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Genes & Diseases 2024年第2期11卷 874-889页

作者： Yancheng Lai xiaole Lu yankai Liao Pei Ouyang Hai Wang Xian Zhang Guanglong Huang Songtao Qi Yaomin Li Department of Neurosurgery Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Laboratory for Precision Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tumor in adults,with a median survival of approximately 15 months.GBM heterogeneity is considered responsible for the treatment resistance and unfavorable prognosis.Proneural-mesenchymal transition(PMT)represents GBM malignant progression and recurrence,which might be a breakthrough to understand GBM heterogeneity and overcome treatment resistance.PMT is a complicated process influenced by crosstalk between GBM and tumor microenvironment,depending on intricate ligand-receptor interactions.In this review,we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing PMT.We also discuss the current therapies targeting the PMT-related autocrine and paracrine pathways.Together,this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

关键词： Autocrine Glioblastoma Ligand-receptor interaction Microenvironment Paracrine Proneural-mesenchymal transition

Residential energy transition and chronic respiratory diseases

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The Innovation 2024年第3期5卷 33-43页

作者： Hongcheng Wei Qiurun Yu Danrong Chen Mingzhi Zhang Quanquan Guan Bo Hang Antoine M.Snijders Adrian Covaci yankai Xia State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166China The Affiliated Wuxi People’s Hospital of Nanjing Medical University Wuxi People’s HospitalWuxi Medical CenterNanjing Medical UniversityWuxi 214023China Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Toxicological Centre University of Antwerp2610 WilrijkBelgium

Obtaining clean energy is of prime importance for planetary health and sustainable development.We aimed to assess the association between residential energy transition and the risk of chronic respiratory diseases.Using data from the Global Health Observatory and Global Burden of Diseases,Injuries,and Risk Factors Study,we delineated the spatial distribution and temporal trends of the population using clean fuels for cooking at a global scale.In the China Health and Retirement Longitudinal Study,we performed rigorous and well-structured multistage analyses incorporating both cross-sectional and prospective data analyses to examine the associations between solid fuel use,residential energy transition,duration of solid fuel use,and the risk of chronic respiratory diseases.Despite great progress,huge disparities in access to clean energy persist globally.Residential energy transition was associated with a lower risk of chronic respiratory diseases.In the period of 2011–2013,compared with persistent solid fuel users,both participants who switched from solid to clean fuels(adjusted risk ratio[RR]0.78,95%confidence interval[CI]0.62–0.98)and persistent clean fuel users(adjusted RR 0.71,95%CI 0.57–0.89)had significantly lower risk of chronic respiratory diseases(p<0.001 for trend).Consistent associations were observed in the period of 2011–2015 and 2011–2018.Household energy transition from solid to clean fuels could reduce the risk of chronic respiratory diseases.This is a valuable lesson for policy-makers and the general public to accelerate energy switching to alleviate the burden of chronic respiratory diseases and achieve health benefits,particularly in low-and middle-income countries.

关键词： cooking income globally

Synergistically enhanced dielectric, insulating and thermally conductive performances of sandwich PMMA based dielectric films

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Progress in Natural Science:Materials International 2024年第3期34卷 591-597页

作者： Dongmei Zhang Yufan Li Yuchao Li Zhonggui Sun Hanxue Zhu Lujia Yang Yanhu Zhan yankai Li Shi Wang Jun-Wei Zha School of Mathematical Sciences Liaocheng University School of Materials Science and Engineering Liaocheng University State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications School of Chemistry and Biological Engineering University of Science and Technology Beijing

A tri-layered(B-G-B) dielectric films were simply prepared by alternatively spin-coating boron nitride/polymethylmethacrylate(BN/PMMA, B) and graphene nanosheets(GNS/PMMA, G) compound solutions. The structure, morphology, thermal conductivity, and particularly the dielectric and relaxation behaviors were systematically studied. Results showed that a good exfoliation and dispersion of BN and GNS can be simply achieved through intensive mechanical compounding with PMMA in the internal mixer. The dielectric constant and breakdown strength of the obtained 1-3-1(B-G-B) sandwich composite film reached 4.3(@1 kHz) and 458.6kV/mm, being 119 % and 113 % higher than that of pure PMMA, respectively. Furthermore, the overall thermal conductivity of sandwich 1-3-1 composite increased by 112 % due to the addition of thermally conductive BN and GNS. The sandwich design strategy provided an effective way of achieving good permittivity, high insulation, and improved thermal conductivity simultaneously, showing potential applications in the miniaturization and integration of electronic devices.

关键词： Breakdown strength Composites Dielectric constant Sandwich structure Thermal conductivity

Heteroatom Structural Engineering Enables Ethenylene-Bridged Bisisoindigo-Based Copolymers to Exhibit Unique n-Type Transistor Performance

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CCS Chemistry 2024年第2期6卷 473-486页

作者： Yuchai Pan Weifeng Zhang yankai Zhou Xuyang Wei Hao Luo Jinbei Wei Liping Wang Gui Yu Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049 School of Material Science and Engineering University of Science and Technology BeijingBeijing 100083

Herein,we report three novel electron-deficient aromatics,ethenylene-bridged bisisoindigos 3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoind-oline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one)(NCCN),3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one)(NFFN),and(3E,3″E)-6,6″-((E)-ethene-1,2-diyl)bis(1,1′-bis(4-decyltetradecyl)-[3,3′-bipyrrolo[2,3-b]pyridinylidene]-2,2′(1H,1′H)-dione)(NNNN),and their derived donor–acceptor(D–A)copolymers,namely poly[3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNCCN-FBT),poly[3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNFFNFBT),and poly[(3E,3″E)-6′,6‴-((E)-ethene-1,2-diyl)bis(1,1′-bis(4-decyltetradecyl)-[3,3′-bipyrrolo[2,3-b]pyridinylidene]-2,2′(1H,1′H)-dione-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNNNN-FBT),in which 5,6-difluoro-4,7-di(thiophen-2-yl)benzo[c][1,2,5]thiadiazole(FBT)acts as the electron-donating units.The ethenylene-bridging unit reduces the steric hindrance of the three bisisoindigos.Incorporation of heteroatoms,such as fluorine and sp2-nitrogen atoms,endows them with multiple CH···F,CH···N,and N···S intramolecular hydrogen bonds/nonbinding interactions,resulting in increasing backbone planarity from NCCN,NFFN,to NNNN,and thus from PNCCN-FBT,PNFFN-FBT,to PNNNN-FBT.We found that all copolymers formed an improved molecular packing in the 1-chloronaphthalene(CN)-processed thin film compared with the 1,2-dichlorobenzene-processed one.The CN-processed PN

关键词： D-A copolymers bisisoindigos heteroatom structural engineering n-type field-effect transistors electron mobilities

Research on the Hotspots and Development of“Internet+Nursing Services”in China:A Bibliometric Analysis Based on CiteSpace

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Journal of Clinical and Nursing Research 2024年第2期8卷 234-243页

作者： yankai Shi Shihua Cao Chen Zhu School of Nursing Hangzhou Normal UniversityHangzhou 311121China School of Nursing Zhejiang Chinese Medical UniversityHangzhou 310053China

Objective:This study aims to explore the current research status,hotspots,and trends of the emerging nursing model of“Internet+nursing service”in China,and to provide theoretical references for further research and development.Methods:The literature related to“Internet+nursing service”was retrieved from the China National Knowledge Infrastructure(CNKI),Wanfang database,VIP database,and SinoMed.Subsequently,visual analysis was performed using the CiteSpace scientific knowledge mapping software.Results:A total of 1223 articles were included.The number of papers published in this field has been increasing yearly,and a core group of authors has been formed.Research institutions are mainly comprised of universities and hospitals and a high percentage of projects were funded provincially and municipally,while the least percentage of projects were funded nationally.The main research hotspots include the nurse standardized management for online appointments,the current application situation for the nursing model,and factors influencing its application amongst the elderly and also in women and children’s groups.Conclusion:Although the“Internet+nursing service”in China is still in its early stages,considerable progress has been made in relevant research.Future research should focus on identifying and omitting factors that hinder the industry’s growth,thereby establishing an effective long-term model of care.

关键词： Internet+ Online nurse Home care Visual analytics Aging

General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis

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Science China Chemistry 2024年第8期 2637-2646页

作者： Meng He yankai Yang Heng Zhang Zhipeng Guan Zhi-Bing Dong Hong Yi Aiwen Lei College of Chemistry and Molecular Sciences and Institute for Advanced Studies (IAS) Wuhan University School of Chemistry and Environmental Engineering Wuhan Institute of Technology

CF2H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF2H reagents as a source of CF2H radical is limited by their reactivity and preparation. Herein, we develop a simple and general visible-light-catalyzed radical difluoromethylation reaction of alkenes, dienes, and heteroaromatics using commercially available, easy-to-handle, and low-cost difluoroacetic anhydride as the CF2H reagent. This scalable protocol enables the convenient synthesis of a range of CF2H-containing compounds under mild conditions, exhibiting a broad substrate scope and functional group tolerance. Potential applications are further demonstrated by gram-scale synthesis, sunlight experiments, derivatization experiments as well as the synthesis of bioactive molecules.

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“去方程化”的分数应用题教学探究

教学与管理 2024年第5期 32-36页

作者：牛延凯山东省淄博市高新区教育和体育事业中心

分数应用题是小学数学的难点,现有教材中大量借助方程处理分数中的复杂数量关系。《义务教育数学课程标准(2022年版)》将方程内容从小学移出后,亟需形成“去方程化”的分数应用题教学变革。分析现有教材的变迁、对比国外教材,可以发现... 详细信息

分数应用题是小学数学的难点,现有教材中大量借助方程处理分数中的复杂数量关系。《义务教育数学课程标准(2022年版)》将方程内容从小学移出后,亟需形成“去方程化”的分数应用题教学变革。分析现有教材的变迁、对比国外教材,可以发现方程并不是分数应用题教学的必要条件。在不借助方程时,首先通过“量”和“率”的分类讨论,把握分数应用题和整数应用题的迁移联系;进一步通过构建数量关系结构,明晰分数问题中加减乘除列式的算术意义;最后通过比、分数、除法之间的大单元联系,实现分数应用题的整体教学。

关键词：小学数学分数应用题方程 “去方程化”

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基于频域特征的航空轴承智能诊断

航空动力学报 2024年第6期39卷 248-258页

作者：李宏宇苏越陈康王俨剀西北工业大学动力与能源学院西安710072

针对航空发动机滚动轴承的故障诊断,提出一种基于频域特征的故障诊断模型。将原始振动信号进行包络解调预处理,仅取每段数据处理后的512个点作为故障特征,将其作为双向循环长短期记忆网络(BiLSTM)模型的输入,可对内圈故障、外圈故障、... 详细信息

针对航空发动机滚动轴承的故障诊断,提出一种基于频域特征的故障诊断模型。将原始振动信号进行包络解调预处理,仅取每段数据处理后的512个点作为故障特征,将其作为双向循环长短期记忆网络(BiLSTM)模型的输入,可对内圈故障、外圈故障、滚动体故障及每种故障所对应3种不同的故障程度进行诊断。该模型不仅弥补完全由原始振动信号输入导致输入数据冗长,特征不明显等缺点,也弥补由人工提取振动特征来进行故障诊断的不确定性。在滚动轴承公开数据集上进行实验,结果表明故障识别的准确度达到99.8%以上。搭建航空轴承实验器来对方法与模型进行检验。基于频域特征的双向循环长短期记忆网络模型能够更准确地对轴承进行故障诊断,所提方法对于航空发动机滚动轴承故障诊断具有重要工程价值。

关键词：故障诊断特征提取神经网络滚动轴承双向循环长短期记忆网络

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某型航空发动机振动值波动故障诊断和排除

振动．测试与诊断 2024年第2期44卷 274-279,408页

作者：丁小飞廖明夫韩方军王俨剀西北工业大学动力与能源学院西安710072 中国航空发动机集团沈阳发动机研究所沈阳110015

针对某型航空发动机试车过程中的稳态振动波动问题,开展了时域和频域分析,指出振动波动是由于低压2倍频和高压基频振动拍振所引起。推导了航空发动机拍振引起的振动响应,建立了某型航空发动机双转子动力学模型,并进行了仿真分析。仿真... 详细信息

针对某型航空发动机试车过程中的稳态振动波动问题,开展了时域和频域分析,指出振动波动是由于低压2倍频和高压基频振动拍振所引起。推导了航空发动机拍振引起的振动响应,建立了某型航空发动机双转子动力学模型,并进行了仿真分析。仿真结果表明,当发动机两个激振力频率相近时,会产生拍振引起振动波动,仿真结果与试验结果相吻合。结合发动机结构和其工作特点,分析了发动机形成低压倍频-高压基频耦合拍振的条件,给出了拍振排除方法,并通过试验验证了方法的正确性。工程上可以通过调整高压和低压转子转差关系,将转速比调整到合理范围内即可消除拍振。

关键词：航空发动机双转子拍振振动波动

Abnormal miR-214/A20 expression might play a role in T cell activation in patients with aplastic anemia

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Blood Science 2020年第3期2卷 100-105页

作者： Zhi Yu Cunte Chen yankai xiao xiaohui Chen Lixing Guo Guangxiao Tan Guixuan Huang Weifeng Luo Ming Zhou Yumiao Li Chen Lin Qi Shen Yuping Zhang Bo Li Department of Hematology First Affiliated HospitalJinan UniversityGuangzhouChina Institute of Hematology School of MedicineJinan UniversityGuangzhouChina Key Laboratory for Regenerative Medicine of Ministry of Education Institute of HematologySchool of MedicineJinan UniversityGuangzhouChina Guangzhou Blood Center GuangzhouChina Department of Hematology Guangzhou First Municipal People’s Hospital Affiliated to Guangzhou Medical CollegeGuangzhouChina Department of Microbiology and Immunology School of MedicineJinan UniversityGuangzhouChina Department of Hematology Second Clinical Medical College of Jinan University(Shenzhen People’s Hospital)ShenzhenChina

Aberrant T cell activation is a major cause of aplastic anemia(AA)pathogenesis.Recent studies have shown that miRNAs regulate T cell activation and are involved in AA.A previous study found that miR-214 was significantly up-regulated upon T cell activation in a CD28-dependent fashion by targeting PTEN.However,the expression characteristics of miR-214 and its target genes in AA have not been defined.In this study,target genes for miR-214 were predicted and confirmed by bioinformatics and luciferase reporter assays.The expression levels of miR-214 and target genes were detected in 36 healthy individuals and 35 patients with AA in peripheral blood mononuclear cells by real-time quantitative reverse transcriptase-polymerase chain reaction.Bioinformatics and luciferase reporter assays identified that miR-214 could bind to the A2030 untranslated regions.Significantly increased miR-214 and the decreased A20 expression level were detected in the AA patients compared with the healthy group.In addition,significantly increased miR-214 was found in non-severe aplastic anemia compared with severe aplastic anemia patients.These results suggested that the A20 gene was a potential target of miR-214,and elevated miR-214 might medicate T cell activation at least in part by regulating A20 expression in AA.We firstly confirmed that miR-214 regulated A20 expression,and aberrant miR-214/A20 expression might contribute to immunopathology in AA.The miR-214 expression might be used as a potential biomarker that assisted in diagnosing AA severity.

关键词： A20 Aplastic anemia miR-214 T cell