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Protein-polysaccharide nanocomplexes as nanocarriers for delivery of curcumin: a comprehensive review on preparation methods and encapsulation mechanisms

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未来食品学报(英文) 2023年第2期3卷 99-114页

作者： Jingyi Xue yangchao luo Department of Nutritional Sciences University of ConnecticutStorrsCT 06269USA

Curcumin, commonly used as a coloring agent as well as food additive, has exhibited great therapeutic efficacy for development of functional foods. In order to expand its applications in food, strategies are needed to tackle the poor water-solubility, bioavailability and bioaccessibility of curcumin. Nanoparticles made from individual biomaterials such as proteins, polysaccharides and lipids have been introduced and their properties have been comprehensively studied. Recently, there has been an increasing interest in nanocomplexes made from two or more biomaterials because of their ability to composite the advantages of various components. This review has specific focus on the nanocomplexes fabricated from proteins and polysaccharides. First, complexation methods with or without chemical covalent bond formation are summarized, while different methods with different degrees of complexation are discussed. The encapsulation strategies of curcumin, both traditional and newly invented, are also compared. Then, the structure and physicochemical properties of the resulting binary or ternary nanocomplexes are discussed in detail, as well as a comparison of the delivery efficiency. Last but not least, the current limitations and future directions in the development of curcumin-loaded biopolymer nanoparticles for the design of future food products are presented.

关键词： Curcumin delivery Polysaccharide Protein Nanocomplexes Binary Ternary

Fabrication strategies and supramolecular interactions of polymer-lipid complex nanoparticles as oral delivery systems

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Nano Research 2021年第12期14卷 4487-4501页

作者： Taoran Wang yangchao luo Department of Nutritional Sciences University of ConnecticutStorrsCT06269USA

Oral administration of nutrient/drug is the most common and preferred route. However, a number of barriers are encountered after ingestion, limiting efficient oral nutrient/drug absorption. Both lipid-based (e.g., nanoemulsion, solid lipid nanoparticles) and polymer-based (e.g., protein and polysaccharide nanoparticles) nanoscale delivery systems have demonstrated capability to overcome some of these physiological barriers during transportation and metabolism stages. To better deal with those barriers, polymer-lipid complex nanoparticles are being explored and developed to merge the beneficial features and overcome the respective shortcomings of lipid-based and polymer-based nanoparticles. This paper aims to provide an overview of the various preparation strategies and supramolecular interactions of orally administered polymer-lipid complex nanoparticles by reviewing recent studies. Two types of polymer-lipid complex nanoparticles have been developed, i.e., lipid core with polymer shell nanoparticles and polymer core with lipid shell nanoparticles (lipid-polymer hybrid nanoparticles). Besides, both natural and synthetic polymers used for fabrication are discussed and their advantages and disadvantages are highlighted. Further research work is needed to optimize the fabrication and scaling up processes, so that these versatile polymer-lipid complex nanoparticles could have a significant impact on the oral delivery of nutrient/drug.

关键词： oral delivery nanoparticles polymer-lipid complex core-shell interactions

Antioxidant Activities and Inhibitory Effects of <i>Auricularia Auricular</i>and Its Functional Formula Diet Against Vascular Smooth Muscle Cell <i>in Vitro</i>

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Food and Nutrition Sciences 2011年第4期2卷 265-271页

作者： yangchao luo Zhenlei Xiao Qin Wang Bo Li Baoping Li 不详

The functional formula diet AHP, containing polysaccharides from Auricularia auricular, polyphenolic compounds from Hawthorn (Crataegus) and Pueraria radix, has been recently developed as a dietary intervention against dyslipidemia in our previous study. In the present study, its antioxidant activities and protective effects against proliferation of vascular smooth muscle cells (VSMCs) were investigated. AHP possessed the potent radical-scavenging effects against hydroxyl and superoxide radicals, and also the inhibitory effects against peroxidation of low density lipoprotein induced by Cu2+ in vitro. The protective effects of AHP against proliferation of VSMCs were evaluated through the methodology of serum pharmacology. The serum containing AHP significantly inhibited the proliferation of VSMCs induced by oxidized low density lipoprotein in a time- and dose-dependent manner, and also promoted the nitric oxide production of VSMCs. Our study indicated that this functional formula diet would be a potent alternative as a functional diet to prevent atherosclerosis at early stage.

关键词： Functional Diet Auricularia Auricula Antioxidant Activity Vascular Smooth Muscle Cells Serum Pharmacology

γ-谷氨酰转肽酶/血小板计数比值对接受一线化疗方案的Ⅲ-Ⅳ期胃癌患者的预后价值

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新疆医科大学学报 2023年第8期46卷 1021-1027页

作者：胡咏黄士月张天丹陈涛罗阳超成都市新都区人民医院病理科成都610500 成都市新都区人民医院检验科成都610500 成都市新都区人民医院肿瘤科成都610500

目的探讨γ-谷氨酰转肽酶(γ-gamma-glutamyl transpeptidase, GGT)/血小板计数(Platelet, PLT)比值(γ-glutamyl transpeptidase to platelet ratio index, GPRI)对接受一线化疗方案的Ⅲ-Ⅳ期胃癌患者预后的预测价值。方法选择138例非手术治疗的Ⅲ-Ⅳ期胃癌患者为研究对象,采集患者化疗前外周静脉血,检测GGT水平及PLT,根据公式GPRI=GGT/PLT(×109/L),计算不同患者的GPRI值。以GPRI>0.39为界值,将患者分为高GPRI组及低GPRI组。对患者进行连续性随访,采用卡方检验分析患者临床病理参数对GPRI比值的影响;利用Kaplan-Meier法及Log-rank检验分析GPRI比值对患者预后的影响。结果 (1)受试者工作特征(Receiver operating characteristic,ROC)曲线分析显示,GPRI、GGT、PLT的最佳临界值分别为0.39、64.68和178.59,ROC曲线下面积(Area under curve,AUC)分别为0.776、0.659和0.705,GPRI判断患者预后的效能明显优于单独检测GGT和血小板。(2)与低GPRI组相比,高GPRI组患者中>1器官转移及腹膜转移发生率、Ⅳ期患者比例、糖苷类肿瘤标志物(CA19-9)>37 U/mL的患者比例均明显较高(P1个器官转移(P=0.002)、腹膜转移(P=0.024)、Ⅳ期(P=0.008)、CA19-9水平(P=0.004)和GPRI>0.39(P=0.033)均是影响患者中位无进展生存期(Progression free survival, PFS)和中位总生存期(Overall survival, OS)的独立性危险因素。(3)所有患者的OS及PFS分别为156 d和217 d。低GPRI组、高GPRI组患者的中位PFS分别为202 d、117 d;中位OS分别为269 d、173 d,差异均有统计学意义(P均1个(χ^(2)=18.24,P<0.01)、Ⅳ期(χ^(2)=19.85,P<0.01)和CA19-9水平升高(χ^(2)=12.65,P<0.01)的亚组患者中,低GPRI组患者的OS均明显好于高GPRI组。结论 GPRI对接受一线化疗方案的Ⅲ-Ⅳ期胃癌患者的预后有较高的预测价值,有望作为晚期胃癌患者的一项新的预后指标。

关键词：胃癌 γ-谷氨酰转肽酶血小板计数一线化疗晚期肿瘤

Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

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Science China Chemistry 2024年第8期67卷 2497-2523页

作者： Yuan Zeng Shuhan Zhang Yuecong Guo Yalin Cong Xu Ding Peihua Li Yunxiang Lin Wenzhi Ren Hui Su Weigang Sun Liuxin Xu Guikai Zhang Shihua Chen Yu Chen Weiren Cheng Shengqi Chu Yong Guan Jinru Han Jie Lin Hengjie Liu Zheyi Liu Pan luo Fanchun Meng Sicong Qiao Zongyin Song Ying Wang Zhao Wu Chenyu Yang Meng Yang Shirui Yang Zi Yin Zhibin Yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia Zhou Wanlin Zhou Pengfei An He Cheng Chunhai Fan Xingjiu Huang Yong Lei Lina Li Mu Li Qinghua Liu Shuming Peng Li Song Zhihu Sun yangchao Tian Fangjun Wang Lihua Wang Liming Wang Shiqiang Wei Aiguo Wu Chunlei Xiao Xueming Yang Panchao Yin Jing Zhang Mingxin Zhang Yaling Wang Chunying Chen Beijing Synchrotron Radiation Facility Institute of High Energy Physics Chinese Academy of Sciences CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Institute of Advanced Science Facilities State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of Sciences CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics and National Center for Nanoscience and Technology of China Chinese Academy of Sciences Henan Institutes of Advanced Technology Zhengzhou University Institute of High Energy Physics Chinese Academy of Sciences Spallation Neutron Source Science Center CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science Laboratory National Center for Nanoscience and Technology College of Chemistry and Chemical Engineering Shanghai Jiao Tong University The Palace Museum Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics Institute of Materiobiology College of Science Shanghai University School of Marine Science and Engineering School of Chemistry and Chemical Engineering Hainan University University of Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China Institute of Solid State Physics Hefei Institutes of Physical Science Chinese Academy of Sciences Institutes of Physical Science and Information Technology Anhui University Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technol

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron sources.We further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： chemical dynamics FEL light sources large scientific facilities neutron sources spectroscopic analysis methods structural information synchrotron radiation X-ray imaging techniques

基于投影的X射线光栅相衬成像系统的仿真模拟

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中国医学物理学杂志 2017年第11期34卷 1124-1130页

作者：骆荣辉吴朝田扬超中国科学技术大学国家同步辐射实验室安徽合肥230026

基于投影的X射线光栅相衬成像技术由于具有较大的成像视场以及可以实现较高能量的成像,有望实现医学临床应用。由于其光学元件较多,在系统设计时确定合适的结构参数是一件复杂而艰难的工作。因此,通过一定的合理假设,构建系统的计算机... 详细信息

基于投影的X射线光栅相衬成像技术由于具有较大的成像视场以及可以实现较高能量的成像,有望实现医学临床应用。由于其光学元件较多,在系统设计时确定合适的结构参数是一件复杂而艰难的工作。因此,通过一定的合理假设,构建系统的计算机数值仿真模型,利用计算机强大的循环计算能力,实现相关参数对系统性能影响的分析进而实现参数优化将是一个很好的选择。根据基于投影的X射线光栅相衬成像装置的结构原理,同时将成像系统抽象为一个线性系统,在此基础上构建出成像系统的数学模型。并将其转变为适合于计算机的离散模型,实现基于投影的X射线光栅相衬成像的模拟仿真。最后,利用国家同步辐射实验室相衬平台采集的数据验证了该模拟方法的正确性。

关键词： X射线光栅相衬成像计算机数值仿真线性系统

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鞍带石斑鱼仔稚(幼)鱼的发育和生长研究

水产养殖 2011年第4期32卷 8-13页

作者：郭仁湘符书源杨薇陈国华骆剑刘扬潮周先雄海南大学海洋学院海南海口570228 海南生利水产繁殖有限公司海南陵水572400 万宁业兴水产养殖有限公司海南万宁571520

对鞍带石斑鱼的仔稚幼鱼形态发育的各个阶段进行了观察与研究,详细描述从初孵仔鱼到幼鱼各个发育时期的形态特征和发育时间。根据卵黄囊的变化,长鳍棘的长出与收缩,鳞片和体色斑纹的出现,鞍带石斑鱼胚后发育可以划分为仔鱼期、稚鱼期、... 详细信息

对鞍带石斑鱼的仔稚幼鱼形态发育的各个阶段进行了观察与研究,详细描述从初孵仔鱼到幼鱼各个发育时期的形态特征和发育时间。根据卵黄囊的变化,长鳍棘的长出与收缩,鳞片和体色斑纹的出现,鞍带石斑鱼胚后发育可以划分为仔鱼期、稚鱼期、幼鱼期。仔鱼期又可分为卵黄囊期仔鱼和后期仔鱼。水温27～30℃,盐度27～31,pH值8.0～8.4的海水中培育,初孵仔鱼至孵化后2日龄为卵黄囊期仔鱼。2日龄仔鱼开口,3日龄至20日龄为后期仔鱼,22日龄至30日龄为稚鱼期,31日龄进入幼鱼期。鞍带石斑鱼胚后发育过程中最明显的变化是背鳍棘和腹鳍棘的生长和收缩,也是生产育苗当中比较关键的仔稚幼鱼变态过程。

关键词：鞍带石斑鱼仔鱼稚鱼幼鱼生长发育

建立生血养巢膏的成型工艺及质量内控评价方法

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中国当代医药 2022年第16期29卷 61-64页

作者：叶晓玲罗瑜赖吉俭广东省韶关市中医院药学部广东韶关512023

目的探究质量内控评价方法对改善生血养巢膏的生产工艺、提高中药膏方的合理性、稳定性及有效性的作用。方法在韶关市中医院2021年3月至10月制备的生血养巢膏成品中随机抽选34例样本作为实验组,2020年3月至10月制备的生血养巢膏成品中... 详细信息

目的探究质量内控评价方法对改善生血养巢膏的生产工艺、提高中药膏方的合理性、稳定性及有效性的作用。方法在韶关市中医院2021年3月至10月制备的生血养巢膏成品中随机抽选34例样本作为实验组,2020年3月至10月制备的生血养巢膏成品中随机抽选34例样本作为参照组。实验组采用质量内控评价方法制备生血养巢膏,参照组采用传统膏方制备工艺方法制备。比较两组的流动性、外观性状、硬度与口感。结果实验组的流动性、外观形状、硬度、口感评分均高于参照组,差异有统计学意义(P<0.05)。结论质量内控评价方法可以有效改善生血养巢膏的生产工艺,明显提高生血养巢膏的流动性、外观性状、硬度及口感评分。

关键词：生血养巢膏质量内控评价方法流动性外观性状硬度口感

VO_(2)/Nb:TiO_(2)外延异质界面金属-绝缘体转变行为的可逆光学调控

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Science China Materials 2021年第7期64卷 1687-1702页

作者：杨远俊王桂林黄文宇王藏敏姚迎学毛小丽林辉张霆仇怀利李中军张汇殷月伟郭金花关勇闫文盛罗震林邹崇文田扬超肖钢李晓光高琛 Department of Physics and Lab of Solid State Microstructures and Quantum ControlSchool of Electronic Science and Applied Physics and School of MicroelectronicsHefei University of TechnologyHefei 230009China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Hefei National Laboratory for physical Sciences at Microscale(HFNL) University of Science and Technology of ChinaHefei 230026China Department of Physics Brown UniversityProvidenceRhode Island 02912USA National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China

由于在光学和电子器件中的潜在应用,强关联电子材料奇异特性的光学调控研究引起了人们的广泛关注.本文中,我们设计和演示了由关联电子氧化物外延薄膜二氧化钒(VO_(2))和0.05 wt%Nb掺杂的导电TiO_(2)单晶构成的垂直异质结,其在纳米尺度... 详细信息

由于在光学和电子器件中的潜在应用,强关联电子材料奇异特性的光学调控研究引起了人们的广泛关注.本文中,我们设计和演示了由关联电子氧化物外延薄膜二氧化钒(VO_(2))和0.05 wt%Nb掺杂的导电TiO_(2)单晶构成的垂直异质结,其在纳米尺度异质界面上的金属-绝缘体转变(metal-insulator transition,MIT)可通过可见光进行有效调控.我们发现该异质结MIT幅度从黑暗状态的~350倍降低到光照状态下的~7倍,并且以幂指数规律依赖于光功率密度.通过打开和关闭光照,能够可逆地、同步地调控异质结的高、低电阻态,且该结电阻的光学调控力度也与光功率密度成幂指数依赖.在低于MIT温度下,当光照功率密度为65.6 mW cm^(-2)时,其开/关比达到320倍;当升高温度时,VO_(2)薄膜转变为金属态时,结电阻的光学调控力度仅有~1倍的变化.上述研究结果归因于异质结势垒高度的降低(净减少~15 meV)和光伏效应诱导的异质界面处VO_(2)的金属化.在低温下,可见光光照激发Nb:TiO_(2)深缺陷能级电子跃迁,诱导异质界面绝缘相VO_(2)金属化;而在MIT温度以上,异质结转变为肖特基型结,光照对金属相VO_(2)能带结构的调控减弱,进而导致结电阻的调控力度大幅降低.该工作表明,非接触式的光学手段可以有效操纵关联电子材料VO_(2)的MIT行为,有望在非致冷型的光电检测和光电开关中得到广泛应用.

关键词：结电阻异质界面奇异特性光电开关光伏效应光电检测二氧化钒金属化