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Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs

Genomics, Proteomics & Bioinformatics 2022年第4期20卷 780-794页

作者： Zhongyang Liu Honglei Li Zhaoyu Jin Yang Li Feifei Guo yangzhige he Xinyue Liu Yaning Qi Liying Yuan Fuchu he Dong Li State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China School of Basic Medical Sciences Anhui Medical UniversityHefei 230032China College of Chemistry and Environmental Science Hebei UniversityBaoding 071002China Suzhou Geneworks Technology Co. Ltd.Suzhou 215028China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China College of Life Sciences Hebei UniversityBaoding 071002China

After decades of development,protein and peptide drugs have now grown into a major drug class in the marketplace.Target identification and validation are crucial for the discovery of protein and peptide drugs,and bioinformatics prediction of targets based on the characteristics of known target proteins will help improve the efficiency and success rate of target selection.However,owing to the developmental history in the pharmaceutical industry,previous systematic exploration of the target spaces has mainly focused on traditional small-molecule drugs,while studies related to protein and peptide drugs are lacking.here,we systematically explore the target spaces in the human genome specifically for protein and peptide drugs.Compared with other proteins,both successful protein and peptide drug targets have many special characteristics,and are also significantly different from those of small-molecule drugs in many aspects.Based on these features,we develop separate effective genome-wide target prediction models for protein and peptide drugs.Finally,a user-friendly web server,Predictor Of Protein and Pept Ide drugs’therapeutic Targets(POPPIT)(http://***/),is established,which provides not only target prediction specifically for protein and peptide drugs but also abundant annotations for predicted targets.

关键词： Protein drug Peptide drug Target analysis Target prediction Web server

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