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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li su Yang Guangdong Key Laboratory of non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured n2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Influence of biomass burning on ozone levels in the Megalopolis of Central Mexico during the COVID-19 lockdown

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Journal of Environmental Sciences 2024年第9期143卷 99-115页

作者： Victor Almanza Luis Gerardo Ruiz-suárez Ricardo Torres-Jardón Agustín García-Reynoso Iván Y.Hernández-Paniagua Institute for Atmospheric Sciences and Climate Change National Autonomous University of MexicoCoyoacan 04510Mexico CityMexico

The massive reductions in anthropogenic emissions resulting from the COVID-19 lockdown provided a unique opportunity to evaluate the effect of mitigation measures aiming to abate air *** Mexico,the total lockdown period took place during the dry-hot season when biomass burning activity is ***,we investigate the role of biomass burning emissions on regional ozone levels in the Megalopolis of Central *** studied period covers the lockdown phases 2 and 3,and the first month of the new *** applied a factor separation technique and process analysis to estimate the pure and synergistic contributions of emission reductions under lockdown and that from biomass burning to daily ozone maximum concentrations in 7 metropolitan areas of different states in the *** results revealed that biomass burning plumes likely masked the effect of massive reductions from mobile emissions,impacted the PBL development during phase 3 and favored transition and mixed nO_(x)-limited and VOC-limited regional *** contributed to increased ozone production in the middle to lower PBL by changing the regional background levels which potentially could bias high ozone production efficiency *** the Megalopolis contribution to economic and societal development at national scale,our study suggests that ozone mitigation measures during the dry-hot season targeting mainly mobile emissions will likely be offset by biomass burning plumes.A regional and synergic policy aiming to control biomass burning would help to reduce the occurrence of high ozone levels in Central Mexico with the co-benefit of tackling short-lived climate pollutants.

关键词： COVID-19 Mexico Megalopolis Ozone Factor Separation Process Analysis

Facile one-step hydrothermal route to MSe/Mo_(3)Se_(4)(M:Zn,Mn,and ni)-based electrode materials for ultralong-life hybrid supercapacitors

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Journal of Materials Science & Technology 2023年第25期156卷 230-240页

作者： B.n.Vamsi Krishna Obula Reddy Ankinapalli Ayyaluri Ramakrishna Reddy Jae su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

Transition metal selenides have attracted great interest in electrochemical energy storage applications because of their good electrochemical activity and conductivity ***,we reported the metal molybdenum selenide(M Se/Mo_(3)Se_(4)(M:Zn,Mn,and ni))electrode materials on their morphological and electrochemical properties by varying the metal ions via a facile hydrothermal *** effects of the structural,morphological,and surface area properties of the prepared powder materials on their electrochemical performance were *** to the hierarchical porous and unique interconnected structure,the nickel molybdenum selenide nanosheet spheres(nMS nSSs)-based electrode material delivered an excellent specific capacity value of 252 mAh g^(-1) at a current density of 1 Ag^(-1).Moreover,the optimized nMS nSSs electrode exhibited outstanding cycling stability with a capacity retention of 80%and a corresponding coulombic efficiency of 99%after 80,000 ***,a pouch-type hybrid supercapacitor(HSC)device was assembled using nMS nSSs material as a positive electrode and activated carbon as a negative electrode in 1 M aqueous KOH ***,the assembled HSC device exhibited superior energy and power density values as well as magnificent cycling *** real-time practical applications,light-emitting diodes and a digital display were powered using two series-connected HSC ***,the obtained tremendous results strongly suggest that the niSe/Mo_(3)Se_(4) nSSs-based materials could be a promising electrode for ultralong-life energy storage applications.

关键词： nickel selenides Molybdenum selenides nanosheet spheres Ultralong-life cycling stability

Comparisons of improved genomic predictions generated by different imputation methods for genotyping by sequencing data in livestock populations

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Journal of Animal Science and Biotechnology 2020年第2期11卷 316-326页

作者： Xiao Wang Guosheng su Dan Hao Mogens SandøLund Haja n.Kadarmideen Quantitative Genomics Bioinformatics and Computational Biology GroupDepartment of Applied Mathematics and Computer ScienceTechnical University of DenmarkRichard Peterson PladsBuilding 3242800 Kongens LyngbyDenmark Center for Quantitative Genetics and Genomics Department of Molecular Biology and GeneticsAarhus University8830 TjeleDenmark Department of Molecular Biology and Genetics Aarhus University8000 Aarhus CDenmark College of Animal Science and Technology Northwest A&F UniversityYangling 712100ShannxiChina

Background:Genotyping by sequencing(GBS)still has problems with missing *** is important for using GBS for genomic predictions,especially for low depths,due to the large number of missing *** allele frequency(MAF)is widely used as a marker data editing criteria for genomic *** this study,three imputation methods(Beagle,IMPUTE2 and FImpute software)based on four MAF editing criteria were investigated with regard to imputation accuracy of missing genotypes and accuracy of genomic predictions,based on simulated data of livestock ***:Four MAFs(no MAF limit,MAF≥0.001,MAF≥0.01 and MAF≥0.03)were used for editing marker data before ***,IMPUTE2 and FImpute software were applied to impute the original ***,IMPUTE2 also imputed the expected genotype dosage after genotype correction(GcIM).The reliability of genomic predictions was calculated using GBS and imputed GBS *** results showed that imputation accuracies were the same for the three imputation methods,except for the data of sequencing read depth(depth)=2,where FImpute had a slightly lower imputation accuracy than Beagle and *** was observed to be the best for all of the imputations at depth=4,5 and 10,but the worst for depth=*** genomic prediction,retaining more SnPs with no MAF limit resulted in higher *** the depth increased to 10,the prediction reliabilities approached those using true genotypes in the GBS *** and IMPUTE2 had the largest increases in prediction reliability of 5 percentage points,and FImpute gained 3 percentage points at depth=*** best prediction was observed at depth=4,5 and 10 using GcIM,but the worst prediction was also observed using GcIM at depth=***:The current study showed that imputation accuracies were relatively low for GBS with low depths and high for GBS with high *** resulted in larger gains in the reliability of genomic predictions for GBS with lowe

关键词： Genomic prediction Genotyping by sequencing Imputation MAF Simulation

Leaf C:n:P stoichiometric homeostasis of a Robinia pseudoacacia plantation on the Loess Plateau

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Journal of Forestry Research 2023年第4期34卷 929-937页

作者： Zhuoxia su Bingqian su Shenglin Mao Zhouping Shangguan State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100ShaanxiPeople’s Republic of China

Homeostasis is the adaptability of a species to a changing ***,the ecological stoichiometric homeostasis of Robinia pseudoacacia *** diff erent climatic regions is poorly understood but could provide insights into its adaptability in the loess hilly *** study sampled 20 year-old *** plantations at 10 sites along a north–south transect on the Loess *** in the ecological stoichiometric characteristics of leaf and soil carbon,nitrogen,and phosphorus were analysed and homeostatic characteristics of leaf ecological stoichiometric parameters in diff erent climates were identifi *** aff ecting leaf stoichiometry were *** results show that *** leaves were rich in nitrogen and defi cient in phosphorous during tree growth and *** and phosphorous levels in the soils of the loess region were lower than the average in soils in the rest of *** ecological stoichiometric parameters of *** leaves in two diff erent climates were considered“strictly homeostasis”.Precipitation,available phosphorus,and soil C:P were the main factors aff ecting the variation of C:n:P stoichiometry of *** *** in the loess hilly region has strong ecologically homeostatic characteristics and suggests that it is well-adapted to the area.

关键词： Loess Plateau Robinia pseudoacacia Ecological stoichiometry Homeostasis

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阿片类药物诱导瘙痒的机制研究进展

中国药理学通报 2025年第1期41卷 29-34页

作者：马芳周培岚苏瑞斌军事医学研究院国家安全特需药品全国重点实验室北京100850 南京中医药大学药学院江苏南京210046

瘙痒是临床使用阿片类药物镇痛的患者普遍存在的严重不良反应之一。大量研究已经阐明阿片类药物的镇痛机制,但阿片类药物诱导瘙痒的机制尚不明确,瘙痒与镇痛之间的关系也模糊不清。目前的研究发现,阿片类药物作用于μ、κ及δ阿片受体后... 详细信息

瘙痒是临床使用阿片类药物镇痛的患者普遍存在的严重不良反应之一。大量研究已经阐明阿片类药物的镇痛机制,但阿片类药物诱导瘙痒的机制尚不明确,瘙痒与镇痛之间的关系也模糊不清。目前的研究发现,阿片类药物作用于μ、κ及δ阿片受体后,直接或间接影响瘙痒关键受体——胃泌素释放肽受体的功能,进而影响瘙痒信息传递。神经介素B、神经肽Y、B型利钠肽等神经肽,以及其他受体如瞬时受体电位香草素1受体、n-甲基-D-天冬氨酸受体、5-羟色胺受体等,在吗啡诱导的瘙痒中也具有重要作用。此外,阿片类药物所致瘙痒的预防和治疗也是围手术期吗啡镇痛的难点和热点之一。因此,明确瘙痒的具体发生机制,对寻找新的研究思路及预防和治疗阿片类药物诱导的瘙痒具有重要意义。

关键词：阿片类诱导的瘙痒瘙痒与镇痛瘙痒机制阿片受体胃泌素释放肽受体瘙痒治疗

Creation and annihilation phenomena of electron and positron pairs in an oscillating field

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Chinese Physics B 2021年第7期30卷 151-156页

作者： M Jiang D D su n S Lin Y J Li School of Science China University of Mining and TechnologyBeijing 100083China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China Beijing national Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

The combination of an oscillating and a static field is used to study the creation and annihilation phenomena during the pair creation *** time evolution,spatial density and momentum distribution of the created particles for a fermionic system are presented,which demonstrate that with the increasing static field intensity,the number of the created particles experiences a distinguishable decrease in every period of the oscillating field,which is caused by the annihilation phenomena between the created electrons and positrons.

关键词： pair creation computational quantum field theory strong laser field

A Crystallization Study of nanocrystalline PZT 53/47 Granular Arrays Using a Sol-Gel Based Precursor

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Journal of Materials Science & Technology 2011年第6期27卷 489-496页

作者： A.surez-Gómez J.M.Saniger-Blesa F.Calderón-Pinar CCADET-Universidad nacional Autónoma de México Cd.UniversitariaCirc.Exterior s/nA.P.70-186Coyoacn 04510México D.F.México Laboratorio de Ingeniería Electroquímica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaCoyoacn 04510México D.F.México Facultad de Física/IMRE San Lzaro y LUniversidad de la Habana

In this work,we intend to perform a detailed study on the crystallization process of PZT 53/47 nanostructured powders by starting out with an amorphous precursor synthesized by a sol-gel based *** interests also lie in the feasibility for controlling the average grain size of the final structure in the submicron range on an ab initio ***,Fourier transform infrared spectroscopy（FT-IR）,Raman（Stokes and Anti-Stokes）,X-ray diffraction（XRD） and scanning electron microscopy（SEM） are used to examine the microstructural characteristics based on previously reported differential thermal analysis/thermal gravimetric analysis（DTA/TGA） *** results show a crystallization temperature of 800℃ to attain pure perovskite phase with excellent morphological quality,average grain size 〈DG〉〈 300 nm and with average crystallite size 〈DC〉〈15 nm.

关键词： Powders-chemical preparation PZT synthesis Sol-gel precursors Microstructure- final Vibrational spectroscopies X-ray diffraction

Advances in Enhancing Hemocompatibility of Hemodialysis Hollow‑Fiber Membranes

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Advanced Fiber Materials 2023年第4期5卷 1198-1240页

作者： Haifeng Ji Yupei Li Baihai su Weifeng Zhao Jayachandran n.Kizhakkedathu Changsheng Zhao College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China Department of nephrology West China HospitalSichuan UniversityChengdu 610041China Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu 610207China Department of Pathology and Lab Medicine&Center for Blood Research&Life Science Institute 2350 Health Sciences MallLife Sciences CentreThe School of Biomedical EngineeringUniversity of British ColumbiaVancouverBC V6T 1Z3Canada

Hemodialysis,the most common modality of renal replacement therapy,is critically required to remove uremic toxins from the blood of patients with end-stage kidney ***,the chronic inflammation,oxidative stress as well as throm-bosis induced by the long-term contact of hemoincompatible hollow-fiber membranes(HFMs)contribute to the increase in cardiovascular diseases and mortality in this patient *** review first retrospectively analyzes the current clini-cal and laboratory research progress in improving the hemocompatibility of *** on different HFMs currently in clinical use and their design are ***,we elaborate on the adverse interactions between blood and HFMs,involving protein adsorption,platelet adhesion and activation,and the activation of immune and coagulation systems,and the focus is on how to improve the hemocompatibility of HFMs in these ***,challenges and future perspectives for improving the hemocompatibility of HFMs are also discussed to promote the development and clinical application of new hemocompatible HFMs.

关键词： Hemodialysis Hollow fiber membranes Hemocompatibility surface modification Hemocompatibility characterization