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Physiological and Biochemical Responses of Perennial Ryegrass Mixed Planting with Legumes under Heavy Metal Pollution

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1749-1765页

作者： Yi Xi Li Zhang yanhong Xu Wei Cheng chao Chen College of Animal Science Guizhou UniversityGuiyang550025China

In artiﬁcially controlled pot experiments,perennial ryegrass was mixed with other leguminous plants(white clo-ver and alfalfa)and treated with lead,zinc and cadmium(337 mg·kg^(-1),648 mg·kg^(-1),and 9 mg·kg^(-1),respectively)to simulate compound pollution *** results showed that the concentrations of heavy metals,trans-port factors,and bioconcentration factors in mixed planting of ryegrass decreased compared with those in *** of whether heavy metal pollution was introduced,mixed planting increased the aboveground and underground biomasses of *** different mixed planting treatments had no signiﬁcant impact on the chlorophyll concentration of *** mowing time,mixed planting treatment,and heavy metal treatment had impacts on antioxidant and osmotic adjustment substances,and there were some *** mixed planting treatment did not signiﬁcantly affect glutathione concentration,cysteine concentration,or nonprotein *** planting generally increased the nitrogen and phosphorus concentrations of ryegrass while reducing the stoichiometric ratio of carbon,nitrogen,and *** results suggest that the mixed planting of ryegrass with legumes promotes the growth of ryegrass in the presence of high concentrations of heavy metal ***,it does not enhance the ability of ryegrass to remediate heavy metal pollution in the soil.

关键词： Perennial ryegrass mixed planting phytoremediation lead zinc and cadmium soil pollution

Fracture Statistics Dominated by Hot-Cutting Defect and Deviation from Weibull Distribution

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Journal of Harbin Institute of Technology(New Series) 2015年第2期22卷 41-48页

作者： chao Zeng Chunqing Wang yanhong Tian Chunjin Hang Wei Liu Rong An State Key Lab of Advanced Welding and Joining Harbin Institute of Technology

This paper characterizes the rarely noticeable hot-cutting defect and statistically models the fracture governed by this new type defect. The morphology of the defect on fired ceramic is examined and quantitatively featured through comparing the fracture strength governed by intrinsic defect and hot-cutting defect. Weibull distribution is utilized to fit the observed strength data and chi-square goodness-of-fit test is conducted to analyze the deviation. Kernel density estimation is introduced to explore the underlying strength distribution dominated by hot-cutting defect. Based on the shape information from kernel density estimating,gamma and lognormal distribution are compared and the hot-cutting defect governing fracture statistics is finally confirmed by chisquare test. Results show that the newly-defined hot-cutting defect is more dangerous than the intrinsic defect and the priori Weibull distribution fails to describe the fracture statistic governed by the edge defect while the lognormal with a slightly right skewed shape fits it very well.

关键词： hot-cutting defect deviation from Weibull Kernel density estimation lognormal distribution

Emplacement Mechanism of the Akebasitao Pluton:Implications for Regional Tectonic Evolution of West Junggar,NW China

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Acta Geologica Sinica(English Edition) 2017年第3期91卷 857-874页

作者： ZHANG Pan WANG Guocan LI Yongtao ZHANG Shengye PENG chao ZHAO Hongwei ZHA yanhong Center for Global Tectonics School of Earth SciencesChina University of GeosciencesWuhan Institute of Geological Survey China University of GeosciencesWuhan Institute of Geophysics and Geomatic China University of GeosciencesWuhan

Late Carboniferous to Early Permian A-type granites are extensively distributed throughout the West Junggar region, NW China, and the Akebasitao pluton is extremely distinguished among these plutons. In this paper, we reported new anisotropy of magnetic susceptible （AMS） data combine with detailed field study and audio magnetotelluric （AMT） sounding to assess the three-dimensional shape and magmatic emplacement mechanism of the Akebasitao pluton. The geological features and the AMT sounding indicate that the pluton had a slightly oblique movement of magma from northwest to southeast, which was most likely to correspond to an asymmetrical torch with a laccolith-shaped upper part, and a lower part formed by sub-vertical ＂root＂ that was located within its northwestern part, probably controlled by the NE-trending Anqi fault. The AMS fabrics of all the specimens reveal a low Pj value （mean of 1.02） and a low T value （mean of -0.024）, suggesting that the deformation of the AMS ellipsoid is relatively weak. The specimens exhibit both oblate and prolate shapes of the AMS ellipsoid. Magnetic lineations and foliations are randomly distributed throughout the pluton without any preferred orientation. These AMS patterns indicate that the pluton formed in a relatively stable structural environment with no regional extrusion. Therefore, we propose a complex emplacement process in which the magmas reached the shallower crust levels via deep-faults and subsequently occupied the room created by doming, accompanied by stoping near the pluton roof. Additionally, the regional tectonic setting was relatively stable during the emplacement of the Akebasitao pluton, indicating the termination of compressional orogeny during the late Late Carboniferous in the West Junggar region. This conclusion perfectly coincides with the regional tectonic paleogeography, magmatic system, and paleostress field.

关键词： three-dimensional shape magnetic fabric emplacement mechanism tectonic setting Akebasitao pluton West Junggar

Research advances in peptide-drug conjugates

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3659-3677页

作者： Liming Gong Heming Zhao yanhong Liu Hao Wu chao Liu Shuangyan Chang Liqing Chen Mingji Jin Qiming Wang Zhonggao Gao Wei Huang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations Department of PharmaceuticsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Yanbian UniversityYanji 133000China

Peptide-drug conjugates(PDCs)are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavable *** an emerging prodrug strategy,PDCs not only preserve the function and bioactivity of the peptides but also release the drugs responsively with the cleavable property of the *** the ability to significantly improve the circulation stability and targeting of drugs in vivo and reduce the toxic side effects of drugs,PDCs have already been extensively applied in drug ***,we review the types and mechanisms of peptides,linkers and drugs used to construct PDCs,and summarize the clinical applications and challenges of PDC drugs.

关键词： Peptide-drug conjugates Peptides Linkers Drug delivery systems Prodrug strategy

钛系颗粒状吸附剂用于盐湖卤水中锂的吸附研究

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当代化工研究 2021年第21期 4-7页

作者：陈琳琳李小为蒋磊马鹏飞杨伟伟朱贤荣巢艳红朱文帅江苏大学化学化工学院江苏212013 江苏特丰新材料科技有限公司江苏212013 江苏大学药学院江苏212013

通过静态吸附实验研究钛系颗粒状吸附剂(GFLTG)对高镁锂比盐湖卤水中锂的吸附性能。结果表明,在水相初始pH=7.2、吸附时间24h的条件下,吸附剂对锂的吸附容量达到12.4mg/g,锂镁分离系数达到1307.5,吸附剂的吸附行为符合拟二级动力学模型... 详细信息

通过静态吸附实验研究钛系颗粒状吸附剂(GFLTG)对高镁锂比盐湖卤水中锂的吸附性能。结果表明,在水相初始pH=7.2、吸附时间24h的条件下,吸附剂对锂的吸附容量达到12.4mg/g,锂镁分离系数达到1307.5,吸附剂的吸附行为符合拟二级动力学模型。循环吸附实验表明,吸附剂具有优异的循环性能和化学稳定性,经过10次循环吸附试验,吸附剂对锂的吸附容量没有太大变化且钛的溶损率都在0.16%以下。

关键词：锂吸附剂吸附盐湖卤水锂离子

Effects of lead pollution on soil microbial community diversity and biomass and on invertase activity

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Soil Ecology Letters 2023年第1期5卷 118-127页

作者： Xin Sun Mingjie Sun Ying chao Xiaoyang Shang Hui Wang Hong Pan Quangang Yang yanhong Lou Yuping Zhuge National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources College of Resources and EnvironmentShandong Agricultural UniversityTai’an 271018China Tai’an Hi-Tech Industrial Development Zone Tai’an 271000China Rizhao Municipal Bureau of Agricultural and Rural Affairs Rizhao 276800China Key Laboratory of Technologies and Models for Cyclic Utilization from Agricultural Resources Ministry of Agriculture and Rural AffairsBeiJing 100125China

Lead(Pb)pollution is one of the most widespread and harmful environmental problems *** of changes in soil properties and microbial functional diversity due to land use is needed to establish a basis for remediation of soil *** study aimed to investigate soils contaminated by Pb from different sources and to analyze the functional diversity and metabolism of soil microbial communities using Biolog *** pollution(>300 mg kg-1)significantly influenced the diversity and metabolic functions of soil microbial ***,Pb contamination significantly reduced soil microbial biomass carbon(C)and nitrogen(N)levels and catalase activity while increasing invertase ***,Biolog EcoPlate assays revealed that Pb pollution reduced the general activities of soil microorganisms,suppressing their ability to utilize C *** Pb-contaminated areas lacking vegetation cover,Shannon,Simpson,and McIntosh diversity indices of soil microorganisms were significantly *** microbial diversity and biomass C and N levels were affected by land use and soil properties,respectively,whereas soil enzyme activity was primarily affected by the interaction between land use and soil *** results provide a reference and a theoretical basis for developing soil quality evaluation and remediation strategies.

关键词： Lead pollution Biolog Microbial functional diversity Soil enzyme activities Environment toxicity

Versatile flexible micelles integrating mucosal penetration and intestinal targeting for effectively oral delivery of paclitaxel

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3425-3443页

作者： chao Liu Wei Liu yanhong Liu Hongxia Duan Liqing Chen Xintong Zhang Mingji Jin Minhu Cui Xiuquan Quan Libin Pan Jiachun Hu Zhonggao Gao Yan Wang Wei Huang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations Department of PharmaceuticsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Laboratory of Chongqing Education CommissionThird Military Medical UniversityChongqing 400038China Department of Gastroenterology Yanbian University HospitalYanji 133000China

The extremely low bioavailability of oral paclitaxel(PTX)mainly due to the complicated gastrointestinal environment,the obstruction of intestinal mucus layer and epithelium ***,it is of great significance to construct a coordinative delivery system which can overcome multiple intestinal physicochemical obstacles *** this work,a high-density PEGylation-based glycocholic acid-decorated micelles(PTX@GNPs)was constructed by a novel polymer,9-Fluorenylmethoxy carbonyl-poly ethylene glycocholic acid(Fmoc-PEG-GCA).The Fmoc motif in this polymer could encapsulate PTX viaπ-πstacking to form the core of micelles,and the low molecular weight and non-long hydrophobic chain of Fmoc ensures the high-density of *** on this versatile and flexible carriers,PTX@GNPs possess mucus trapping escape ability due to the flexible PEG,and excellent intestine epithelium targeting attributed to the high affinity of GCA with apical sodium-dependent bile acid *** in vitro and in vivo results showed that this oral micelle could enhance oral bioavailability of PTX,and exhibited similar antitumor efficacy to Taxol injection via intravenous *** addition,oral PTX@GNPs administered with lower dosage within shorter interval could increase in vivo retention time of PTX,which supposed to remodel immune microenvironment and enhance oral chemotherapy efficacy by synergistic effect.

关键词： Mucus penetration Oral nanoparticles Bile acids Trans-epithelium Chemotherapy Paclitaxel Bioavailability Intestineepithelium targeting

Identification of the hydrogen utilization pathway for the electrocatalytic hydrogenation of phenol

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Science China Chemistry 2021年第9期64卷 1586-1595页

作者： Ling Zhou Xiaorong Zhu Hui Su Hongzhen Lin yanhong Lyu Xu Zhao Chen Chen Nana Zhang chao Xie Yingying Li Yuxuan Lu Jianyun Zheng Benrt Johannessen San Ping Jiang Qinghua Liu Yafei Li Yuqin Zou Shuangyin Wang State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical Engineeringthe National Supercomputer Centers in ChangshaHunan UniversityChangsha410082China College of Chemistry and Materials Science Nanjing Normal UniversityNanjing210023China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230026China i-LAB Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou215123China Department of Educational Science Hunan First Normal UniversityChangsha410205China Australian Synchrotron ClaytonVictoria3168Australia Western Australian School of Mines:Minerals Energy and Chemical Engineering and Fuels and Energy Technology InstituteCurtin UniversityPerthWA6102Australia

Electrochemical hydrogenation(ECH)of biomass-derived platform molecules is a burgeoning route for the sustainable utilization of ***,the noble-metal-catalyzed ECH of phenolic compounds suffers from intense competition with hydrogen evolution *** prepared Pt Rh bimetallic nanoparticles dispersed on highly ordered mesoporous carbon nanospheres,which improves the utilization efficiency of adsorbed hydrogen(H_(ad))to ECH in H-UPD region(>0 V ***).Further analysis reveals(i)the strong overlapping between the d-orbitals of Pt and Rh enhances specific adsorption of phenol;(ii)incorporation of Rh devotes an electronic effect on weakening the alloy-H_(ad)interaction to increase the FE of *** calculations confirm the selectivity difference and the ECH parallel pathways:cyclohexanol and cyclohexanone are formed via hydrogenation/dehydrogenation of the intermediate ^(*)C_(6)H_(10) *** findings deepen our fundamental understanding of the ECH process,and cast new light on exploration of highly efficient electrocatalysts for biomass upgrading.

关键词： electrohydrogenation aromatic hydrogenation biomass conversion Pt Rh alloy

Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4267-4283页

作者： Yi Liu yanhong Ji Ruiyi Jiang chao Fang Gang Shi Lin Cheng Yinan Zuo Yixin Ye Xiaolan Su Junshu Li Huiling Wang Yuan Wang Yi Lin Lei Dai Shuang Zhang Hongxin Deng Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University610041 ChengduSichuanThe People’s Republic of China Department of Gastrointestinal Surgery West China Hospital and State Key Laboratory of BiotherapySichuan University610041 ChengduSichuanThe People’s Republic of China Respiratory Microbiome Laboratory Institute of Respiratory HealthFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan University610041 ChengduSichuanThe People’s Republic of China Department of Biotherapy Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center for Biotherapy610041 ChengduSichuanThe People’s Republic of China

Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly *** the increased incidence of cancer and the population ageing trend globally,it is very important to explore how ageing impairs tissue wound healing and spontaneous *** a murine model of DSS-induced acute colitis and AOM/DSS-induced colitis-associated cancer(CAC),we found ageing significantly decreases intestinal wound healing and simultaneous CAC initiation,although ageing does not affect the incidence of AOM-induced,sporadic non-inflammatory ***,reduced fibroblasts were observed in the colitis microenvironment of ageing *** conditional lineage tracing,an important source of fibroblasts potentially derived from intestinal smooth muscle cells(ISMCs)was identified orchestrating intestinal wound healing and CAC initiation in young ***,the number of transformed fibroblasts from ISMCs significantly decreased in ageing mice,accompanied by decreased intestinal wound healing and decreased CAC ***-fibroblasts transformation in young mice and reduction of this transformation in ageing mice were also confirmed by ex-vivo intestinal muscular layer culture *** further found that activation of YAP/TAZ in ISMCs is required for the transformation of ISMCs into ***,the reduction of YAP/TAZ activation in ISMCs during intestinal wound healing was observed in ageing *** knockdown of YAP/TAZ in ISMCs of young mice results in reduced fibroblasts in the colitis microenvironment,decreased intestinal wound healing and decreased CAC initiation,similar to the phenotype of ageing *** addition,the data from intestine samples derived from inflammatory bowel disease(IBD)patients show that activation of YAP/TAZ also occurs in ISMCs from these ***,our work reveals an important role of the ageing stromal microenvironment in intestinal wound healing and CAC ini

关键词： healing wound impaired