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Identification of cell surface markers for acute myeloid leukemia prognosis based on multi-model analysis

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Journal of Biomedical Research 2024年第4期38卷 397-412页

作者： Jiaqi tang Lin Luo Bakwatanisa Bosco Ning Li bin Huang Rongrong Wu Zihan Lin ming Hong Wenjie Liu Lingxiang Wu Wei Wu Mengyan Zhu Quanzhong Liu peng Xia Miao Yu Diru Yao Sali lv Ruohan Zhang Wentao Liu Qianghu Wang Kening Li Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Department of Hematology of the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Northern Jiangsu Institute of Clinical MedicineHuai'anJiangsu 223300China Collaborative Innovation Center for Personalized Cancer Medicine Jiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentNanjing Medical UniversityNanjingJiangsu 211166China Department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Department of Pharmacology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China The Affiliated Cancer Hospital of Nanjing Medical University Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210002China

Given the extremely high inter-patient heterogeneity of acute myeloid leukemia(AML),the identification of biomarkers for prognostic assessment and therapeutic guidance is *** surface markers(CSMs)have been shown to play an important role in AML leukemogenesis and *** the current study,we evaluated the prognostic potential of all human CSMs in 130 AML patients from The Cancer Genome Atlas(TCGA)based on differential gene expression analysis and univariable Cox proportional hazards regression *** using multi-model analysis,including Adaptive LASSO regression,LASSO regression,and Elastic Net,we constructed a 9-CSMs prognostic model for risk stratification of the AML *** predictive value of the 9-CSMs risk score was further validated at the transcriptome and proteome *** Cox regression analysis showed that the risk score was an independent prognostic factor for the AML *** AML patients with high 9-CSMs risk scores had a shorter overall and event-free survival time than those with low ***,single-cell RNA-sequencing analysis indicated that patients with high 9-CSMs risk scores exhibited chemotherapy ***,PI3K inhibitors were identified as potential treatments for these high-risk *** conclusion,we constructed a 9-CSMs prognostic model that served as an independent prognostic factor for the survival of AML patients and held the potential for guiding drug therapy.

关键词： acute myeloid leukemia cell surface markers prognosis drug sensitivity multi-model analysis

Hard X-ray Imager (HXI) onboard the ASO-S mission

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Research in Astronomy and Astrophysics 2019年第11期19卷 49-62页

作者： Zhe Zhang Deng-Yi Chen Jian Wu Jin Chang Yi-ming Hu Yang Su Yan Zhang Jian-Ping Wang Yao-ming Liang Tao Ma Jian-Hua Guo ming-Sheng Cai Yong-Qiang Zhang Yong-Yi Huang Xiao-Yan peng Zong-bin tang Xuan Zhao Hong-He Zhou Lian-Guo Wang Jing-Xing Song Miao Ma Guang-Zhou Xu Jian-Feng Yang Di Lu Ying-Hong He Jin-You Tao Xiao-Long Ma Bao-Gang lv Yan-Ping Bai Cai-Xia Cao Yu Huang Wei-Qun Gan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China National Space Science Center Chinese Academy of SciencesBeijing 100190China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China

Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar *** is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 *** imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 *** engineering prototype has been developed and tested to verify the feasibility of *** this paper,we present background,instrument design and the development and test status of the prototype.

关键词： instrumentation:detectors space vehicles:instruments Sun:X-ray techniques:imaging spectroscopy

间充质干细胞源性外泌体:骨质疏松治疗新策略

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中华骨质疏松和骨矿盐疾病杂志 2019年第4期12卷 421-428页

作者：陈铭李毅尹鹏滨郭忠奎顾亚吕厚辰张里程唐佩福中国人民解放军总医院第一医学中心骨科

骨质疏松是一种以骨量降低、骨微结构破坏、骨脆性增高为特征的代谢性骨病,易增加骨折风险。骨质疏松的主要原因在于成骨细胞介导的骨形成与破骨细胞介导的骨吸收之间的动态失衡,进一步研究其发病机制、探索新型治疗策略意义重大。间充... 详细信息

骨质疏松是一种以骨量降低、骨微结构破坏、骨脆性增高为特征的代谢性骨病,易增加骨折风险。骨质疏松的主要原因在于成骨细胞介导的骨形成与破骨细胞介导的骨吸收之间的动态失衡,进一步研究其发病机制、探索新型治疗策略意义重大。间充质干细胞(mesenchymal stem cell,MSC)可通过旁分泌途径产生的外泌体参与骨代谢过程中的多个环节,修复并调控骨相关细胞增殖、迁移、分化功能,促进血管再生与调节免疫炎性反应,有望成为未来治疗骨质疏松的新方向。本文对MSC源性外泌体与骨质疏松之间的关系进行综述,探究其实现治疗效应的潜在机制,分析其优势与可行性,旨在为MSC源性外泌体在骨质疏松的临床诊治与基础研究中的应用提供参考。

关键词：间充质干细胞外泌体骨质疏松治疗

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草菇低温胁迫初期应答关键通路的探究

菌物学报 2021年第5期40卷 1074-1086页

作者：吕贝贝吴潇莫芹孙宇蒋玮黄艳娜武国干宋丽莉王金斌李鹏刘刚唐雪明上海市农业科学院生物技术研究所上海201106 上海市农业遗传育种重点实验室上海201106

本研究利用表达谱芯片技术解析了低温胁迫初期(0–120min)不同低温处理时间草菇转录组水平的变化。芯片结果分析发现在低温诱导过程中,低温处理20min内变化基因的功能为单加氧酶、氧化还原酶和细胞内的氧化还原。低温处理40min时表达差... 详细信息

本研究利用表达谱芯片技术解析了低温胁迫初期(0–120min)不同低温处理时间草菇转录组水平的变化。芯片结果分析发现在低温诱导过程中,低温处理20min内变化基因的功能为单加氧酶、氧化还原酶和细胞内的氧化还原。低温处理40min时表达差异基因具有结合RNA的功能。80min的时间段内,基因的功能比较集中于核酸物质和能量的代谢。CYP450的代谢途径在20–40min、60–80min和100–120min低温处理的菌丝体中均有显著性变化,表明这一通路在草菇低温处理过程中表现活跃。基因表达趋势分析发现34个表达差异基因富集到显著表达趋势模型,基因共表达网络分析发现VVO04066位于网络的核心地位,推测VVO04066通过提高磷酸肌醇特异性磷脂酶C(PI-PLC)的胞内水平,促进糖蛋白和几丁质的合成,从而完成草菇细胞的低温胁迫应答。

关键词：草菇表达谱芯片耐低温 CYP450 VVO_04066

CACA guidelines for holistic integrative management of rectal cancer

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Holistic Integrative Oncology 2023年第1期2卷 1-31页

作者： Committee of Colorectal Cancer Society Chinese Anti-Cancer Association Guiyu Wang Daiming Fan Jin Gu Kefeng Ding Xuedong Fang Lin Shen Zhongfa Xu Jianmin Xu Jianchun Cai Lianming Cai Sanjun Cai Gong Chen Jiansi Chen Longwei Cheng Yong Cheng Pan Chi binbin Cui Guanghai Dai Chuangang Fu Yanhong Gu Guodong He Junhong Hu Jing Huang Rui Huang Zhongcheng Huang Zheng Jiang Zhigang Jie Haixing Ju Hai Li Jian Li Jun Li ming Li Yaoping Li Yunfeng Li Guole Lin Haiying Liu ming Liu Qian Liu Zhizhong Pan Yifan peng Niansong Qian Meng Qiu Li Ren Yueming Sun Jianqiang tang Qingchao tang Yuan tang Kaixiong Tao Min Tao Haijiang Wang Meng Wang Zejun Wang Zhengguang Wang Ziqiang Wang Ziwei Wang Shaozhong Wei Baocai Xing bin Xiong Ye Xu Su Yan bin Yang Chunkang Yang Qinghua Yao Yingjiang Ye Ying Yuan Guozhi Zhang Haizeng Zhang Hongmei Zhang Zhen Zhang Yunshi Zhong Ji Zhu Yuan Zhu Yuping Zhu Shuangmei Zou Yuliuming Wang Jingfang lv Enrui Liu ming Yang Qian Zhang Weiyuan Zhang Lin Zhang Jun Luo Zhaoxu Zheng Zhixun Zhao Zheng Liu Jinhua Tao Haiyang Huang Tianli Chen Xishan Wang 不详 Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina State key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anChina Department of Gastrointestinal SurgeryⅢ Peking University Cancer HospitalBeijingChina Department of Gastrointestinal Surgery Peking University Shougang HospitalBeijingChina Department of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationKey Laboratory of Molecular Biology in Medical SciencesZhejiang Provincial Clinical Research Center for CANCER)The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Gastrointestinal and Colorectal Surgery The China-Japan Union Hospital of Jilin University(The Third Hospital of Jilin University)ChangchunChina Department of Gastrointestinal Oncology Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijingChina Gastrointestinal Department of The Third Affiliated Hospital of Shandong First Medical University TaianShandongChina Department of Colorectal Surgery Zhongshan Hospital Fudan UniversityShanghaiChina Shanghai Engineering Research Center of Colorectal Cancer Minimally Invasive Technology ShanghaiChina Zhongshan Hospital Xiamen University XiamenChina Department of Abdominal Oncology Surgery Ganzhou Cancer HospitalGanzhouJiangxiChina Fudan University Shanghai Cancer Center ShanghaiChina Department of colorectal surgery Sun Yat-sen University Cancer CenterGuangzhouChina Guangxi Medical University Cancer Hospital NanningChina Jilin Cancer Hospital ChangchunChina Department of Gastrointestinal Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Colorectal Surgery Fujian Medical University Union HospitalFuzhou

Purpose Colorectal cancer is a common malignant tumor *** China,the ratio of rectal cancer to coloncancer in terms of incidence is close to 1:*** rectal cancer accounts for more than half of all cases of rectal *** recent years,the proportion of rectal cancer has trended downward,however the incidence of rectal cancer inyounger adults is *** CACA Guidelines for Holistic Integrative Management of Rectal Cancer were editedto help improve the diagnosis and comprehensive treatment in *** This guideline has been prepared by consensuses reached by the CACA Committee of Colorectal CancerSociety,based on a careful review of the latest evidence including China’s studies,and referred to domestic and internationalrelative guidelines,also considered China’s specific national conditions and clinical *** The CACA Guidelines for Holistic Integrative Management of Rectal Cancer include the epidemiology of rectalcancer,prevention and screening,diagnosis,treatment of nonmetastatic and metastatic rectal cancer,follow-up,and whole-course rehabilitation *** Committee of Colorectal Cancer Society,Chinese Anti-Cancer Association,standardizes the diagnosisand treatment of rectal cancer in China through the formulation of the CACA Guidelines.

关键词： Rectal cancer Guideline Screening Diagnosis Treatment Rehabilitation management Holistic integrative medicine

Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen Yan-Fen Chai Xiao-Hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang Deng Jie Fu Bang-Jiang Fang Mai-Ying Fan Li Gui Ping Gong Wei Guo Shu-bin Guo Liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun Jiang Wang-Xiang Jiang Jia-Liang Liu Xiao-Ran Liu Zhi Liu Chuan-Zhu lv Feng Lu Tan-Shi Li Xin Li Yong Li Shang-Lun Li Shuang-ming Li Xiao-Gang Li Bao-Jun Li Pei-Wu Li Chun-Sheng Li Zhi-Jun Li Chang-Luo Li Xiang-Min Li Yin-Ping Li Zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing Liao Jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma Lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-Yang peng peng Qiao Pei Shu-ming Pan Guo-Zhong Qing Li-Jie Qin Wu-Ying Qiao Fei Shao Wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian Jian-Guang Tian Chao-Yang Tong Zi-Ren tang Meng-Xiong tang Guo-Ping Wu Zhi Wan Tao Wang Xin Wang peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang Ling Wu Wei Wei Hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen Yi Li-Shan Yang Shi-Jiao Yan Jin-Jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-Zhi Ye Xian-Liang Yan Fu-bing Zhou Rong-bin Zhou ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang Jian-Feng Zhang Yi-Min Zhu Jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise