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p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular smooth muscle cells

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Frontiers of Medicine 2016年第3期10卷 320-329页

作者： Hui Han yanjia chen Zhengbin Zhu Xiuxiu Su Jingwei Ni Run Du Ruiyan Zhang Wei Jin Department of Cardiology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients.p-Cresyl sulfate （PCS） is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE/- mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group （n = 20） and PCS-treated group （n = 20）. Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells （VSMCs） were treated with phosphate buffer solution or 500 ltmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.

关键词： p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell

Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis

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Science China Life Sciences 2024年

作者： Nianci Xue Xia Xia Yini Wang Xianju Li Nairen Zheng Yi Wang Baoying Gong Bin Zhang yanjia chen Yue chen Yanjuan Li Hong Cao Wofeng Liu Hongqiang Huang Shuo Yang Lisen Sui Lin Meng Jianwen Guo Jun Qin State Key Laboratory of Traditional Chinese Medicine Syndrome State Key Laboratory of Dampness Syndrome of Chinese Medicine SyndromeDepartment of NeurologyThe Secondary Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Chinese MedicineGuangdong Provincial Academy of Chinese Medical Sciences State Key Laboratory of Medical Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences (Beijing)Beijing Institute of Lifeomics Guangzhou University of Chinese Medicine Guangdong Mechanical&Electrical Polytechnic Department of epilepsy The Secondary Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Traditional Chinese Medicine Guangzhou Cadre and Talent Health Management Center (Guangzhou 11th People's Hospital)

Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva ***,the clinical utility of current saliva biomarker studies is limited by the lack of reference intervals (RIs) to correctly interpret the testing ***,we developed a rapid and robust saliva proteome profiling workflow,obtaining coverage of>1,200 proteins from a 50-μL unstimulated salivary flow with 30 min *** the workflow,we investigated protein variation in a cohort of 1,743 healthy *** significant differences in non-linear saliva proteomes among age groups resulted in the establishment of age-related RIs covering 1,123 salivary protein *** then utilized a cohort of 30 epilepsy patients as a case study to illustrate the practical application of RIs in identifying disease-enriched outlier proteins,elucidating their cellular origins,determining disease diagnosis,and visualizing outlier proteins in each epilepsy *** study showed the classification model based on the RI achieved PR-AUC of 0.815 (95%CI:0.813–0.826).Additionally,we validated these results in an independent test ***,the epilepsy cohort could be further stratified into 2 major subtypes,with one subtype characterized by disrupted metabolic proteins and containing mostly Focal Cortical Dysplasia (FCD) type III epilepsy ***,our study provided a proof-of-principle workflow for the use of salivary proteome for health monitoring,epilepsy diagnosis and subtyping.

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陶渊明“不解音声”是个伪命题

铜仁学院学报 2018年第4期20卷 18-26页

作者：陈延嘉长春师范大学<昭明文选>研究所吉林长春130022

自沈约《宋书》首次提出陶"潜不解音声"一千多年来,后世多以讹传讹,其实是一个伪命题。陶渊明既通音声,也没有蓄无弦琴。讹传的原因是把陶渊明偶一为之的事在传说中添枝加叶,后人据此又给予过度解读。

关键词：陶渊明音声七弦琴

海上光伏外围防护-固定式透空堤结构型式研究进展

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太阳能学报 2024年第8期45卷 332-341页

作者：练继建陈艳佳王孝群王晓伟刘润天津大学水利工程智能建设与运维全国重点实验室天津300072 天津大学建筑工程学院天津300072 河北工程大学水利水电学院邯郸056038 河北省智慧水利重点实验室邯郸056038

固定式透空堤能改善海上漂浮式光伏发电系统的深海运维环境。依据不同的消浪原理和构造将固定式透空堤分为排桩透空堤、桩基透空堤、沉箱透空堤、桩基沉箱透空堤、横板透空堤和组合透空堤6种型式,针对固定式透空堤的研究和发展进行文献... 详细信息

固定式透空堤能改善海上漂浮式光伏发电系统的深海运维环境。依据不同的消浪原理和构造将固定式透空堤分为排桩透空堤、桩基透空堤、沉箱透空堤、桩基沉箱透空堤、横板透空堤和组合透空堤6种型式,针对固定式透空堤的研究和发展进行文献综述,回顾和讨论不同结构型式研究方法、结构特点、消浪性能和实际工程应用等方面的内容,总结了当前研究存在的不足并展望了未来发展方向。

关键词：光伏发电海洋工程防波堤水工结构海上漂浮式光伏透水结构

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直埋光缆接头盒浸水防治的措施

电信工程技术与标准化 2005年第2期18卷 40-42页

作者：陈彦佳毛宓黑龙江省佳木斯通信传输局佳木斯154003

直埋光缆线路接头盒浸水问题是一直困扰光缆线路维护的一个难题,本文通过对凡士林规格及性能的分析,利用凡士林对光缆接头盒进行密封安装实验。实验表明凡士林防水性能良好,适合作预防光缆接头盒浸水材料。

关键词：光缆接头盒直埋光缆光缆线路规格防水性能维护浸水凡士林难题

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一种紧凑型开关电源设计

电工技术 2023年第14期 104-107页

作者：黄超陈彦佳余快中国电子科技集团公司第二十四研究所重庆400060

针对体积受限的二次供电需求,介绍了基于反激拓扑的开关电源设计过程。采用集成电流型PWM控制器,设计了输入欠压保护、过流/短路保护功能。在较小尺寸下制作了一款输入电压16~50 V,输出5 V/4 A的电源模块。测试结果表明样品电路保护功... 详细信息

针对体积受限的二次供电需求,介绍了基于反激拓扑的开关电源设计过程。采用集成电流型PWM控制器,设计了输入欠压保护、过流/短路保护功能。在较小尺寸下制作了一款输入电压16~50 V,输出5 V/4 A的电源模块。测试结果表明样品电路保护功能齐备,具有较高的输出电压精度和良好的动态响应性能。

关键词：紧凑型反激电流模式环路补偿

EB病毒相关胃癌地域分布特点及临床病理特征分析

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中华肿瘤杂志 2020年第11期42卷 943-948页

作者：胡春芳林华陈艳佳戴洪甜王炳智薛丽燕国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院病理科 100021 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院病案室 100021 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院统计室 100021

目的分析EB病毒相关胃癌(EBVaGC)的地域分布特点及临床病理特征。方法采用EB病毒编码的RNA(EBER)原位杂交染色方法,检测中国医学科学院肿瘤医院4081例手术切除胃腺癌标本中EBVaGC所占的比例,比较EBVaGC在不同地区的分布差异,并分析其与... 详细信息

目的分析EB病毒相关胃癌(EBVaGC)的地域分布特点及临床病理特征。方法采用EB病毒编码的RNA(EBER)原位杂交染色方法,检测中国医学科学院肿瘤医院4081例手术切除胃腺癌标本中EBVaGC所占的比例,比较EBVaGC在不同地区的分布差异,并分析其与其他临床病理特征的关系。结果4081例胃腺癌中EBVaGC占3.0%(123/4081)。胃腺癌患者在90例以上的10个省、直辖市、自治区中,籍贯为吉林省的胃腺癌患者中EBVaGC所占比例最高,为7.6%,其后依次为辽宁省(5.4%)、安徽省(4.1%)、北京市(3.9%)、内蒙古自治区(3.7%)、山西省(3.4%)、黑龙江省(3.0%)、山东省(2.1%)、河北省(1.6%),而河南省的胃腺癌患者中未检测到EBVaGC病例,省、直辖市、自治区间差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,性别(0R=2.231,95%C/为1.290〜3.858)、WH0病理分型(OR=2.338,95%C/为2.051〜2.664)及N分期(OR=0.420,95%CI为0.284〜0.621)是EBVaGC的独立影响因素,男性、组织学类型为伴有淋巴间质的癌、淋巴结无转移的胃腺癌中EBVaGC所占比例更高,结论EBVaGC在不同地区的胃腺癌中分布存在差异,患者的性别、WHO病理分型和N分期与EBVaGC关系密切。

关键词：胃腺癌 EB病毒原位杂交地区分布临床病理特征