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医院药师参与药学科普工作的现状及其发展路径探讨

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中国药业 2024年第14期33卷 1-5页

作者：杨晗郭毅高洋洋吴仁政杨薇樊萍四川大学华西医院临床药学部四川成都610041

目的了解医院药师开展药学科普工作的现状,提升其参与科普工作的能力。方法采用整体抽样法,选择在四川省不同级别医院工作的437名药师为调研对象,于2024年1月3日至7日利用“问卷星”微信小程序向其发放并回收调查问卷。了解其对药学... 详细信息

目的了解医院药师开展药学科普工作的现状,提升其参与科普工作的能力。方法采用整体抽样法,选择在四川省不同级别医院工作的437名药师为调研对象,于2024年1月3日至7日利用“问卷星”微信小程序向其发放并回收调查问卷。了解其对药学科普工作的了解程度和认可度等。结果共发放调查问卷437份,有效回收432份,有效回收率为98.86%。药师学历以本科为主,职称主要为药师和主管药师,工作年限≥10年的较多,经常、偶尔、未接受过科普相关培训的药师分别有28名(6.48%)、230名(53.24%)、174名(40.28%)。药师对参与科普工作3个问题的认可度均大于90%;对参与科普工作个人综合能力5个问题的评价较好的比例均不足50%(最低为10.88%),对现有科普作品及其审核机制5个问题的满意度为58.56%~75.23%。药师实际参与最多的科普工作形式为撰写科普文章(163人);接触较多及认为最受公众欢迎的科普形式均为短视频(332人,395人);认为公众最需要的药学科普内容为特殊人群用药(351人);最希望科普作品具有的整体风格为通俗易懂(400人);认为目前药师开展科普工作中存在的最大问题为缺少时间和精力(313人)。结论建议针对药师搭建完整的科普培养体系,鼓励药师积极参与药学科普创作和宣传,通过药师参与药学科普创作可促进药学服务水平提升。

关键词：药学科普药学服务药师问卷调查能力提升

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不同木耳膳食纤维提取及产品开发研究进展

农产品加工 2024年第3期 92-94页

作者：孔璐怡曹宇婷何静羽朱超凡高阳杨通化师范学院食品科学与工程学院吉林通化134002 通化师范学院长白山食用植物资源开发工程中心吉林通化134002

综述了黑木耳和玉木耳膳食纤维提取的多种方法及有关木耳的产品开发现状,以期为木耳的膳食纤维提取及深加工方向提供理论参考。

关键词：木耳膳食纤维提取产品开发

BiodMHC:an online server for the prediction of MHC class Ⅱ-peptide binding affinity

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Journal of Genetics and Genomics 2009年第5期36卷 289-296页

作者： Lian Wang Danling Pan Xihao Hu Jinyu Xiao yangyang gao Huifang Zhang Yan Zhang Juan Liu Shanfeng Zhu School of Computer Wuhan University Wuhan 430079 China School of Computer Science Fudan University Shanghaz 200433 China Shanghai Key Lab of Intelligent Information Processing Fudan University Shanghai 200433 China

Effective identification of major histocompatibility complex （MHC） molecules restricted peptides is a critical step in discovering immune epitopes. Although many online servers have been built to predict class Ⅱ MHC-peptide binding affinity, they have been trained on different datasets, and thus fail in providing a unified comparison of various methods. In this paper, we present our implementation of seven popular predictive methods, namely SMM-align, ARB, SVR-pairwise, Gibbs sampler. ProPred, LP-top2, and MHCPred, on a single web server named BiodMHC （http：//***/BiodMHC/***, the software is available upon request）. Using a standard measure of AUC （Area Under the receiver operating characteristic Curves）, we compare these methods by means of not only cross validation but also prediction on independent test datasets. We find that SMM-align, ProPred, SVR-pairwise, ARB, and Gibbs sampler are the five best-performing methods. For the binding affinity prediction of class Ⅱ MHC-peptide, BiodMHC provides a convenient online platform for researchers to obtain binding information simultaneously using various methods.

关键词： MHC Ⅱ MHC-peptide binding predictions web server

CPSF30-L-mediated recognition of mRNA m^(6)A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis

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Molecular Plant 2021年第4期14卷 688-699页

作者： Yiteng Hou Jing Sun Baixing Wu yangyang gao Hongbo Nie Zhentian Nie Shuxuan Quan Yong Wang Xiaofeng Cao Sisi Li State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Depatment of Biology Southerm University of Science and Technology.ShenzhenGuangdong 518055China State Key Laboratory of Crop Biology College of Life SciencesShandong Agicultural UniversityTar'anShandong 271018China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Molecular Plant Sciences Chinese Academy of SciencesBeing 100101China Present address:Guangdong Provinclal Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineRNA Biomedical InstituteMedical Research CenterSun Yat Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China These authors contributed equaly to this article.

N6-methyladenosine(m^(6)A),a ubiquitous internal modification of eukaryotic mRNAs,plays a vital role in almost every aspect of mRNA ***,there is little evidence documenting the role of m^(6)A in regulating alternative polyadenylation(APA)in *** is controlled by a large protein-RNA complex with many components,including CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30(CPSF30).In Arabidopsis,CPSF30 has two isoforms and the longer isoform(CPSF30-L)contains a YT512-B Homology(YTH)domain,which is unique to *** this study,we showed that CPSF30-L YTH domain binds to m^(6)A in v *** the cpsf30-2 mutant,the transcripts of many genes including several important nitrate signaling-related genes had shifts in polyadenylation sites that were correlated with m^(6)A peaks,indicating that these gene transcripts carrying m^(6)A tend to be regulated by ***-type CPSF30-L could rescue the defects in APA and nitrate metabolism in cpsf30-2,but m^(6)A-binding-defective mutants of CPSF30-L could *** together,our results demonstrated that m^(6)A modification regulates APA in Arabidops is and revealed that the m^(6)A reader CPSF30-L affects nitrate signaling by controlling APA,shedding new light on the roles of the m^(6)A modification during RNA 3-end processing in nitrate metabolism.

关键词： m^(6)A modification alternative polyadenylation nitrate metabolism CPSF30

Microstructure and Corrosion Resistance of a Novel AlNiLa Lightweight Medium Entropy Amorphous Alloy Composites

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Journal of Wuhan University of Technology(Materials Science) 2022年第6期37卷 1185-1191页

作者： ZHANG Shuyan ZHANG Zhibin gao yangyang WANG Xin SHEN Baolong LIANG Xiubing Ocean College Zhejiang UniversityZhoushan 316021China Defense Innovation Institute Academy of Military Sciences of the PLA of ChinaBeijing 100071China School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing 211189China

A new type of lightweight AlNiLa medium entropy amorphous alloy composite ribbons(labled as MEAAC ribbons)were prepared by vacuum arc melting technology and high-speed single roller meltspinning *** microstructure and thermal stability of MEAAC ribbons were examined using X-ray diffraction,differential scanning calorimeter,and scanning electron ***,the hardness and surface roughness of these ribbons were measured by Vickers microhardness tester and atomic force *** potentiodynamic polarization curves and electrochemical impedance spectroscopy(EIS)were applied to investigate the corrosion behavior of these MEAAC ribbons in simulated seawater(3.5wt%NaCl corrosive solution)at room *** results demonstrate that AlNiLa MEAAC ribbons in the as-received state are mainly composed of amorphous phase and intermetallic *** hardness values of all melt-spun ribbons are above 310 HV_(0.1).With the increase of Al content,the linear polarization resistances of four various AlNiLa MEAAC ribbons are negligibly different *** is also found that Al_(45)Ni_(27.5)La_(27.5) MEAAC ribbons have the most positive corrosion potential and the smallest corrosion current density at the same time;hence it may be a kind of potential material for metal surface protection in harsh ocean environment.

关键词： medium entropy amorphous alloy composites rapid solidification microstructure corrosion resistance thermal stability

国家组织药品集中带量采购政策对某院门诊药房降压药物使用的影响分析

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中国药业 2024年第5期33卷 14-18页

作者：王茂郑明琳何璐璐王世燕高洋洋樊萍四川大学华西医院四川成都610041

目的探讨国家组织药品集中带量采购(简称国家集采)政策对某院门诊患者降压药物使用情况的影响。方法以医院门诊药房国家集采政策实施前(2018年1月至12月)及实施后(2020年1月至12月)23种降压药物为目标药品,共涉及10种中选品种;利用医院... 详细信息

目的探讨国家组织药品集中带量采购(简称国家集采)政策对某院门诊患者降压药物使用情况的影响。方法以医院门诊药房国家集采政策实施前(2018年1月至12月)及实施后(2020年1月至12月)23种降压药物为目标药品,共涉及10种中选品种;利用医院信息系统收集目标药品的价格、销售数量和金额,比较用药频度(DDDs)、限定日费用(DDC)。结果国家集采政策实施后,其中11种降压药物的价格降幅为5.86%~89.70%,23种降压药物的销售金额累计减少2705.60万元。DDDs排名前3的目标药品未发生变化,为苯磺酸氨氯地平片(商品名洛活喜)、富马酸比索洛尔片(商品名康忻)、坎地沙坦酯片(商品名维尔亚);10种中选品种的DDDs排名均居前列。DDC排名前4的目标药品未发生变化,为厄贝沙坦氢氯噻嗪片(商品名安博诺)、厄贝沙坦片(商品名安博维)、缬沙坦胶囊(商品名代文)、氯沙坦钾片;10种中选品种的DDC相对较低,且非中选品种的DDC均降低。结论国家集采政策的实施促使药品价格趋于合理,减轻了患者用药的经济负担,优化了医保资金的使用,提高了医疗保障水平。

关键词：国家组织药品集中带量采购门诊药房降压药物用药频度限定日费用

The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

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Cancer Biology & Medicine 2024年第1期21卷 65-82页

作者： Sen Wang Benling Xu yangyang Zhang Guangyu Chen Peng Zhao Quanli gao Long Yuan Department of Gastrointestinal Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Immunotherapy Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(CRC).Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/d MMR CRC but performed poorly in patients with MSS/p MMR *** recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC *** and clinical evidence have suggested that anti-PD-1/PD-L1 antibody efficacy can be improved by altering the composition of the intestinal flora in ***,we summarize the studies related to the influence of intestinal flora on anti-PD-1/PD-L1 antibody efficacy in CRC and discuss the potential underlying mechanism(s).We have focused on the impact of the intestinal flora on the efficacy and safety of anti-PD-1/PD-L1 antibodies in CRC and how to better utilize the intestinal flora as an adjuvant to improve the efficacy of anti-PD-1/PD-L1 *** addition,we have provided a basis for the potential of the intestinal flora as a new treatment modality and indicator for determining patient prognosis.

关键词： Intestinal flora anti-PD-1/PD-L1 therapy colorectal cancer immune checkpoint inhibitor CD8~+T cell

某三级甲等综合医院门诊药房中成药药品说明书信息标注情况分析

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中国药业 2024年第10期33卷 16-20页

作者：杜雅丽胡晨吉何璐璐郭毅高洋洋王世燕樊萍四川大学华西医院临床药学部四川成都610041

目的完善医院门诊药房中成药药品说明书的信息标注,促进临床合理用药。方法通过医院信息系统收集某三级甲等(简称三甲)综合医院门诊药房83种中成药的药品说明书,参照相关法规、指南等分析各项目信息标注情况。结果83份药品说明书中,非... 详细信息

目的完善医院门诊药房中成药药品说明书的信息标注,促进临床合理用药。方法通过医院信息系统收集某三级甲等(简称三甲)综合医院门诊药房83种中成药的药品说明书,参照相关法规、指南等分析各项目信息标注情况。结果83份药品说明书中,非处方药中除11份未标注警示语外,其余各项目均标注完整;处方药药品说明书【药品名称】【成分】【性状】【功能主治】【规格】等17项内容均标注完整,【药代动力学】【老年患者用药】【儿童用药】【孕妇及哺乳期妇女用药】【药物相互作用】等7项有缺项。结论该院门诊药房使用的中成药药品说明书信息标注存在缺项严重、表述模糊、界定不清的情况,建议相关部门加强对中成药药品说明书的管理,督促药品上市许可持有人进行修改和完善,以保障临床用药安全。

关键词：三级甲等综合医院门诊药房中成药药品说明书信息标注用药安全合理用药

儿童急性淋巴细胞白血病睾丸复发的临床特征及预后因素分析

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中华儿科杂志 2024年第3期62卷 262-267页

作者：王凝高洋洋戚本泉阮敏吕惠张小燕张然然刘天峰陈玉梅邹尧郭晔杨文钰张丽竺晓凡陈晓娟中国医学科学院血液病医院(中国医学科学院血液学研究所)儿童血液病诊疗中心、实验血液学国家重点实验室、国家血液系统疾病临床医学研究中心、细胞生态海河实验室、天津医学健康研究院天津300020

目的探讨急性淋巴细胞白血病(ALL)睾丸复发患儿的临床特征及预后影响因素。方法回顾性分析2011年11月至2022年12月中国医学科学院血液病医院收治的37例ALL睾丸复发患儿的年龄、复发时间、复发部位、复发后治疗等临床资料,按照不同临床... 详细信息

目的探讨急性淋巴细胞白血病(ALL)睾丸复发患儿的临床特征及预后影响因素。方法回顾性分析2011年11月至2022年12月中国医学科学院血液病医院收治的37例ALL睾丸复发患儿的年龄、复发时间、复发部位、复发后治疗等临床资料,按照不同临床资料对患儿进行分组,采用Kaplan-Meier进行单因素分析评估各组患儿总生存率(OS)及无事件生存率(EFS),采用Cox比例风险回归模型进行多因素分析,评估OS及EFS的独立影响因素。结果37例ALL睾丸复发患儿初诊年龄为(5±3)岁,复发时间为(37±15)个月,随访时间为43(22,56)个月,其中23例(62%)为孤立睾丸复发。37例ALL睾丸复发患儿5年OS和5年EFS分别为(60±9)%和(50±9)%。单因素分析显示睾丸复发时间>28个月组2年EFS优于复发时间≤28个月组[(69±10)%比(11±11)%],孤立睾丸复发组2年EFS优于联合复发组[(66±11)%比(20±13)%],复发后含嵌合抗原受体T细胞(CAR-T)治疗组2年EFS优于不含CAR-T治疗的患儿[(78±10)%比(15±10)%],差异均有统计学意义(均P<0.05)。ETV6-RUNX1是最常见的分子生物学异常(38%,14/37),4年OS和4年EFS分别为(80±13)%、(64±15)%。多因素分析显示复发时间≤28个月(HR=3.09,95%CI 1.10~8.72)、联合复发(HR=4.26,95%CI 1.34~13.53)、复发后治疗含CAR-T(HR=0.15,95%CI 0.05~0.51)均是患儿2年EFS的独立影响因素(均P<0.05)。结论儿童ALL睾丸复发时间较晚,通常发生在初诊ALL 3年后,生存率低,ETV6-RUNX1是最常见的分子生物学异常,预后相对较好,早期复发、联合复发者预后差,CAR-T治疗可以显著提高儿童ALL睾丸复发者的生存率。

关键词：白血病复发睾丸儿童