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Near-field multiple super-resolution imaging from Mikaelian lens to generalized Maxwell's fish-eye lens

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Chinese Physics B 2022年第10期31卷 153-158页

作者： yangyang zhou Huanyang Chen Institute of Electromagnetics and Acoustics and Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamen 361005China

Super-resolution imaging is vital for optical applications, such as high capacity information transmission, real-time bio-molecular imaging, and nanolithography. In recent years, technologies and methods of super-resolution imaging have attracted much attention. Different kinds of novel lenses, from the superlens to the super-oscillatory lens, have been designed and fabricated to break through the diffraction limit. However, the effect of the super-resolution imaging in these lenses is not satisfactory due to intrinsic loss, aberration, large sidebands, and so on. Moreover, these lenses also cannot realize multiple super-resolution imaging. In this research, we introduce the solid immersion mechanism to Mikaelian lens(ML) for multiple super-resolution imaging. The effect is robust and valid for broadband frequencies. Based on conformal transformation optics as a bridge linking the solid immersion ML and generalized Maxwell's fish-eye lens(GMFEL), we also discovered the effect of multiple super-resolution imaging in the solid immersion GMFEL.

关键词： multiple super-resolution imaging Mikaelian lens generalized Maxwell's fish-eye lens conformal transformation optics

A CRISPR-Cas9 screen shows the combination efficacy of lenvatinib plus epidermal growth factor receptor inhibitors for treatment of liver cancer

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Cancer Biology & Medicine 2022年第2期19卷 136-139页

作者： Yuchen Guo yangyang zhou Wenxin Qin State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200032China

Recently,in cooperation with the Netherlands Cancer Institute,we demonstrated that epidermal growth factor receptor(EGFR)activation limited the response of liver cancer to *** original article was published in Nature as a cover story,which resulted in considerable attention from major scientific ***,we were invited by Cancer Biology&Medicine to provide comments on preclinical and clinical findings about the combination of lenvatinib plus EGFR inhibitors as a promising strategy for hepatocellular carcinoma(HCC)*** liver cancer represents the sixth most common malignancy and the third leading cause of cancer-related mortality worldwide,with an estimated 906,000 new cases and 830,000 deaths in 20201.

关键词： treatment finding inhibitors

What is the promising anode material for Na ion batteries?

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Science Bulletin 2018年第3期63卷 146-148页

作者： yangyang zhou Yali Yang Menggai Jiao Zhen zhou School of Materials Science and Engineering National Institute for Advanced Materials Institute of New Energy Material Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University

In the current world,people have ever-increasing demand for *** fuels are now the primary source of energy,and their excess use results in severe problems,such as environmental pollution and global ***,it is essential to develop a new society based on sustainable energies such as wind,tidal and solar energy *** to the intermittence and instability of the above new energies,smart grids with the core technology

关键词：阳极材料 Na 电池离子过量使用环境污染精力太阳能

Aerosol transmission,an indispensable route of COVID-19 spread:case study of a department-store cluster

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 165-176页

作者： Guanyu Jiang Can Wang Lu Song Xing Wang yangyang zhou Chunnan Fei He Liu School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Indoor Air Environmental Quality Control Tianjin 300350China Tianjin Haihe Hospital Tianjin 300350China Tianjin Centers for Disease Control and Prevention Tianjin 300350China

Patients with COVID-19 have revealed a massive outbreak around the world,leading to widespread concerns in global *** out the transmission route of COVID-19 is necessary to control further *** analyzed the data of 43 patients in Baodi Department Store(China)to supplement the transmission route and epidemiological characteristics of COVID-19 in a cluster *** median was estimated to endure 5.95 days(2-13 days).Almost 76.3%of patients sought medical attention immediately upon illness *** median period of illness onset to hospitalization and confirmation were 3.96 days(0-14)and 5.58 days(1-21),*** with different cluster case could demonstrate unique epidemiological characteristics due to the particularity of outbreak ***-CoV-2 can be released into the surrounding air through patient's respiratory tract activities,and can exist for a long time for long-distance ***-CoV-2 RNA can be detected in aerosol in different sites,including isolation ward,general ward,outdoor,toilet,hallway,and crowded public *** factors influencing were analyzed and indicated that the SARS-CoV-2 transportation in aerosol was dependent on temperature,air humidity,ventilation rate and inactivating chemicals(ozone)*** for the infection route of case numbers 2 to 6,10,13,16,17,18,20 and 23,we believe that aerosol transmission played a significant role in analyzing their exposure history and environmental conditions in Baodi Department *** transmission could occur in some cluster cases when the environmental factors are suitable,and it is an indispensable route of COVID-19 spread.

关键词： SARS-CoV-2 COVID-19 Environmental factor Aerosol transmission Epidemiologic characteristic

CHD3 chromatin-remodeling factor PICKLE regulates floral transition partially via modulating LEAFY expression at the chromatin level in Arabidopsis

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Science China(Life Sciences) 2016年第5期59卷 516-528页

作者： Xing Fu Chaonan Li Qing Liang yangyang zhou Hang He Liu-Min Fan State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University Beijing 100871 China

PICKLE(PKL), a putative CHD3 chromatin remodeling factor, has been suggested to be involved in multiple processes in Arabidopsis. Here, we confirmed the late-flowering phenotype caused by pkl mutation with pkl mutants in two different ecotypes, and investigated the possible mechanisms that account for PKL regulation of flowering time. Quantitative RT-PCR and RNA-seq assays showed that expression of the LEAFY gene(LFY) and a number of LFY-regulated floral homeotic genes were down-regulated in seedlings of the pkl mutants. As predicted, overexpression of LFY restored normal flowering time of pkl mutants. Our results suggest that PKL may be involved in regulating flowering time via LFY expression. To uncover the underlying mechanism, Ch IP-PCR using anti-PKL was performed on materials from three developmental stages of seedlings. Our results showed that PKL associated with the genomic sequences of LFY, particularly at 10-day and 25-day after germination. We also showed that loss of PKL affected H3K27me3 level at the promoter of LFY. Taken together, our data suggest that transcriptional regulation of LFY at the chromatin level by PKL may at least partially account for the late-flowering phenotype of pkl mutants.

关键词： chromatin-remodeling factor PICKLE floral transition LEAFY Arabidopsis

Microwave-assisted acid-induced formation of linker vacancies within Zr-based metal organic frameworks with enhanced heterogeneous catalysis

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Chinese Chemical Letters 2021年第2期32卷 787-790页

作者： Yu Liang Chenhui Li Lanjun Chen Jia Huo Mohammed Loubidi yangyang zhou Yanbo Liu State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical Engineering.Hunan UniversityChangsha 410082China Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion.Hunan University of Science and Technology Xiangtan 411201China

Herein,we report a microwave-assisted acid-induced post-treatment method for the formation of linker vacancies within Zr-based metal organic frameworks(Zr-MOFs).The number of linker vacancies can be easily regulated with this method by changing the concentration of the HCl solution and the duration of microwave *** optimized defective UiO-66 showed higher linker defects with a higher specific surface area and thermal *** results of the catalytic cyclization of citronella showed that the Zr-MOFs with more defects exhibited enhanced catalytic *** work may provide a new method for the creation of defective MOFs with high activity and stability.

关键词： Metal-organic frameworks Microwave Acid etching Linker vacancy Stability Heterogeneous catalysis

Optimization of Agrobacterium tumefaciens-Mediated Genetic Transformation of Maize

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Phyton-International Journal of Experimental Botany 2022年第2期91卷 363-374页

作者： Mengtong Liu yangyang zhou Tongyu Liu Jianyu Lu Jing Qu Shuyan Guan Yiyong Ma College of Life Sciences Jilin Agricultural UniversityChangchun130118China College of Agronomy Jilin Agricultural UniversityChangchun130118China

Immature embryos of inbred maize(Zea mays)lines(H8183,H8184,and H8185)were used for Agrobacterium *** used theβ-glucuronidase gene(GUS)as the target gene and the glufosinate resistance gene(bar)as the selection *** conducted research on several aspects,such as different genotypes,coculture conditions,screening agent concentrations,and concentrations of indole-3-butytric acid(IBA),6-benzylaminopurine(6-BA),and ascorbic acid(Vc)in the differentiation *** optimized the genetic transformation system,and the obtained results indicated that among the three lines studied,the induction rate of H8185 was the highest at 93.2%,followed by H8184,with H8183 having the lowest induction rate(80.1%).The best coculture method was that using the N6 coculture medium layered with a sterile filter *** orthogonal analysis,we found that the optimal combination of the three factors in the differentiation medium was A_(3)(1 mg mL^(−1)IBA),B_(3)C_(1)(1.6 mg mL^(−1)6-BA),and D_(3)(1.5 mg mL^(−1)Vc).Through GUS staining analysis,Bar test-strip analysis,and polymerase chain reaction,five transgenic plants were finally *** study established the optimal conditions for genetic transformation in maize.

关键词： Maize optimization genetic regeneration immature embryos Agrobacterium-mediated transformation

Identification,expression analysis,and functional characterization of ghrelin and its receptors in spotted sea bass(Lateolabrax maculatus)

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Marine Life Science & Technology 2020年第4期2卷 349-359页

作者： Peng Yu yangyang zhou Xin Qi Hongying Fan Kaiqiang Zhang Xiaoyan Zhang Yun Li Haishen Wen Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China

Ghrelin(Ghrl),an appetite-inducing peptide hormone secreted by the stomach,is the endogenous ligand for the growth hormone secretagogue receptor(Ghs-r).In this study,we identified the preproghrelin gene and its receptors in spotted sea bass(Lateolabrax maculatus).The ghrl gene consisted of an open reading frame(ORF)of 324 nucleotides encoding 107 amino acids,and the premature protein contained a 20-amino-acid mature *** a syntenic analysis,we also validated the annotation of growth hormone secretagogue receptor la(ghs-rla)and growth hormone secretagogue receptor la-1ike(ghs-rla-like),which contained seven-transmembrane structures,in spotted sea *** ORF of ghs-rla consisted of 1152 bp that encoded a 383-amino-acid protein,and(ghs-rla-like) contained an ORF of 2631 bp and produced a protein with 876 amino acids.A phylogenetic analysis showed that spotted sea bass ghrl and its receptors clustered with those of other fishes and were more distantly related to those of other *** situ hybridization revealed that ghrl was highly expressed in the stomach and localized in the mucosa and *** expression of these genes varied during short-term starvation in a time-dependent *** vitro studies showed that after incubation with Ghrl for 3 h enhanced the expression of motilin(mln),gastrin(gas)and cholecystokinin(cck)、but this effect vanished after 6 h of *** summary,Ghrl and its receptors might play important roles in the regulation of food intake in spotted sea bass.

关键词： Ghrl Ghs-r-In vitro experiment Localization Spotted sea bass Short-term starvation

A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3367-3382页

作者： Zhejie Chen Wei Hao Caifang Gao yangyang zhou Chen Zhang Jinming Zhang Ruibing Wang Yitao Wang Shengpeng Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Macao Centre for Research and Development in Chinese Medicine University of MacaoMacao 999078China College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China

With the development of synthesis technology, modified messenger RNA(mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 ***-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment.

关键词： Polyphenol mRNA IL-10 Colitis Inflammatory bowel disease Drug delivery mRNA delivery Supramolecular binding