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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Using Multivalued Logic in Relational Database Containing Null Value

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Journal of Computer Science & Technology 1996年第4期11卷 421-426页

作者：马宗民 yanli ShenyangInstituteofAutomation ChineseAcademyofSciencesShengany110015 LiaoningWorkersMovementCollege

In this paper, several kinds of multivalued logic for relational database and their developing process are presented on the basis of null value's semantics. A new 5 valued logic is led into relational database containing null talue. The feasibility and necessity of using 5 valued logic are expounded. Comparative calculation and logical calculation under 5 valued logic are defined at the end of the paper.

关键词： Null value relational database multivalued logic

Smart Caching for QoS-Guaranteed Device-to-Device Content Delivery

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China Communications 2018年第1期15卷 128-139页

作者： yanli Xu The College of Information Engineering Shanghai Maritime University

Caching at user equipment(UE) provides a feasible way for device-to-device(D2D) content delivery among proximal users without deploying additional infrastructures. To support D2D content delivery for mobile traffics with quality-of-service(QoS) requirements, smart caching problem is essential to be solved especially when there is no prior knowledge on demands of proximal users. In this paper, impacts of Qo S requirements and limited caching capacity on UE caching are analyzed, respectively, based on which a caching scheme is proposed. With the proposed caching scheme, UE can determine whether caching a content or not intelligently to guarantee a content request via D2D communications in the network. Simulation results are presented which verify the analyzed influencing factors on D2D caching and the proposed QoS-provisioning caching scheme.

关键词： D2D communication content de-livery caching strategy overflow probability

New Mehrotra's second order predictor-corrector algorithm for P_*(κ) linear complementarity problems

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Journal of Systems Engineering and Electronics 2010年第4期21卷 705-712页

作者： Mingwang Zhang yanli Lu College of Science China Three Gorges University Yichang 443002 R R. China

It has been shown in various papers that most interior-point algorithms for linear optimization and their analysis can be generalized to P_＊（κ） linear complementarity *** paper presents an extension of the recent variant of Mehrotra＇s second order algorithm for linear *** is shown that the iteration-complexity bound of the algorithm is O（4κ ＋ 3）√14κ ＋ 5 nlog（x0）Ts0/ε,which is similar to that of the corresponding algorithm for linear optimization.

关键词： linear complementarity problem P_*(κ)-matrix Mehrotra-type predictor-corrector algorithm polynomial complexity.

Mechanism of Residual Stress Reduction in Low Alloy Steel by a Low Frequency Alternating Magnetic Treatment

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Journal of Materials Science & Technology 2012年第9期28卷 803-808页

作者： yanli Song Lin Hua School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Residual stress reduction in low alloy steel by a low frequency alternating magnetic treatment and its mechanism were investigated. Experimental results revealed that average stress reductions of 20%-24% were obtained in the welded samples. Moreover, compared with the zones with lower initial stress levels, more remarkable stress reductions were obtained in the stress concentration zones. The microstructures and magnetic domains were observed by scanning electron microscopy （SEM） and atomic force microscopy （AFM）. Based on the analysis of the microstructure and magnetic domain changes, the mechanism of stress reduction by the magnetic treatment has been concluded：（1） the magneto-plastic deformations mainly due to the more uniform redistribution of dislocations are the fundamental cause of stress relaxation; and （2） surface topography is also proved to affect the magnetic treatment results to some degree by influencing magnetic domains.

关键词： Magnetic treatment Residual stress reduction Magneto-plastic deformations Surface topography

Partial Correlation Analysis Based Identification of Distribution Network Topology

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1493-1504页

作者： yanli Liu Peng Wang School of electrical and information engineering Tianjin UniversityTianjin300072China

Accurately identifying distribution network topol-ogy,which tends to be a mesh configuration with increasing penetration rate of distributed energy resources(DERs),is critical for reliable operation of a smart distribution *** among node voltages makes existing topology identification methods unstable and *** partial correlation analysis can reveal the intrinsic correlation of two variables by eliminating the influence of other variables,this paper develops a novel data-driven method based on partial correlation analysis to identify distribution network topology(radial,mesh,or including DERs)using only historical voltage amplitude ***,maximum spanning tree of network is generated through Prim ***,the loops of network are identified by taking tree neighbors as controlling variables in partial correlation ***,a new topology verification mechanism based on partial correlation analysis is developed to correct wrong connections caused by *** results on IEEE 33-node system,IEEE 123-node system and practical distribution network demonstrate that our method outperforms common data-driven methods,and can robustly identify both radial and mesh distribution network with ***-Data-driven,linear correlation,partial correlation,smart meter,topology identification.

关键词： Data-driven linear correlation partial correlation smart meter topology identification.

Separation of the Martensite in TiNi Fiber Reinforced Aluminum Matrix Composite

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Journal of Materials Science & Technology 2004年第4期20卷 390-394页

作者： YaniunZHENG LishanCUI yanli DazhiYANG DepartmentofMaterialsScienceandEngineering UniversityofPetroleumBeijing102249China DepartmentofMaterialsScienceandEngineering BeijingUniversityofAeronauticsandAstronauticsEngineeringBeijing100083China DepartmentofMaterialsEngineering DalianUniversityofTechnologyDalian116024China

The reverse martensitic transformation of TiNi shape memory alloy fibers embedded in a pure aluminum matrix was studied in this paper. Results showed that the phase composition of the TiNi alloy fibers prior to prestraining at the room temperature had a significant influence on the differential scanning calorimetry (DSC) results of the composites. By a comparison to the high temperature X-ray diffraction (XRD) results, it was confirmed that the martensite was divided into two groups: the self-accommodating martensite (SAM) and the preferentially oriented martensite (POM). The evolving process of the separation of martensite was discussed.

关键词： Shape memory alloy TiNi Composite Martensitic transformation

Rush-hour aromatic and chlorinated hydrocarbons in selected subway stations of Shanghai,China

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Journal of Environmental Sciences 2012年第1期24卷 131-141页

作者： yanli Zhang Chunlei Li Xinming Wang Hai Guo yanli Feng Jianmin Chen State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Department of Environmental Sciences and Engineering Fudan UniversityShanghai 200433China Department of Civil and Structural Engineering The Hong Kong Polytechnic UniversityHung HornKowloonHong KongChina School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200072China

Air samples were collected simultaneously at platform,mezzanine and outdoor in five typical stations of subway system in Shanghai,China using stainless steel canisters and analyzed by gas chromatography-mass selective detector （GC-MSD） after cryogenic ***,toluene,ethylbenzene and xylenes （BTEX） at the platforms and mezzanines inside the stations averaged （10.3±2.1）,（38.7±9.0）,（19.4±10.1） and （30.0±11.1） μg/m 3,respectively;while trichloroethylene （TrCE）,tetrachloroethylene （TeCE） and para-dichlorobenzene （pDCB）,vinyl chloride and carbon tetrachloride were the most abundant chlorinated hydrocarbons inside the stations with average levels of （3.6±1.3）,（1.3±0.5）,（4.1±1.1）,（2.2±1.1） and （1.2±0.3） μg/m 3,*** levels of major aromatic and chlorinated hydrocarbons were higher indoor （platforms and mezzanines） than outdoor with average indoor/outdoor （I/O） ratios of 1.1–9.5,whereas no significant indoor/outdoor differences were found except for benzene and *** highly significant mutual correlations （p0.01） for BTEX between indoor and outdoor and their significant correlation （p0.05） with methyl tert-butyl ether （MTBE）,a marker of traffic-related emission without other indoor and outdoor sources,indicated that BTEX were introduced into the subway stations from indoor/outdoor air exchange and traffic emission should be their dominant *** and pDCB were mainly from indoor emission and TeCE might have both indoor emission sources and contribution from outdoor air,especially in the mezzanines.

关键词： subway volatile organic compounds aromatic hydrocarbons chlorinated hydrocarbons methyl tert-butyl ether Shanghai

Chiral covalent organic frameworks for asymmetric catalysis and chiral separation

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Science China Chemistry 2017年第8期60卷 1015-1022页

作者： Liu,Guofeng Sheng,Jianhui Zhao,yanli Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Macromolecular Science Fudan University Shanghai 200433 China

Covalent organic frameworks(COFs), covalently assembled from the condensation reactions of organic building blocks, are a fascinating class of functional porous materials with two-or three-dimensional crystalline organic structures. Generally, it is preferable to use symmetric and rigid building blocks to construct highly crystalline COFs with desired topology. On the other hand, the incorporation of chiral functional moieties in the building blocks would open up new applications such as asymmetric catalysis and chiral separation. This mini review highlights the principle strategies in the design and synthesis of chiral COFs. The interesting and potential applications of these chiral COFs for asymmetric catalysis and chiral separation are also *** mini review aims to provide an up-to-date advancement of chiral COFs for asymmetric catalysis and chiral separation.

关键词： asymmetric catalysis building blocks chiral separation covalent organic frameworks porous materials