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业务量工程中负载均衡与能量效率的折中——基于博弈论的多目标优化

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计算机应用研究 2016年第6期33卷 1612-1615页

作者：赵阳明章小宁电子科技大学通信学院成都611731

研究了如何对业务量工程中的两个重要目标:负载均衡和能量效率进行公平折中。为此,基于纳什议价的框架,建立威胁值博弈模型来对业务量路由进行协商。为了避免博弈者自私决策而导致不公平的解或是议价失败,还将威胁值博弈拓展成重复博弈... 详细信息

研究了如何对业务量工程中的两个重要目标:负载均衡和能量效率进行公平折中。为此,基于纳什议价的框架,建立威胁值博弈模型来对业务量路由进行协商。为了避免博弈者自私决策而导致不公平的解或是议价失败,还将威胁值博弈拓展成重复博弈,并用机制设计来保证议价结果存在以及得到的解的公平性。通过严格的数学证明,以及在NSFNET中的应用可以看出,提出的方案不仅易于实施,还能保证对负载均衡和能量效率两个目标折中的公平性。

关键词：流量工程负载均衡能量效率纳什议价多目标优化

Single-cell transcriptome analysis dissects lncRNA-associated gene networks in Arabidopsis

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Plant Communications 2024年第2期5卷 94-105页

作者： zhaohui He yangming Lan Xinkai Zhou Bianjiong Yu Tao Zhu Fa Yang Liang-Yu Fu Haoyu Chao Jiahao Wang Rong-Xu Feng Shimin Zuo Wenzhi Lan Chunli Chen Ming Chen Xue zhao Keming Hu Dijun Chen State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China Department of Bioinformatics College of Life SciencesZhejiang UniversityHangzhou 310058China Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Key Laboratory of Plant Functional Genomics of the Ministry of Education College of AgricultureYangzhou UniversityYangzhou 225009China Co-Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province/Key Laboratory of Crop Genetics and Physiology of Jiangsu Province Yangzhou UniversityYangzhou 225009China Zhejiang Zhoushan High School Zhoushan 316099China National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan LaboratoryWuhan 430070China

The plant genome produces an extremely large collection of long noncoding RNAs(lncRNAs)that are generally expressed in a context-specific manner and have pivotal roles in regulation of diverse biological ***,we mapped the transcriptional heterogeneity of lncRNAs and their associated gene reg-ulatory networks at single-cell *** generated a comprehensive cell atlas at the whole-organism level by integrative analysis of 28 published single-cell RNA sequencing(scRNA-seq)datasets from juvenile Arabidopsis *** then provided an in-depth analysis of cell-type-related lncRNA signatures that show expression patterns consistent with canonical protein-coding gene *** further demon-strated that the cell-type-specific expression of lncRNAs largely explains their tissue *** addi-tion,we predicted gene regulatory networks on the basis of motif enrichment and co-expression analysis of lncRNAs and mRNAs,and we identified putative transcription factors orchestrating cell-type-specific expression of *** analysis results are available at the single-cell-based plant lncRNA atlas data-base(scPLAD;https://***/scPLAD/).Overall,this work demonstrates the power of inte-grative single-cell data analysis applied to plant lncRNA biology and provides fundamental insights into lncRNA expression specificity and associated gene regulation.

关键词： single-cell transcriptomics long noncoding RNAs lncRNAs gene regulatory networks GRNs plants

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刍议房建工程电力增容改造施工技术

城市建筑 2012年第9S期9卷 105-106页

作者：赵阳铭江西中联建设集团有限公司江西330002

本文以辽宁省交通高等专科学校明博楼电容改造为例,首先介绍了增容改造方案的确定过程、工程难点及相应的技术措施,最后提出了增容过程中需注意的问题。

关键词：房建电力增容施工技术

Ultrafast Laser-Induced Excellent Thermoelectric Performance of PEDOT:PSS Films

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Energy & Environmental Materials 2024年第3期7卷 425-431页

作者： Xuewen Wang Yuzhe Feng Kaili Sun Nianyao Chai Bo Mai Sheng Li Xiangyu Chen Wenyu zhao Qingjie Zhang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and EngineeringWuhan University of TechnologyNo.122Luoshi Rd.Wuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory No.1Yangming Rd.Foshan 528200China

Because poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)is water processable,thermally stable,and highly conductive,PEDOT:PSS and its composites have been considered to be one of the most promising flexible thermoelectric ***,the PEDOT:PSS film prepared from its commercial aqueous dispersion usually has very low conductivity,thus cannot be directly utilized for TE ***,a simple environmental friendly strategy via femtosecond laser irradiation without any chemical dopants and treatments was *** optimal conditions,the electrical conductivity of the treated film is increased to 803.1 S cm^(-1)from 1.2 S cm^(-1)around three order of magnitude higher,and the power factor is improved to 19.0μW m^(-1)K^(-2),which is enhanced more than 200 *** mechanism for such remarkable enhancement was attributed to the transition of the PEDOT chains from a coil to a linear or expanded coil conformation,reduction of the interplanar stacking distance,and the removal of insulating PSS with increasing the oxidation level of PEDOT,facilitating the charge *** work presents an effective route for fabricating high-performance flexible conductive polymer films and wearable thermoelectric devices.

关键词： electrical conductivity PEDOT:PSS thermoelectric film ultrafast laser irradiation

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大学生课堂笔记能力提升策略

中国冶金教育 2024年第5期 29-32,37页

作者：赵亚东何寒张阳明安阳工学院机械工程学院河南安阳455000

分析了高校教师在大学生课堂笔记中可以发挥的作用,提出了具体策略:将课堂笔记列入课程考核环节,注意控制讲课的节奏和加强言语及视觉上的提示,以营造记课堂笔记的良好环境;采取引导式笔记策略帮助学生提高课堂笔记的质量,并适当利用翻... 详细信息

分析了高校教师在大学生课堂笔记中可以发挥的作用,提出了具体策略:将课堂笔记列入课程考核环节,注意控制讲课的节奏和加强言语及视觉上的提示,以营造记课堂笔记的良好环境;采取引导式笔记策略帮助学生提高课堂笔记的质量,并适当利用翻转课堂策略,以改善传统教学模式下学生被动记笔记的状态;充分利用其它辅助策略如提供课堂笔记指南、展示笔记样本、收集笔记等,以鼓励学生积极记课堂笔记。

关键词：高校教师课堂笔记引导式笔记翻转课堂

Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the antigenic properties of H5N1 avian influenza viruses

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Science China(Life Sciences) 2019年第1期62卷 76-83页

作者： Chunyang Gu Xianying Zeng yangming Song Yanbing Li Liling Liu Yoshihiro Kawaoka Dongming zhao Hualan Chen State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Division of Virology Department of Microbiology and Immunology Institute of Medical Science University of Tokyo

Antigenic drift forces us to frequently update influenza vaccines; however, the genetic basis for antigenic variation remains largely unknown. In this study, we used clade 7.2 H5 viruses as models to explore the molecular determinants of influenza virus antigenic variation. We generated eight monoclonal antibodies(MAbs) targeted to the hemagglutinin(HA) protein of the index virus A/chicken/Shanxi/2/2006 and found that two representative antigenically drifted clade 7.2 viruses did not react with six of the eight MAbs. The E131 N mutation and insertion of leucine at position 134 in the HA protein of the antigenically drifted strains eliminated the reactivity of the virus with the MAbs. We also found that the amino acid N131 in the H5 HA protein is glycosylated. Our results provide experimental evidence that glycosylation and an amino acid insertion or deletion in HA influence antigenic variation.

关键词： Influenza virus H5N1 antigenic variation genetic basis

Berry texture QTL and candidate gene analysis in grape(Vitis vinifera L.)

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Horticulture Research 2023年第12期10卷 152-164页

作者： Hong Lin Li Ma Qiuyu Guo Cheng Liu yangming Hou Zhendong Liu Yuhui zhao Changyue Jiang Xiuwu Guo Yinshan Guo College of Horticulture Shenyang Agricultural University120 Dongling RoadShenyang110866China Ministry of Education Key Laboratory of Protected Horticulture Shenyang Agricultural UniversityShenyang110866China

Berry texture is a noteworthy economic trait for grape;however,the genetic bases and the complex gene expression and regulatory mechanism for the diverse changes in berry texture are still poorly *** this study,the results suggest that it is difficult to obtain high-mesocarp firmness(MesF)and high-pericarp puncture hardness(PPH)grape cultivars with high pericarp brittleness(PerB).The high-density linkage map was constructed using whole-genome resequencing based on 151 F1 individuals originating from intraspecific hybridization between the firm-flesh cultivar‘Red Globe’and soft-flesh cultivar‘Muscat Hamburg’.The total length of the consensus map was 1613.17 cM,with a mean genetic distance between adjacent bin markers of 0.59 ***-seven quantitative trait loci(QTLs)for berry MesF,PPH,and PerB were identified in linkage groups(LGs)1,3,4,6,8,9,10,11,14,16,and 17,including twelve QTLs that were firstly detected in LGs 6,11,and *** promising candidate genes were identified from the stable QTL regions in LGs 10,11,14,and *** particular,VvWARK2 and VvWARK8 refer to chromosome 17 and are two promising candidate genes for MesF and PPH,as the VvWARK8 gene may increase pectin residue binding with WARK for high berry firmness maintenance and the allele for VvWARK2 carrying the‘CC’and‘GA’genotypes at Chr17:1836764 and Chr17:1836770 may be associated with non-hard texture grape *** addition,real-time quantitative polymerase chain reaction(RT-qPCR)verification revealed that the promising candidate transcription factor genes VvMYB4-like,VvERF113,VvWRKY31,VvWRKY1,and VvNAC83 may regulate cell wall metabolism candidate gene expression for grape berry texture changes.

关键词： cultivar fir Berry

Synthetic Analogues of Betulinic Acid as Potent Inhibitors of PS1/BACE1 Interaction to Reduce Aβ Generation

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Chinese Journal of Chemistry 2017年第1期35卷 103-112页

作者： Chenlu Zhang Xiaoyin Wang Jin Cui Xiaohang Li yangming Zhang Xin Wang Haifeng Gu Wei Li Xin Xie Jian zhao Gang Pei Fajun Nan National Center for Drug Screening State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Translational Medical Center for Stem Cell Therapy Shanghai East Hospital School of Medicine Tongii University Shanghai 200092 China

The lupane-type triterpenoids are endowed with a wide range of biological activities such as antiviral, anti-inflammatory and anticancer activity. We describe here its potential application in Alzheimer＇s disease （AD） treatment as an inhibitor of PS1/BACE1 interaction. 3-a-Akebonoic acid, which emanated from a high throughput screening （HTS）, was discovered to interfere with P S 1/BACE 1 interaction and reduce amyloid β-protein （Aβ） production. In view of the limited source, we instead used naturally rich betulinic acid （compound 2） as starting material for lead optimization and a focused library of its derivatives was constructed to gain a better understanding of the structure activity relationship （SAR） of triterpenoid-type inhibitor of PS1/BACE1 interaction. Compound 22 was finally chosen as the most potent PS 1/BACE 1 interaction inhibitor, which reduced Aβgeneration effectively.

关键词： Alzheimer's disease PS 1/BACE 1 interaction Aβ betulinic acid SAR

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浅议高层建筑给排水工程设计与施工

科技传播 2011年第11期3卷 82-82,85页

作者：王苗连金国军赵扬明浙江嘉华装饰有限公司浙江绍兴312000

高层建筑中给排水系统的工程质量对用户的生活便利及舒适程度有着至关重要的影响。本文从给排水工程的设计和施工两方面入手,通过分析给排水工程施工中的难点问题,提出了有针对性的解决方案以及相关质量控制措施,以保证工程质量,提高建... 详细信息

高层建筑中给排水系统的工程质量对用户的生活便利及舒适程度有着至关重要的影响。本文从给排水工程的设计和施工两方面入手,通过分析给排水工程施工中的难点问题,提出了有针对性的解决方案以及相关质量控制措施,以保证工程质量,提高建筑使用性能。

关键词：高层建筑给排水设计施工质量控制