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检索条件"作者=Yangfang Li~*,Xiuxia Wang,Xue Feng,Shangying Liao,Chunsheng Han State key laboratory of reproductive biology,institute of zoology,chinese academy of sciences,beijing 100101"

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Generation of male germ cells from mouse induced pluripotent stem cells in vitro

Generation of male germ cells from mouse induced pluripotent...

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2012全国发育生物学大会

作者： yangfang li~**,xiuxia wang,xue feng,shangying liao,chunsheng han state key laboratory of reproductive biology,institute of zoology,chinese academy of sciences,beijing 100101

Germ cells are the only cell type that passes genetic information to the next *** most metazoan species, primordial germ cells(PGCs) were induced from epiblasts by signals from the neighboring *** vitro derivation of germ cells from the pluripotent stem cells(PSCs) such as embryonic stem cells(ESCs) and induced PSCs(iPSCs) are of great values for the treatment of infertility,for animal breeding,and for studying the mechanism of germ cell development. Although the derivations of male germ cells from PSCs have been previously reported,most of the studies failed to conduct the induction in a well-controlled and highly efficient ***,we report the derivation of induced PGC-like cells (iPGCLCs) from mouse iPSCs via induced epiblast-like cells(iEpiLCs) as being monitored by the expression of enhanced green fluorescent protein gene under the control of the promoter of stimulated by retinoic acid 8(Stra8-EGFP).The identity of iPGCLCs was characterized by examining the expression of multiple marker genes as well as by the recovery of spermatogenesis after they were transplanted to the testis of infertile WW ***,iPGCLCs were either induced to germline stem cell-like cells(iGSCLCs) or reverted back to embryonic germ cell-like cells(iEGLCs). Conclusions:We have established an efficient procedure for inducing iPSCs into iPGCLCs that can be further expanded and induced to more developed germ *** work indicates that the technology of in vitro germ cell induction is becoming more sophisticated and can be further improved.

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