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Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposureinduced anxiety-like behaviors in offspring

Environmental Science and Ecotechnology 2023年第1期13卷 125-133页

作者： Xingwang Ding Ya Wen Xuan Ma Yuepei Zhang Yuting Cheng Zhaofeng Liu Weiyue Hu yankai Xia State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical University101 Longmian AvenueJiangning DistrictNanjing211166China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical University101 Longmian AvenueJiangning DistrictNanjing211166China Department of Chronic Non-Communicable Disease Control Wuxi Liangxi District Center for Disease Control and PreventionWuxi214011China Department of Nutrition and Food Safety School of Public HealthNanjing Medical UniversityNanjing211166China

Pyridaben(PY)is a widely used organochlorine acaricide,which can be detected in the peripheral blood of pregnant *** evidence suggests that PY has reproductive ***,it remains uncertain whether prenatal PY exposure impacts neurobehavioral development in ***,we administered PY to pregnant mice at a dose of 0.5 and 5 mg kg^(-1)day^(-1)via gavage and observed anxietylike behaviors in PY offspring aged five *** then integrated the metabolome and transcriptome of the offspring's brain to explore the underlying *** data indicated that the vitamin B6 metabolism pathway was significantly affected,and the pyridoxal 50-phosphate(PLP)concentration and the active form of vitamin B6 was significantly ***,the transcriptome data showed that both PLP generation-related Pdxk and anxiety-related Gad1 were significantly ***,there was a decreasing trend in the concentration of GABA in the hippocampal DG ***,we supplemented PLP at a dose of 20 mg kg^(-1)day^(-1)to the PY offspring via intraperitoneal injection at three *** found up-regulated expression of Pdxk and Gad1 and restored anxiety-like *** study suggests that prenatal exposure to PY can disrupt vitamin B6 metabolism,reduce the concentration of PLP,down-regulate the expression levels of Pdxk and Gad1,inhibit the production of GABA,and ultimately lead to anxiety-like behaviors in offspring.

关键词： Pyridaben Prenatal exposure Pyridoxal 50-phosphate Anxiety-like behaviors

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Unmanned aerial systems coordinate target allocation based on wolf behaviors

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Science China(Information Sciences) 2019年第1期62卷 205-207页

作者： Haibin DUAN Qing YANG Yimin DENG Pei LI Huaxin QIU Tianjie ZHANG Daifeng ZHANG Mengzhen HUO yankai SHEN Bio-inspired Autonomous Flight Systems (BAFS) Research Group State Key Laboratory of Virtual Reality Technology and SystemsSchool of Automation Science and Electrical EngineeringBeihang University (BUAA)

Unmanned aerial systems (UASs), especially the cluster of UAS, are highly focused and widely used in various domains. The application of small and inexpensive UAS with a large-scale group to perform complex tasks has ... 详细信息

关键词： UAS Unmanned aerial systems coordinate target allocation based on wolf behaviors

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Ecological City Planning in Urban Planning and Design

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Journal of Architectural Research and Development 2019年第6期3卷 25-28页

作者： Yitong Li yankai Wang Inner Mongolia University of Technology New DistrictHohhotInner Mongolia010051China

Based on the actual situation,this paper summarizes and analyzes the key points of eco-city planning in urban planning and design,and hopes to provide help to researchers in related fields after the discussion.

关键词： Urban planning and design Eco-cities Planning analysis

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Profiles of metabolic gene expression in the white adipose tissue, liver and hypothalamus in leptin knockout(Lep^(△I14/△I14)) rats

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The Journal of Biomedical Research 2017年第6期31卷 528-540页

作者： Leijian Guan Kaixuan Xu Shuyang Xu Ningning Li Xinru Wang yankai Xia Di Wu State Key Laboratory of Reproductive Medicine Institute of Toxicology School of Public Health Nanjing Medical University Xuzhou Central Hospital The Affiliated Xuzhou Hospital of Medical College of Southeast University School of Life Sciences and Technology Tongji University

Leptin deficiency is principally linked to metabolic disorders. Leptin knockout（Lep△I14/△I14 Sprague Dawley rats created by CRISPR/Cas9 is a new model to study metabolic disorders. We used a whole rat genome oligonucleotide microarray to obtain tissue-specific gene expression profiles of the white adipose tissue, liver and hypothalamus in Lep△I14/△I14）and wild-type（WT） rats. We found 1,651 differentially expressed（enriched） genes in white adipose tissue,916 in the liver, and 306 in the hypothalamus in the Lep△I14/△I14 rats compared to WT. Gene ontology category and KEGG pathway analysis of the relationships among differentially expressed genes showed that these genes were represented in a variety of functional categories, including fatty acid metabolism, molecular transducers and cellular processes. The reliability of the data obtained from microarray was verified by quantitative real-time PCR on 14 representative genes. These data will contribute to a greater understanding of different metabolic disorders, such as obesity and diabetes.

关键词： Lep△I14/△I14 microarray analysis white adipose liver hypothalamus

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Address to Sino-Italy Clothing Brands Forum (Milano)——Zhang yankai *** of China National Textile and Apparel Council (CNTAC)

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China Textile 2012年第7期 24-27页

作者： Zhang yankai V.President of China National Textile and Apparel Council (CNTAC) Zhao Hong

Good Morning! Dear Ladies and Gentlemen, On behalf of CNTAC, I would like to share with you the information of Chinese textile industry and look out into the prospect for Sino-ltalian cooperation between our two ind... 详细信息

关键词：中国纺织工业协会 MILANO 服装品牌论坛地址

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Short-term efficacy and safety of cardiac contractility modulation in patients with heart failure

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China Medical Abstracts(Internal Medicine) 2024年第3期41卷 164-165页

作者： GUO yankai Dept Pacing&Electrophysiol Xinjiang Key LabCardiac Electrophysiol&Cardiac Remodel1st Affil HospXinjiang Med UnivUrumqi 830054China

Objective To investigate the short-term efficacy and safety of cardiac contractility modulation (CCM) in patients with heart *** This was a cross-sectional study of patients with heart failure who underwent CCM placem... 详细信息

关键词： patients cardiac heart

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Heteroatom Structural Engineering Enables Ethenylene-Bridged Bisisoindigo-Based Copolymers to Exhibit Unique n-Type Transistor Performance

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CCS Chemistry 2024年第2期6卷 473-486页

作者： Yuchai Pan Weifeng Zhang yankai Zhou Xuyang Wei Hao Luo Jinbei Wei Liping Wang Gui Yu Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049 School of Material Science and Engineering University of Science and Technology BeijingBeijing 100083

Herein,we report three novel electron-deficient aromatics,ethenylene-bridged bisisoindigos 3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoind-oline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one)(NCCN),3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one)(NFFN),and(3E,3″E)-6,6″-((E)-ethene-1,2-diyl)bis(1,1′-bis(4-decyltetradecyl)-[3,3′-bipyrrolo[2,3-b]pyridinylidene]-2,2′(1H,1′H)-dione)(NNNN),and their derived donor–acceptor(D–A)copolymers,namely poly[3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNCCN-FBT),poly[3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNFFNFBT),and poly[(3E,3″E)-6′,6‴-((E)-ethene-1,2-diyl)bis(1,1′-bis(4-decyltetradecyl)-[3,3′-bipyrrolo[2,3-b]pyridinylidene]-2,2′(1H,1′H)-dione-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNNNN-FBT),in which 5,6-difluoro-4,7-di(thiophen-2-yl)benzo[c][1,2,5]thiadiazole(FBT)acts as the electron-donating *** ethenylene-bridging unit reduces the steric hindrance of the three *** of heteroatoms,such as fluorine and sp2-nitrogen atoms,endows them with multiple CH···F,CH···N,and N···S intramolecular hydrogen bonds/nonbinding interactions,resulting in increasing backbone planarity from NCCN,NFFN,to NNNN,and thus from PNCCN-FBT,PNFFN-FBT,to *** found that all copolymers formed an improved molecular packing in the 1-chloronaphthalene(CN)-processed thin film compared with the 1,2-d

关键词： D-A copolymers bisisoindigos heteroatom structural engineering n-type field-effect transistors electron mobilities

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Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin

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Cellular & Molecular Immunology 2019年第5期16卷 483-494页

作者： yankai Wen Chenchen Wang Jinyang Gu Chang Yu Kaixia Wang Xuehua Sun Yun Sun Hailong Wu Ying Tong Qiang Xia Xiaoni Kong Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghaiChina Department of Transplantation Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Liver Diseases Shuguang Hospital affiliated to Shanghai University of Chinese Traditional MedicineShanghaiChina Department of Rehabilitation Medicine The First Affiliated HospitalZhejiang UniversityHangzhouChina Department of Hyperbaric Oxygen The First Affiliated HospitalZhejiang UniversityHangzhouChina State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceInnovation Center for Cell Signaling NetworkInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina

Induction of osteopontin(OPN),a well-known pro-inflammatory molecule,has been observed in acetaminophen(APAP)-induced ***,the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully *** employing a hepatotoxic mouse model induced by APAP overdose,we demonstrate that both serum and hepatic OPN levels were significantly elevated in response to APAP *** in vivo and in vitro studies clearly indicated that the induced expression of hepatic OPN was mainly located in necrosis areas and produced by dying or dead *** experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1(CYP2E1).Interestingly,this inhibition of CYP2E1 expression did not occur in unfasted Opn−/−mice,but was significant in fasted Opn−/−mice and maintained for 2hours after APAP challenge in fasted Opn−/−*** addition,despite the early protective role of OPN deficiency on APAP-induced hepatotoxicity,OPN deficiency retarded injury resolution by sensitizing hepatocytes to apoptosis and impairing liver ***,we demonstrated that a siRNA-mediated transient hepatic Opn knockdown could sufficiently and significantly protect animals from APAP-induced hepatotoxicity and *** conclusion,this study clearly defines the cell source of OPN induction in response to APAP treatment,provides a novel insight into the metabolic role of OPN to APAP overdose,and suggests an Opn-targeted therapeutic strategy for the treatment or prevention of APAP-induced hepatotoxicity.

关键词： acetaminophen CYP2E1 hepatotoxicity ketone body osteopontin

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The Nature of Rural Revitalization Planning and Its System Construction

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Journal of Architectural Research and Development 2019年第6期3卷 29-32页

作者： yankai Wang Yitong Li Inner Mongolia University of Technology New DistrictHohhotInner Mongolia010051China

In this paper,combining with the actual,the nature of rural revitalization of the planning and the analysis system construction key points,rural revitalization of the planning and the development of general planning and management,there are significant difference between the determination of the plan should be in-depth understanding of the basic properties and development of the rural state,from the objective perspective to understand basic properties and law of development of countryside,rural development planning in difficulty and defects,which can develop in line with the actual situation of the rural planning and design system,can better improve the utilization of *** that after the study,can provide reference to the relevant field of researchers.

关键词： Rural revitalization planning Properties System building

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Ongoing Positive Selection Drives the Evolution of SARS-CoV-2 Genomes

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1214-1223页

作者： Yali Hou Shilei Zhao Qi Liu Xiaolong Zhang Tong Sha yankai Su Wenming Zhao Yiming Bao Yongbiao Xue Hua Chen Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

SARS-CoV-2 is a new RNA virus affecting humans and spreads extensively throughout the world since its first outbreak in December,*** the transmissibility and pathogenicity of SARS-CoV-2 in humans after zoonotic transfer are actively evolving,and driven by adaptation to the new host and environments is still under *** the evolutionary mechanism underlying epidemiological and pathological characteristics of COVID-19 is essential for predicting the epidemic trend,and providing guidance for disease control and *** novel strategies for identifying natural selection using within-species polymorphisms and 3,674,076 SARSCoV-2 genome sequences of 169 countries as of December 30,2021,we demonstrate with population genetic evidence that during the course of SARS-CoV-2 pandemic in humans,1)SARS-CoV-2 genomes are overall conserved under purifying selection,especially for the 14 genes related to viral RNA replication,transcription,and assembly;2)ongoing positive selection is actively driving the evolution of 6 genes(e.g.,S,ORF3a,and N)that play critical roles in molecular processes involving pathogen–host interactions,including viral invasion into and egress from host cells,and viral inhibition and evasion of host immune response,possibly leading to high transmissibility and mild symptom in SARS-CoV-2 *** to an established haplotype phylogenetic relationship of 138 viral clusters,a spatial and temporal landscape of 556 critical mutations is constructed based on their divergence among viral haplotype clusters or repeatedly increase in frequency within at least 2 clusters,of which multiple mutations potentially conferring alterations in viral transmissibility,pathogenicity,and virulence of SARS-CoV-2 are highlighted,warranting attention.

关键词： COVID-19 SARS-CoV-2 Viral evolution Natural selection Darwinian selection

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