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Identification of Key Genes as Potential Drug Targets for Gastric Cancer

清华大学学报:自然科学版(英文版) 2023年第4期28卷 649-664页

作者： Md.Tofazzal Hossain Md.Selim Reza Yin peng Shengzhong Feng yanjie Wei Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganj 8100Bangladesh Guangdong Provincial Key Laboratory for Genome Stability and Disease Prevention and Regional Immunity and Diseases Department of PathologyShenzhen UniversityShenzhen 518060China

Gastric cancer(GC)is one of the most common cancers and ranks the third in cancer mortality all over the *** goal of this study was to identify potential hub-genes,highlighting their functions,signaling pathways,and candidate drugs for the treatment of GC *** used publicly available next generation sequencing(NGS)data to identify differentially expressed(DE)*** top DE genes were mapped to STRING database to construct the protein-protein interaction(PPI)network and top hub genes were selected for further *** found a total of 1555 DE genes with 870 upregulated and 685 downregulated genes in *** selected the top 400(200 upregulated and 200 downregulated)genes to construct a PPI network and extracted the top 15 hub *** gene ontology(GO)term and kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses of the 15 hub genes exposed some important functions and signaling pathways that were significantly associated with GC *** survival analysis of the hub genes disclosed that the lower expressions of the three hub genes CDH2,COL4A1,and COL5A2 were associated with better survival of GC *** three genes might be the candidate biomarkers for the diagnosis and treatment of ***,we considered 3 key proteins(genomic biomarkers)(COL4A1,CDH2,and CO5A2)as the drug target proteins(receptors),performed their docking analysis with the 102 meta-drug agents,and found Everolimus,Docetaxel,Lanreotide,Venetoclax,Temsirolimus,and Nilotinib as the top ranked 6 candidate drugs with respect to our proposed target proteins for the treatment against GC ***,the proposed drugs might play vital role for the treatment against GC patients.

关键词： gastric cancer hub genes candidate genes molecular docking candidate drugs

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竹纤维微生物肥对‘巨峰’葡萄发育和土壤养分的影响

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中外葡萄与葡萄酒 2021年第4期 45-49页

作者：彭言劼宋春草康颖张丹丹潘露嘉潘自辉陈小溪周勇乐山师范学院四川乐山614000 竹类病虫防控与资源开发四川省重点实验室四川乐山614000 峨眉山生物多样性保护与利用研究所四川乐山614000 湖北省林业调查规划院武汉430079 襄阳市林业科学技术推广站湖北襄阳441022

水肥优化管理是葡萄栽培中提质增效的关键环节。为探索竹纤维微生物肥在葡萄上的应用效果,以四川乐山的‘巨峰’葡萄为试材,调查该肥料对葡萄果实品质、光合能力和果园土微环境等方面的影响。结果表明:竹纤维微生物肥施用后果实粒径显... 详细信息

水肥优化管理是葡萄栽培中提质增效的关键环节。为探索竹纤维微生物肥在葡萄上的应用效果,以四川乐山的‘巨峰’葡萄为试材,调查该肥料对葡萄果实品质、光合能力和果园土微环境等方面的影响。结果表明:竹纤维微生物肥施用后果实粒径显著增大,粒质量、可溶性固形物分别比对照提升了21.0%和1.54%,固酸比高达37.3∶1,且果色更深;叶片净光合速率较对照提升27.3%,气孔导度和叶绿素等光合指标高于对照;土壤有效磷和速效钾含量分别比对照高出了2.8%和7.9%,土壤含水量高出对照27.8%。综上结果表明,竹纤维微生物肥能够显著提升‘巨峰’葡萄果实品质和增强叶片光合能力,且具有良好的增肥保墒效果。

关键词：竹纤维微生物肥巨峰品质光合作用土壤养分

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原位纳米ZrB_(2)颗粒增强7085铝合金的微观组织与力学性能研究

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铸造技术 2023年第6期44卷 568-575页

作者：怯喜周王宇慧彭艳杰杨子易陈刚许晓静江苏大学材料科学与工程学院江苏镇江212000 江苏大学先进制造与现代装备技术工程研究院江苏镇江212013

本文通过原位合成技术,成功制备了纳米ZrB_(2)颗粒增强7085铝合金基复合材料。采用金相显微镜、扫描电子显微镜、透射电子显微镜、X射线衍射仪进行表征,并进行力学性能测试,研究了ZrB_(2)纳米增强体对7085铝合金的显微组织和力学性能的... 详细信息

本文通过原位合成技术,成功制备了纳米ZrB_(2)颗粒增强7085铝合金基复合材料。采用金相显微镜、扫描电子显微镜、透射电子显微镜、X射线衍射仪进行表征,并进行力学性能测试,研究了ZrB_(2)纳米增强体对7085铝合金的显微组织和力学性能的影响。结果表明,ZrB_(2)纳米增强体可以显著提高7085铝合金的强度。但是随着增强体体积分数增大,ZrB_(2)颗粒团聚现象加剧,不利于复合材料的塑韧性提高。同时,在复合材料中引入微量稀土元素Sc可使纳米ZrB_(2)颗粒团聚现象得到改善,并进一步细化基体晶粒,使复合材料的强度和延长率都得到提高。当ZrB_(2)含量为2%(体积分数)、Sc含量为0.4%(质量分数)时,复合材料的抗拉强度为534 MPa、伸长率为10.2%,相较于7085铝合金基体分别提高了17.4%、14.6%。

关键词：原位纳米ZrB_(2)颗粒 7085铝合金稀土Sc 力学性能

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Effect of transport agent boron triiodide on the synthesis and crystal quality of boron arsenide

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 662-670页

作者： Zhenxing Liu Fangjie Deng Yuan Zhou yanjie Liang Cong peng Bing peng Feiping Zhao Zhihui Yang Liyuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Changsha 410083China

Cubic boron arsenide(BAs)has attracted great attention due to its high thermal conductivity,however,its controllable,stable,and ideal preparation remains ***,we investigated the effect of iodine-containing transport agents I_(2) and boron triiodide(BI_(3))on BAs synthesized and grown through chemical vapor *** show that similar to the commonly used I_(2),BI_(3) accelerates the synthesis and improves the mass fraction of BAs from ~12% to over 90% at 820℃ and 1.5 MPa,a value beyond the promoting effect of only increasing temperature and *** agents enhance the quality of BAs crystals by reducing the full width at half maximum by up to 10%-20%.I_(2) agglomerates the grown crystals with twin defects(~50 nm wide),and BI_(3) improves the crystal anisotropy and element uniformity of BAs crystals with narrow twins(~15 nm wide)and increases the stoichiometry ratio(~0.990)to almost *** to the boron interstitials from the excessive boron supply,the spacing of layers in {111} increases to 0.286 nm in the presence of I_(2).Owing to its coordinated effect,BI_(3) only slightly influences the layer spacing at 0.275 nm,which is close to the theoretical value of 0.276 *** the chemical vapor transport,the anisotropic crystals with flat surfaces exhibit single-crystal characteristics under the action of BI_(3).Different from that of I_(2),the coordinated effect of BI_(3) can promote the efficient preparation of high-quality BAs crystal seeds and facilitate the advanced application of BAs.

关键词： boron arsenide transport agent boron-arsenic reaction iodine boron triiodide

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Adaptive dynamic reconfiguration mechanism of unmanned swarm topology based on an evolutionary game

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Journal of Systems Engineering and Electronics 2023年第3期34卷 598-614页

作者： YU Minggang NIU yanjie LIU Xueda ZHANG Dongge ZHENG peng HE Ming LUO Ling Institute of Command and Control Engineering Army Engineering University of the PLANanjing 210007China Institute of Communication Engineering Army Engineering University of the PLANanjing 210007China

Autonomous cooperation of unmanned swarms is the research focus on“new combat forces”and“disruptive technologies”in military *** mechanism design is the fundamental way to realize autonomous *** the realistic requirements of a swarm network dynamic adjustment under the background of high dynamics and strong confrontation and aiming at the optimization of the coordination level,an adaptive dynamic reconfiguration mechanism of unmanned swarm topology based on an evolutionary game is *** paper analyzes military requirements and proposes the basic framework of autonomous cooperation of unmanned swarms,including the emergence of swarm intelligence,information network construction and collaborative mechanism ***,based on the framework,the adaptive dynamic reconfiguration mechanism is discussed in detail from two aspects:topology dynamics and strategy ***,the unmanned swarms’community network is designed,and the network characteristics are ***,the mechanism characteristics are analyzed by numerical simulation,focusing on the impact of key parameters,such as cost,benefit coefficient and adjustment rate on the level of swarm ***,the conclusion is made,which is expected to provide a theoretical reference and decision support for cooperative mode design and combat effectiveness generation of unmanned swarm operations.

关键词： unmanned swarm operation autonomous collaboration topology reconstruction evolutionary game

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基于光频域反射仪的分布式光纤传感及应用进展(特邀)

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激光与光电子学进展 2024年第1期61卷 54-71页

作者：王义平钟华健单荣毅梁文发彭振威孟彦杰廖常锐付彩玲深圳大学射频异质异构集成全国重点实验室广东省光纤传感技术粤港联合研究中心深圳市物联网光子器件与传感系统重点实验室广东深圳518060 深圳大学物理与光电工程学院光电子器件与系统教育部/广东省重点实验室深圳市超快激光微纳制造重点实验室广东深圳518060 人工智能与数字经济广东省实验室(深圳) 广东深圳518107

光频域反射仪(OFDR)具有高空间分辨率、高精度和高灵敏度等多种分布式传感能力,其在油气资源勘探、结构健康监测,以及医疗微创介入手术等多种场合展示出了巨大的应用潜力。然而,扫频非线性噪声、相干衰落噪声,以及光纤中微弱的瑞利后向... 详细信息

光频域反射仪(OFDR)具有高空间分辨率、高精度和高灵敏度等多种分布式传感能力,其在油气资源勘探、结构健康监测,以及医疗微创介入手术等多种场合展示出了巨大的应用潜力。然而,扫频非线性噪声、相干衰落噪声,以及光纤中微弱的瑞利后向散射信号是影响光频域反射仪性能的主要因素。本文介绍了光频域反射仪基本原理和波长、相位两种传感解调方法,详细阐述了多种抑制扫频非线性噪声和相干衰落噪声的方法,同时介绍了光频域反射仪在三维形状、大应变、高温、折射率等4个方面的传感应用进展。

关键词：光频域反射仪扫频非线性相干衰落三维形状大应变高温

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Fiber-Optic Surface Plasmon Resonance Sensor With Multi-Alternating Metal Layers for Biological Measurement

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Photonic Sensors 2013年第3期3卷 202-207页

作者： yanjie WANG Shengwei MENG Yuzhang LIANG Lixia LI Wei peng College of Physics and Optoelectrical Engineering Dalian University of Technology Dalian 116023 China

Optical fiber based SPR sensors have attracted more and more attention due to their unique advantages over the prism-based SPR sensors. A novel fiber-optic SPR sensor with multi-alternating metal layers for biochemical analysis is presented in this paper. Based on the fundamental SPR theory of the fiber optic sensing technology, we theoretically investigated the effects of the existence of alternating layers deposited on sensing region SPR wavelength changes. The emphasis was placed on the numerical simulation of the fiber-optic SPR sensor＇s sensitivity which could be affected by its technical parameters such as the metal thickness, number of alternating layers. Results showed that, compared to the normal SPR sensor with the single metal layer, the proposed sensor had a wider detecting range of the refractive index and higher sensitivity, which can find applications in biological analysis.

关键词： Surface plasmon resonance fiber optics biological detection alternating metal layers

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ICU患者多重耐药菌感染特点及预后影响因素分析

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中国医药导报 2024年第19期21卷 18-22页

作者：彭虎杨延洁杨羚辜新张莉新疆医科大学护理学院新疆乌鲁木齐830000 新疆医科大学第一附属医院护理部新疆乌鲁木齐830054

目的分析重症监护室(ICU)患者多重耐药菌(MDRO)感染特点和预后影响因素,为MDRO的预防和治疗提供参考。方法回顾性收集2018年1月至2023年12月收治于新疆医科大学第一附属医院ICU发生MDRO感染的401例患者的临床资料,并根据是否院内死亡分... 详细信息

目的分析重症监护室(ICU)患者多重耐药菌(MDRO)感染特点和预后影响因素,为MDRO的预防和治疗提供参考。方法回顾性收集2018年1月至2023年12月收治于新疆医科大学第一附属医院ICU发生MDRO感染的401例患者的临床资料,并根据是否院内死亡分为病死组(98例)和生存组(303例),使用Excel2019和SPSS 27.0对其感染特点和预后影响因素进行总结分析。结果401例ICU患者发生MDRO感染中共检出MDRO 825株,其中革兰氏阴性菌648株(78.5%),前6位分别为:鲍曼不动杆菌(28.0%)、肺炎克雷伯菌(15.2%)、大肠埃希菌(8.7%)、铜绿假单胞菌(6.9%)、洋葱伯克霍尔德菌(6.2%)、嗜麦芽窄食单胞菌(3%);革兰氏阳性菌177株(21.5%),主要为屎肠球菌(6.5%)、金黄色葡萄球菌(4.7%)、表皮葡萄球菌(4.5%)。多因素logistic回归分析结果显示:心脑血管疾病(OR=5.047,95%CI:2.539~10.034,P<0.01)、肺部疾病(OR=3.223,95%CI:1.884~5.512,P<0.01)和机械通气(OR=1.510,95%CI:1.340~15.304,P<0.05)为影响患者预后不良的独立危险因素。结论ICU患者MDRO感染菌株分别以鲍曼不动杆菌和屎肠球菌为主,感染菌株种类较多,心脑血管疾病、肺部疾病和机械通气是影响其预后不良的独立危险因素。

关键词：重症监护室多重耐药菌感染预后

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Starch-based adhesive hydrogel with gel-point viscoelastic behavior and its application in wound sealing and hemostasis

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Journal of Materials Science & Technology 2021年第4期63卷 228-235页

作者： Yuxuan Mao peng Li Jiewei Yin yanjie Bai Huan Zhou Xiao Lin Huilin Yang Lei Yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteSoochow UniversitySuzhou215000China Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou215000China School of Public Health Soochow UniversitySuzhou215000China Center for Health Science and Engineering(CHSE) School of Materials Science and EngineeringHebei University of TechnologyTianjin300000China School of Mechanical Engineering Jiangsu University of TechnologyChangzhou213000China

Hydrogels with tissue adhesiveness have demonstrated great promise for wearable electronics,artificial skin,soft robotics,and tissue ***,adhesive hydrogels that are capable of sealing and hemostasis of wound with severe hemorrhage still *** this purpose,a series of ionically crosslinked starch hydrogels were developed *** viscoelastic properties and tissue adhesiveness of the starch hydrogels were *** is shown that the starch and cross linkers had significant influence on the viscoelastic properties of the starch hydrogels,which further resulted in varied tissue *** the starch gels,there was one exhibiting a unique and stable"Gel Point"viscoelastic characteristic and it was named as gel-point adhesive hydrogel(GPAH).GPAH showed electrical conductivity,high tissue adhesiveness,high stretch-ability,self-healing capability,injectability,and *** GPAH also exhibited high cytocompatibility,low hemolysis risk,and strong antibacterial *** wound sealing and hemostatic performance of GPAH was further evaluated by a rat femoral artery injury *** blood loss after the sealing of GPAH(2.4±1.3 g)was significantly decreased compared to the group using gauze for sealing(6.3±1.5 g).Meanwhile,GPAH did not cause pathological changes of the soft tissues surrounding the *** above results indicate that GPAH,with high tissue adhesiveness,suitable viscoelastic property,strong antibacterial capacity,as well as electro-conductivity,bears great potential for the applications in smart wound management.

关键词： sealing viscoelastic hydrogel

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基于激光遥感的甲烷泄漏源搜索系统

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河南师范大学学报（自然科学版） 2024年第4期52卷 57-62页

作者：贾彦杰杨旸彭睿王川孙冬远于立成田亚莉邱选兵国家管网集团西南管道有限责任公司成都610041 海隆石油集团(上海)信息技术有限公司上海200949 太原科技大学应用科学学院山西省精密测量与在线检测装备工程研究中心太原030024

为了弥补传统人工在天然气生产、运输和存储过程甲烷泄漏巡检中存在的劳动强度大、容易漏检、耗时耗力等不足,提出了一种基于激光遥感吸收光谱技术的甲烷泄漏搜索系统.选用近红外1653.7 nm的TO封装DFB激光器作为光源,以收发一体的卡塞... 详细信息

为了弥补传统人工在天然气生产、运输和存储过程甲烷泄漏巡检中存在的劳动强度大、容易漏检、耗时耗力等不足,提出了一种基于激光遥感吸收光谱技术的甲烷泄漏搜索系统.选用近红外1653.7 nm的TO封装DFB激光器作为光源,以收发一体的卡塞格林光学结构进行发射激光和接收来自反射回来的微弱光信号,采用嵌入式单片机实现光信号的调制与解调.以开源ArduPilot AMP2.8作为无人机的飞控,采用433 MHz无线模块进行甲烷泄漏数据实时传送,计算机接收端以LabView虚拟仪器开发了接收应用程序进行数据的接收、显示和存储.以体积分数为10-3的甲烷气袋为搜索目标,采用Z字形搜索算法模拟了现场甲烷泄漏搜索实验.实验结果表明,该算法具有较高的检测精度和定位准确性,能够准确地检测到甲烷泄漏源位置.这为天然气泄漏源的快速检测和定位提供了有效的技术支持.

关键词：天然气泄漏激光遥感无人机 Z字形搜索

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