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Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19

Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 772-783页

作者： Jingjing Li Kai Zhang Di wua Lianjie Ren Xinyu Chu Chao Qin Xiaopeng Han Taijun Hang Yungen Xu Lei Yang Lifang Yina Jiangsu Province Engineering Research Center for R&D and Evaluation of Intelligent Drugs and Key Functional Excipients China Pharmaceutical UniversityNanjing 210009China Department of Pharmaceutical Analysis School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Strong infectivity enables coronavirus disease 2019(COVID-19)to rage throughout the ***,the lack of drugs with definite therapeutic effects further aggravates the spread of the *** is one of the most promising anti-severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)***,the limited clinical effects make its therapeutic effect controversial,which may result from the poor accumulation and activation of remdesivir in the ***,we developed lyophilized remdesivir liposomes(Rdv-lips)which can be reconstituted as liposomal aerosol for pulmonary delivery to improve the in vivo behavior of existing remdesivir cyclodextrin conclusion compound(Rdv-cyc)*** encapsulation endowed remdesivir with much higher solubility and better *** in vitro liposomal aerosol characterization demonstrated that Rdv-lips possessed a mass median aerodynamic diameter of 4.118μm and fine particle fraction(n 50%,indicating good pulmonary delivery *** to the Rdv-cyc intravenous injection group,the Rdv-lips inhalation group displayed a nearly 100-fold increase in the remdesivir-active metabolite nucleotide triphosphate(nTP)concentration and better nTP accumulation in the lung than the Rdv-cyc inhalation group.A faster transition from remdesivir to nTP of Rdv-lips(inhalation)could also be observed due to better cell *** to other preparations,the superiority of Rdv-lips was further evidenced by the results of an in vivo safety study,with little possibility of inducing *** conclusion,Rdv-lips for pulmonary delivery will be a potent formulation to improve the in vivo behavior of remdesivir and exert better therapeutic effects in COVID-19 treatment.

关键词： COVID-19 Remdesivir Pulmonary delivery Liposomal aerosol nucleotide triphosphate

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ViT-based Terrain Recognition System for wearable soft exosuit

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Biomimetic Intelligence & Robotics 2023年第1期3卷 57-64页

作者： Fangliang Yang Chunjie Chen Zhuo Wang Hui Chen Yao Liu Gang Li Xinyu wua Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Shenzhen College of Advanced Technology University of Chinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Lab of Robotics and Intelligent System Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong-Hong Kong-Macao Joint Laboratory of Human–Machine Intelligence-Synergy Systems Shenzhen 518055China SIASUn Robot and Automation CO. LtdShenyang 110169China

Terrain classification and force assistance strategies in complex environments have always piqued the interest of many *** wearable soft exosuits,inaccurate terrain recognition can easily introduce undesired assist forces that can easily injure the *** of these problems,we introduced a depth camera into the exosuit system,perform classification of terrain based on a Vision Transformer(ViT),and optimized the control algorithm,which is known as a ViT-Based Terrain Recognition System(TTRS).First,we used the Transformer algorithm to achieve a considerable classification effect in terrain *** also introduced terrain recognition as prior knowledge into the force assistance strategy of the exosuit,providing different force assistance to the exosuit in different ***,we performed human experiments with seven able-bodied people(six males and one female).The promising results demonstrate that our classification accuracy can reach 99.2%under six different terrains and that it can smoothly switch the force–assist curve in different terrains to better adapt to the complex terrain and improve the walking *** aforementioned terrain recognition algorithms and force–assist strategies may positively influence the study of soft exosuit,powered prostheses,and orthotics.

关键词： Vision Transformer(ViT) Depth camera Wearable soft exosuit Force assistance strategy Terrain recognition

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Hospital-Based Phenotypic Features and Treatment Outcomes of Chinese Women with Polycystic Ovary Syndrome: The Effect of Body Mass Index and Geographic Distribution

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Engineering 2021年第2期7卷 170-177页

作者： Jingshu Gao Hongli Ma Yu Wang Xinming Yang Yijuan Cao Bei Zhang Conghui Han Xiaoke wua First Affiliated Hospital Heilongjiang University of Chinese MedicineHarbin 150040China Xuzhou Central Hospital Xuzhou 221009China

Genetic,lifestyle,and environmental factors contribute to the etiology of polycystic ovary syndrome(PCOS).Increased body mass index(BMI)exacerbates the reproductive and metabolic parameters and reduces the fecundity of women with *** is a secondary analysis of a large-sample,multicenter,randomized controlled trial conducted at 21 sites in Chinese mainland.A total of 1000 women diagnosed with PCOS were enrolled in this *** these,998 women with PCOS were included in the *** BMI was associated with more severe menstrual irregularities,elevated testosterone level,higher prevalence of metabolic syndrome,and poorer quality of *** rates of ovulation per woman for the normal,overweight,and obese BMI groups were 83.0%,78.2%,and 63.6%,respectively(Pnd the rates of live birth were 23.6%,18.1%,and 15.3%(P=0.030).northern PCOS patients showed more severe reproductive,glucose,and lipid profiles;less exercise;and lower total ovulation rates compared with PCOS patients from Southern China(74.8%vs 81.2%,absolute difference 6.4%,95%confidence interval 1.2%–11.5%).The results show the typical phenotypic features of Han women with PCOS in northern and Southern *** women living in northern China showed a higher BMI,more severe glycolipid metabolism profiles,and subsequently worse clinical outcomes by the same interventions than those living in Southern *** difference in phenotypic features can be explained mostly by differences in BMI and the resulting difference in ovulation.

关键词： Polycystic ovary syndrome Body mass index Phenotype Chinese cohort Geographic distribution

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紧扣语文要素,挖掘范本功能

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天津教育 2021年第14期 153-154页

作者：陈娬福建省福安师范学校附属小学

习作单元的每一个板块都聚焦表达方法的学习,教学时应紧扣语文要素,挖掘范本功能,确定教学重点和思路,精心设计学习活动,才能构成完整而清晰的教学线索,从而增值范本价值。

关键词：语文要素范本功能单元整体想象表达

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Enrichment of heavy metal elements and their adsorption on iron oxides during carbonate rock weathering process

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Progress in natural Science:Materials International 2009年第9期19卷 1133-1139页

作者： Shanqin ni a, Yiwen Jua, Quanlin Hou a,*, Shijie Wang b, Qing Liua, Yudong wua, Lingling Xiao a a College of Earth Science, Graduate University of Chinese Academy of Sciences, Beijing 100049, China b State Key Laboratory of Environment Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China College of Earth Science Graduate University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Environment Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China

Analysis of trace elements in the Lower Palaeozoic carbonate rock strata of the Beijing area shows that the Cr, Zn, Cd and Pb contents increase from primary carbonate rocks to weathered carbonate rocks and from primary carbonate rocks to the soil coexisting with carbonate rock. Distributions of Cr, Zn, Cd and Pb have the same trends as that of Fe2O3. Iron oxides play different roles at different stages of weathering of carbonate rock. The adsorption of Cr, Zn, Cd and Pb on Fe2O3 is greater than on FeO in soil. However, FeO, as a main component of clay mineral, is a better adsorbent of Cr, Zn, Cd and Pb than Fe2O3 in weathered and primary carbonate rocks. According to R-type clustering analysis, the main components of carbonate rock are divided into marine and continental sediments. Correlation analysis shows that heavy metal elements mainly exist in continental substances.

关键词： Carbonate rock Heavy metal elements Adsorbent Enrichment

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Effects of water extracts of Davallia formosana on ovariectomized mice

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Chinese Herbal Medicines 2018年第1期10卷 66-72页

作者： chia-feng wu cheng-yu chen ming-chang wu jen-shinn lin department of food science national pingtung university of science and technologypingtung 91201china department of medicinal plant development yupintang traditional chinese medicine foundationkaohsiung 000800china

Objective： The Taiwan Residents native fern, Davallia formosana, is used to treat bone diseases in traditional Chinese medicine, but, very few animal tests to verify. To study how this fern and its active components alter bone metabolism. Methods： The effects of low and high doses of D. formosana water extracts （DFW, 50 and 200 mg/（kg·d）） and （-）-epicatechin-3-O-D-allopyranoside isolates of DFW （ECAP, 0.06 and 2.5 mg/（kg·d）） on protein lev- els of important indicators of osteoclast and osteoblast activities were examined. Ovariectomized mice were used as a model of osteoporosis. Bone morphogenetic protein 2 （BMP-2）, collagen 1 （COL-1）, alka- line phosphatase （ALP）, runt-related transcription factor 2 （RUnX2）, osteocalcin （OCn）, and osteopontin （OPn） were analyzed using western blotting of femur tissue. Interleukin （IL）-1β and tumor necrosis fac- tor （TnF）-a were measured in the serum, and hematoxylin and eosin staining were used to assess bone morphology. Results： Treatment with DFW or ECAP significantly induced BMP-2, COL-l, ALP, RUnX2, OCn, and OPn protein expression, indicating stimulation of osteogenesis. The treatments also reduced IL-1β and TnF- expression, indicating inhibition of osteoclastogenesis. In histological examinations, mice treated with DFW or ECAP had more bone trabeculae. The results demonstrate that DFW and ECAP inhibit osteo- clast differentiation and promote osteoblast differentiation, and effectively ameliorate ovariectomy （OVX）- induced osteoporosis. Conclusion： ECAP is a major component of DFW, which may have therapeutic potential for the treatment of diseases associated with excessive osteoclastic and insufficient osteogenic activity. ECAP may not be the specific active molecule because it is unstable in the stomach. However, the major active molecule needs to be confirmed using a relevant pharmacological model.

关键词： Davallia formosana Hayata osteoporosis osteogenesis osteoclastogenesis

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2-胺基(芳氧基)-5，8，9-三甲基噻吩并吡啶并[4，3-d]嘧啶-4(3H)-酮的合成和生物活性

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有机化学 2008年第4期28卷 632-637页

作者：刘建超贺红武丁明武华中师范大学化学学院农药与化学生物学教育部重点实验室武汉430079 中南大学化学化工学院长沙410083

利用串联Aza-Wittig法合成了两类共计16个未见文献报道的噻吩并吡啶并嘧啶类化合物,通过IR,1HnMR,EI-MS,元素分析等方法对所合成的化合物进行了结构表征,化合物II-1还通过了X单晶衍射的进一步确证.并初步测定了所合成化合物的杀虫、杀... 详细信息

利用串联Aza-Wittig法合成了两类共计16个未见文献报道的噻吩并吡啶并嘧啶类化合物,通过IR,1HnMR,EI-MS,元素分析等方法对所合成的化合物进行了结构表征,化合物II-1还通过了X单晶衍射的进一步确证.并初步测定了所合成化合物的杀虫、杀菌和除草活性.结果表明:所测化合物的杀虫活性较差,但大部分化合物具有一定的除草活性和良好的杀菌活性.

关键词： Aza-Wittig法吡啶并[4 3-d]嘧啶除草活性杀菌活性

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A new and simple method for count and identification of avian influenza viruses in water

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生物物理学报 2009年第S1期25卷 511-512页

作者： Yanyun wua, b, Hongxuan Hea, Chengmin Wanga, Guangju Jib a.Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R.China.b.Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R.China

To detect and enrich avian influenza viruses from environmental water samples, a modified VIRADEn (viruses’ adsorption-enumeration) method was established. Avian

关键词： Avian influenza viruses modified VIRADEn Enrichment Detection

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中德海洋学核心期刊论文国际合著的比较分析

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现代情报 2016年第2期36卷 150-156页

作者：万琪华薇娜南京大学信息管理学院江苏南京210023

本研究选取Web of Science数据库,收集中国和德国发表的海洋学论文,将论文分为国际合著组与非国际合著组,利用文献计量学的方法,借助EXCEL、SPSS和UCInET软件,比较两国各年的发文量、论文的篇均作者和篇均参考文献数、收录期刊的影响因... 详细信息

本研究选取Web of Science数据库,收集中国和德国发表的海洋学论文,将论文分为国际合著组与非国际合著组,利用文献计量学的方法,借助EXCEL、SPSS和UCInET软件,比较两国各年的发文量、论文的篇均作者和篇均参考文献数、收录期刊的影响因子、论文的被引频次以及合著国家。研究结果显示,中国海洋学领域的国际合著起步晚于德国,但发展迅速,近年来中国海洋学国际合著的论文量已超过德国;同时中国海洋学国际合著论文的质量和学术影响力都弱于德国,并且中国海洋学论文合著国家的范围也小于德国海洋学的合著国家。

关键词：海洋学中国德国核心期刊论文国际合著文献计量

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日本的产业政策及其借鉴

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软科学 2008年第4期22卷 93-97页

作者：张宏武时临云天津商业大学经济学院天津300134 天津商业大学商学院天津300134

首先在对日本产业政策演变过程进行探讨的基础上对日本产业政策的特点进行了评价,最后在指出借鉴国外的产业政策必须和本国的文化背景相结合的同时,提出了在制定我国产业政策时的一些政策建议。如要用超长期的观点提出每一时期的目标取... 详细信息

首先在对日本产业政策演变过程进行探讨的基础上对日本产业政策的特点进行了评价,最后在指出借鉴国外的产业政策必须和本国的文化背景相结合的同时,提出了在制定我国产业政策时的一些政策建议。如要用超长期的观点提出每一时期的目标取向;要逐渐由介入性的、强制的产业政策转向中介的、指针性的产业政策等。

关键词：产业政策国际借鉴日本

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