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Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

Acta Pharmaceutica Sinica B 2024年第1期14卷 350-364页

作者： Yongshun Zhang Lan Yang yangsen ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng Ma Tao Gong Ling Zhang Zhirong Zhang Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)***,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB ***,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor *** demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell ***,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in *** order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor *** anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy.

关键词： Triple therapy Adeno-associated virus PTEN PPSG@anti-PD-1 CpG Immunogenic cell death Antitumor immune response Immune memory

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母猪精准养殖智能感知技术研究进展

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华南农业大学学报 2024年第5期45卷 635-648页

作者：刘龙申柳荦周杰欧扬森薛鸿翔南京农业大学人工智能学院江苏南京210031 农业农村部养殖装备重点实验室江苏南京210031 南京农业大学动物医学院江苏南京210095 南京农业大学工学院江苏南京210031

母猪的生长状况、繁殖性能与健康状况是猪场管理的重要生产要素,直接关系到猪场的经济效益。我国母猪养殖还存在生产管理智能化水平低、健康管理效率低、生产力水平低等突出问题,制约了我国养殖业的高质量发展。本文从母猪生长信息感知... 详细信息

母猪的生长状况、繁殖性能与健康状况是猪场管理的重要生产要素,直接关系到猪场的经济效益。我国母猪养殖还存在生产管理智能化水平低、健康管理效率低、生产力水平低等突出问题,制约了我国养殖业的高质量发展。本文从母猪生长信息感知技术、繁殖行为监测技术、健康状态感知技术等3个方面,总结了母猪精准养殖管理中生长、生理、健康监测的研究和发展现状,分析了母猪精准养殖技术的薄弱环节,对母猪养殖智慧管控系统的建设提出了建议,并对未来的发展趋势进行了展望,以期为我国养猪业绿色高效智能转型升级与智能养猪工厂的建设提供参考。

关键词：精准养殖母猪养猪场智能感知行为表型监测健康管理

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Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2219-2233页

作者： Fuhua Wu Shuang Luo Yongshun Zhang yangsen ou Hairui Wang Zhaofei Guo Chunting He Shuting Bai Penghui He Min Jiang Xiaoyan Chen Guangsheng Du Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines,the epidemic prevention and control are still ***,we employ a capsid and antigen structure engineering(CASE)strategy to manufacture an adenoassociated viral serotype 6-based vaccine(S663V-RBD),which expresses trimeric receptor binding domain(RBD)of spike protein fused with a biological adjuvant ***,the engineered S663V-RBD could rapidly induce a satisfactory RBD-specific IgG titer within 2 weeks and maintain the titer for more than 4 *** to the licensed BBIBP-CorV(Sinopharm,China),a single-dose S663V-RBD induced more endurable and robust immune responses in mice and elicited superior neutralizing antibodies against three typical SARS-CoV-2 pseudoviruses including wild type,C.37(Lambda)and B.1.617.2(Delta).More interestingly,the intramuscular injection of S663V-RBD could overcome pre-existing immunity against the *** its effectiveness,the CASE-based S663VRBD may provide a new solution for the current and next pandemic.

关键词： AAV vectors Capsid engineering Vaccine Antigen structure design SARS-CoV-2

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Long-range asymmetric Cherenkov radiation

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 170-171页

作者： Gang Zhong Qingdong ou Macao Institute of Materials Science and Engineering(MIMSE) Faculty of Innovation EngineeringMacao University of Science and TechnologyTaipaMacao 999078China

Cherenkov radiation(CR)is gaining increasing attention as a high-output power Terahertz radiation source,and it plays a significant role in particle detectors,accelerators,and space science[1].This captivating phenomenon was first observed by Cerenkov in 1934 and was later explained theoretically by Tamm and Frank in 1937,earning them the Nobel Prize in Physics in *** occurs when charged particles move faster than the phase velocity of light in a specific medium.

关键词： asymmetric faster explained

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The low Mach number limit of non-isentropic magnetohydrodynamic equations with large temperature variations in bounded domains

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Science China Mathematics 2024年第4期67卷 787-818页

作者： Min Liang Yaobin ou School of Mathematics Renmin University of ChinaBeijing 100872China

This paper verifies the low Mach number limit of the non-isentropic compressible magnetohydrodynamic(MHD)equations with or without the magnetic diffusion in a three-dimensional bounded domain when the temperature variation is large but *** uniform estimates of strong solutions are established in a short time interval independent of the Mach number,provided that the slip boundary condition for the velocity and the Neumann boundary condition for the temperature are imposed and the initial data is well-prepared.

关键词： low Mach number limit non-isentropic compressible magnetohydrodynamic equations large temperature variations bounded domains

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High-throughput screening of single-atom catalysts confined in monolayer black phosphorus for efficient nitrogen reduction reaction

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Nano Research 2024年第4期17卷 2360-2367页

作者： Xiao-Yan Li Manyi Duan Pengfei ou Department of Electrical and Computer Engineering University of TorontoTorontoOntario M5S 1A4Canada School of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610101China Department of Chemistry Northwestern UniversityEvanstonIL 60208USA

The discovery of metal-nitrogen centers as the active sites for electrolysis has aroused significant interest in utilizing single-atom catalysts for nitrogen reduction reaction(NRR).Properly designed nanostructured catalysts that strongly interact with nitrogen molecules(N_(2))can promote adsorption and activation,thereby resulting in efficient catalysts with high stability,activity,and *** this study,using density functional theory calculations,we selected monolayer black phosphorus(BP)as the substrate and screened a series of single-atom transition metals confined in tri-coordinated and tetra-coordinated active centers(without and with N dopants)to electro-catalyze *** a result,we have identified two promising candidates(Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4)),which exhibit not only low overpotentials of 0.56 and 0.49 V but also high thermodynamic and electrochemical stability,as well as good selectivity towards NRR over the competing hydrogen evolution *** also demonstrate the ability of Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4) to activate and hydrogenate N_(2) by donating electrons and regulating charge *** study not only predicts new BP-based promising catalysts but also provides guidance for the rational design of high-performance NRR electrocatalysts under ambient conditions.

关键词： N_(2) electroreduction reaction single-atom catalysts black phosphorus density functional theory high-throughput calculations

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Block Basis for Modular Coinvariants of Pseudo-Reflection Groups

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Algebra Colloquium 2024年第1期31卷 41-48页

作者： Ke ou School of Statistics and Mathematics Yunnan University of Finance and Economics Kunming 650221China

We investigate the block basis for modular coinvariants of finite pseudo-reflection *** are particularly interested in the case of a subgroup G of the parabolic subgroups of GLn(q)which generalizes the Weyl groups of ... 详细信息

关键词： modular invariant theory pseudo-reflection group block basis coinvariant

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Asymmetric time-varying integral barrier Lyapunov function based adaptive optimal control for nonlinear systems with dynamic state constraints

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Frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 887-902页

作者： Yan WEI Mingshuang HAO Xinyi YU Linlin ou College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China

This paper investigates the issue of adaptive optimal tracking control for nonlinear systems with dynamic state *** asymmetric time-varying integral barrier Lyapunov function(ATIBLF)based integral reinforcement learning(IRL)control algorithm with an actor–critic structure is first *** ATIBLF items are appropriately arranged in every step of the optimized backstepping control design to ensure that the dynamic full-state constraints are never ***,optimal virtual/actual control in every backstepping subsystem is decomposed with ATIBLF items and also with an adaptive optimized ***,neural networks are used to approximate the gradient value *** to the Lyapunov stability theorem,the boundedness of all signals of the closed-loop system is proved,and the proposed control scheme ensures that the system states are within predefined compact ***,the effectiveness of the proposed control approach is validated by simulations.

关键词： State constraints Asymmetric time-varying integral barrier Lyapunov function(ATIBLF) Adaptive optimal control Nonlinear systems

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Pixel-level crack segmentation of tunnel lining segments based on an encoder–decoder network

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 681-698页

作者： Shaokang Hou Zhigang ou Yuequn HUANG Yaoru LIU State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China China Renewable Energy Engineering Institute Beijing 100120China State Key Laboratory of Stimulation and Regulation of Water Cycles in River Basins China Institute of Water Resources and Hydropower ResearchBeijing 100038China Hunan Provincial Water Resources Development&Investment Co. Ltd.Changsha 410007China

Regular detection and repair for lining cracks are necessary to guarantee the safety and stability of *** development of computer vision has greatly promoted structural health *** study proposes a novel encoder–decoder structure,CrackRecNet,for semantic segmentation of lining segment cracks by integrating improved VGG-19 into the U-Net *** image acquisition equipment is designed based on a camera,3-dimensional printing(3DP)bracket and two laser rangefinders.A tunnel concrete structure crack(TCSC)image data set,containing images collected from a double-shield tunnel boring machines(TBM)tunnel in China,was *** data preprocessing operations,such as brightness adjustment,pixel resolution adjustment,flipping,splitting and annotation,2880 image samples with pixel resolution of 448×448 were *** model was implemented by Pytorch in PyCharm processed with 4 NVIDIA TITAN V *** the experiments,the proposed CrackRecNet showed better prediction performance than U-Net,TernausNet,and *** paper also discusses GPU parallel acceleration effect and the crack maximum width quantification.

关键词： tunnel lining segment crack detection semantic segmentation convolutional neural network encoder-decoder structure

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Performance Prediction Based Workload Scheduling in Co-Located Cluster

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2043-2067页

作者： Dongyang ou Yongjian Ren Congfeng Jiang School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China

Cloud service providers generally co-locate online services and batch jobs onto the same computer cluster,where the resources can be pooled in order to maximize data center resource *** to resource competition between batch jobs and online services,co-location frequently impairs the performance of online *** study presents a quality of service(QoS)prediction-based schedulingmodel(QPSM)for *** performance prediction of QPSM consists of two parts:the prediction of an online service’s QoS anomaly based on XGBoost and the prediction of the completion time of an offline batch job based on ***-line service QoS anomaly prediction is used to evaluate the influence of batch jobmix on on-line service performance,and batch job completion time prediction is utilized to reduce the total waiting time of batch *** the same number of batch jobs are scheduled in experiments using typical test sets such as CloudSuite,the scheduling time required by QPSM is reduced by about 6 h on average compared with the first-come,first-served strategy and by about 11 h compared with the random scheduling *** with the non-co-located situation,QPSM can improve CPU resource utilization by 12.15% and memory resource utilization by 5.7% on *** show that the QPSM scheduling strategy proposed in this study can effectively guarantee the quality of online services and further improve cluster resource utilization.

关键词： Co-located cluster workload scheduling online service batch jobs data center

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