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Targeting a disintegrin and metalloprotease(ADAM)17-CD122 axis enhances CD8^(+)T cell effector differentiation and anti-tumor immunity

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3097-3111页

作者： Lina sun Anjun Jiao Haiyan Liu Renyi Ding Ning Yuan Biao Yang Cangang Zhang Xiaoxuan Jia Gang Wang yanhong su Dan Zhang Lin Shi Chenming sun Aijun Zhang Lianjun Zhang Baojun Zhang Department of Pathogenic Microbiology and Immunology School of Basic Medical SciencesXi’an Jiaotong UniversityXi’anShaanxi 710061China Institute of Infection and Immunity Translational Medicine InstituteXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi’anShaanxi 710061China Xi’an Key Laboratory of Immune Related Diseases Xi’anShannxi 710061China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhouJiangsuChina Department of Pediatrics Qilu Hospital of Shandong UniversityJinanChina National Key Laboratory of Immunity and Inflammation Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou 215123 JiangsuChina Key Laboratory of Synthetic Biology Regulatory Elements Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou 215123 JiangsuChina

CD8^(+)T cell immune responses are regulated by multi-layer networks,while the post-translational regulation remains largely *** ectodomain shedding is an important post-translational process orchestrating receptor expression and signal transduction through proteolytic cleavage of membrane ***,by targeting the sheddase A Disintegrin and Metalloprotease(ADAM)17,we defined a post-translational regulatory mechanism mediated by the ectodomain shedding in CD8^(+)T *** and proteomic analysis revealed the involvement of post-translational regulation in CD8^(+)T cells.T cellspecific deletion of ADAM17 led to a dramatic increase in effector CD8^(+)T cell differentiation and enhanced cytolytic effects to eliminate pathogens and ***,ADAM17 regulated CD8^(+)T cells through cleavage of membrane ***17 inhibition led to elevated CD122 expression and enhanced response to IL-2 and IL-15 stimulation in both mouse and human CD8^(+)T ***,inhibition of ADAM17 in CD8^(+)T cells improved the efficacy of chimeric antigen receptor(CAR)T cells in solid *** findings reveal a critical post-translational regulation in CD8^(+)T cells,providing a potential therapeutic strategy of targeting ADAM17 for effective anti-tumor immunity.

关键词： immunity stimulation involvement

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基于DEMATEL模型的智慧物流人才培养影响因素研究

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物流科技 2024年第7期47卷 45-47页

作者：苏彦红刘敏于丽静烟台南山学院山东烟台265713

通过总结分析近年来智慧物流人才的文献,明确对智慧物流人才研究的重点。从职业素养、知识储备、能力要求三方面建立智慧物流人才需求指标体系,通过专家打分,利用DEMATEL模型分析各指标之间的因果关系及在指标体系中的作用,为智慧物流... 详细信息

通过总结分析近年来智慧物流人才的文献,明确对智慧物流人才研究的重点。从职业素养、知识储备、能力要求三方面建立智慧物流人才需求指标体系,通过专家打分,利用DEMATEL模型分析各指标之间的因果关系及在指标体系中的作用,为智慧物流人才培养提供依据。

关键词： DEMATEL 智慧物流人才因素

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T cells in health and disease

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3296-3345页

作者： Lina sun yanhong su Anjun Jiao Xin Wang Baojun Zhang Department of Pathogenic Microbiology and Immunology School of Basic Medical SciencesXi’an Jiaotong UniversityXi’anShaanxi 710061China Institute of Infection and Immunity Translational Medicine InstituteXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi’anShaanxi 710061China Xi’an Key Laboratory of Immune Related Diseases Xi’anShannxi 710061China

T cells are crucial for immune functions to maintain health and prevent disease.T cell development occurs in a stepwise process in the thymus and mainly generates CD4^(+)and CD8^(+)T cell *** antigen stimulation,naïve... 详细信息

关键词： stimulation maintain stepwise

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Photosensitizer conjugate-functionalized poly(hexamethylene guanidine) for potentiated broad-spectrum bacterial inhibition and enhanced biocompatibility

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Chinese Chemical Letters 2020年第9期31卷 2516-2519页

作者： Fengfeng Xiao Bing Cao Liewei Wen yanhong su Meixiao Zhan Ligong Lu Xianglong Hu MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityJinanUniversityZhuhai 519000China

Pathogen infection is the main cause of human morbidity and *** antibiotics usually sterilize bacteria in chemical ways,which tends to develop serious antibiotic *** polymers exhibit good bacterial inhibition with less resistance,but often face severe cytotoxicity toward normal *** optimization of polymeric antimicrobials for enhanced bactericidal capacity and improved biocompatibility is quite *** addition,photodynamic therapy(PDT) is a therapeutic modality with less susceptibility to develop ***,a typical commercial polymeric antimicrobial,polyhexamethylene guanidine(PHMG) was selected for current proof-of-concept optimization due to its excellent bactericidal capacity but moderate ***-Y(EoS)was copolymerized to afford EoS-labeled polymer conjugates,poly(2-(dimethylamino) ethyl methacrylate-co-eosin),P(DMAEMA-co-EoS),which was conjugated with PHMG to afford a novel polymeric antimicrobial,P(DMAEMA-co-EoS)-b-PHMG-b-P(DMAEMA-co-EoS),noted as *** could efficiently kill broad-spectrum bacteria by physical damage and photodynamic *** with PHMG,the bacterial inhibition of PEoS-PHMG was potentiated after the ***,PEoS-PHMG exhibited low cytotoxicity and minimal hemolysis,which was demonstrated by cell viability assays toward LO2 cells and RAW 264.7 cells as well as hemolytic assays against red blood *** results confirmed that the resultant PEoS-PHMG could act as promising alternative antibacterial materials with excellent broad-spectrum bacterial inhibition and favorable biocompatibility.

关键词： Poly(hexamethylene guanidine) Photodynamic therapy Eosin-Y Broad-spectrum bacterial Inhibition Biocompatibility

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基于UWB的室内物料搬运机器人设计

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机电技术 2024年第4期 73-78,84页

作者：李延平刘杰苏焱鸿张优优谢斌肖宇湖南工程学院湘潭411100 湖南工学院衡阳421000 湖南电气职业技术学院湘潭411100 长沙市固捷电子有限公司长沙410000

文章针对目前室内物料搬运机器人的定位精度低、在获取机器人的姿态信息时对IMU或其他导航器件的依赖性很大等问题,基于UWB设计了一种室内物料搬运机器人。文章从硬件与软件两个方面对机器人进行设计,该机器人导航不需要用到IMU等相关器... 详细信息

文章针对目前室内物料搬运机器人的定位精度低、在获取机器人的姿态信息时对IMU或其他导航器件的依赖性很大等问题,基于UWB设计了一种室内物料搬运机器人。文章从硬件与软件两个方面对机器人进行设计,该机器人导航不需要用到IMU等相关器件,即可获取机器人的实时姿态信息,并且能够使机器人完成物料运送等工作。设计采用TDOA定位算法实现机器人的定位,通过改进的K-C算法提升定位精度,基于UWB的机器人姿态解算算法获取得到机器人的机体姿态数据,经试验验证了该算法的有效性和机器人的可靠性。

关键词： UWB 搬运机器人定位导航 K-C算法

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电刺激对过氧化氢诱导衰老肌管细胞能量代谢的影响

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体育科研 2024年第2期45卷 67-72,96页

作者：苏艳红毕亮龚文翰宋涛李婷婷张世超辽宁师范大学体育学院辽宁大连116029 遵义医科大学基础医学院贵州遵义563000 北京体育大学北京100084

目的:运用电刺激肌管细胞收缩模拟骨骼肌收缩,并观察其对过氧化氢(H_(2)O_(2))诱导的C2C12细胞衰老模型能量代谢相关指标表达的影响,以此研究体外肌管收缩对衰老骨骼肌细胞能量代谢影响的分子机制。方法:使用不同浓度的H_(2)O_(2)诱导... 详细信息

目的:运用电刺激肌管细胞收缩模拟骨骼肌收缩,并观察其对过氧化氢(H_(2)O_(2))诱导的C2C12细胞衰老模型能量代谢相关指标表达的影响,以此研究体外肌管收缩对衰老骨骼肌细胞能量代谢影响的分子机制。方法:使用不同浓度的H_(2)O_(2)诱导肌管细胞建立衰老模型,并用β-半乳糖苷酶染色检测衰老水平;电刺激干预培育成功的衰老肌细胞,并分为对照组(C组)、H_(2)O_(2)诱导衰老组(H组)、对照+电刺激组(CE组)、H_(2)O_(2)诱导衰老+电刺激组(HE组)。各组细胞通过Western blot法对PGC-1α蛋白表达进行检测,ATP水平测试盒测量ATP水平。结果:经过浓度为100μmol/L H_(2)O_(2)诱导肌管细胞24 h后成功构建骨骼肌细胞衰老模型。与C组比较,H组的ATP水平表达呈非常显著性的下降(P<0.01);CE组的ATP水平较C组呈非常显著性升高(P<0.01);HE组的ATP水平虽低于C组,但高于H组,且呈非常显著性差异(P<0.01);与C组相比,H组PGC-1α蛋白表达下降,呈非常显著性差异(P<0.01);HE组PGC-1α蛋白表达虽低于C组,但较H组呈非常显著性升高(P<0.01)。结论:H_(2)O_(2)是诱导骨骼肌肌管细胞衰老的一种有效方式,衰老肌管细胞的ATP和PGC-1α蛋白表达水平显著下降,进行电刺激干预后可以有效提高衰老肌管细胞ATP水平和PGC-1α蛋白表达。

关键词：电刺激衰老肌管细胞过氧化氢能量代谢

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Impact of Different Rates of Nitrogen supplementation on Soil PhysicochemicalProperties and Microbial Diversity in Goji Berry

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 467-486页

作者： Xiaojie Liang Wei An Yuekun Li Yajun Wang Xiaoya Qin yanhong Cui Shuchai su State Key Laboratory of Efficient Production of Forest Resources The College of ForestryBeijing Forestry UniversityBeijing100083China National Wolfberry Engineering Research Center Wolfberry Science Research InstituteNingxia Academy of Agriculture and Forestry SciencesYinchuan750002China

Goji berry(Lycium barbarum L.)is substantially dependent on nitrogen fertilizer application,which can signiﬁ-cantly enhance fruit yield and Goji berry industrial development in Ningxia,*** study aimed to analyze the functions of differential nitrogen application rates including low(N1),medium(N2),and high(N3)levels in soil microbial community structure(bacterial and fungal)at 2 diverse soil depths(0-20,20-40 cm)through high-throughput sequencing technology by targeting 16S RNA gene and ITS1&ITS2 *** the observed physicochemical parameters exhibited signiﬁcant improvement(psuggested no obvious(p>0.05)differences among three group treatments(N1,N2,and N3).Furthermore,the functional enrichment analysis demonstrated signiﬁcant(psupplemented fertilizers is conducive to increasing soil nitrogen utilization rate,which can contribute to sustainable agriculture practices through improved soil quality,and microbial community structure and functions.

关键词： Goji berry production Ningxia,China differential nitrogen supplementation rates 16S RNA gene and IT1&IT2 region sequencing soil physicochemical properties

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The Application of Research Study in Higher Vocational Medical College Teaching

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International Journal of Technology Management 2014年第3期 56-57页

作者： su yanhong Zhu Huifang Lei Ming Langfang Health Vocational College Hebei 065000 China

The research study is a new learning mode emerging in recent years, which can cultivate students＇ many aspects of ability. In the higher vocational colleges, obstetrics and gynecology department is a subject of strong theory and practice, which has a higher requirement for students＇ autonomous learning and ability to independently solve and analyze the problems. And it applies to the higher vocational obstetrics and gynecology subject teaching, which conforms to the refornl and development of clinical teaching in obstetrics and gynecology, and it is good for cultivating the medical talents suitable for social need with high quality and strong practice ability.

关键词： research study department of gynecology and obstetrics teaching

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高速切削加工技术在模具制造中的应用

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工具技术 2008年第11期42卷 65-68页

作者：苏艳红成都航空职业技术学院机械系成都市610021

介绍了作为"第三代制模技术"的高速切削加工技术在模具制造中的应用优势,以及高速切削加工模具的关键技术(包括机床、刀具和加工策略等)。以便携式电脑电池盖注射模主型腔的制造为例,给出了工艺方案和高速切削加工参数。

关键词：高速切削加工模具制造机床刀具加工策略

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Combination of Aromatase Inhibitors with Metronomic Capecitabine: A New Chemoendocrine Treatment for Advanced Breast Cancer

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Journal of Cancer Therapy 2019年第2期10卷 146-156页

作者： Wei Shi Xinyue Wang Xiwen Bi Wen Xia Jiajia Huang yanhong su Zhangzan Huang Zhongyu Yuan Department of Medical Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China

Purpose: Endocrine therapy is one of the main treatment options for hormone receptor (HR)-positive advanced breast cancer (ABC). However, whether the combination of endocrine therapy with chemotherapy is practicable and more effective than endocrine therapy alone remains unknown. The aim of this study was to investigate the clinical efficacy of the aromatase inhibitors (AIs) combined with metronomic capecitabine to provide the clinical evidence for further research in patients with HR-positive ABC. Methods: Data from 407 patients with HR-positive ABC were retrospectively analyzed. A total of 305 patients were given AIs alone, and 102 patients were given AIs plus capecitabine as first-line treatment. Progression-free survival (PFS) was the primary endpoint. Results: The median follow-up for all patients was 47.0 months (range, 3 - 119 months). The median overall survival (OS) and PFS were 52.0 months and 24.2 months, respectively. The median PFS in the combination group was significantly longer than that in the AIs group (22.0 months vs. 14.0 months, p = 0.002). Additionally, patients in the combination group had significantly longer OS than patients in the AI group (66.0 months vs. 49.0 months, p = 0.003). Multivariate analysis showed that combination therapy was a significant favorable predictor for PFS and OS. Furthermore, young age (24 months) improved the benefit from combination therapy. Conclusions: AIs plus metronomic capecitabine significantly improves PFS and OS in patients with HR-positive ABC. Thus, chemo-endocrine therapy should be further explored.

关键词： Advanced Breast Cancer HR Edocrine Resistance Chemoendocrine Therapy survival

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