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Dense hydrous silica carrying water to the deep Earth and promotion of oxygen fugacity heterogeneity

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Matter and Radiation at Extremes 2022年第6期7卷 76-78页

作者： yanhao lin Ho-Kwang Mao Center for High Pressure Science and Technology Advanced Research Beijing 100193People’s Republic of China

Water has remarkable effects on the properties of mantle rocks,but,owing to the high temperatures in the mantle,uncertainties remain about how and how much water is transported into the deep *** studies have shown that stishovite and post-stishovites as highpressure phases of SiO2 have the potential to carry weight percent levels of water into the Earth’s interior along the geotherm of the subducting oceanic *** slabs are subducted to the deepest mantle,dehydration of these dense hydrous silica phases has the potential to change the physicochemical properties of the mantle by reducing melting points,forming new high-pressure phases,and enhancing the oxygen fugacity heterogeneity of the lower mantle.

关键词： Earth mantle silica

Isotopic evidence for volatile replenishment of the Moon during the Late Accretion

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National Science Review 2019年第6期6卷 1247-1254页

作者： yanhao lin Wim van Westrenen Department of Earth Sciences Vrije Universiteit Amsterdam

The traditional view of a dry, volatile-poor Moon has been challenged by the identification of water and other volatiles in lunar samples, but the volatile budget delivery time（s）, source（s） and temporal evolution remain poorly constrained. Here we show that hydrogen and chlorine isotopic ratios in lunar apatite changed significantly during the Late Accretion（LA, 4.1–3.8 billion years ago）. During this period,deuterium/hydrogen ratios in the Moon changed from initial carbonaceous-chondrite-like values to values consistent with an influx of ordinary-chondrite-like material and pre-LA elevated δ37Cl values drop towards lower chondrite-like values. Inferred pre-LA lunar interior water contents are significantly lower than pristine values suggesting degassing, followed by an increase during the LA. These trends are consistent with dynamic models of solar-system evolution, suggesting that the Moon's（and Earth's） initial volatiles were replenished ～0.5 Ga after their formation, with their final budgets reflecting a mixture of sources and delivery times.

关键词： hydrogen and chlorine isotopes lunar apatite volatile replenishment Late Accretion

Oxygen as a catalyst in the Earth's interior?

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National Science Review 2021年第4期8卷 7-8页

作者： yanhao lin Wim van Westrenen Center for High Pressure Science and Technology Advanced Research Earth and Planets Laboratory Carnegie Institution for Science Department of Earth Sciences Faculty of Science Vrije Universiteit Amsterdam

The abundance of the element oxygen is not only crucial for life at the surface of the Earth, but also greatly affects the properties and dynamics of the interior of our planet. The combination of a highly oxidized at... 详细信息

关键词： DIFFERENTIATION SOLUBILITY HYDROGEN WATER

The Deep Earth Engine Driving Major Surface Events

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 68-69页

作者： MAO Ho-kwang DING Yang HU Qingyang lin yanhao LIU Jin ZHANG Li Center for High Pressure Science&Technology Advanced Research Beijing 100094China

During Earth’s 4.6 billion-year history,its surface has experienced environmental changes that drastically impacted *** changes have been mostly attributed to near-surface processes or astronomical events with little consideration of Earth’s deep *** progresses in high-pressure geochemistry and geophysics,however,indicate that deep Earth processes may have played a dominant role in the surface(Mao and Mao,2020).

关键词： deep lower mantle oxygen cycle subducting water great oxidation event

Renewable biomass reinvigorates sustainable water-energy nexus

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Science Bulletin 2024年第16期69卷 2543-2554页

作者： Hongxu Chen Jiatao Xu Zhiyong Jason Ren Hailong lin Leli Zhang EReaihan yanhao Yuan Zihan Wang Zhidan Liu Laboratory of Environment-Enhancing Energy(E2E) College of Water Resources and Civil EngineeringChina Agricultural UniversityBeijing 100083China Key Laboratory of Agricultural Engineering in Structure and Environment Ministry of Agriculture and Rural AffairsBeijing 100083China Department of Civil and Environmental Engineering Princeton UniversityPrinceton NJ 08544USA Andlinger Center for Energy and the Environment Princeton UniversityPrinceton NJ 08544USA Department of Earth and Environmental Engineering Columbia UniversityNew York NY 10027USA State Key Laboratory of Efficient Utilization of Agricultural Water Resources Beijing 100083China

The water-energy nexus has garnered worldwide *** dual-functional research aimed at coproducing freshwater and electricity faces significant challenges,including sub-optimal capacities("1+1lination and robust clean electricity *** hydrothermally activated basswood,our solar desalination exceeded the 100% efficiency bottleneck even under reduced solar *** simple size-tuning,we achieved a high evaporation rate of 3.56 kg h^(-1)m^(-2)and an efficiency of 149.1%,representing 128%-251% of recent values without sophisticated surface *** incorporating an electron-ion nexus with interfacial Faradaic electron circulation and co-ion-predominated micro-tunnel hydrodynamic flow,we leveraged free energy from evaporation to generate long-term electricity(0.38 W m^(-3)for over 14 d),approximately 322% of peer performance *** inter-functional nexus strengthened dual functionalities and validated general engineering *** presented strategy holds significant promise for global human–society–environment sustainability.

关键词： Biomass Water-energy nexus Solar desalination Clean energy Hydrothermal carbonization Sustainable development

新生儿机械通气与呼吸机相关性肺炎相关性研究

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中国医药科学 2018年第2期8卷 55-57页

作者：林炎浩广东省和平县妇幼保健院广东和平517200

目的探究新生儿呼吸机相关性肺炎(VAP)与患儿机械通气的相关性。方法对2013年1月～2016年12月期间我院160例新生儿行机械通气者进行回顾性分析,收集新生儿一般资料后,根据患儿是否出现VAP将患者分为两组,分析造成患儿VAP发生的影响因素... 详细信息

目的探究新生儿呼吸机相关性肺炎(VAP)与患儿机械通气的相关性。方法对2013年1月～2016年12月期间我院160例新生儿行机械通气者进行回顾性分析,收集新生儿一般资料后,根据患儿是否出现VAP将患者分为两组,分析造成患儿VAP发生的影响因素,同时以Logistic分析机械通气与VAP发生的相关性。结果分析患儿资料A组与B组在出生体重、插管次数、气管内吸引、机械通气时间以及胎龄,差异有统计学意义(P0.05);同时使用Logistic回归分析差异项,患儿VAP发生与新生儿出生体重、插管次数、气管内吸引、机械通气时间以及胎龄有关。结论新生儿VAP发生与患儿机械通气有明显相关性,患儿通气时间越长VAP发生率越高,同时新生儿VAP发生受多种因素影响。

关键词： VAP 影响因素新生儿机械通气

无创辅助通气在新生儿监护病房的临床应用观察

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中外医学研究 2019年第8期17卷 14-16页

作者：林炎浩和平县妇幼保健院广东和平517200

目的:观察在新生儿监护病房开展无创辅助通气的临床效果。方法:选取笔者所在医院2017年1月-2018年12月新生儿监护病房收治的52例呼吸窘迫综合征患儿,随机分为对照组(n=26,采取固尔舒联合常规机械通气治疗)与观察组(n=26,固尔舒联合经鼻... 详细信息

目的:观察在新生儿监护病房开展无创辅助通气的临床效果。方法:选取笔者所在医院2017年1月-2018年12月新生儿监护病房收治的52例呼吸窘迫综合征患儿,随机分为对照组(n=26,采取固尔舒联合常规机械通气治疗)与观察组(n=26,固尔舒联合经鼻正压辅助通气治疗),对两组临床疗效及相关指标进行观察。结果:观察组有效率与对照组比较差异无统计学意义(P>0.05);观察组患儿住院时间、通气时间均较对照组明显要短(P0.05),治疗12、24 h,两组患儿Pa O2/Fi O2、Pa O2和p H值均较治疗前明显提升,Pa CO2值出现下降,差异有统计学意义(P0.05);在并发症发生率上,观察组较对照组明显要低(P<0.05)。结论:在新生儿监护病房中对呼吸窘迫患儿采取无创辅助通气,疗效显著,且并发症少,值得推广使用。

关键词：新生儿监护病房无创机械通气早产儿呼吸窘迫综合征

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布地奈德混悬液对小儿哮喘的临床疗效

当代医学 2018年第16期24卷 97-98页

作者：林炎浩广东省河源市和平县妇幼保健院儿科广东河源517200

目的探究小儿哮喘患儿在使用布地奈德混悬液的临床疗效。方法研究对象为2015年6月~2017年6月收入的80例小儿哮喘患儿,用随机排列表法分成治疗1组与治疗2组,40例治疗1组采用布地奈德混悬液治疗,另40例治疗2组采用博利康尼雾化吸入。比较... 详细信息

目的探究小儿哮喘患儿在使用布地奈德混悬液的临床疗效。方法研究对象为2015年6月~2017年6月收入的80例小儿哮喘患儿,用随机排列表法分成治疗1组与治疗2组,40例治疗1组采用布地奈德混悬液治疗,另40例治疗2组采用博利康尼雾化吸入。比较两组患儿实施不同治疗对治疗效果的影响。结果治疗1组治疗总有效率(97.50%)显著比治疗2组(90.00%)高(c2=4.800,P<0.05),而在不良反应发生率上两组相比,治疗1组显著较低(c2=6.275,P<0.05)。结论将布地奈德混悬液应用于小儿哮喘患者时,不仅有着较低的不良反应发生率,还能显著提升治疗效果,此方法值得应用与推广。

关键词：小儿哮喘患儿布地奈德混悬液治疗效果

Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants

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Science China(Life Sciences) 2024年第1期67卷 83-95页

作者： Guangshan Xie lin Zhu Siwen Liu Cun Li Xin Diao yanhao Zhang Xiuli Su Yuanyuan Song Guodong Cao Li Zhong Pui Wang Xiaojuan Liu Bobo Wing-Yee Mok Shusheng Zhang Dong-Yan Jin Jie Zhou Honglin Chen Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Hong Kong Baptist UniversityHong Kong SARChina State Key Laboratory for Emerging Infectious Diseases and Department of MicrobiologyLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Biomedical Sciences The University of Hong KongHong Kong SARChina HKBU Shenzhen Institute of Research and Continuing Education Shenzhen 518000China

SARS-CoV-2 continues to threaten human society by generating novel variants via mutation and *** high number of mutations that appeared in emerging variants not only enhanced their immune-escaping ability but also made it difficult to predict the pathogenicity and virulence based on viral nucleotide *** markers for evaluating the pathogenicity of new variants are therefore *** comparing host responses to wild-type and variants with attenuated pathogenicity at proteome and metabolome levels,six key molecules on the polyamine biosynthesis pathway including putrescine,SAM,dc-SAM,ODC1,SAMS,and SAMDC were found to be differentially upregulated and associated with pathogenicity of *** validate our discovery,human airway organoids were subsequently used which recapitulates SARS-CoV-2 replication in the airway epithelial cells of COVID-19 *** ODC1 as a proof-ofconcept,differential activation of polyamine biosynthesis was found to be modulated by the renin-angiotensin system(RAS)and positively associated with ACE2 *** experiments demonstrated that ODC1 expression could be differentially activated upon a panel of SARS-CoV-2 variants of concern(VOCs)and was found to be correlated with each VOCs’pathogenic ***,the presented study revealed the discriminative ability of key molecules on polyamine biosynthesis as a predictive marker for virulence evaluation and assessment of SARS-CoV-2 variants in cell or organoid *** work,therefore,presented a practical strategy that could be potentially applied as an evaluation tool for the pathogenicity of current and emerging SARS-CoV-2 variants.

关键词： SARS-CoV-2 multi-omics attenuated variant predictive pathogenic marker polyamine biosynthesis