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Weak Hardy-type spaces associated with ball quasi-Banach function spaces I:Decompositions with applications to boundedness of Calderón-Zygmund operators

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Science China Mathematics 2021年第9期64卷 2007-2064页

作者： yangyang zhang Dachun Yang Wen Yuan Songbai Wang Laboratory of Mathematics and Complex Systems(Ministry of Education of China) School of Mathematical SciencesBeijing Normal UniversityBeijing100875China College of Mathematics and Statistics Hubei Normal UniversityHuangshi435002China

Let X be a ball quasi-Banach function space on R^(n).In this article,we introduce the weak Hardytype space WH_(X)(R^(n)),associated with X,via the radial maximal *** that the powered HardyLittlewood maximal operator satisfies some Fefferman-Stein vector-valued maximal inequality on X as well as it is bounded on both the weak ball quasi-Banach function space WX and the associated space,we then establish several real-variable characterizations of WH_(X)(R^(n)),respectively,in terms of various maximal functions,atoms and *** an application,we obtain the boundedness of Calderón-Zygmund operators from the Hardy space H_(X)(R^(n))to WH_(X)(Rn),which includes the critical *** these results are of wide ***,when X:=M^(q)_(p)(R^(n))(the Morrey space),X:=L^(p)(R^(n))(the mixed-norm Lebesgue space)and X:=(EΦq)t(Rn)(the Orlicz-slice space),which are all ball quasi-Banach function spaces rather than quasiBanach function spaces,all these results are even *** to the generality,more applications of these results are predictable.

关键词： ball quasi-Banach function space weak Hardy space Orlicz-slice space maximal function atom molecule Calderón-Zygmund operator

复合添加MgO和La_(2)O_(3)对纳米微晶氧化铝陶瓷微观结构的影响

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硅酸盐通报 2024年第1期43卷 339-346页

作者：李慧张金平高景霞王二萍张洋洋黄河科技学院工学部郑州450006

纳米微晶氧化铝磨料具有良好的通用性和高精度磨削能力,且性价比较高,在机械制造、轴承、模具、汽车等领域有广泛的应用潜力。本研究以勃姆石(γ-AlOOH)为原料,MgO、La_(2)O_(3)为添加剂,采用溶胶-凝胶工艺合成纳米微晶氧化铝。通过差... 详细信息

纳米微晶氧化铝磨料具有良好的通用性和高精度磨削能力,且性价比较高,在机械制造、轴承、模具、汽车等领域有广泛的应用潜力。本研究以勃姆石(γ-AlOOH)为原料,MgO、La_(2)O_(3)为添加剂,采用溶胶-凝胶工艺合成纳米微晶氧化铝。通过差示扫描量热仪、X射线衍射仪、扫描电子显微镜和从头算分子动力学方法模拟计算研究了添加剂对微晶氧化铝相转化、物相组成、微观结构及力学性能的影响。结果表明:复合添加MgO和La2O3可以使氧化铝中间相θ-Al_(2)O_(3)向α-Al_(2)O_(3)转化的温度从1257℃降低到1105℃,将致密化温度从1600℃降低到1350℃,将微晶氧化铝的晶粒尺寸从1.04 mm减小到120 nm,实现了低温致密烧结。

关键词：纳米微晶 Al_(2)O_(3) MgO La_(2)O_(3) 溶胶-凝胶添加剂低温烧结

索拉菲尼诱导的细胞凋亡和自噬对HeLa细胞耐药性的影响

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基础医学与临床 2024年第4期44卷 467-473页

作者：杨铠菲朱静格张洋洋赵俊果高雨悦胡焕焕姬国杰新乡医学院三全学院生命科学技术学院河南新乡453000 新乡医学院三全学院生育力保存重点实验室河南新乡453000 新乡医学院三全学院生物与基础医学实验教学中心河南新乡453000

目的探究索拉菲尼(sorafenib)通过细胞凋亡和自噬对人宫颈癌细胞系HeLa增殖的影响,及对HeLa细胞耐药性的影响。方法用间歇诱导法构建耐药细胞株,以0、2.5、5.0、7.5、10.0、15.0、20.0μmol/L为梯度的索拉菲尼处理HeLa细胞,每个浓度维... 详细信息

目的探究索拉菲尼(sorafenib)通过细胞凋亡和自噬对人宫颈癌细胞系HeLa增殖的影响,及对HeLa细胞耐药性的影响。方法用间歇诱导法构建耐药细胞株,以0、2.5、5.0、7.5、10.0、15.0、20.0μmol/L为梯度的索拉菲尼处理HeLa细胞,每个浓度维持1周,并筛选出可稳定传代的耐药细胞株;MTT法检测索拉菲尼对细胞增殖的影响;流式细胞术分析细胞周期分布情况;RT-qPCR检测亲本株和耐药株在不同药物浓度下耐药和凋亡基因表达水平的变化。Western blot检测与自噬相关的标志物蛋白LC3-Ⅰ和LC3-Ⅱ的变化。结果成功获得稳定的耐药株;经药物处理的细胞更多的被阻滞在G1期。在耐药细胞中,凋亡抑制基因Bcl-2表达量显著降低;凋亡基因Bax表达量明显增加;耐药基因表达明显升高。Western blot中耐药细胞LC3-Ⅱ/LC3-Ⅰ显著高于亲本细胞(P<0.05)。结论索拉菲尼通过阻滞细胞周期抑制HeLa细胞增殖并诱导其自噬。细胞自噬在宫颈癌治疗过程中可能参与了细胞耐药的发展,促进细胞存活;在一定程度下,药物诱导的细胞自噬能激活耐药细胞的凋亡信号通路,促进细胞耐药逆转。

关键词：索拉菲尼宫颈癌细胞耐药性自噬凋亡细胞周期

冻融循环后红砂岩静动态劈裂拉伸性能对比分析

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煤炭科学技术 2023年第3期51卷 94-99页

作者：张阳阳黄伟淮南联合大学建筑与艺术学院安徽淮南232038

研究冻融循环作用后岩石的劈裂拉伸性能对分析寒区岩体稳定性具有重要的参考价值,以寒区典型的红砂岩为研究对象,对红砂岩开展了0、5、10、15、20次冻融循环试验,研究了冻融循环次数对红砂岩纵波波速、干密度和孔隙率的影响规律,采用岩... 详细信息

研究冻融循环作用后岩石的劈裂拉伸性能对分析寒区岩体稳定性具有重要的参考价值,以寒区典型的红砂岩为研究对象,对红砂岩开展了0、5、10、15、20次冻融循环试验,研究了冻融循环次数对红砂岩纵波波速、干密度和孔隙率的影响规律,采用岩石试验机和ø50 mm分离式Hopkinson压杆实验系统,进行了不同冻融循环次数后红砂岩试样的静、动态力学性能试验,分析了冻融循环次数对红砂岩静、动态强度、变形和破坏形态的影响,基于纵波波速的变化定义了红砂岩的冻融损伤度。研究结果表明:随着循环次数的增加,红砂岩内部裂隙不断扩展,矿物颗粒之间黏结力逐渐减弱,试件的纵波波速和干密度逐渐减小,而孔隙率和损伤度逐渐增大;红砂岩的静、动态劈裂拉伸强度随冻融次数的增加逐渐下降,而达到峰值应力所需的时间逐渐增加,20次冻融循环后,红砂岩试件的静、动态劈裂强度分别降低了41.88%和21.93%。相同冻融循环次数条件下,红砂岩试件的动态劈裂强度比静态劈裂强度提高了2.0~3.5倍。静态劈裂条件下,红砂岩试件呈中心劈裂破坏模式,与静态相比,试件的动态破碎形态在加载两端出现明显的压碎区域,且区域面积随循环次数的增加不断增大,破碎区的碎块尺寸逐渐减小。红砂岩内部的损伤度随循环次数的增加呈对数增大。

关键词：岩石力学冻融循环静态力学动态力学分离式Hopkinson压杆劈裂破碎形态

Transcriptome and proteome analysis reveals the characteristics of carbon metabolism in the mycelial development of Gomphus purpuraceus

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Food Science and Human Wellness 2024年

作者： yangyang Geng Shixin zhang Yana Liu Likang Qin School of Liquor and Food Engineering Guizhou University Guizhou Institute of Walnut Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education) College of Life Sciences/Institute of Agro-bioengineering Guizhou University Guizhou Academy of Forestry Guizhou Industrial Technology Research Institute of Rare Edible and Medicinal Fungi co. Ltd

Gomphus purpuraceus is an ancient wild edible mushroom. However， the niche and lignocellulose degradation system of G. purpuraceus have remained cryptic. In the current study， transcriptome and proteome sequencing of G. purpuraceus in four mediums was performed. A total of 3489 differentially expressed genes (DEGs) and 891 differentially expressed proteins (DEPs) were screened out. For the lignocellulose degradation system， a total of 61 expressed genes were annotated， including 19 genes encoding cellulase， 8 genes encoding hemicellulase， 5 genes encoding pectinase， 22 genes encoding lignin oxidase， and 7 lignin degrading auxiliary enzyme. From two-omics， morphology， and enzyme activities， we speculated that G. purpuraceus might have a limited capacity to degrade polysaccharides (starch and lignocellulose). In addition， trace amount of fumonisins (FB1 and FB2) were found in the G. purpuraceus. These results provided a new perspective for understanding the key pathways and hub genes involved in carbon metabolism of G. purpuraceus development.

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Phomaketals A and B,pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.

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Chinese Chemical Letters 2024年第7期35卷 350-354页

作者： Chuan Li yangyang Han Yanan Zhai Ke Li Xingzhong Liu Zhuan zhang Cai Jia Yongsheng Che NHC Key Laboratory of Biotechnology of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Toxicology&Medical Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850China Department of Microbiology College of Life SciencesNankai UniversityTianjin 300071China

Phomaketals A(1)and B(2),two tropolonic meroterpenoids with the unprecedented pentacyclic skeletons,were isolated from the solid-substrate fermentation cultures of a eupC overexpressed mutant strain of the fungus Phoma sp.,together with a biogenetically related secondary metabolite pughiinin B(3),and the known one noreupenifeldin B(4).The structures of 1–3 were elucidated primarily by nuclear magnetic resonance(NMR)*** absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations and the calculated NMR with DP4+analysis,while that of 3 was established by single-crystal X-ray diffraction analysis using Cu Kα***,phomaketals A(1)and B(2)could be derived from the hypothetical tropolonic sesquiterpene intermediates neosetophomone B(6)and 9-R-neosetophomone B(6),respectively,via different reactions *** 1 showed antiproliferative effect only against the SUPB15 cells,with an 50%inhibitory concentration(IC50)value of 4.85μmol/L,while the co-isolated known meroterpenoid 4 displayed potent effects against three tumor cell lines,SUPB15,EL4,and H9,showing IC50values of 0.36–27.08μmol/L.

关键词： Phoma sp. Tropolonic sesquiterpenes Biosynthetic pathways Hetero-Diels–Alder Cytotoxicity

Energy-Efficient Routing Algorithm Based on Multipath Routing in Large-Scale Networks

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Computers, Materials & Continua 2021年第8期68卷 2029-2039页

作者： Haijun Geng Qidong zhang Jiangyuan Yao Wei Wang Zikun Jin Han zhang yangyang zhang School of Computer and Information Technology Shanxi UniversityShanxi030006China School of Computer Science and Cyberspace Security Hainan UniversityHaikou570228China School of Cyber Space and Technology Beihang UniversityBeijing100191China College of Engineering Northeastern University Boston02115MAUSA

A reduction in network energy consumption and the establishment of green networks have become key scientific problems in academic and industrial *** energy efficiency schemes are based on a known traffic matrix,and acquiring a real-time traffic matrix in current complex networks is ***,this research investigates how to reduce network energy consumption without a real-time traffic *** particular,this paper proposes an intra-domain energy-efficient routing scheme based on multipath *** analyzes the relationship between routing availability and energy-efficient routing and integrates the two mechanisms to satisfy the requirements of availability and energy *** main research focus is as follows:(1)A link criticality model is evaluated to quantitatively measure the importance of links in a network.(2)On the basis of the link criticality model,this paper analyzes an energy-efficient routing technology based on multipath routing to achieve the goals of availability and energy efficiency simultaneously.(3)An energy-efficient routing algorithm based on multipath routing in large-scale networks is proposed.(4)The proposed method does not require a real-time traffic matrix in the network and is thus easy to apply in practice.(5)The proposed algorithm is verified in several network *** results show that the algorithm can not only reduce network energy consumption but can also ensure routing availability.

关键词： Energy-efficient routing multipath routing link criticality model energy-saving ratio large-scale network

Highly efficient catalytic valorization of biomass-derived hexoses and furfuryl alcohol in the presence of polymer-based catalysts

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Green Energy & Environment 2019年第4期4卷 424-431页

作者： yangyang zhang Xinli Tong Linhao Yu Lingwu Meng Pengfei Guo Song Xue Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical Engineering Tianjin University of Technology

The catalytic transformation of furfuryl alcohol and hexose into value-added chemicals have been investigated with a series of polymer-based catalysts including poly(styrenesulfonic acid)(PSS),graphite oxide-doped poly(styrenesulfonic acid)(PSS-GO),and graphite-doped poly(-styrenesulfonic acid)(PSS-C).It is found that the selective conversion of furfuryl alcohol to methyl levulinate(MLE)was successfully performed with PSS as the catalyst,in which a 96.4%yield is attained in methanol ***,the efficient dehydration of D-fructose to produce 5-hydroxymethylfurfural(HMF)has also been achieved using PSS-GO as the catalyst,where a 76.5%yield of HMF was obtained in Nmethylpyrrodinone *** effects of reaction temperature,time and solvent were ***,the used catalysts have been respectively characterized by XRD,TG,FTIR,SEM and TEM techniques to reveal the physical properties and structures of these polymeric catalytic materials.

关键词： Catalysis Furfuryl alcohol Fructose 5-Hydroxymethylfurfural Biomass transformation

The auxin transporter OsAUX1 regulates tillering in rice(Oryza sativa)

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Journal of Integrative Agriculture 2024年第5期23卷 1454-1467页

作者： Luqi Jia Yongdong Dai Ziwei Peng Zhibo Cui Xuefei zhang yangyang Li Weijiang Tian Guanghua He Yun Li Xianchun Sang Chongqing Key Laboratory of Crop Molecular Improvement/Rice Research Institute Academy of Agricultural SciencesSouthwest UniversityChongqing400715China Rice and Sorghum Research Institute Sichuan Academy of Agricultural Sciences/Key Laboratory of Southwest Rice Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsDeyang 618000China

Tillering is an important agronomic trait of rice(Oryza sativa)that affects the number of effective panicles,thereby affecting *** phytohormone auxin plays a key role in *** we identified the high tillering and semi-dwarf 1(htsd1)mutant with auxin-deficiency root characteristics,such as shortened lateral roots,reduced lateral root density,and enlarged root ***1 showed reduced sensitivity to auxin,but the external application of indole-3-acetic acid(IAA)inhibited its *** identified the mutated gene in htsd1 as AUXIN1(OsAUX1,LOC_Os01g63770),which encodes an auxin influx *** promoter sequence of OsAUX1 contains many SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)binding sites,and we demonstrated that SPL7 binds to the OsAUX1 *** BRANCHED1(OsTB1),a key gene that negatively regulates tillering,was significantly downregulated in *** was enhanced in the OsTB1 knockout mutant,and the external application of IAA inhibited tiller elongation in this *** OsTB1 restored the multi-tiller phenotype of *** results suggest that SPL7 directly binds to the OsAUX1 promoter and regulates tillering in rice by altering OsTB1 expression to modulate auxin signaling.

关键词： rice(Oryza sativa L.) tillering indole-3-acetic acid(IAA) OsAUX1 OsTB1