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低温下玄武岩纤维混凝土劈拉强度尺寸效应试验

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哈尔滨工业大学学报 2025年第1期57卷 101-109页

作者：余文轩范美妤金浏杜修力清华大学土木水利学院北京100084 城市减灾与防灾防护教育部重点实验室(北京工业大学) 北京100124

为研究极端低温作用下结构尺寸和纤维体积分数对玄武岩纤维混凝土劈拉强度的定量影响规律和作用机制,设计了4种尺寸(边长分别为70、100、150和200 mm)、4种纤维体积分数(分数范围0%~0.5%)的玄武岩纤维混凝土立方体试块在常温和低温下(... 详细信息

为研究极端低温作用下结构尺寸和纤维体积分数对玄武岩纤维混凝土劈拉强度的定量影响规律和作用机制,设计了4种尺寸(边长分别为70、100、150和200 mm)、4种纤维体积分数(分数范围0%~0.5%)的玄武岩纤维混凝土立方体试块在常温和低温下(温度范围20~-90℃)进行了静态劈拉破坏试验。试验结果表明:不同类型混凝土的劈拉强度均随温度降低而线性增大(最大增幅接近130%),呈现出显著的低温增强效应;玄武岩纤维的掺入能略微强化混凝土劈拉强度的低温增强效应。不同纤维体积分数玄武岩纤维混凝土的劈拉强度均呈现出一定的纤维增强效应,并且随体积分数增加而增强;极端低温作用下玄武岩纤维的主导破坏模式由拔出破坏转变为拉断破坏,导致纤维增强效应随温度下降而变强。劈拉强度的尺寸效应随温度下降而更明显,但玄武岩纤维的掺入能减弱尺寸效应(最大削弱程度达25.8%)。本文研究能为玄武岩纤维混凝土材料在极端低温环境下的大规模工程结构应用提供有效参考。

关键词：玄武岩纤维混凝土极端低温纤维含量劈裂拉伸尺寸效应

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng fan Zhiwen Luo Xueran Kang Renwen Wan fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

脂质转移蛋白SiLTP1基因参与谷子耐盐响应初探

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作物学报 2025年第1期51卷 58-67页

作者：孟凡花刘敏沈傲刘炜山东省农业科学院农作物种质资源研究所山东济南250100 上海应用技术大学生态技术与工程学院上海201418

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁... 详细信息

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁迫过程。前期本课题组克隆到一个谷子中编码脂质转移蛋白的基因SiLTP1,本研究通过构建其原核表达载体和植物双元过表达载体,获得了该基因的原核表达蛋白及同源转化过表达阳性植株,经进一步筛选获得4个纯合株系。体外耐盐性试验显示, SiLTP1的原核表达蛋白具有一定耐盐性;转基因植株苗期耐盐生理指标测定显示,SiLTP1过表达植株在遭受盐胁迫时,植株体内MDA积累减少,抗氧化酶含量升高,可积累更少的过氧化氢,从而降低胁迫对植株的氧化损伤,显示基因过表达植株具有更好的耐盐性。本研究结果初步揭示, SiLTP1可正向调控谷子的耐盐性,其在谷子耐盐抗逆方面具有潜在功能,为耐盐谷子品种改良及新品种培育提供了理论基础和候选基因资源。

关键词：脂质转移蛋白 SiLTP1 盐胁迫谷子耐盐响应

Identification of Nucleus Sterility Candidate Genes Using a Resequencing Technique in Sweet Pepper Sterile Line AB91

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Agricultural Sciences 2021年第2期12卷 138-157页

作者： yaning Meng Libin Yan Hongxiao Zhang Yanqin fan The Institute of Cash Crops Hebei Academy of Agriculture and Forestry Sciences Shijiazhuang China

Breeding hybrids with nuclear malesterile lines is an important method for the cross-breeding of sweet peppers. To date, few reports have been published on the nuclear malesterility gene of sweet pepper. Yet, there are approximately 20 pepper nuclear malesterility lines in the world. Using the self-developed testing material, sweet pepper nuclear malesterile dual-purpose line AB91, the genome-wide resequencing technique was applied to find that the mutation site causing the abortion of sweet pepper nuclear malesterility AB91 is on chromosome #5. The mutation gene Capana05g000747 was filtered out and validated by the flight mass spectrometry genotyping and quantitative realtime PCR method and determined to be the gene causing the abortion of sweet pepper nuclear male sterility AB91. The gene Capana05g000747 mutation site is a non-synonymous mutation site located at the 6th exon, the base C mutated into A, and the amino acid changed from alanine to serine. The three-dimensional protein structure of fertile and sterile plant Capana05g000747 was predicted. The results showed that the three-dimensional structure of the two proteins differed significantly. Sequence alignment analysis showed that the gene Capana05g000747 has a similar function to gene At2g02148. The gene At2g02148 contains a pentatricopeptide repeat protein which has important physiological functions in the gene expression process of organelles and is closely related to the performance of malesterility genes. Therefore, Capana05g000747 was selected as an important candidate gene for sweet pepper nuclear male sterile testing material AB91.

关键词： Sweetpepper Nuclear Malesterile Line Genome-Wide Resequencing Technique Candidate Gene

Flight dynamics modeling of a small ducted fan aerial vehicle based on parameter identifcation

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Chinese Journal of Aeronautics 2013年第6期26卷 1439-1448页

作者： Wang Zhengjie Liu Zhijun fan Ningjun Guo Meifang School of Mechatronical Engineering Beijing Institute of Technology North Institute for Science & Technical Information

This paper presents a simple and useful modeling method to acquire a dynamics model of an aerial vehicle containing unknown parameters using mechanism modeling,and then to design different identifcation experiments to identify the parameters based on the sources and features of its unknown *** on the mathematical model of the aerial vehicle acquired by modeling and identifcation,a design for the structural parameters of the attitude control system is carried out,and the results of the attitude control flaps are verifed by simulation experiments and flight tests of the aerial *** of the mathematical simulation and flight tests show that the mathematical model acquired using parameter identifcation is comparatively accurate and of clear mechanics,and can be used as the reference and basis for the structural design.

关键词： Aerodynamics Experimental aerodynamics Flight vehicle design Multidisciplinary design optimization Structural design

Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 391-401页

作者： Yongxuan Shang Mingyu fan Shuyong Jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University State Key Laboratory of Metal Material for Marine Equipment and Application Iron & Steel Research Institute of Ansteel Group Corporation

Carbon can change the phase components of low-density steels and influence the mechanical properties. In this study, a new method to control the carbon content and avoid the formation of δ-ferrite by decarburization treatment was proposed. The microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically examined. Crussard–Jaoul(C–J) analysis was employed to examine the work hardening characteristics during the tensile test. During decarburization by heat treatments, the carbon content within the austenite phase decreased, while Mn and Al were almost unchanged; this made the steel with full austenite transform into the austenite and ferrite dual phase. Meanwhile,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the same. In addition, the formation of other carbides restrained. Carbon loss induced a decrease in strength due to the weakening of the carbon solid solution. For the steel with the single austinite, the deformation mode of austenite was the dislocation planar glide, resulting in the formation of microbands. For the dual-phase steel, the deformation occurred by the dislocation planar glide of austenite first, with the increase in strain, the cross slip of ferrite took place, forming dislocation cells in ferrite. At the late stage of deformation, the work hardening of austinite increased rapidly, while that of ferrite increased slightly.

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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying fang Xiao-Rui Pan Xin-Xing Zeng Zheng-Zheng Li Bo-fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

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血管化类器官的构建策略

中国组织工程研究 2025年第13期29卷 2774-2783页

作者：刘明昱范文娟海南医学院海南省海口市571199 漯河医学高等专科学校河南省漯河市462002

背景:有效促进类器官内部血管发生是目前类器官培养中的焦点问题,作为一种新近发展的生物培养技术,血管化的类器官在研究活体组织的发育、疾病形成的机制、组织替代疗法以及药物筛选等方面,都有很大的研究和应用价值。目的:对近年来类... 详细信息

背景:有效促进类器官内部血管发生是目前类器官培养中的焦点问题,作为一种新近发展的生物培养技术,血管化的类器官在研究活体组织的发育、疾病形成的机制、组织替代疗法以及药物筛选等方面,都有很大的研究和应用价值。目的:对近年来类器官血管化的方法或策略进行归纳总结,分析类器官血管化形成机制以及构建策略,以期为更加深入地研究类器官的发生机制和为临床转化提供可靠的思路。方法:检索PubMed及中国知网数据库收录的相关文献。英文检索词为“organoids,Vascularization,Vascular,Vascular development,vessel”,中文检索词为“血管发生,血管生成,类器官,干细胞,血管化,预血管化”,最终纳入77篇文献进行归纳总结。结果与结论:①类器官血管化形成机制涉及3个关键因素,即种子细胞、细胞因子与细胞外基质。种子细胞为血管化类器官提供了关键的细胞来源,细胞因子为类器官内部的血管发生起了重要的信号引导作用,细胞外基质为血管细胞提供了外在的生长环境,促进类器官血管化的发生。②血管化类器官的构建策略包括细胞自我重组、微血管碎片渗入、宿主体内移植以及微流控芯片等。体外诱导多能干细胞向血管内皮祖细胞分化能顺利与邻近组织整合并具有血管生成的潜力,故可利用多能干细胞的自我重组功能构建血管化类器官。微血管碎片保留了其细胞复杂性、天然结构和表型可塑性,更利于模拟天然微血管从而促进类器官的血管化。宿主体内移植是目前类器官实现完整血液灌流的最佳方法,而微流控芯片则为实现类器官体外血液供应提供了解决方案。③类器官的多种构建策略如多类干细胞共分化、信号分子的精准调控、微血管渗入和活体宿主移植等,一定程度上在类器官中引入血管成分,使得类器官在功能和成熟度上更接近相应组织。然而缺乏血流灌注仍然是一个难题,迄今为止,仅宿主体内移植才能在类器官中实现有效的血流灌注,因此类器官在血管化方面仍面临许多挑战。

关键词：类器官血管化血管发生自我重组共培养种子细胞体内移植内皮细胞干细胞综述

A novel approach to the attitude stabilization structure for ducted-fan operative aerial robots:Finding improvements for modeling error and strong external transient disturbance

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Chinese Journal of Aeronautics 2022年第2期35卷 250-264页

作者： Wei fan Bin XU Changle XIANG Yibo ZHANG Haiyang YANG School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401135China School of Automation Beijing Institute of TechnologyBeijing 100081China

This research concerns a novel attitude stabilization structure for a ducted-fan aerial robot to work against modeling error and strong external transient disturbance,and it focuses on two main control targets:modeling error compensation,and the improvement of disturbance resistance along the rolling *** the first research objective,we proposed an adaptive nominal controller with the reconfigurable control law design based on the estimation of the modeling error found in the *** of simulations and corresponding flight tests verified that the proposed adaptive control structure is robust against both constant and time-varying modeling *** the other research objective,a SAC(Stability Augmentation Control)structure was devised based on the CMG(Control Moment Gyroscope)theory in order to provide extra moment which effectively withstands the transient disturbance beyond the CDG(Critical Disturbance Gain).Furthermore,we studied the corresponding controller for the SAC via the SMC(sliding mode control)theory,while the working mechanism and performance of the SAC were verified through a specially devised prototype.

关键词： Adaptive control Disturbance rejection Ducted-fan aircraft Modeling error Stability augmentation systems