) through Type Ⅱ pathway.Herein,we designed and synthesized a novel cationic conjugated oligomer oligo(phenylene vinylene)(OPV)and studied its antibacterial photodynamic activity against both Gram-negative Escherichia coli(E.coli)and Gram-positive bacteria methicillin-resistant Staphylococcus aureus(MRSA).Importantly,the OpV can rapidly produce reactive oxygen species(ROs)through double pathways,Type Ⅰ and Ⅱ mechanism under white light irradiation,and efficiently kill E.coli and MRSA at a nanomolar level.The dual type photosensitizing capability makes OPV promising for enhanced PDT to treat pathogens and tumors in complex environments.

关键词： Conjugated oligomers Antibacterial photodynamic therapy Oligo(phenylene vinylene) Reactive oxygen species Typelandll pathways

A preliminary site selection system for underground hydrogen storage in salt caverns and its application in Pingdingshan,China

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Deep Underground Science and Engineering 2024年第1期3卷 117-128页

作者： Liangchao Huang yanli Fang Zhengmeng Hou Yachen Xie Lin Wu Jiashun Luo Qichen Wang Yilin guo Wei Sun Sino‐German Research Institute of Carbon Neutralization and Green Development Zhengzhou UniversityZhengzhouChina Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal ZellerfeldGermany Research Centre of Energy Storage Technologies Clausthal University of TechnologyGoslarGermany Sino‐German Energy Research Center Sichuan UniversityChengduChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanChina Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunmingChina

Large‐scale underground hydrogen storage(UHS)provides a promising method for increasing the role of hydrogen in the process of carbon neutrality and energy transition.Of all the existing storage deposits,salt caverns are recognized as ideal sites for pure hydrogen storage.Evaluation and optimization of site selection for hydrogen storage facilities in salt caverns have become significant issues.In this article,the software CiteSpace is used to analyze and filter hot topics in published research.Based on a detailed classification and analysis,a“four‐factor”model for the site selection of salt cavern hydrogen storage is proposed,encompassing the dynamic demands of hydrogen energy,geological,hydrological,and ground factors of salt mines.Subsequently,20 basic indicators for comprehensive suitability grading of the target site were screened using the analytic hierarchy process and expert survey methods were adopted,which provided a preliminary site selection system for salt cavern hydrogen storage.Ultimately,the developed system was applied for the evaluation of salt cavern hydrogen storage sites in the salt mines of Pingdingshan City,Henan Province,thereby confirming its rationality and effectiveness.This research provides a feasible method and theoretical basis for the site selection of UHS in salt caverns in China.

关键词： analytic hierarchy process(AHP) evaluation index hydrogen storage salt cavern site selection

Dithizone-functionalized C18 online solid-phase extraction-HPLC-ICP-MS for speciation of ultra-trace organic and inorganic mercury in cereals and environmental samples

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Journal of Environmental Sciences 2022年第5期34卷 403-410页

作者： Ying Wang Ailing Zhu Yingying Fang Changjun Fan yanli guo Zhiqiang Tan Yongguang Yin Yong Cai Guibin Jiang Laboratory of Environmental Nanotechnology and Health Effect Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Shimadzu China Innovation Center Shimadzu(China)Co.LTDBeijing 100020China Department of Chemistry and Biochemistry Florida International UniversityMiamiFL 33199United States

A simple and efficient dithizone-functionalized solid-phase extraction(SPE)procedure,online coupled with high-performance liquid chromatography(HPLC)-inductively coupled plasma mass spectrometry,was developed for the first time for enrichment and determination of ultra-trace mercury(Hg)species(inorganic divalent Hg(Hg(Ⅱ)),methylmercury(CH_(3)Hg(Ⅱ))and ethylmercury(C_(2)H_(5)Hg(Ⅱ))in cereals and environmental samples.In the proposed method,functionalization of the commercial C_(18) column with dithizone,enrichment,and elution of the above Hg species can be completed online with the developed SPE device.A simple solution of 2-mercaptoethanol(1%(V/V))could be used as an eluent for both the SPE and HPLC separation of Hg species,significantly simplifying the method and instrumen-tation.The online SPE method was optimized by varying dithizone dose,2-mercaptoethanol concentration,and sample volume.In addition,the effect of pH,coexisting interfering ions,and salt effect on the enrichment was also discussed.Under the optimized conditions,the detection limits of Hg species for 5 mL water sample were 0.15 ng/L for Hg(Ⅱ),0.07 ng/L for CH_(3)Hg(Ⅱ),and 0.04 ng/L for C_(2)H_(5)Hg(Ⅱ)with recoveries in the range of 85%-100%.The developed dithizone-functionalized C_(18) SPE column can be reused after a single function-alization,which significantly simplifies the enrichment step.Moreover,the stability of Hg species enriched on the SPE column demonstrated its suitability for field sampling of Hg species for later laboratory analysis.This environment-friendly method offers a robust tool to detect ultra-trace Hg species in cereals and environmental samples.

关键词： Mercury speciation Online solid-phase extraction HPLC-ICP-MS Dithizone Cereals Natural water

A Case of Waldenström Macroglobulinemia with Acute Kidney Injury as the First Manifestation and Literature Review

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Proceedings of Anticancer Research 2024年第3期8卷 127-132页

作者： Yang Xu Shanshan guo yanli Gou Xijie Zheng Department of Nephrology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Waldenström macroglobulinemia is a rare lymphoid tumor accounting for 2% of all hematological malignancies. Renal complications are less common compared to multiple myeloma, with the most frequent renal manifestations being microproteinuria and microhematuria. This paper presents a case of Waldenström macroglobulinemia with acute kidney injury as the initial manifestation. A 75-year-old male was admitted to the Affiliated Hospital of Hebei University after elevated blood creatinine levels were detected for one day. Upon admission, his blood creatinine was 255 μmol/L, urine protein was 1+, urine erythrocytes were negative, electrophoresis showed IgM positivity in the κ-region, and a bone marrow biopsy indicated a tendency towards lymphoplasmacytic lymphoma. The patient was discharged after receiving a treatment regimen of prednisone acetate, thalidomide, and cyclophosphamide, and continued oral medication outside the hospital. The patient returned two weeks later due to diarrhea and was found to have a blood creatinine level of 985 μmol/L, along with severe acidosis and hyperkalemia. The patient refused renal replacement therapy and was not followed up, resulting in a poor prognosis. Additionally, a review of the literature is provided to contextualize this case within the broader scope of existing research.

关键词： Waldenström macroglobulinemia Acute kidney injury Prognosis Literature review

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Corrigendum to“Dithizone-functionalized C18 online solid-phase extraction-HPLC-ICP-MS for speciation of ultra-trace organic and inorganic mercury in cereals and environmental samples”Journal of Environmental Science 115(2022)403-410

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Journal of Environmental Sciences 2023年第2期124卷 963-964页

The authors regretThe authors would like to apologize for any inconvenience caused.

关键词： Figure mercury phase

基于组合赋权-DEA的跨境铁路外部环境风险评价

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铁道工程学报 2024年第1期41卷 107-113页

作者：李艳丽马帅李利军郭湛石家庄铁道大学石家庄050043 中国铁道科学研究院集团有限公司北京100081

研究目的:跨境铁路大多穿越不同国家,铁路沿线的自然、社会环境条件复杂多变,给跨境铁路外部环境安全带来巨大威胁。为保障跨境铁路平稳运行,采用组合赋权-DEA方法在全面识别跨境铁路沿线风险的基础上进行风险评价,旨在为跨境铁路风险... 详细信息

研究目的:跨境铁路大多穿越不同国家,铁路沿线的自然、社会环境条件复杂多变,给跨境铁路外部环境安全带来巨大威胁。为保障跨境铁路平稳运行,采用组合赋权-DEA方法在全面识别跨境铁路沿线风险的基础上进行风险评价,旨在为跨境铁路风险管理工作提供借鉴。研究结论:(1)全面识别跨境铁路沿线外部环境风险,从自然环境与社会环境方面共选取30个风险指标构建跨境铁路外部环境风险评价指标体系,结合AHP-熵权法对各风险指标组合赋权;(2)应用基于DEA的风险评价方法,以各风险指标发生的概率和后果为变量,对跨境铁路外部环境风险进行评价和排序;(3)研究结果显示,跨境铁路侵限风险应予以重点关注,安保区内违法生产经营次之;(4)本文研究可为跨境铁路沿线外部环境安全管理工作提供新的思路,保障跨境铁路运输更加平稳高效运行。

关键词： AHP 熵权法 DEA 跨境铁路铁路安全

Recycling decision,fairness concern and coordination mechanism in EC-CLSC

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Journal of Control and Decision 2021年第2期8卷 184-191页

作者： Yuyan Wang Zhaoqing Yu yanli guo School of Management Science and Engineering Shandong University of Finance and EconomicsJinanShandong 250014People’s Republic of China

Taking the e-commerce platform’s fairness concern into account,three decision-making models of e-commerce closed-loop supply chain are constructed.Then,the recycling decisions under three models are studied and the impact of fairness concern is analysed.The‘effort costs sharing contract’is proposed to realise the coordination of the supply chain.Finally,the conclusions are verified by numerical analysis.The results show that the e-commerce platform’s fairness concern reduces own profit and the remanufacturer’s profit,and decreases system efficiency.The‘effort costs sharing contract’can realise the centralised model where recycling price of waste products is the highest,commission is the lowest,and system profit is the highest.In the coordinated system,the higher the proportion of remanufacturer sharing effort costs,the higher the profit of remanufacturer.

关键词： E-commerce closed-loop supply chain e-commerce platform fairness concern recycling decision

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关中东部商代遗存的文化因素分析

考古与文物 2024年第2期 89-103页

作者：李振飞郭妍利西北大学文化遗产学院陕西师范大学历史文化学院

本文运用文化因素分析法,将关中东部商代文化遗存分为A类商文化、B类本土文化、C类先周文化、D类北方文化、E类早期巴蜀文化五类文化因素。五类文化因素中前四类最为重要,其从早商到晚商时期的变化反映了本土文化因素的稳步发展、商文... 详细信息

本文运用文化因素分析法,将关中东部商代文化遗存分为A类商文化、B类本土文化、C类先周文化、D类北方文化、E类早期巴蜀文化五类文化因素。五类文化因素中前四类最为重要,其从早商到晚商时期的变化反映了本土文化因素的稳步发展、商文化的日渐淡出、周文化的有力推进、北方文化的持续进入,显示了各支文化对关中东部商代不同时期的关注和经略。

关键词：关中东部商代文化因素分析