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Nociceptors and Macrophages in Bacterial Meningitis:Partners in Crime?

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Neuroscience Bulletin 2024年第3期40卷 418-420页

作者： Fang gao Hongzhen Hu The Kimberly and Eric J.Waldman Department of Dermatology Icahn School of Medicine at Mount SinaiNew York NY10029USA The Nash Family Department of Neuroscience Icahn School of Medicine at Mount SinaiNew York NY10029USA The Mark Lebwohl Center for Neuroinfammation and Sensation Icahn School of Medicine at Mount SinaiNew York NY10029USA Friedman Brain Institute Icahn School of Medicine at Mount SinaiNew York NY10029USA

Bacterial meningitis is a serious and potentially life-threatening infection that affects the protective layers surrounding the brain and spinal cord,known as the *** types of bacteria,including Streptococcus pneumoniae,Neisseria meningitidis,and Haemophilus influenzae,can cause this *** populations,such as infants,children,immunocompromised adults,and the elderly,are particularly vulnerable to these *** of bacterial meningitis can manifest suddenly and may include high fever,severe and persistent headache,stiff neck,vomiting,sensitivity to light,and confusion or changes in mental state[1,2].Identifying these symptoms in infants can be more challenging and may lead to long-term disability or death[3].Despite the effectiveness of vaccines,it is crucial to understand how bacteria invade the brain and how our innate immune system responds to infection(Fig.1).

关键词： protective infection suddenly

Three-dimensional porous In_(2)O_(3) arrays for self-powered transparent solar-blind photodetectors with high responsivity and excellent spectral selectivity

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Nano Research 2024年第5期17卷 4471-4477页

作者： Nana Zhang Xinyu gao Haoran Guan Simin Sun Jiaming Liu Zhitao Shao Qiyue gao Yuan Zhang Ruyu Sun Guang Yang Feng gao Wei Feng College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China

Transparent solar-blind ultraviolet photodetectors(SBUV PDs)have extensive applications in versatile scenarios,such as optical ***,it is still challenging to simultaneously achieve high responsivity,high transparency,and satisfying self-powered ***,we demonstrated high-performance,transparent,and self-powered photoelectrochemical-type(PEC)SBUV PDs based on vertically grown ultrathin In_(2)O_(3) nanosheet arrays(NAs)with a three-dimensional(3D)porous *** 3D porous structure simultaneously improves the transmittance in the visible light region,accelerates interfacial reaction kinetics,and promotes photogenerated carrier *** performance of In_(2)O_(3) NAs photoanodes exceeds most reported self-powered PEC SBUV PDs,exhibiting a high transmittance of approximately 80%in the visible light region,a high responsivity of 86.15 mA/W for 254 nm light irradiation,a fast response speed of 15/18 ms,and good multicycle *** In_(2)O_(3) NAs also show excellent spectral selectivity with an ultrahigh solar-blind rejection ratio of 1319.30,attributed to the quantum confinement effect induced by the ultrathin feature(2-3 nm).Furthermore,In_(2)O_(3) NAs photoanodes show good capability in underwater optical *** work demonstrated that a 3D porous structure is a powerful strategy to synchronously achieve high responsivity and transparency and provides a new perspective for designing high-performance,transparent,and self-powered PEC SBUV PDs.

关键词： In_(2)O_(3) three-dimensional porous transparent photoelectrochemical solar-blind photodetectors

Sonodynamic therapy for the treatment of atherosclerosis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 666-677页

作者： Yan Zhang Ying Yang Yudi Feng Xueyan gao Liping Pei Xiaopan Li Bingxin gao Lin Liu Chengzeng Wang Shuochen gao The Department of Ultrasound The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China The Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China

Atherosclerosis(AS)is a chronic inflammatory disease of large and medium-sized arteries that leads to ischemic heart disease,stroke,and peripheral vascular *** the current treatments,mortality and disability still remain *** therapy(SDT),a non-invasive and localized methodology,has been developed as a promising new treatment for inhibiting atherosclerotic progression and stabilizing *** progress has been made through cell and animal assays,as well as clinical *** example,the effect of SDT on apoptosis and autophagy of cells in AS,especially macrophages,and the concept of non-lethal SDT has also been *** this review,we summarize the ultrasonic parameters and known sonosensitizers utilized in SDT for AS;we elaborate on SDT's therapeutic effects and mechanisms in terms of macrophages,T lymphocytes,neovascularization,smooth muscle cells,lipid,extracellular matrix and efferocytosis within plaques;additionally,we discuss the safety of SDT.A comprehensive summary of the confirmed effects of SDT on AS is conducted to establish a framework for future researchers.

关键词： Atherosclerosis Sonodynamic therapy Sonosensitizer Ultrasound Reactive oxygen species

OnFractional(g,f,n′,m)-Critical Covered Graphs

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Journal of the Operations Research Society of China 2024年第2期12卷 446-460页

作者： Wei gao Wei-Fan Wang School of Information Science and Technology Yunnan Normal UniversityKunming 650500YunnanChina Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina

The main contribution in this article is threefold:(1)we show the necessary and sufficient condition for graphs to be fractional(g,f)-covered which can be expressed in different forms,and extended to fractional(g,f,m)-covered graphs;(2)the concept of fractional-critical covered graph is put forward and its necessary and sufficient condition is given;(3)we present the degree condition for a graph to be fractional(g,f,n′,m)-critical covered,and show that degree bound is sharp when m is ***,the related result in fractional(a,b,n′,m)-critical covered setting is also verified.

关键词： Network Fractional factor Data transmission Fractional covered graph Fractional critical covered graph

改进人工免疫算法的多机协同空战目标分配方法

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西北工业大学学报 2019年第2期37卷 354-360页

作者：高阳阳陈双艳余敏建海静房瑞跃中国人民解放军93175部队空军工程大学空管领航学院中国人民解放军94754部队中国人民解放军95026部队

针对多机协同空战目标分配问题,在我方综合优势函数建模的基础上,提出了一种改进人工免疫算法。首先采用随机生成法和人工构造法创建2个初始种群,保证了初始种群的多样性;然后采用2种不同的选择、交叉、变异操作进行进化;接着采用设计... 详细信息

针对多机协同空战目标分配问题,在我方综合优势函数建模的基础上,提出了一种改进人工免疫算法。首先采用随机生成法和人工构造法创建2个初始种群,保证了初始种群的多样性;然后采用2种不同的选择、交叉、变异操作进行进化;接着采用设计的新移民算子进行种群间信息交换,进一步增加种群多样性,提高搜索效率。最后设计实验将改进人工免疫算法与3种类型的人工免疫算法进行了对比。仿真结果表明:改进人工免疫算法能够有效改善早熟收敛问题,提高搜索效率,获得最优分配方案,适用于多机协同空战目标分配问题,满足实际作战需求。

关键词：多机协同目标分配改进人工免疫算法移民算子分配方案

Spatiotemporal pattern of climate change in the China-Myanmar Economic Corridor from 1901 to 2018

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Journal of Mountain Science 2024年第1期21卷 131-145页

作者： YANG Xiaoliu LI Yungang gao Lu Institute of Geography Fujian Normal UniversityFuzhou 350117China School of Geographical Sciences Fujian Normal UniversityFuzhou 350117China Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650500China Fujian Provincial Engineering Research Center for Monitoring and Accessing Terrestrial Disasters Fujian Normal UniversityFuzhou 350117China Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China

The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.

关键词： China-Myanmar Economic Corridor CRU Air temperature Precipitation Spatiotemporal pattern

Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

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Neural Regeneration Research 2024年第10期19卷 2144-2156页

作者： Ying Ma Yue Qiao Xiang gao Spinal Cord and Brain Injury Research Group Stark Neuroscience Research InstituteIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关键词： antidepressants chronic pain depression exercise hippocampal neurogenesis inflammation inhibition neuroinflammation physical activity deficits social isolation spinal cord injury

New sustainable polymers with on-demand depolymerization property

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Science China Chemistry 2024年第9期67卷 2803-2841页

作者： yangyang Sun Zesheng An Yanshan gao Rongrong Hu Ye Liu Hua Lu Xiao-Bing Lu Xuan Pang Anjun Qin Yong Shen Youhua Tao Yu-Zhong Wang Junpeng Wang Gang Wu Guang-Peng Wu Tie-Qi Xu Xing-Hong Zhang Yuetao Zhang Zhenbiao Zhang Jian-Bo Zhu Miao Hong Zhibo Li State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China State Key Laboratory Base of Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsDalian University of TechnologyDalian 116024China Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(MoE) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)College of ChemistryState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610064China School of Polymer Science and Polymer Engineering the University of AkronAkronOH 44325USA MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

To combat the crisis of today's synthetic polymers arising from unsustainable production and disposal,it is essential for the synthetic polymer community to reshape the current polymer industry with sustainable *** an emerging class of sustainable polymers,the development of chemically depolymerizable polymers(CDPs),which can undergo closed-loop depolymerization/repolymerization cycles to reproduce virgin polymers without the loss of properties from recovered monomers,offers an ideal solution to preserve finite natural resources,provides a feasible solution to the end-of-life issue of polymer waste,and thereby establishes a circular materials ***,two grand key challenges have been encountered in the establishment of practically useful CDPs:how to balance polymerization and depolymerization ability and how to unify conflicted depolymerizability and physical ***,this critical review article presents our vision for summarizing feasible strategies to overcome the above two significant challenges and the design principles for constructing an ideal CDP by highlighting selected major progress made in this rapidly expanding field.

关键词： chemically depolymerizable polymers sustainable polymers depolymerization monomer recovery degradation plastics

Incentive Feedback Stackelberg Strategy in Mean-Field Type Stochastic Difference Games

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Journal of Systems Science & Complexity 2024年第4期37卷 1425-1445页

作者： gao Wenhui LIN Yaning ZHANG Weihai School of Mathematics and Statistics Shandong University of TechnologyZibo 255000China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

This paper designs an incentive Stackelberg strategy for the discrete-time stochastic systems with mean-field *** conditions for the existence of such a design are ***,the incentive strategy is obtained as a feedback form including the deviation of the state and its mathematical ***,the stability analysis is *** is found that the stability can be guaranteed by the *** addition,the specific algorithm is proposed and its effectiveness is checked by two examples.

关键词： Discrete-time mean-field stochastic systems incentive strategy Stackelberg game teamoptimal solution