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阿司匹林肠溶片联合甲泼尼龙琥珀酸钠治疗儿童过敏性紫癜的效果观察

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临床医学工程 2024年第5期31卷 551-552页

作者：韩思张阳阳张菱玉平顶山市第一人民医院儿科河南平顶山467000

目的观察阿司匹林肠溶片联合甲泼尼龙琥珀酸钠治疗儿童过敏性紫癜的效果。方法选择2022年4月至2023年4月我院收治的过敏性紫癜患儿92例,随机分为两组各46例,两组患儿入院后均给予基础治疗,对照组予以口服阿司匹林肠溶片,观察组在对照组... 详细信息

目的观察阿司匹林肠溶片联合甲泼尼龙琥珀酸钠治疗儿童过敏性紫癜的效果。方法选择2022年4月至2023年4月我院收治的过敏性紫癜患儿92例,随机分为两组各46例,两组患儿入院后均给予基础治疗,对照组予以口服阿司匹林肠溶片,观察组在对照组基础上注射用甲泼尼龙琥珀酸钠,两组均维持1周治疗。比较两组的临床疗效、症状消退时间、炎性反应及不良反应。结果观察组总有效率高于对照组,皮疹、关节肿痛、便血及肾损伤消退时间短于对照组(P0.05)。结论阿司匹林肠溶片联合甲泼尼龙琥珀酸钠治疗儿童过敏性紫癜的临床疗效显著,能够缩短患儿症状消退时间,减轻炎性反应,且不会增加药物不良反应,安全性高。

关键词：儿童过敏性紫癜阿司匹林肠溶片甲泼尼龙琥珀酸钠效果

Controllable synthesis of metallic Bi from commercial Bi_2O_3 via one-pot solvothermal reduction method

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Chinese Journal of Chemical Engineering 2017年第9期25卷 1202-1206页

作者： Lei Yang yangyang zhang Hua Li Hezhou Liu State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University

Metallic bismuth crystal is one important and interesting semimetal that has attracted great attention owing to its unique thermal and electrical properties. Herein, we report a facile, green, cost-effective and sustainable solvothermal process using ethanol, glycol, isopropanol, phenylcarbinol as solvent and commercial Bi_2O_3 as the starting material to produce high-purity metallic Bi with tunable morphologies on large scale. It is found that all alcohols are capable of reducing Bi_2O_3 to Bi and the reducibility of glycol is proved to be the strongest. The highest purity of the resultant Bi is calculated to be 99.74%. What's more, the morphology of final Bi particles is controllable by adding various types and concentrations of additives. As a consequence, our work lays the root for the large scale solvothermal production of high-purity Bi particles with various regular morphologies.

关键词： Solvothermal Alcohol Metal Morphology Bismuth Reduction

血清微小RNA-21与2型糖尿病合并非酒精性脂肪性肝病的相关性研究

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中华糖尿病杂志 2024年第2期16卷 220-225页

作者：张洋洋吕亚亚左玉琼陈倩权金星刘静刘菊香宁夏医科大学临床医学院银川750000 甘肃省人民医院内分泌科、甘肃省内分泌代谢病重点实验室兰州730000 甘肃省人民医院病案管理科兰州730000

目的探讨血清微小RNA-21(miR-21)与2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)间的相关性。方法为横断面研究。选取2022年8月至2023年6月在甘肃省人民医院内分泌科住院的T2DM患者及同时期该院体检中心年龄、性别和体重指数(BMI)匹... 详细信息

目的探讨血清微小RNA-21(miR-21)与2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)间的相关性。方法为横断面研究。选取2022年8月至2023年6月在甘肃省人民医院内分泌科住院的T2DM患者及同时期该院体检中心年龄、性别和体重指数(BMI)匹配的健康体检者作为研究对象。根据有无NAFLD将T2DM患者分为单纯T2DM组和T2DM合并NAFLD组,同期健康体检者纳入健康对照组。收集所有研究对象的年龄、性别、糖尿病病程、身高、体重,并计算BMI,检测其miR-21、哺乳动物雷帕霉素靶蛋白(mTOR)、高密度脂蛋白胆固醇(HDL-C)、白细胞介素-6(IL-6)、糖化血红蛋白(HbA_(1c))、空腹血糖(FPG)、空腹胰岛素(FINS),并计算稳态模型评估胰岛素抵抗指数(HOMA-IR)。采用单因素方差分析、Kruskal-WallisH检验或χ^(2)检验进行组间比较,采用Spearman相关性分析法分析miR-21水平与各指标间的相关性,采用逐步线性回归分析法分析血清miR-21水平的独立影响因素。结果共纳入研究对象136例,包括T2DM患者91例,健康体检者45例。其中单纯T2DM组45例,T2DM合并NAFLD组46例,健康对照组45例。与健康对照组相比,单纯T2DM与T2DM合并NAFLD组研究对象血清miR-21均降低(P<0.05)。Spearman相关性分析结果显示,调整年龄、性别、糖尿病病程和BMI后,血清miR-21水平与HDL-C、mTOR均呈正相关(r值分别为0.228和0.175,均P<0.05),与HbA_(1c)、FPG、FINS、HOMA-IR、IL-6均呈负相关(r值分别为-0.320、-0.230、-0.178、-0.283和-0.361,均P<0.05)。逐步线性回归结果显示,BMI、HbA_(1c)和IL-6均为血清miR-21水平的独立影响因素(t值分别为2.360、-2.354和-3.188,均P<0.05)。结论血清miR-21水平与T2DM合并NAFLD相关,miR-21水平下调可能与胰岛素抵抗、炎症反应和糖脂代谢途径相关。

关键词：糖尿病,2型非酒精性脂肪性肝病炎症反应胰岛素抵抗微小RNA-21

Weak Hardy-type spaces associated with ball quasi-Banach function spaces I:Decompositions with applications to boundedness of Calderón-Zygmund operators

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Science China Mathematics 2021年第9期64卷 2007-2064页

作者： yangyang zhang Dachun Yang Wen Yuan Songbai Wang Laboratory of Mathematics and Complex Systems(Ministry of Education of China) School of Mathematical SciencesBeijing Normal UniversityBeijing100875China College of Mathematics and Statistics Hubei Normal UniversityHuangshi435002China

Let X be a ball quasi-Banach function space on R^(n).In this article,we introduce the weak Hardytype space WH_(X)(R^(n)),associated with X,via the radial maximal *** that the powered HardyLittlewood maximal operator satisfies some Fefferman-Stein vector-valued maximal inequality on X as well as it is bounded on both the weak ball quasi-Banach function space WX and the associated space,we then establish several real-variable characterizations of WH_(X)(R^(n)),respectively,in terms of various maximal functions,atoms and *** an application,we obtain the boundedness of Calderón-Zygmund operators from the Hardy space H_(X)(R^(n))to WH_(X)(Rn),which includes the critical *** these results are of wide ***,when X:=M^(q)_(p)(R^(n))(the Morrey space),X:=L^(p)(R^(n))(the mixed-norm Lebesgue space)and X:=(EΦq)t(Rn)(the Orlicz-slice space),which are all ball quasi-Banach function spaces rather than quasiBanach function spaces,all these results are even *** to the generality,more applications of these results are predictable.

关键词： ball quasi-Banach function space weak Hardy space Orlicz-slice space maximal function atom molecule Calderón-Zygmund operator

胸腺肽类药物辅助治疗重症肺炎有效性和安全性的系统综述与用药合理性讨论

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中华疾病控制杂志 2024年第5期28卷 596-606页

作者：蒋子昀张阳阳杨会林周建国李迅北京中医药大学管理学院北京100029 北京中医药大学第二临床医学院北京100078 北京中医药大学房山医院北京102488 北京易康医疗科技有限公司北京100062 北京中医药大学循证医学中心北京100029

目的评价胸腺肽类药物辅助治疗重症肺炎的有效性和安全性并探讨应用的合理性。方法检索中国知网、万方数据、维普、Sinomed、Pubmed、Embase、Cochrane Library数据库自建库至2023年12月发表的胸腺肽类药物辅助治疗重症肺炎的随机对... 详细信息

目的评价胸腺肽类药物辅助治疗重症肺炎的有效性和安全性并探讨应用的合理性。方法检索中国知网、万方数据、维普、Sinomed、Pubmed、Embase、Cochrane Library数据库自建库至2023年12月发表的胸腺肽类药物辅助治疗重症肺炎的随机对照试验(randomized controlled trial, RCT),经过严格的筛选后,使用Cochrane偏倚风险评估工具评估文献质量,使用Revman 5.4软件进行统计分析。结果纳入28项RCT(2 228例患者)。结果显示胸腺肽组死亡率(RR=0.51, 95%CI:0.32~0.83,P=0.006)、有效率(RR=1.24, 95%CI:1.19~1.30,P0.05)。亚组分析显示≥60岁的人群ICU住院天数缩短更多。证据质量普遍较低,部分指标存在较高异质性。结论基于现有证据,胸腺肽类药物辅助治疗重症肺炎有一定优势,但当前的证据存在局限性,不足以支持其在国内广泛应用的合理性,未来需要开展更多高质量的RCT,并且对药物的安全性和经济学效益进行深入研究。

关键词：重症肺炎胸腺肽胸腺五肽系统综述免疫治疗

Optimal patching locations and orientations for maximum energy harvesting efficiency of ultrathin flexible piezoelectric devices mounted on heart surface

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Theoretical & Applied Mechanics Letters 2022年第3期12卷 178-183页

作者： yangyang zhang Ji Wang Chaofeng Lü Faculty of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China College of Civil Engineering and Architecture Soft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310058China

Flexible piezoelectric energy harvesters(PEHs)have gained lots of attention in recent years,because of their potential biomechanical applications,such as powering implantable *** in vivo animal experiments have demonstrated that the output power of a flexible PEH varies remarkably with patching orientations and locations,but the underlying mechanism remains unclear ***,an electromechanical model for a flexible PEH installed on a beating heart is proposed,and a concise relationship between the output power of the device and myocardium strain is *** results demonstrate that the patching orientations have a significant impact on the output power of the PEH,and the optimal patching orientations for all patching locations are approximately 15–20 degree for PEHs mounted on the left *** simple theoretical method provided here would be universally effective for choosing the optimal patching locations and orientations of flexible PEHs installed on a nonhomogeneous deformed surface.

关键词： Biomechanical energy harvester Flexible electronics Heart motion Myocardial strain

乡村振兴背景下吉林省农业产业人才链建设措施探析

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南方农业 2024年第18期18卷 87-89页

作者：王乐祝芳馨张洋洋白城师范学院管理与法学学院吉林白城137000

加快农业产业建设是推动吉林省乡村振兴的关键。人才链能够赋能产业链,对吉林省农业产业发展至关重要。为促进吉林省农业产业高质量发展,总结人才链建设要点,论述吉林省农业产业发展现状,提出发挥教育资源优势,增加人力资本产出;创新人... 详细信息

加快农业产业建设是推动吉林省乡村振兴的关键。人才链能够赋能产业链,对吉林省农业产业发展至关重要。为促进吉林省农业产业高质量发展,总结人才链建设要点,论述吉林省农业产业发展现状,提出发挥教育资源优势,增加人力资本产出;创新人才共享模式,激发社会资本活力;健全人才管理体制,调配农村人才合理流动;增加社会资产投入,满足人才各项发展需求等建设措施。

关键词：乡村振兴农业产业人才链吉林省

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古黄河三角洲典型钻孔XJ01第四纪沉积物地球化学特征

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矿产勘查 2024年第6期15卷 938-945页

作者：姚维军梁兴江张洋洋江苏省地质勘查技术院江苏南京210049

江苏古黄河三角洲为全球海陆相互作用研究的典型地区,研究其第四纪沉积环境演化有助于进一步认识和理解海陆变迁、气候变化特征。本文基于XJ01典型钻孔第四纪沉积物的常量、微量元素地球化学,开展了沉积环境示踪。常量元素Al_(2)O_(3)、... 详细信息

江苏古黄河三角洲为全球海陆相互作用研究的典型地区,研究其第四纪沉积环境演化有助于进一步认识和理解海陆变迁、气候变化特征。本文基于XJ01典型钻孔第四纪沉积物的常量、微量元素地球化学,开展了沉积环境示踪。常量元素Al_(2)O_(3)、Fe_(2)O_(3)、FeO、MgO、CaO、MnO、P_(2)O_(5)、TiO_(2)总体上与SiO_(2)呈负相关关系。钻孔中地球化学元素曲线中,CIA、SiO_(2)/Al_(2)O_(3)、SiO_(2)/(Al_(2)O_(3)+Fe_(2)O_(3))、SiO_(2)/(K_(2)O+Na_(2)O+CaO+MgO)等变化趋势基本一致,微量元素Be、Rb、Cr、Cu与Rb/Sr变化趋势基本一致。地球化学元素曲线钻孔中沉积物分为10个带,分带反映该孔第四纪沉积环境由还原到氧化、水环境由深水到浅水、沉积相由陆相到海相、古气候由湿热到干冷频繁交替的特征。该研究成果为恢复古黄河三角洲地区第四纪地质演化过程提供了基础地质资料。

关键词：古黄河三角洲第四纪地球化学沉积环境

Application of Optically Stimulated Luminescence Technique in Exploring a Concealed Sandstone-type Uranium Deposit

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Acta Geologica Sinica(English Edition) 2022年第2期96卷 571-581页

作者： KANG Huan CHEN Yuelong XUE Guoliang ZHAO Junxiang zhang Na zhang yangyang State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094China Key Laboratory of Crustal Dynamics Institute of Crustal DynamicsChina Earthquake AdministrationBeijing 100085China

Identifying ore-induced geochemical anomalies at the surface that indicate concealed deposits in buried areas remains a significant challenge in geochemical exploration. In this study, in order to trace the source of the geochemical anomalies, systematic luminescence intensity analyses were conducted on quartz grains from the Quaternary regolith at the Hadatu sandstone-type uranium deposit in the Erenhot Basin. The optically stimulated luminescence(OSL) ages were much older than the depositional ages of the Quaternary regolith. Moreover, quartz OSL ages were closely related to both borehole grades and sampling depths. Thus, the abnormal mineral OSL ages from near-surface sediments were ultimately controlled by the sandstone-type uranium deposits. This is identical to the rapid changes of quartz OSL ages(0.063 ka/cm) and equivalent doses(0.19 Gy/cm) with depths in a given sampling site. The instantaneous soil radon concentration was positively correlated with the quartz OSL apparent age, indicating their ore-induced origin and, as a result, their effectiveness in the exploration of concealed uranium deposits. Other parameters, including mobile-state uranium and;Po contents, were poorly correlated with quartz OSL ages and therefore should only be used with caution for geochemical exploration. This is the first time an attempt has been made to discriminate the ore-induced sources for different surface anomaly parameters, including instantaneous soil radon, mobile-state uranium and;Po contents for concealed sandstonetype uranium deposits.

关键词： OSL dating geochemical anomaly ore-induced anomaly concealed sandstone-type uranium deposit