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High-brightness near-infrared luminescent bioprobes based on lanthanide-doped NaCrFnanoparticles

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Science China Materials 2024年

作者： Yun Xing Shiqi Yu Datao Tu Xueyuan chen State Key Laboratory of Structural Chemistry Fujian Key Laboratory of Nanomaterials and CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China University of Chinese Academy of Sciences

Over the past decade, near-infrared （NIR） luminescent materials have emerged as a frontier in photonics and material science, finding diverse applications in bioimaging, encryption,and photodetection[1]. Particularly, NIR nanoprobes are widely utilized in life science and clinical medicine because of their high spatial resolution, deep tissue penetration, low optical absorption and scattering, and minimal autofluorescence[2,3].

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Lung health for all:Focus more on the cardiopulmonary risk in patients with COPD

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Chinese Medical Journal 2024年第13期137卷 1513-1515页

作者： Rongchang chen Jiefu Yang Guangzhou Institute of Respiratory Health(Stake Key Lab of Respiratory Disease) The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510000China Shenzhen Institute of Respiratory Diseases Shenzhen People’s HospitalShenzhenGuangdong 518000China Department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100000China

Chronic obstructive pulmonary disease(COPD),the third leading cause of death worldwide,led to approximately 3.23 million deaths in 2019 and imposed significant economic and health ***,cardiovascular mortality accounts for approximately one-third of deaths in patients with COPD,[1]particularly in those with mild or moderate disease severity.[2]Studies have also identified a substantial increase in the risk of cardiovascular events in patients with COPD.[3,4]Given the notable risk of cardiopulmonary(pulmonary and cardiovascular)events in COPD,the management of COPD should incorporate strategies aiming at reducing the risk of cardiopulmonary *** treatment of patients with COPD may reduce their risk of cardiopulmonary events and potentially enhance survival *** understanding the risk of cardiovascular events in patients with COPD is crucial for comprehensive management of ***,this article aims to offer an update on the risk of cardiovascular events in COPD and emphasize the importance of cooperation between pulmonologists and cardiologists.

关键词： patients cardiopulmonary cardiovascular

Transcatheter aortic valve replacement:A journey of two decades and beyond

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Chinese Medical Journal 2024年第9期137卷 1012-1015页

作者： Tianyuan Xiong Mao chen Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Cardiac Structure and Function Institute of Cardiovascular DiseasesWest China HospitalSichuan UniversityChengduSichuan 610041China

The number of patients with calcic aortic stenosis(AS)is 9.4 million according to 2019 Global Disease Burden estimates,which will continue to increase as the population ages.[1]For the treatment of symptomatic severe AS,transcatheter aortic valve replacement(TAVR)has evolved to be a well-established option across all risk spectra,with a rapid growth of procedures *** rise of TAVR initiates the revolution of the management of valvular heart diseases,from patient surveillance,the staging of disease,the use of multimodality imaging,the concept of the Heart Team,new designs and iterations of devices to technical innovations and the discovery of unmet clinical *** a consequence of the global adoption of TAVR,geographical differences in the epidemiology of AS and patient characteristics have also been further identi*** examination of the changing patient population,current applications and breakthroughs,and remaining challenges are crucial for the future of this ***,we discuss the temporal utilization of TAVR,the accumulation of evidence and progress of devices,the selection of patients,and some ongoing topics concerning the improvement of TAVR.

关键词： epidemiology breakthrough beyond

New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma Krystyna Rytel Yu chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

Energizing Yiwu with Language Learning Yiwu businesswomen are picking up more English as business booms

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China Report ASEAN 2024年第7期9卷 50-52页

作者： chen Ke 不详

Recently,a video of a businesswoman in Yiwu practicing English received impressive views and *** echoed sentiments like,“Yiwu businesswomen are so dedicated,”and“They are either making money or studying to make mon... 详细信息

关键词： money business women

Analysis of Hospital Budget Management Control Based on Smart Hospital

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Journal of Clinical and Nursing Research 2024年第5期8卷 169-173页

作者： Yuqi chen Changzhou Wujin People’s Hospital Changzhou Eighth People’s HospitalChangzhou 213000China

Hospitals are crucial healthcare facilities where patients seek treatment,and effective budget management within hospitals significantly impacts their operational efficiency and financial *** the age of information technology and advanced healthcare solutions,the emergence of smart hospitals represents a new trend in the medical industry’s *** modern information technology can enhance the development of hospital IT systems and drive budget management toward greater *** paper begins by analyzing the influence of smart hospitals on hospital budget *** then examines the current state of budget management control within smart ***,it proposes several strategies for budget management control in smart hospitals,aiming to provide guidance for relevant stakeholders.

关键词： Smart hospital Hospital management Budget management Financial control Control strategies

Analysis of Influencing Factors of Work Motivation of Government Employees Based on MaxDiff Model:Evidence from Jiangmen City

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Proceedings of Business and Economic Studies 2024年第4期7卷 226-230页

作者： Weijie chen School of Economics and Management Guangxi Normal UniversityGuilin 541006Guangxi Zhuang Autonomous RegionChina

The purpose of this paper is to use the MaxDiff model to explore the factors influencing the work motivation of staff in certain government agencies in Jiangmen City,and to conduct relevant empirical *** study aims to propose strategies for improving work motivation among these staff *** results indicate that the most significant factors affecting the work motivation of staff in Jiangmen government agencies are salary and remuneration,additional welfare benefits,and the power to make decisions about their own *** contrast,factors such as a sense of belonging to the work unit,recognition of their work,and job security are less ***,it is recommended that government agencies in Jiangmen City increase the salaries and benefits of their staff and provide them with more decision-making *** approach will stimulate their desire to work,enhance their motivation,improve the efficiency of government agencies,and elevate the level of public ***,these measures will support the construction of a harmonious,stable,and orderly society.

关键词： Government agency workers Job motivation MaxDiff model

Intensive care unit-acquired weakness: Recent insights

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Journal of Intensive Medicine 2024年第1期4卷 73-80页

作者： Juan chen Man Huang Department of General Intensive Care Unit The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009ZhejiangChina

Intensive care unit-acquired weakness(ICU-AW)is a common complication in critically ill patients and is associated with a variety of adverse *** include the need for prolonged mechanical ventilation and ICU stay;higher ICU,in-hospital,and 1-year mortality;and increased in-hospital ***-AW is associated with multiple risk factors including age,underlying disease,severity of illness,organ failure,sepsis,immobilization,receipt of mechanical ventilation,and other factors related to critical *** pathological mechanism of ICUAW remains unclear and may be considerably *** review aimed to evaluate recent insights into ICU-AW from several aspects including risk factors,pathophysiology,diagnosis,and treatment strategies;this provides new perspectives for future research.

关键词： Intensive care unit-acquired weakness Muscle weakness Muscle atrophy Risk factor Mechanism Treatment

Polygonatum sibiricum polysaccharides attenuated colitis via regulating gut microbiota mediated colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway

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Food Science and Human Wellness 2024年

作者： Zhong-Yu Yuan Xin-Yu Wang Jun Wang Yuan Xu Jing chen Shu-Qi Yu Zhi-Ming chen Pei-Lu chen Ji-Xiao Zhu Wei-Feng Huang Guang-Hui Xu Li-Tao Yi Department of Chemical and Pharmaceutical Engineering， College of Chemical Engineering， Huaqiao University Xiamen Medicine Research Institute Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine， Jiangxi University of Chinese Medicine Department of Gastroenterology and Hepatology， The First Affiliated Hospital of Xiamen University， Xiamen University Institute of Pharmaceutical Engineering， Huaqiao University Fujian Provincial Key Laboratory of Biochemical Technology， Huaqiao University

Polygonatum sibiricum has long been a popular functional food in Asia， known for its anti-inflammatory properties. However， its efficacy in alleviating colitis has yet to be investigated. This study aimed to explore the therapeutic potential of Polygonatum sibiricum polysaccharides (PSP) in dextran sulfate sodium (DSS)-induced colitis， focusing on the related pyroptosis mechanisms. Scanning electron microscopy (SEM) analysis showed that PSP possesses a smooth surface with no pore structure and a dense， lamellar structure adorned with numerous spherical entities. PSP treatment significantly reduced colitis symptoms and decreased pro-inflammatory cytokines， likely through suppression of the TLR4/NF-κB signaling pathway. Additionally， PSP attenuated NLRP3/ASC/Caspase-1/GSDMD-mediated pyroptosis and mitochondria damage in the colon， while enhanced the expression of tight junction and adherens junction proteins. Microbiota sequencing showed that PSP increased the abundance of phylum Bacteroidota and genus such as Muribaculaceae， Lactobacillus， Clostridia， and Lachnospiraceae， while decreased the phylum Proteobacteria and the genus Enterobacter， Escherichia-Shigella， and Blautia. In conclusion， this study demonstrates that PSP exerts the potential therapeutic role against colitis， which was mediated by the regulation of gut microbiota and the inhibition of colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway.

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