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Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice

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Acta Pharmaceutica Sinica B 2017年第2期7卷 159-166页

作者： Yihuang Lin Yu Yan Huifang Zhang Yucai Chen yangyang he Shoubao Wang Lianhua Fang Yang Lv Guanhua Du State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular Diseases Beijing Key Laboratory of Drug Targets Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

The purpose of this study was to investigate the effects of salvianolic acid A(SAA) in systemic lupus erythematosus(SLE) induced by pristane in BALB/c mice.Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane.Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls.The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin(H&E) and periodic acid-Schiff(PAS) staining.Western blot analysis of renal tissue was also employed.SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects.SAA treatment also significantly inhibited the phosphorylation of IKK,IκB and NFκB in renal tissues of lupus mice.In conclusion,the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK,IκB and NFκB.

关键词： Salvianolic acid A SLE Renal injury Autoantibodies Pristane BALB/c mice NFκB

Ratiometric fluorescent detection of acidic pH in lysosome with carbon nanodots

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Chinese Chemical Letters 2017年第10期28卷 1969-1974页

作者： yangyang he Zhanxian Li Qingyan Jia Bingjie Shi Hongyan Zhang Liuhe Wei Mingming Yu College of Chemistry and Molecular Engineering Zhengzhou University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

It is significant for cell physiology to keep the homeostasis of p H, and it is highly demanded to develop ratiometric fluorescent sensors toward p H. In this work, under mild condition, through the electrostatic interaction between carbon nanodots（CDs） and organic molecules, two novel ratiometric fluorescence hybrid nanosensors were fabricated for sensing acidic p H. These nanohybrid systems possess dual emission peaks at 455 and 527 nm under a single excitation wavelength of 380 nm in acidic p H condition.With the increasing of p H, the fluorescence of the 1,8-naphthalimide derivative completely quenches,while the blue fluorescence of CDs keeps constant. Furthermore, the CDsàorganic molecular nanohybrids exhibit excellent anti-disturbance ability, reversible p H sensing ability, and a linear response range in wide p H range respectively. Besides the ability to target lysosome, with one of the nanosensor, stimulated p H change has been successfully tracked in a ratiometric manner via fluorescence imaging.

关键词： Acidic pH Fluorescence Carbon dot Hybrid nanosensor Lysosome-targeted

Enhanced green fluorescence and afterglow in （Zn, Mg）2GeO4: Mn2+, Cd2+

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Science China(Physics,Mechanics & Astronomy) 2017年第9期Mechanics & Astronomy) .卷 81-84页

作者： Yan Cong yangyang he DaPeng Dong LiMei Wang Zhen Zhang ZiWen Wang Bin Dong School of Physics & Materials Engineering Dalian Nationalities University

Long-lasting phosphorescent（LLP）materials have attracted considerable attention since green and blue emitting persistent Eu2+doped alkaline earth phosphors were reported in the mid-1990s[1-3].Over the past few decades,a considerable effort has been made to design novel LLP materials for a wide range of applications such as emergency lighting,interior decoration,road signs,and in vivo bioimaging[4-6].For these applications,long persistence times are often desirable.Two types of active center involved are:emitters and

关键词： Zn Enhanced green fluorescence and afterglow in Mg LLP Mn

荆芥和砂仁挥发油对米象熏蒸活性的协同作用及成分研究

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中国粮油学报 2024年第3期39卷 11-18页

作者：杨悦玲苏懿清何洋洋梁宗锁王芳梁倩西南林业大学林学院昆明650224 浙江理工大学绍兴生物医药研究院绍兴312000

研究20种植物挥发油对米象(Sitophilus oryzae Linnaeus)成虫的熏蒸活性以及混配的协同作用。采用水蒸气蒸馏法提取20种植物挥发油,通过气相-质谱法和化合物消除法,确定熏蒸活性和协同作用最好的2种挥发油的活性成分。结果表明:20种植... 详细信息

研究20种植物挥发油对米象(Sitophilus oryzae Linnaeus)成虫的熏蒸活性以及混配的协同作用。采用水蒸气蒸馏法提取20种植物挥发油,通过气相-质谱法和化合物消除法,确定熏蒸活性和协同作用最好的2种挥发油的活性成分。结果表明:20种植物挥发油中荆芥挥发油对米象的熏蒸活性最好,LC_(50)为13.27 mg/L。砂仁挥发油表现出最大的协同作用,共毒性因子为107.14。通过化合物消除法评价荆芥挥发油和砂仁挥发油的主要活性成分分别为胡薄荷酮和(-)-4-萜品醇,对米象熏蒸活性的LC_(50)分别为7.34、8.35 mg/L,优于荆芥挥发油的熏蒸活性。胡薄荷酮和(-)-4-萜品醇按照质量比例61.13∶6.13和1∶1的比例混配,LC_(50)分别为5.91、8.29 mg/L,随着胡薄荷酮比例的增大,混剂对米象的熏蒸活性增强。研究证实了胡薄荷酮和(-)-4-萜品醇作为植物源杀虫剂具有防治米象的潜力。

关键词：荆芥挥发油砂仁挥发油米象化合物消除法混配

溶胶-凝胶法制备超级电容器纳米电极材料的研究进展

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当代化工研究 2024年第3期 33-35页

作者：贺洋洋周颖盐城工学院江苏224000

溶胶-凝胶法是一种常用的制备超级电容器纳米电极材料的方法。利用溶胶-凝胶法制备超级电容器纳米电极材料将为获得具有优异电化学性能的材料提供了重要的方法和基础。本文介绍了电容器的制备方法及优缺点,通过分析溶胶-凝胶法制备超级... 详细信息

溶胶-凝胶法是一种常用的制备超级电容器纳米电极材料的方法。利用溶胶-凝胶法制备超级电容器纳米电极材料将为获得具有优异电化学性能的材料提供了重要的方法和基础。本文介绍了电容器的制备方法及优缺点,通过分析溶胶-凝胶法制备超级电容器纳米电极材料的工艺参数、影响因素与优化策略,通过探讨溶胶-凝胶法的发展历程和相关研究成果,希望可以为今后超级电容器纳米电极材料的研究提供参考。

关键词：溶胶-凝胶法超级电容器纳米电极材料制备路径

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大坝安全监测数据降噪的流形学习方法

水利水电科技进展 2024年第4期44卷 59-64页

作者：冯燕明何杨杨左生龙张帅徐朗苏怀智中国电建集团昆明勘测设计研究院有限公司云南昆明650032 河海大学水灾害防御全国重点实验室江苏南京210098 河海大学水利水电学院江苏南京210098 中国电建集团国际工程有限公司北京100089

针对大坝变形、渗流、应力应变等安全监测数据难以避免受到噪声污染,且传统线性降噪方法去噪效果不佳的问题,提出了基于相空间重构与流形学习相组合的大坝安全监测数据非线性降噪方法。该方法在重构大坝安全监测数据时间序列相空间的基... 详细信息

针对大坝变形、渗流、应力应变等安全监测数据难以避免受到噪声污染,且传统线性降噪方法去噪效果不佳的问题,提出了基于相空间重构与流形学习相组合的大坝安全监测数据非线性降噪方法。该方法在重构大坝安全监测数据时间序列相空间的基础上,通过交叉应用局部切空间排列方法与极大似然估计、自适应邻域等方法,以重构的相空间为桥梁,提取大坝安全监测数据序列深层次信息,得到降噪后的大坝安全监测数据。工程实测数据验证结果表明,相比小波软阈值法和固定邻域-LTSA法,本文提出的方法降噪效果更优,具有一定的工程应用价值。

关键词：大坝安全监测数据降噪处理流形学习相空间重构

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半封闭式铸件消失模铸造工艺技术研究与实践

云南冶金 2024年第3期53卷 135-139页

作者：高显宏何阳阳何玉鸿杨诚云南云铝绿源慧邦工程技术有限公司云南昆明654300

针对大中型半封闭式铸件出现塌箱、涨箱缺陷,分析了缺陷产生的生产环节及其原因并制定相应改进措施。实践证明,半封闭件以上口平面倾斜45°角进行埋箱造型,利于型砂填充震实;制作外接负压管,浇铸时内外负压均开,确保型腔内外负压均衡,... 详细信息

针对大中型半封闭式铸件出现塌箱、涨箱缺陷,分析了缺陷产生的生产环节及其原因并制定相应改进措施。实践证明,半封闭件以上口平面倾斜45°角进行埋箱造型,利于型砂填充震实;制作外接负压管,浇铸时内外负压均开,确保型腔内外负压均衡,提升浇铸合格率。

关键词：半封闭式消失模铸造外接负压缺陷铸件

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阳极钢爪铁液熔炼工艺技术研究及实践

云南冶金 2024年第3期53卷 146-149页

作者：何玉鸿高显宏何阳阳杨诚云南云铝绿源慧邦工程技术有限公司云南昆明650502

针对牌号为ZG200-400阳极钢爪铁液熔炼工艺技术铁液化学成分不合格问题,对影响阳极钢爪铁液熔炼的主要因素设备的选型、配料、熔炼工艺及化学成分进行分析,采用改进中频炉管理,优化配料装料管理、熔炼工艺及化学成分控制的方法,经过实践... 详细信息

针对牌号为ZG200-400阳极钢爪铁液熔炼工艺技术铁液化学成分不合格问题,对影响阳极钢爪铁液熔炼的主要因素设备的选型、配料、熔炼工艺及化学成分进行分析,采用改进中频炉管理,优化配料装料管理、熔炼工艺及化学成分控制的方法,经过实践,中频炉运行故障率降低了64%;钢爪铁液出炉温度不合格次数降低了53%;钢爪铁液化学成分不合格次数降低了76%。

关键词：阳极钢爪铁液熔炼中频炉工艺控制

Enhanced green fluorescence and afterglow in (Zn, Mg)_2GeO_4: Mn^(2+), Cd^(2+)

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Science China(Physics,Mechanics & Astronomy) 2017年第9期60卷 76-79页

作者： Yan Cong yangyang he DaPeng Dong LiMei Wang Zhen Zhang ZiWen Wang Bin Dong School of Physics & Materials Engineering Dalian Nationalities University

Long-lasting phosphorescent(LLP)materials have attracted considerable attention since green and blue emitting persistent Eu^(2+) doped alkaline earth phosphors were reported in the mid-1990s[1-3].Over the past few decades,a considerable effort has been made to design novel LLP materials for a wide range of applications such as emergency lighting,interior decoration,road signs,and in vivo bioimaging[4-6].For these applications,long persistence times are often desirable.Two types of active center involved are:emitters

关键词：长余辉发光材料绿色荧光增强型陷阱分布 Zn 材料设计光致发光材料余辉时间