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Neural Regeneration Research 2011年第36期6卷 2829-2833页

作者： Yong Huang Huiling Xiao Junqi Chen Shanshan Qu Yu Zheng yangjia lu Xinsheng Lai School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 Guangdong Province China Department of Acupuncture and Massage Guangzhou University of Traditional Chinese Medicine Guangzhou 510407 Guangdong Province China

Deactivation is common in cerebral functional imaging. However, the physiological mechanisms responsible for this phenomenon remain poorly understood. The present study analyzed 12 ischemic stroke patients, who were randomly assigned to two groups： one group underwent sham needling and true needling at the Waiguan （SJ 5） in the healthy upper limb and the other group underwent sham and true needling at a sham point. Functional magnetic resonance imaging results showed no activation points in brain tissues following needling at SJ 5. However, compared with sham needling at SJ 5, true needling at SJ 5 deactivated Broadmann 4, 6, 24, and 32 areas. In addition, compared to needling at the sham point, true needling at SJ 5 deactivated bilateral hypothalamus. Results demonstrated that SJ 5 needling in the healthy upper limb resulted in specific directional brain action, as manifested by deactivation of cerebral areas related to motor （Broadmann 4 and 6）, emotion （hypothalamus）, and cognition （Broadmann 24, 32）.

关键词： acupuncture cerebral functional imaging Chinese medicine functional MRI ischemic stroke Waiguan (SJ 5) neural regeneration

Activated and deactivated functional brain areas in the Deqi state: A functional MRI study

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Neural Regeneration Research 2012年第30期7卷 2362-2369页

作者： Yong Huang Tongjun Zeng Guifeng Zhang Ganlong Li Na lu Xinsheng Lai yangjia lu Jiarong Chen Traditional Chinese Medicine School Southern Medical University Guangzhou 510515 Guangdong Province China Rehabilitation Department First People's Hospital Shunde District Foshan 528300 Guangdong Province China Academic Affairs Department Xinxing Chinese Medicine School Xinxing 527400 Guangdong Province China Traditional Chinese Medicine Department Huarui Hospital Southern Medical University Guangzhou 510360 Guangdong Province China Medicophysics Department Guangzhou Medical University Guangzhou 510182 Guangdong Province China Acupuncture and Massage College Guangzhou Traditional Chinese Medicine University Guangzhou 510405 Guangdong Province China Traditional Chinese Medicine Department Guangdong Medical College Dongguan 523808 Guangdong Province China First School of Clinical Medicine Southem Medical University Guangzhou 510515 Guangdong Province China

We compared the activities of functional regions of the brain in the Deqi versus non-Deqi state, as reported by physicians and subjects cludng acupuncture, Twelve healthy volunteers received sham and true needling at the Waiguan （TE5） acupoint. Real-time cerebral functional MRI showed that compared with non-sensation after sham needling, true needling activated Brodmann areas 3, 6, 8, 9, 10, 11, 13, 20, 21, 37, 39, 40, 43, and 47, the head of the caudate nucleus, the parahippocampal gyrus, thalamus and red nucleus. True needling also deactivated Brodmann areas 1,2, 3, 4, 5, 6, 7, 9. 10. 18.***.31.40 and 46.

关键词： needling sham needling Waiguan (TE5) sham point Deqi functional MRI brain region activation deactivation neural regeneration

Differences in functional magnetic resonance imaging following cutaneous and routine acupuncture at different acupoints

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Neural Regeneration Research 2011年第15期6卷 1169-1174页

作者： yangjia lu Junxian Wu Yanqi Zou Junqi Chen Baoci Shan Jiarong Chen Yong Huang Teaching Research Department of Acupuncture School of Traditional Chinese Medicine Southem Medical University Guangzhou 510515 Guangdong Province China Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

Few studies have examined the effects of different stimuli at a single acupoint using functional magnetic resonance *** present study applied acupuncture at the Neiguan（PC 6）,Waiguan（SJ 5）,Zhigou（SJ 6） and Yanglingquan（GB 34） acupoints in healthy *** was used to examine the activation of brain areas in response to different types of acupuncture（cutaneous or routine acupuncture） at each *** were no significant differences in the distribution of activation in the regions of interest between cutaneous and routine acupuncture at the Neiguan,Waiguan,and Zhigou acupoints,but some differences were observed between the two methods of acupuncture at the Yanglingquan *** were no significant differences in the intensity of induced activation between cutaneous and routine acupuncture at the Neiguan,Zhigou and Yanglingquan acupoints,but the activation intensity in the right cerebellum induced by routine acupuncture at the Waiguan acupoint was greater than that induced by cutaneous *** confirmed that cutaneous and routine acupuncture at the Neiguan,Waiguan,Zhigou and Yanglingquan acupoints activated different functional brain areas,and caused activation of different intensities in some areas.

关键词： functional magnetic resonance imaging cutaneous acupuncture routine acupuncture Neiguan (P C6) Waiguan (SJ 5) Zhigou (SJ 6) Yanglingquan (GB 34) neural regeneration

Cerebral functional imaging of Waiguan (SJ 5) acupoint specificity using single-photon emission computed tomography

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Neural Regeneration Research 2011年第6期6卷 428-434页

作者： Yong Huang yangjia lu Ganlong Li Xinsheng Lai Hong Zhang Chunzhi Tang JunjunYang Gustav Wik School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 Guangdong Province China Department of Acupuncture and Massage Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 Guangdong Province China Department of Clinical Medicine University of Bergen Sandviken Hospital Bergen 116011 Norway

The action of needling in acupoint therapy has to first be regulated and integrated by the brain, and then it affects the target organ and manifests its therapeutic effects, which is dependent on the specificity of the acupoints. The authors put forward the hypothesis of the ＂acupoint-related brain＂. Single-photon emission computed tomography was used to explore the activation of brain regions following true needling in true acupoint Waiguan （SJ 5）, sham needling in true acupoint Waiguan, true needling in a sham point, and sham needling in a sham point. The relative specificity of Waiguan in normal persons was analyzed by observing changes in regional cerebral blood flow. Compared with the sham needling in true acupoint group and sham needling in the sham point group, acupuncture at Waiguan can activate brain regions controlling movement. Compared with true needling in the sham point group, acupuncture at Waiguan can also activate brain regions controlling movement. The results suggest that the specificity of needling at an acupoint is related to certain activated cerebral functional regions, which are associated with the clinical application of the acupoint.

关键词： acupoint specificity Waiguan (SJ 5) needling sham needling sham point single-photon emission computed tomography

Acupoints combination correlates with activation of cerebral areas A functional MRI study

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Neural Regeneration Research 2011年第9期6卷 671-675页

作者： Xinsheng Lai Yong Huang Chunzhi Tang Junjun Yang Yanqi Zou Junxian Wu yangjia lu Renyong Lin Department of Meiridan Study School of Acupuncture and Massage Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 Guangdong Province China Department of Acupuncture and Moxibustion School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 Guangdong Province China

Acupoint combination is a method used for acupoint treatment of patients. Traditionally, acupoints are matched along the meridian distribution, which is a common rule in clinical practice, but the underlying mechanism remains unclear. Cerebral scans with functional magnetic resonance imaging （fMRI） have been used in the study of acupuncture and acupoint specifically. In this study, fMRI was used to detect the activation of the brain areas under different acupoints, matched along different meridians, to elucidate the acupoint combination via a modern medical approach. Forty healthy volunteers were randomly divided into the following groups： Waiguan point （SJ 5）, Waiguan （SJ 5）＋ Zhigou （SJ 6）（2 acupoints come from the same meridian）, Waiguan （SJ 5）＋ Neiguan （PC 6）（2 acupoints come from 2 meridians with the relationship of interior-exterior）, Waiguan （SJ 5）＋ Yanglingquan （GB 34）（2 acupoints come from 2 meridians with the same name-Shaoyang Meridian）, and sham point groups （needling in different points on the right hand）. A real-time cerebral fMRI scan was simultaneously performed. The cerebral activation rate, and the number and strength of different regions of interest were compared among the groups. The fMRI cerebral imaging confirmed that there were some differences in the activation of cerebral areas by the needlings in SJ 5, and in combination with other acupoints. Needling at SJ 5 alone greatly activated the right cerebellum, while needling at both SJ 5 and different co-needling points activated different cerebral functional areas.

关键词： acupuncture Waiguan point acupoint combination cerebral functional imaging functional MRI

Positron emission tomography study of the specificity of Waiguan (SJ 5) acupoint

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Neural Regeneration Research 2011年第18期6卷 1391-1397页

作者： Xinsheng Lai Chunzhi Tang Guifeng Zhang Junjun Yang Gustav Wik Baoci Shan yangjia lu Yong Huang Department of Acupuncture and Massage Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 Guangdong Province China School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 Guangdong Province China Department of Clinical Medicine University of Bergen Sandviken Hospital Bergen 116011 Norway Institute of High Energy Physics Chinese Academy of Science Beijing 100049 China

Functional brain imaging studies of the specificity of acupoint stimulation have revealed that needling at particular acupoints can induce activation of corresponding brain areas, examined in physiological and pathological states. The present study examined Waiguan （SJ 5） as the acupoint of interest. We tested five conditions： a true needling at true acupoint group, a sham needling at true acupoint group, a true needling at sham acupoint group, a sham needling at sham acupoint group, and a healthy control group. We examined changes in glucose metabolism in different functional cortical regions to determine the specific brain activation elicited by acupuncture at Waiguan. The results revealed that true and sham acupuncture at the same acupoint activated different brain regions. In addition, applying acupuncture at a genuine acupoint and a neighboring sham acupoint activated different brain regions. These findings suggest that acupuncture at Waiguan causes activation in some brain regions.

关键词： acupoint specificity needling Waiguan (SJ 5) positron emission tomography cerebral function imaging

Specific cerebral activation following true and sham Waiguan(SJ 5) needling Functional magnetic resonance imaging evidence

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Neural Regeneration Research 2010年第22期5卷 1712-1716页

作者： Yong Huang Xinsheng Lai Baoci Shan Chunzhi Tang Junjun Yang Tongjun Zeng Guifeng Zhang Jiarong Chen yangjia lu Department of Acupuncture and Moxibustion School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 Guangdong Province China Department of Meridian Study School of Acupuncture and Massage Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 Guangdong Province China Institute of High Energy Physics Chinese Academy of Science Beijing 100049 China Doctoral Candidate First School of Clinical Medicine Southern Medical University Guangzhou 510515 Guangdong Province China

Positive activation and negative activation of glucose metabolism can be detected in different brain regions under acupuncture conditions using functional magnetic resonance imaging （fMRI） which reveals acupoint function and location-acupoint specificity. This study observed the regional cerebral activation of the Waiguan （SJ 5） acupoint following true needling at the true Waiguan acupoint, sham needling at the true Waiguan acupoint and true needling at a sham point using fMRI. The fMRI results demonstrated that compared with sham needling, true needling at Waiguan activated the BA8 area and left cerebellum. Compared with needling at the sham point, needling at Waiguan activated the BA2 area, the left cerebellum and the right inferior semilunar lobule. Thus the activated brain areas caused by needling Waiguan may be the basis for treatment of certain diseases.

关键词： functional magnetic resonance imaging acupoint specific true/sham needling true/sham acupoint traditional Chinese medicine neural regeneration

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辨证分型论治配合激素治疗狼疮性肾炎46例

陕西中医 2007年第12期28卷 1597-1600页

作者：庞学丰卢阳佳巩志富广西中医学院附属瑞康医院 530011

目的:观察辨证分型论治配合激素治疗狼疮性肾炎的疗效。方法:采用辨证分为3型(热毒炽盛型、肝肾阴虚型、脾肾阳虚型)论治配合激素治疗本病46例,并设对照组对比。结果:治疗组总有效率93.5%,对照组总有效率76.2%。治疗组优于对照组(P<0.01... 详细信息

目的:观察辨证分型论治配合激素治疗狼疮性肾炎的疗效。方法:采用辨证分为3型(热毒炽盛型、肝肾阴虚型、脾肾阳虚型)论治配合激素治疗本病46例,并设对照组对比。结果:治疗组总有效率93.5%,对照组总有效率76.2%。治疗组优于对照组(P<0.01)。提示:本方法对本病有缓解症状,稳定病情,减少药物不良反应的功效。

关键词：肾炎/中医药疗法狼疮性辨证论治

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针灸治疗近视取穴规律文献研究

中医杂志 2011年第16期52卷 1413-1416页

作者：陈嘉荣卢阳佳黄泳林仁勇南方医科大学第一临床医学院广东省广州市510515 南方医科大学中医药学院

目的总结针灸治疗近视临床对照试验中的十四经腧穴取穴规律。方法检索1980年1月至2010年4月中国期刊全文数据库、中国生物医学文献光盘数据库、中文科技期刊全文数据库、万方数据资源系统中针灸治疗近视的随机临床对照/临床对照研究。... 详细信息

目的总结针灸治疗近视临床对照试验中的十四经腧穴取穴规律。方法检索1980年1月至2010年4月中国期刊全文数据库、中国生物医学文献光盘数据库、中文科技期刊全文数据库、万方数据资源系统中针灸治疗近视的随机临床对照/临床对照研究。将纳入文献中腧穴按其筛选方法分类整理,设计资料提取表,统计各穴位出现的频数,对最后纳入腧穴按照其所在十四经分布、所属部位、所属特性等加以分类,进行相关数据处理。结果共纳入文献82篇,使用腧穴几乎涉及所有经脉,其中足太阳膀胱经的使用频率最大,其所属腧穴睛明、攒竹等作为主穴使用191次,占所有主要穴位的31.01%;所属腧穴胆俞等作为配穴共使用21次,占所有配穴的19.44%。其次为足少阳胆经,其所属腧穴风池作为主穴使用52次,占主要穴位的7.18%。82篇文献中十四经腧穴使用频数前12腧穴依次为:睛明(65)、攒竹(62)、风池(52)、太阳(47)、承泣(45)、四白(40)、合谷(33)、鱼腰(32)、丝竹空(30)、肝俞(24)、瞳子髎(22)、肾俞(21)。结论针灸治疗近视经脉主要以足太阳膀胱经为主,多以眼周腧穴作为治疗主穴。

关键词：近视穴位针灸取穴规律

磁共振成像影像导航及靶区选择在经颅磁刺激治疗中的应用

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中国组织工程研究 2024年第26期28卷 4234-4241页

作者：王荔陈鹏韦秀英卢阳佳赖思嘉王凯华广西中医药大学附属国际壮医医院脑病科广西壮族自治区南宁市530200 广西中医药大学附属国际壮医医院放射科广西壮族自治区南宁市530200 广西中医药大学针灸推拿学院广西壮族自治区南宁市530200

背景:在经颅磁刺激临床实际应用中,是否能准确瞄准刺激脑区可影响经颅磁刺激的实际治疗效果。近年来,随着神经导航系统、移动式增强现实技术的发展,以及多种不同模态磁共振成像数据分析方法的出现,刺激靶区定位的准确性和靶区选择的优... 详细信息

背景:在经颅磁刺激临床实际应用中,是否能准确瞄准刺激脑区可影响经颅磁刺激的实际治疗效果。近年来,随着神经导航系统、移动式增强现实技术的发展,以及多种不同模态磁共振成像数据分析方法的出现,刺激靶区定位的准确性和靶区选择的优化有望得到进一步的提高。目的:综述基于磁共振成像的影像导航定位原理及在经颅磁刺激中的应用,归纳不同模态磁共振成像数据分析在指导经颅磁刺激靶区选择上的作用。方法:应用计算机在PubMed、中国知网和万方数据库检索相关文献,以“transcranial magnetic stimulation,coil positioning,neuronavigation,augmented reality,magnetic resonance imaging,经颅磁刺激,线圈定位,神经导航,增强现实,核磁共振成像,原理”为主要检索词,最终纳入63篇文献进行分析。结果与结论:①传统经颅磁刺激线圈放置方法中,“5 cm规则”、国际脑电10-20定位法最为常用,这些方法具有简便、经济的优点,但过于依赖操作者的经验,存在不同操作者的技术差异。②基于立体定向技术发展而来的神经导航系统是目前可视化程度及准确度最高的辅助经颅磁刺激线圈放置的引导方式,它通过MRI数据采集、脑三维重建、头模配准及立体几何定位等步骤来实现可视化定位,具有较高的临床治疗及科研应用价值,但因其设备较为昂贵,目前在医疗机构中尚未普及。③对于不同层次的医疗单位,移动式移动式增强现实技术不失为一种经济、高效的神经导航系统替代方案,它通过磁共振成像数据采集、构建二维/三维图像、虚拟图像与真实脑图像叠加来实现头皮下脑组织可视化定位,具有直观性强、成本低廉的优势,可在基层医疗单位推广应用。④尽管相对脑电10-20定位策略,可视化定位的临床疗效优越性目前尚未充分体现,但随着研究者对人脑多种不同模态磁共振成像扫描数据的挖掘,有望进一步优化经颅磁刺激治疗靶区选择的策略,提高经颅磁刺激治疗应答率和个性化程度,这在将来是极具潜力和挑战的研究方向。

关键词：经颅磁刺激线圈定位靶区选择脑三维重建立体定向技术神经导航系统移动式增强现实脑3D解剖成像脑功能成像脑结构成像