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Clinical implication of naive and memory T cells in locally advanced cervical cancer:A proxy for tumor biology and short-term response prediction

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BIOCELL 2023年第6期47卷 1365-1375页

作者： YUTING WANG PEIWEN FAN yaning feng XUAN YAO YANCHUN PENG RUOZHENG WANG Key Laboratory of Cancer Immunotherapy and Radiotherapy Chinese Academy of Medical SciencesAffiliated Cancer Hospital of Xinjiang Medical UniversityUrumqiChina Key Laboratory of Oncology of Xinjiang Uyghur Autonomous Region Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqiChina State Key Laboratory of Pathogenesis Preventionand Treatment of High Incidence Diseases in Central AsiaThe Third Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Chinese Academy of Medical Sciences Oxford Institute(CAMS Oxford Institute) University of OxfordOxfordUK

Background:This study was designed to investigate the feasibility of tumor-infiltrating immune cells with different phenotypic characteristics for predicting short-term clinical responses in patients with locally advanced cervical cancer(LACC).Methods:Thirty-four patients who received concurrent chemoradiotherapy and twenty-one patients who merely underwent radiotherapy were enrolled in this *** retrospectively analyzed the T cell markers(i.e.,CD3,CD4,CD8),memory markers(i.e.,CD45,CCR7),and differentiation markers(i.e.,CD27)in the peripheral blood and tumor tissues of patients with LACC before treatment based on flow *** also analyzed the relationship of T cell subsets between peripheral blood and tumor tissues,and their correlation with complete response or partial ***:The percentage of central memory CD8^(+)TCM(CD8^(+)CD45RA^(−)CD27^(+)CCR7^(+))cells in LACC patients was significantly lower than that of the control *** percentage of CD8^(+)TN in the peripheral blood of LACC patients was significantly higher than that of tumor ***8^(+)TEM in the peripheral blood was significantly lower than that of tumor *** percentage of CD8^(+)TN and CD8^(+)TCM in human papillomavirus(HPV)positive samples was significantly higher than that of HPV-negative ***,the percentage of CD8^(+)TCM in tumor tissues was significantly higher in cancer tissue samples with lymph nodes compared with those ***:A higher proportion of CD4^(+)TCM and a lower proportion of CD8^(+)TN in the tumor microenvironment of LACC may contribute to the therapy response prediction.

关键词： T cells Locally advanced cervical cancer Short-term curative Biomarkers

Image Matching Based on image Fusion and Hopfield Neural Network

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通讯和计算机（中英文版） 2005年第11期2卷 24-28页

作者： Zhenghao shi yaning feng School of Computer Science Xi＇an University of Technology Xi ＇an 710048 China Dept. of Environmental Technology ＆ Urban Planning Nagoya Institute of Technology Nagoya 464-0857 Japan

To improve the accuracy and real-time performance of image matching, a novel image matching method is proposed, which combines image fusion theory and the optimization capability of Hopfield neural networks. Firstly, according to their complementarities, images of the same scene obtained by different sensors are fused into a single image which contains a more accurate description of the scene than any of the individual source images. Then, image matching features are extracted by The Directional Wavelet Transform (DWT). Finally, image matching process is optimized by Hopfield neural networks, where the problem of image matching is treated as the minimization of the energy function of the Hopfield neural network. Experimental results demonstrate the efficiency and the effectiveness of the proposed method.

关键词： Hopfield Image Matching Wavelet Translation Image Fusion

Swirling flow and capillary diameter effect on the performance of an active dry powder inhalers

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Medicine in Novel Technology and Devices 2023年第2期18卷 215-225页

作者： Mohammad Hasan Taheri Nematollah Askari yaning feng Malikeh Nabaei Mohammad S.Islam Ali Farnoud Xinguang Cui Department of Mechanical Engineering Faculty of Imam KhomeiniBehshahr BranchTechnical and Vocational University(TVU)MazandaranIran School of Aerospace Engineering Huazhong University of Science and TechnologyWuhanChina Faculty of Biomedical Engineering Amirkabir University of Technology(Tehran Polytechnic)TehranIran School of Mechanical and Mechatronic Engineering University of Technology Sydney(UTS)15 BroadwayUltimoNSW2007Australia Computational Health Center Helmholtz MunichMunichGermany

For patients with lung disease,dry powder inhalers(DPI)are profoundly *** current study introduces and develops a series of dry powder inhalers(DPIs).A capsule-based(size 0)active DPI was *** study aims to investigate whether swirling flow and outlet capillary diameter(dc_out)affect the percentage of emitted doses(ED)released from the *** vanes were added to the capillary inlet to produce a swirling *** fluid dynamics(CFD)was applied to simulate the *** results were compared with previous in vitro and numerical studies to validate the *** on the derived results,the small swirl parameter(SP)enhances the secondary flow and recirculation *** increases the central jet flow,which increases the ED value by about 5–20%compared to no-swirl ***,as the airflow rate increases,the recirculation zone enlarges,vorticities become dominant,and asymmetrical flow patterns ***,ED%drops significantly(more than 50%).As d_(c_out)decreases,the vorticities around the outlet capillary become more potent,which is ***,the emptying of the capsule does not happen *** research provides a perspective on the device's design and DPI performance.

关键词： Computational fluid dynamics Dry powder inhalers Swirling flow

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部分旋流对加力燃烧室流动和燃烧性能的影响

推进技术 2024年第2期45卷 114-123页

作者：毕亚宁范育新肖锋马宗伯陈玉乾南京航空航天大学能源与动力学院江苏南京210016

为改善先进加力/冲压燃烧室燃烧组织困难等问题,采用设置进口部分旋流,在燃烧室中产生局部离心力来增强油气掺混和加速火焰传播。通过数值模拟和试验的方法,研究了不同旋流进口位置及角度下部分旋流加力/冲压燃烧室的流动特性、燃烧效... 详细信息

为改善先进加力/冲压燃烧室燃烧组织困难等问题,采用设置进口部分旋流,在燃烧室中产生局部离心力来增强油气掺混和加速火焰传播。通过数值模拟和试验的方法,研究了不同旋流进口位置及角度下部分旋流加力/冲压燃烧室的流动特性、燃烧效率及值班点火火焰发展过程。研究发现:多区域旋流进口与不同旋流角度的组合会使流动损失增大,但可以在燃烧室建立一个局部超重力场,增强油气掺混和加速点火过程火焰传播。相比于无旋流,旋流进口可以提高值班火焰传播速度;旋流进口最高可提升2.35%的燃烧效率。

关键词：加力燃烧室超重力燃烧旋流离心力流动特性

Reactant Concentration and Carbonization to the Controllable Fabrication of Carbon Aerogels

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Reactant Concentration and Carbonization to the Controllable...

不同环境温度对人体呼吸道内颗粒物沉积规律的影响

中国材料大会2012

作者： yaning feng Liling Ge Bailing Jiang Lei Miao Tanemura Masaki Xi'an University of Technology Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Department of Frontier Materials Graduate School of Engineering Nagoya Institute of Technology

ISBN: (纸本)9783037856062

To improve the controllability of the fabrication of carbon aerogels, the effects of the concentration of the reactant （RF%） on the structural properties of organic resorcinol-formaldehyde （RF） gel and the effects of the carbonization temperature on nano-structure of carbon aerogels were discussed. The concentration of the reaction was turned from 5%,10%,20%,30%,40%, 50%,55% and 60% to prepare the samples. The RF aerogels were carbonized at temperature of 700℃, 900℃ and 1050℃. The shrinkage and nitrogen gas adsorption were measured. Experimental results showed that the structural stability of the organic RF aerogel can be improved by decreasing the shrink in drying process and increasing the condensation of reactant in the starting solution to a certain value, such as 55%. The ordered pore size distribution of carbon aerogels with less structure defects is able to be produced through the effective particle fusing at the carbonization temperature as high as 1050℃.

关键词： Structural stability Carbon aerogels Condensation of reactant Carbonization

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医用生物力学 2023年第4期38卷 670-676页

作者：冯亚宁崔新光华中科技大学航空航天学院武汉430074

目的探究环境温度对人体呼吸道内气体流动和颗粒物沉积规律的影响。方法采用计算流体动力学(computational fluid dynamics,CFD)方法模拟具有黏液层的人体呼吸道内的气固两相流;考虑6种不同环境温度(-25、-15、0、15、26.7、45℃)和8种... 详细信息

目的探究环境温度对人体呼吸道内气体流动和颗粒物沉积规律的影响。方法采用计算流体动力学(computational fluid dynamics,CFD)方法模拟具有黏液层的人体呼吸道内的气固两相流;考虑6种不同环境温度(-25、-15、0、15、26.7、45℃)和8种不同粒径(1~8μm)的颗粒物。结果气流流速与6种温度下平均气流流速的差异可达39.42%;气流湍流动能与6种温度下湍流动能平均值的差异可达到11.59%;气流温度变化与6种温度下气流温度变化平均值的差异可高达82.4%。颗粒总沉积率与6种温度下总沉积率平均值的差异可达14.72%;颗粒局部沉积率与6种温度下局部沉积率平均值的差异可达到37.08%。结论环境温度差异会影响人体呼吸道内部的气流流场性质,进而会影响颗粒物在呼吸道内的沉积规律。因此,获得精准的颗粒物在人体呼吸道内的运动沉积规律,有必要考虑环境温度的影响。

关键词：环境温度人体呼吸道气体流动颗粒物沉积

基于窄槽式集热器的日光温室昼夜双循环热湿调控研究

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工程热物理学报 2024年第4期45卷 962-969页

作者：陈辛格伍纲冯朝卿姬亚宁马前磊程瑞锋内蒙古工业大学能源与动力工程学院呼和浩特010051 中国农业科学院农业环境与可持续发展研究所北京100081

位于中高纬度地区的温室,都难以避免冬季夜间相对湿度过高、温度较低的问题。本研究以中国日光温室为研究对象,提出了一种将窄槽式集热器与固体除湿剂相结合的温室热湿调控系统。通过光学模拟和几何计算,当窄槽式集热器的放置倾角为30?... 详细信息

位于中高纬度地区的温室,都难以避免冬季夜间相对湿度过高、温度较低的问题。本研究以中国日光温室为研究对象,提出了一种将窄槽式集热器与固体除湿剂相结合的温室热湿调控系统。通过光学模拟和几何计算,当窄槽式集热器的放置倾角为30?时,能够在北纬40°的北京冬季,为窄槽式集热器提供80%以上的光线接收率。该系统在冬季夜间,将温室内相对湿度从94.2%的高湿区间降低到81.3%的作物正常生长区间,室内平均温度上升1.2℃。白天脱附阶段,窄槽式集热器的最高出口温度为136℃,平均集热效率为0.62。该系统结合太阳能中温集热技术与可再生的固体除湿剂,将冬季日光温室内的空气环境调整到了作物生长的适宜区间。

关键词：窄槽式集热器太阳能温室固体除湿剂

基于熵权法-TOPSIS的冶金企业作业循环更新研究

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安全 2021年第1期42卷 57-61,68页

作者：冯亚凝周艳天津理工大学环境科学与安全工程学院天津300384

为更加合理、客观地制定安全操作规程更新周期,切实保障冶金工业人员作业安全,本文以安全管理原理和作业循环检查规范为依据,采用危险与可操作性分析方法(HAZOP),系统辨识某冶金高炉车间岗位人员操作行为;通过资料分析,建立典型操作程... 详细信息

为更加合理、客观地制定安全操作规程更新周期,切实保障冶金工业人员作业安全,本文以安全管理原理和作业循环检查规范为依据,采用危险与可操作性分析方法(HAZOP),系统辨识某冶金高炉车间岗位人员操作行为;通过资料分析,建立典型操作程序信息表,选用风险发生次数、受伤程度、经济损失、作业次数4个指标作为综合评价依据;将熵权法与逼近理想解排序法(TOPSIS)结合,确定客观权重,并分析操作偏差危害程度与最劣方案的贴近程度,确定各操作规程更新周期为月检、季检、半年检、年检。结果表明:模型排序与现实情况相符,检查更新周期有效规范人员操作偏差,扩展作业循环分析规范的适用性。

关键词：作业循环检查熵权法逼近理想解排序法更新周期

抗CD47胞外区骆驼多克隆抗体的制备及鉴定

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生物技术通报 2015年第8期31卷 200-205页

作者：贾二坷冯亚宁李江伟新疆大学生命科学与技术学院新疆生物资源基因工程重点实验室乌鲁木齐830046

验证人CD47蛋白能否在新疆双峰驼中产生高滴度抗体;为制备高亲和力的抗CD47纳米抗体提供实验依据。构建CD47胞外区原核表达载体,诱导表达及纯化CD47蛋白,免疫新疆双峰驼。通过酶联免疫吸附试验(ELISA)和Western blot分别检测骆驼多克隆... 详细信息

验证人CD47蛋白能否在新疆双峰驼中产生高滴度抗体;为制备高亲和力的抗CD47纳米抗体提供实验依据。构建CD47胞外区原核表达载体,诱导表达及纯化CD47蛋白,免疫新疆双峰驼。通过酶联免疫吸附试验(ELISA)和Western blot分别检测骆驼多克隆抗体的效价及与CD47蛋白特异性结合活性。结果显示,成功构建CD47胞外区原核表达载体,获得纯度大于90%的CD47蛋白,表达纯化的CD47重组蛋白可与抗CD47单抗B6H12.2特异结合;ELISA测定CD47重组蛋白免疫骆驼7次后,抗CD47多克隆抗血清的效价至少达到1∶200 000,免疫印迹检测表明抗CD47骆驼抗血清与CD47重组蛋白、Jurkat和Raji细胞表面表达的CD47均能特异结合。重组人CD47蛋白可以在骆驼体内激发高滴度抗体反应。

关键词： CD47 多克隆抗体新疆双峰驼纳米抗体