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C5a受体C5AR1在肿瘤发生发展及免疫治疗中的研究进展

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中国肿瘤生物治疗杂志 2023年第2期30卷 161-166页

作者：井红艳(综述) 聂琰晖杨毅(审阅) 江西中医药大学药学院江西南昌330004 长三角药物高等研究院长三角药物高等工程学院江苏南通226133 百奥赛图(北京)医药科技股份有限公司抗体新药研究院北京102609

C5AR1是补体激活片段C5a的受体,主要在粒细胞、单核细胞、树突状细胞和髓源性抑制细胞(MDSC)以及肿瘤细胞上表达。C5a可以刺激中性粒细胞产生炎性介质,也可以募集MDSC等免疫抑制细胞形成免疫抑制微环境,促进肿瘤的生长和转移,从而在肿... 详细信息

C5AR1是补体激活片段C5a的受体,主要在粒细胞、单核细胞、树突状细胞和髓源性抑制细胞(MDSC)以及肿瘤细胞上表达。C5a可以刺激中性粒细胞产生炎性介质,也可以募集MDSC等免疫抑制细胞形成免疫抑制微环境,促进肿瘤的生长和转移,从而在肿瘤的发生发展中起到重要的作用。C5AR1已成为肿瘤治疗的新靶点,C5AR1靶向药与免疫检查点抑制剂联用能够起到协同抑制肿瘤的作用。就C5AR1的基本信息,促进肿瘤发生、生长和转移的机制,以及以C5AR1为靶点的抗肿瘤药的开发现状进行综述,以期为后续的机制研究、药物开发提供参考。

关键词： C5a C5AR1 肿瘤免疫治疗靶点

二黄汤对哮喘模型大鼠肺组织中TGF-β_1及体内IL-33的影响

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天津医药 2014年第4期42卷 337-340页

作者：聂艳辉霍博雅孙会珍辽宁医学院辽宁锦州121000 辽宁医学院附属第三医院中医科

目的观察二黄汤对哮喘模型大鼠肺组织中转化生长因子β1(TGF-β1)及体内白介素-33(IL-33)的影响。方法 50只SD大鼠随机均分为正常组、哮喘组、布地奈德组、高剂量二黄汤组(含生药量68 g/kg)和低剂量二黄汤组(含生药量17 g/kg)。以卵清... 详细信息

目的观察二黄汤对哮喘模型大鼠肺组织中转化生长因子β1(TGF-β1)及体内白介素-33(IL-33)的影响。方法 50只SD大鼠随机均分为正常组、哮喘组、布地奈德组、高剂量二黄汤组(含生药量68 g/kg)和低剂量二黄汤组(含生药量17 g/kg)。以卵清白蛋白致敏与激发建立哮喘大鼠模型,随后分别用布地奈德、二黄汤干预治疗。肺组织切片HE染色观察病理变化并检测气道管壁厚度(Wat)及气道平滑肌厚度(Wam),用免疫组化法检测肺组织TGF-β1蛋白的表达,酶联免疫法检测血清及支气管肺泡灌洗液(BALF)中IL-33的含量。结果所有药物干预组较哮喘组炎症细胞浸润明显减轻;布地奈德组、高剂量二黄汤组和低剂量二黄汤组Wat均较哮喘组下降(μm2/μm:54.99±8.82、52.28±7.61、58.53±7.63 vs 79.50±5.64,P<0.05);布地奈德组、高剂量二黄汤组和低剂量二黄汤组Wam均较哮喘组下降(μm2/μm:22.74±2.73、20.63±1.72、21.20±4.50 vs 30.16±1.68,P<0.05);与正常组比较,哮喘组BALF、血清中IL-33的浓度增高,经药物干预后,布地奈德组、高剂量二黄汤组和低剂量二黄汤组低于哮喘组(P<0.05),但3干预组间差异无统计学意义;哮喘组TGF-β1高于正常组(IOD:12.60±2.25 vs 1.67±0.17),布地奈德组(5.51±2.48)、高剂量二黄汤组(5.22±2.52)和低剂量二黄汤组(6.92±2.18)均低于哮喘组(P<0.05),3干预组间差异无统计学意义。哮喘大鼠的气道壁厚度和平滑肌厚度与TGF-β1、IL-33呈正相关。结论二黄汤可在一定程度上干预哮喘大鼠气道重塑,其作用可能是通过调节TGF-β1和IL-33实现的。

关键词：哮喘气道重塑二黄汤转化生长因子-β1 白细胞介素-33 transforming growth factor-β1 leukotriene-3

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天津市医疗机构预约挂号服务的调查与分析

继续医学教育 2021年第6期35卷 54-57页

作者：王小军聂艳辉邓超天津市北辰医院卫生应急办公室天津300400 天津中医药大学管理学院天津301617 天津市武清区人民医院党委办公室天津301700

目的了解“预约挂号”现状,提出优化建议。方法采用问卷调查了解预约挂号情况;运用描述性分析研究预约挂号的使用及满意度;利用χ2检验分析影响患者预约挂号的因素。结果55.16%受访者对预约挂号服务较为了解,29.60%受访者总是和经常使... 详细信息

目的了解“预约挂号”现状,提出优化建议。方法采用问卷调查了解预约挂号情况;运用描述性分析研究预约挂号的使用及满意度;利用χ2检验分析影响患者预约挂号的因素。结果55.16%受访者对预约挂号服务较为了解,29.60%受访者总是和经常使用预约挂号,超过70%的受访者认为预约挂号比较繁琐,60.54%的受访者对预约挂号较为满意,4.93%的受访者总是或经常爽约。结论预约挂号存在社会知晓率、使用率和满意度均较低的问题,应宣传和推广预约挂号,完善预约平台,通过畅通退号和爽约惩罚遏制爽约。

关键词：医疗机构预约挂号满意度

Adsorption characteristics of copper ion on nanoporous silica

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Acta Geochimica 2019年第4期38卷 517-529页

作者： yanhui Niu Wenbin Yu Zonghua Qin Xin nie Shuguang Yang Quan Wan State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of Sciences99 Lincheng West RoadGuanshanhu DistrictGuiyang 550081GuizhouChina University of Chinese Academy of Sciences Beijing 100049China School of Chemistry and Materials Science Guizhou Education University115 Gaoxin RoadWudang DistrictGuiyang 550018GuizhouChina CAS Center for Excellence in Comparative Planetology Hefei 230026AnhuiChina

Adsorption by nanoporous media is critically involved in many fundamental geological and geochemical processes including chemical weathering,element migration and enrichment,environmental pollution,***,the adsorption behavior of metal ions on nanoporous materials has not been systematically *** this study,MCM-41 material with a monodisperse pore size(4.4 nm)and a large BET specific surface area(839 m^2/g)was hydrothermally prepared and used as a model silica adsorbent to study the adsorption characteristics of Cu^2+as a representative metal *** Cu^2+adsorption capacity was found to increase with increasing suspension pH in the range from 3 to 5 and to decrease in the presence of *** 25℃,pH=5,and a solid-to-liquid ratio of 5 g/L,the adsorption capacity was determined to be 0.29 mg/g,which can be converted to a dimensionless partition coefficient of 45,indicating a strong enriching effect of nanoporous *** adsorption isotherm and kinetic data were fitted to several commonly used thermodynamic,kinetic,and diffusion *** adsorption mechanism was also studied by Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and synchrotron-based X-ray absorption *** results suggest that Cu2+ion adsorption is an entropy-driven endothermal process,possibly involving both outer-sphere and inner-sphere complexes.

关键词： Nanoporous silica Copper ion Adsorption

Influences of flexible defect on the interplay of supercoiling and knotting of circular DNA

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Communications in Theoretical Physics 2021年第7期73卷 136-145页

作者： Caiyun Xiong Xiaolin nie Yixue Peng Xun Zhou Yangtao Fan Hu Chen yanhui Liu College of Physics Guizhou UniversityGuiyang 550025China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices PenTung Sah Institute of Micro-Nano Science and TechnologyXiamen UniversityXiamen361005China Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Lab for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen361005China Breeding and Reproduction in The Plateau Mountainous Region Ministry of Education(Guizhou University)Guizhou Guiyang550025China

Knots are discovered in biophysical systems,such as DNA and *** portions in knotted DNA are significantly bent and their corresponding bending angles are comparable with or larger than the sharp bending angle resulting in flexible *** role of flexible defects in the interplay of supercoiling and knotting of circular DNA were predicted by a Monte Carlo *** knotted DNA with a particular knot type,a flexible defect noticeably enhances the supercoiling of the knotted DNA and the decreasing excitation energy makes the knotted portion more compact.A reduction in twist rigidity and unwinding of flexible defects are incorporated into the numerical simulations,so that interplay of supercoiling and knotting of circular DNA is studied under torsional *** unwinding not only results in a wider linking number distribution,but also leads to a drift of the distribution to lower values.A flexible defect has obvious effects on knotting *** summation of equilibrium distribution probability for nontrivial knotted DNA with different contour length does not change with excitation energy monotonically and has a maximum at an intermediate value of excitation energy around 5 *** the phase space of knot length and gyration radius of knotted DNA,knot length does not anticorrelate with its gyration radius,which is attributed to the flexible defect in the knotted portion,which leads to the release of bending energy and inhibited the competition between entropy and bending energy.

关键词： knot flexible defect DNA topology knotted DNA Monte-Carlo simulation

‘嘎拉’苹果小孢子来源纯合基因型植株叶片再生体系研究

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果树学报 2018年第5期35卷 620-630页

作者：李芙蓉邓舒张春芬肖蓉侯丽媛石江鹏董艳辉聂园军曹秋芬山西大学生物工程学院太原030006 山西省农业科学院果树研究所太原030001 山西省农业科学院生物技术研究中心太原030031 山西省农业科学院农业资源与经济研究所太原030031

【目的】建立‘嘎拉’苹果小孢子来源纯合基因型植株高效再生体系,探索一个简单有效的苹果纯合基因型株系叶片外植体诱导再生不定芽的方法。【方法】以‘嘎拉’苹果花药离体培养获得的纯合基因型株系离体叶片为外植体,进行再生培养,检... 详细信息

【目的】建立‘嘎拉’苹果小孢子来源纯合基因型植株高效再生体系,探索一个简单有效的苹果纯合基因型株系叶片外植体诱导再生不定芽的方法。【方法】以‘嘎拉’苹果花药离体培养获得的纯合基因型株系离体叶片为外植体,进行再生培养,检测‘嘎拉’各纯合基因型株系的不定芽再生能力;通过优化植物生长调节剂、叶片预处理和培养方式,建立苹果纯合基因型植株高效再生体系。【结果】苹果纯合基因型株系中双单倍体株系DH2-10的再生率最高,四倍体纯系DH2-15次之,单倍体株系DH2-3再生率较低,三倍体纯系DH2-40在培养中难以再生。不同基因型适宜的激素质量浓度不同,相较于双单倍体株系,四倍体纯系DH2-15在较高细胞分裂素水平再生率较好。再生培养过程中,整叶带伤口的外植体预处理方式优于叶片切块接种的方式,接种苗龄40 d左右的叶片有更好的再生率。【结论】建立了苹果纯合基因型高频高效离体再生体系:双单倍体株系DH2-10在最适再生培养基MS+0.5 mg·L^(-1)IBA+5 mg·L^(-1)6-BA上培养,再生周期为23~35 d,再生系数为7.27,再生率达100%。四倍体纯合基因型株系DH2-15适宜在MS+0.5 mg·L^(-1)IBA+6 mg·L^(-1)6-BA培养基上进行再生培养,再生率为93.33%。建立的再生体系可用于纯合基因型株系的快速增殖和遗传转化。

关键词： '嘎拉’苹果小孢子来源纯合基因型再生体系

Genotypic variance in 13C-photosynthate partitioning and within-plant boll distribution in cotton

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Journal of Cotton Research 2020年第2期3卷 124-133页

作者： nie Junjun QIN Dulin MAO Lili LIU yanhui DONG Hezhong SONG Xianliang SUN Xuezhen State Key Laboratory of Crop Biology College of AgronomyShandong Agricultural UniversityTaian 271018ShandongChina Cotton Research Center Shandong Academy of Agricultural SciencesJinan 250100ShandongChina Technical Guidance Station of Cotton Production in Shandong Province Jinan 250013ShandongChina Qufu Agricultural Bureau Qufu 273100ShandongChina.

Background:Photosynthate partitioning and within-plant boll distribution play an important role in yield formation of cotton;however,if and how they interact to mediate yield remains *** objective of this study was to investigate the genotypic variance in photosynthate partitioning and within-plant boll distribution,with a focus on their interactions with regard to yield and yield components.A field experiment was conducted in the Yellow River region in China in 2017 and 2018 using a randomized complete block design with three *** partitioning of three commercial cultivars(DP 99 B,Lumianyan 21 and Jimian 169),varying in yield potential,to different organs(including bolls)at early flowering,peak flowering,and peak boll-setting stages,as well as withinplant boll distribution at harvest,and their effects on yield formation were ***:Lint yield of Jimian 169 was the highest,followed by Lumianyan 21 and DP 99 *** differences were observed in the number of inner bolls and boll weight among the three cultivars.J169 partitioned significantly more photosynthate to the fruit and fiber than Lumianyan 21 and DP 99 B and allocated over 80%of assimilates to the inner ***,Lumianyan 21 allocated a higher proportion of photosynthate to bolls and fiber,with12.5%–17.6%more assimilates observed in the inner bolls,than DP 99 ***:Genotypic variance in lint yield can be attributed to differences in the number of inner bolls and boll weight,which are affected by photosynthate ***,the partitioning of photosynthate to fiber and inner bolls can be used as an important reference for cotton breeding and cultivation.

关键词： Genotypic variance Within-plant boll distribution Photosynthate partitioning Yield Yield components

Nanopriming with selenium doped carbon dots improved rapeseed germination and seedling salt tolerance

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The Crop Journal 2024年第5期12卷 1333-1343页

作者： Mohammad Nauman Khan Chengcheng Fu Xiaohui Liu yanhui Li Jiasen Yan Lin Yue Jiaqi Li Zaid Khan Lixiao nie Honghong Wu National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops MOA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze RiverThe Center of Crop NanobiotechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Hubei Hongshan Laboratory Wuhan 430070HubeiChina School of Breeding and Multiplication(Sanya Institute of Breeding and Multiplication) Hainan UniversitySanya 572000HainanChina College of Food and Pharmaceutical Engineering Guizhou Institute of TechnologyGuiyang 550003GuizhouChina College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642GuangdongChina Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityShenzhen 511464GuangdongChina Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 511464GuangdongChina

Soil salinity is a big environmental issue affecting crop *** seed nanopriming has been widely used to improve seed germination and seedling growth under salinity,our knowledge about the underlying mechanisms is still ***,we newly synthesized selenium-doped carbon dots nanoparticles coated with poly acrylic acid(poly acrylic acid coated selenium doped carbon dots,PAA@Se-CDs)and used it to prime seeds of *** TEM(transmission electron microscope)size and zeta potential of PAA@Se-CDs are 3.8±0.2 nm and-30 mV,*** 8 h priming,the PAA@Se-CDs nanoparticles were detected in the seed compartments(seed coat,cotyledon,and radicle),while no such signals were detected in the NNP(no nanoparticle control)group(SeO_2 was used as the NNP).Nanopriming with PAA@Se-CDs nanoparticles increased rapeseeds germination(20%)and seedling fresh weight(161%)under saline conditions compared to NNP ***@Se-CDs nanopriming significantly enhanced endo-β-mannanase activities(255%increase,21.55μmol h^(-1)g^(-1)vs.6.06μmol h^(-1)g^(-1),at DAS 1(DAS,days after sowing)),total soluble sugar(33.63 mg g^(-1)FW(fresh weight)vs.20.23 mg g^(-1)FW)and protein contents(1.96μg g^(-1)FW vs.1.0μg g^(-1)FW)to support the growth of germinating seedlings of rapeseeds under salt stress,in comparison with NNP co *** respiration rate and ATP content were increased by 76%and 607%,*** oxidative damage of salinity due to the overaccumulation of reactive oxygen species(ROS)was alleviated by PAA@Se-CDs nanopriming by increasing the antioxidant enzyme activities(SOD(superoxide dismutase),POD(peroxidase),and CAT(catalase)).Another mechanism behind PAA@Se-CDs nanopriming improving rapeseeds salt tolerance at seedling stage was reducing sodium(Na^(+))accumulation and improving potassium(K^(+))retention,hence increasing the K^(+)/Na^(+)ratio under saline ***,our results not only showed that seed nanopriming with PAA@Se-CDs could be a

关键词： PAA@Se-CDs Nanopriming Salt stress Antioxidant system K^(+)/Na^(+) balance ATP production

液压对高速立式加工中心定位精度的影响与消除

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现代制造工程 2013年第9期 62-64页

作者：曾鹏聂剑门延会四川宜宾职业技术学院宜宾644003 四川宜宾普什机床有限公司宜宾644007

针对高速立式加工中心的定位精度进行进一步的研究。通过理论分析和实验论证,发现液压系统对高速立式加工中心的定位精度有较明显的影响,并通过实验的方法进行了验证,提出了改进措施。改进后的液压系统中加装了振动消除装置,能有效地消... 详细信息

针对高速立式加工中心的定位精度进行进一步的研究。通过理论分析和实验论证,发现液压系统对高速立式加工中心的定位精度有较明显的影响,并通过实验的方法进行了验证,提出了改进措施。改进后的液压系统中加装了振动消除装置,能有效地消除液压系统带来的干扰,大大提高了高速立式加工中心的定位精度和加工质量。

关键词：位置定位精度重复定位精度液压控制加工中心