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Quantitative measurement of cerebral blood flow on patients with early syphilis

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Nuclear Science and Techniques 2005年第2期16卷 117-119页

作者： ZHONGJi-Jun WUJin-Chang yangyi TANGJun liUZeng-li SHIXin DepartmentofNuclearMedicine theSecondAffiliatedHospitaltoSuzhouUniversituSuzhou215004

To study quantitative change of cerebral blood flow (CBF) on patients with early syphilis, we have estab- lished a method on absolute measurement of rCBF by using SPECT with Ethyl Cysteinate Dimmer (ECD) as imaging agent, and the method was applied to measure rCBF on patients with early syphilis. The rCBF values measured by this method are highly consistent with the values measured by other classical methods such as SPECT (123I-IMP) and PET (15O-H2O). The rCBF values for early syphilis patients and the normal control show some statistical differences. A routine quantitative absolute measurement of rCBF featured with simple procedures is therefore on the way of maturation.

关键词：定量测量梅毒早期脑血流乙基半胱氨酸调光器放射医学诊断

SETD2 mediates immunotherapy and radiotherapy efficacy via regulating DNA damage responses and genomic stability in lung adenocarcinoma

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Genes & Diseases 2023年第2期10卷 336-339页

作者： Zihang Zeng Yanping Gao Jiali li Jianguo Zhang yangyi li Fajian He Zhengrong Huang linzhi Han Yan Gong Conghua Xie Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Tumor Precision Diagnosis and Treatment Technology and Translational Medicine Hubei Engineering Research CenterZhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Hubei Key Laboratory of Tumor Biological Behaviors Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Hubei Cancer Clinical Study Center Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China

SETD2 is the main transferase for the trimethylation of histone H3 at lysine 36 (H3K36me3) in mammals. SETD2 plays important role in repairing DNA double strand breaks and maintaining chromatin integrity.1 In renal carcinoma, SETD2 deficiency caused DNA replication fork instability and DNA damage.2 The absence of SETD2 was also reported to have strong tumor-promoting effects in lung adenocarcinomas (LUAD).3 However, the other roles of SETD2 remain poorly understood in LUAD. In this study, we utilized comprehensive omics-data analysis to determine that SETD2 was associated with DNA damage and immune-related signals in LUAD. SETD2 knockdown induced DNA damage and cGAS activation in LUAD cells, and reduced the number of cells at the G1 phase. Moreover, SETD2 deficiency was conducive to mutation burden, immune cell infiltration, and immunotherapy responses. High SETD2 expression was associated with high radiocurability. These findings suggest that SETD2 may be a promising biomarker of therapeutic responses for LUAD patients, and offer novel insights into immunotherapy and radiotherapy.

关键词： SETD2 damage immunotherapy

The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

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Journal of Pharmaceutical Analysis 2023年第7期13卷 788-805页

作者： He li Tianyuan Ye Xingyang liu Rui Guo Xiuzhao Yang yangyi li Dongmei Qi Yihua Wei Yifan Zhu Lei Wen Xiaorui Cheng Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Xiamen Key Laboratory for TCM Dampness Disease Neurology&Immunology ResearchDepartment of Traditional Chinese MedicineXiang'an HospitalSchool of MedicineXiamen UniversityXiamenFujian361102China Experimental Center Shandong University of Traditional Chinese MedicineJinan250355China

Based on single-cell sequencing of the hippocampi of 5×familiar Alzheimer's disease(5×FAD)and wild type mice at 2-,12-,and 24-month of age,we found an increased percentage of microglia in aging and Alzheimer's disease(AD)*** brain barrier injury may also have contributed to this *** regulation by microglia plays a major role in the progression of aging and AD,according to the functions of 41 intersecting differentially expressed genes in *** crosstalk between C−C motif chemokine ligand(CCL)and major histocompatibility complex-1 bridges intercellular communication in the hippocampus during aging and *** amyloid precursor protein(APP)and colony stimulating factor(CSF)signals drive 5×FAD to deviate from aging track to AD occurrence among intercellular communication in *** are involved in the progression of aging and AD can be divided into 10 functional *** strength of the interaction among microglial subtypes weakened with aging,and the CCL and CSF signaling pathways were the fundamental bridge of communication among microglial subtypes.

关键词： Alzheimer's disease Microglia Immune Crosstalk Chemokine Colony-stimulating factor

Guidance for use of weights: an analysis of different types of weights and their implications when using SAS PROCs

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General Psychiatry 2019年第1期32卷 49-55页

作者： Sabrina Richardson Tuo lin yangyi li Xiaohui Niu Manfei Xu Valerie Stander Xin M Tu The Henry M.Jackson Foundation for the Advancement of Military Medicine Inc BethesdaMarylandUnited States Military Population Health Naval Health Research CenterSan DiegoCaUnited States Clinical and Translational Research Institute University of California San DiegoSan DiegoCaliforniaUSA School of Mathematical and Statistical Sciences Clemson UniversityClemsonSouth CarolinaUSA College of Informatics Huazhong Agriculture UniversityWuhanChina Shanghai Mental Health Center Medical CollegeShanghai Jiao Tong UniversityShanghaiChina

SAS and other popular statistical packages provide support for survey data with sampling weights. For example, PROC MEANS and PROC LOGISTIC in SAS have their counterparts PROC SURVEYMEANS and PROC SURVEYLOGISTIC to facilitate analysis of data from complex survey studies. On the other hand, PROC MEANS and many other classic SAS procedures also provide an option for including weights and yield identical point estimates, but different standard errors (SEs), as their corresponding survey procedures. This paper takes an in-depth look at different types of weights and provides guidance on use of different SAS procedures.

关键词： Guidance use of weights analysis

MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

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中国药理学通报 2015年第B11期31卷 54-55页

作者： SUNYang liQi GUIHuan yangyi-li liUXia DeptofPharmacology SchoolofPharmacySecondMilitaryMedicalUniversityShanghai200433 CancerandDevelopemntalBiologyLaboratory nationalCancerInstituteNationalInstitutesofHealthFrederickMD21702USA

The vagus nerve can control inflammatory response through a ＇ cholinergic anti-inflammatory pathway＇, which is mediated by the α7-nicotinic acetylcholine receptor （α7nAChR） on macrophages. However, the intracel- lular mechanisms that link α7nAChR activation and pro-inflammatory cytokine production remain not well under- stood. In this study, we found that miR-124 is upregulated by cholinergic agonists in LPS-exposed cells and mice. Utilizing miR-124 mimic and siRNA knockdown, we demonstrated that miR-124 is a critical mediator for the cho- linergic anti-inflammatory action. Furthermore, our data indicated that miR-124 modulates LPS-induced cytokine production by targeting signal transducer and activator of transcription 3 （STAT3） to decrease IL-6 production and TNF-α converting enzyme （TACE） to reduce TNF-ot release. These results also indicate that miR-124 is a potential therapeutic target for the treatment of inflammatory diseases.

关键词： microRNA-124 cholinergic anti-inflammatory action α7nAChR macrophages septic shock STAT3 TACE

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比较两组连续性结果的样本计算

上海精神医学 2017年第4期29卷 250-256页

作者： Julia Z. ZHENG yangyi li Tuo liN Angelica ESTRADA Xiang LU Changyong FENG Department of Immunology and Microbiology McGill University Montreal Canada Department of Mathematics State University of New York in Stony Brook Stony Brook NY USA Department of Mathematics University of California in San Diego San Diego CA USA Department of Physics University of California in San Diego San Diego CA USA Department of Biostatistics and Computational Biology University of Rochester Rochester NY USA

概述:所有的临床研究都需要对样本量进行辨证。然而,对于众多生物医学和临床研究人员来说,把握度和样本量看起来就像一个统计学家的魔术。在本文中,我们讨论了把握度和样本量的计算,并说明生物医学和临床研究人员在该分析的可行性和意... 详细信息

概述:所有的临床研究都需要对样本量进行辨证。然而,对于众多生物医学和临床研究人员来说,把握度和样本量看起来就像一个统计学家的魔术。在本文中,我们讨论了把握度和样本量的计算,并说明生物医学和临床研究人员在该分析的可行性和意义中具有重要作用。因此,把握度分析的确是一个互动的过程,并且科学研究人员和统计人员在研究团队中是平等合作的伙伴。

关键词：样本量连续性结果临床研究把握度

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北京故宫传统色彩当代视觉转译设计方法研究

服装设计师 2024年第11期 31-38页

作者：李洋艺中国艺术研究院研究生院

该文是关于北京故宫博物院文创产品传统色彩的当代转译设计方法研究。北京故宫博物院文创产品设计注重挖掘藏品内涵,将中华优秀传统文化与当代设计方式有机结合起来。借鉴中华优秀传统文化且以当代审美转译为富有文化内涵的文创产品是... 详细信息

该文是关于北京故宫博物院文创产品传统色彩的当代转译设计方法研究。北京故宫博物院文创产品设计注重挖掘藏品内涵,将中华优秀传统文化与当代设计方式有机结合起来。借鉴中华优秀传统文化且以当代审美转译为富有文化内涵的文创产品是博物馆文创产品设计创新的方法之一。在博物馆文创产品设计过程中,对优秀传统文化元素的运用并不是简单的复制,而是需要通过提炼、转译成精确的视觉元素及其恰当地运用的“再设计”过程。色彩是人类认识事物、抒发情感的一种表达方式,人类对色彩有一定的感知,早在原始社会,氏族之间用色彩与形状设计图腾来区分你我、标记领地。当代设计师通过色彩设计传递情感、价值观和文化内涵;而传统色彩是博物馆文创产品设计不可或缺的艺术形式,恰当地应用可以赋予文创产品深厚的文化底蕴,激发更多人对传统文化艺术的热爱。该文从明晰色彩的象征性表达、构建色彩的文化意境、当代审美与传统色彩融合等层面,探索由北京故宫传统色彩向当代视觉转译的设计方法,并恰当地应用在故宫博物院文创产品设计之中,使其突出故宫文化的独特性。

关键词：故宫博物院文创产品故宫传统色彩

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借鉴经典的设计方法--以20世纪欧美三款椅子为例

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中国艺术 2022年第3期 60-67页

作者：李洋艺中国艺术研究院研究生院设计学系

本文以20世纪欧美设计师设计的伊姆斯休闲椅、超轻椅、普鲁斯特扶手椅为例,分析在技术进步、市场需求、文化传承、社会发展等因素的驱动下,设计师对经典椅子的新思考、再设计,同时,论证了设计师借鉴经典是不断创新设计的方法之一,有利... 详细信息

本文以20世纪欧美设计师设计的伊姆斯休闲椅、超轻椅、普鲁斯特扶手椅为例,分析在技术进步、市场需求、文化传承、社会发展等因素的驱动下,设计师对经典椅子的新思考、再设计,同时,论证了设计师借鉴经典是不断创新设计的方法之一,有利于传承优秀的传统设计思想,促使当代设计多元化发展。

关键词：伊姆斯休闲椅超轻椅普鲁斯特扶手椅借鉴经典设计方法

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论澳门文化创意产品设计现存问题

中国艺术 2023年第1期 94-101页

作者：李洋艺中国艺术研究院研究生院

澳门是一个拥有多元文化的城市,不仅能够让人感受到浓郁的本土风情,也能使人领略到以儒家和道家为主的中国传统文化,以及以葡萄牙文化为主的西方文化风情。在澳门,文化创意产品的发展有得天独厚的条件。而如今澳门地区的文化创意产品却... 详细信息

澳门是一个拥有多元文化的城市,不仅能够让人感受到浓郁的本土风情,也能使人领略到以儒家和道家为主的中国传统文化,以及以葡萄牙文化为主的西方文化风情。在澳门,文化创意产品的发展有得天独厚的条件。而如今澳门地区的文化创意产品却存在许多问题,包括同质化现象、文化与审美缺失等。本文主要评述澳门文化创意产品设计中的问题,并结合其他优秀文化创意产品案例进行详尽分析,提出未来发展的可行性建议。

关键词：澳门文化创意产品设计同质化

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