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Membrane bioreactors for hospital wastewater treatment: recent advancements in membranes and processes

Frontiers of Chemical Science and Engineering 2022年第5期16卷 634-660页

作者： Yan Zhao yangbo qiu Natalie Mamrol Longfei Ren Xin Li Jiahui Shao Xing Yang Bart van der Bruggen Department of Chemical Engineering KU LeuvenB-3001 LeuvenBelgium School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Discharged hospital wastewater contains various pathogenic microorganisms,antibiotic groups,toxic organic compounds,radioactive elements,and ionic *** contaminants harm the environment and human health causing the spread of ***,effective treatment of hospital wastewater is an urgent task for sustainable ***,with controllable porous and nonporous structures,have been rapidly developed for molecular *** particular,membrane bioreactor(MBR)technology demonstrated high removal efficiency toward organic compounds and low waste sludge *** further enhance the separation efficiency and achieve material recovery from hospital waste streams,novel concepts of MBRs and their applications are rapidly evolved through hybridizing novel membranes(non hydrophilic ultrafiltration/microfiltration)into the MBR units(hybrid MBRs)or the MBR as a pretreatment step and integrating other membrane processes as subsequent secondary purification step(integrated MBR-membrane systems).However,there is a lack of reviews on the latest advancement in MBR technologies for hospital wastewater treatment,and analysis on its major challenges and future *** review started with an overview of main pollutants in common hospital wastewater,followed by an understanding on the key performance indicators/criteria in MBR membranes(i.e.,solute selectivity)and processes(e.g.,fouling).Then,an in-depth analysis was provided into the recent development of hybrid MBR and integrated MBR-membrane system concepts,and applications correlated with wastewater sources,with a particular focus on hospital *** is anticipated that this review will shed light on the knowledge gaps in the field,highlighting the potential contribution of hybrid MBRs and integrated MBRmembrane systems toward global epidemic prevention.

关键词： membrane technology membrane bioreactor hospital wastewater hybrid MBR integrated MBR-membrane system

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肺原位腺癌的诊断与治疗进展

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中国肺癌杂志 2017年第9期20卷 641-644页

作者：裘杨波申屠阳上海交通大学附属胸科医院/上海市肺部肿瘤临床医学中心上海200039

肺原位腺癌(adenocarcinoma in situ,AIS)于2011年在肺腺癌国际多学科分类中新增,2015版世界卫生组织(World Health Organization,WHO)肺肿瘤分类中补充,由于AIS处于肺腺癌发展的早期阶段,加深对其病理、诊断、鉴别与治疗策略等方面的认... 详细信息

肺原位腺癌(adenocarcinoma in situ,AIS)于2011年在肺腺癌国际多学科分类中新增,2015版世界卫生组织(World Health Organization,WHO)肺肿瘤分类中补充,由于AIS处于肺腺癌发展的早期阶段,加深对其病理、诊断、鉴别与治疗策略等方面的认识,对改善肺腺癌的治疗预后具有重要意义。本综述将对目前AIS的发生发展、病理特征、鉴别诊断和治疗策略等方面的研究做一系统回顾,旨在为AIS的进一步研究提供理论基础。

关键词：肺原位腺癌病理特征诊断治疗

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早期肺癌进展趋势的影响因素和CT研判

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中国肺癌杂志 2018年第10期21卷 793-799页

作者：裘杨波毛锋张辉申屠阳上海交通大学附属胸科医院/上海市肺部肿瘤临床医学中心上海200030

背景与目的不同类型的肺部结节具有不同的体积倍增时间(volume doubling time, VDT)。目前针对不同病理类型早期肺腺癌VDT的研究较少。本研究通过回顾性分析143例早期肺腺癌的影像资料,探讨早期肺腺癌的进展趋势及相关影响因素,为临床... 详细信息

背景与目的不同类型的肺部结节具有不同的体积倍增时间(volume doubling time, VDT)。目前针对不同病理类型早期肺腺癌VDT的研究较少。本研究通过回顾性分析143例早期肺腺癌的影像资料,探讨早期肺腺癌的进展趋势及相关影响因素,为临床制订其随访策略提供参考。方法依据2015版世界卫生组织肺肿瘤分类标准和第8版肿瘤肿瘤-淋巴结-转移(tumor-node-metastasis, TNM)分期标准,对143例早期肺腺癌进行分类及分期。参考修正版Schwartz公式计算不同病理类型肺腺癌的VDT。结果 143例早期肺腺癌中,有50例(34.97%)出现进展,多因素分析显示影响因素包括随访时间、结节大小、病理类型、结节类型和病理分期。附壁生长为主型肺腺癌(lepidic predominant adenocarcinoma, LPA)的VDT为(594±272)d,伴少量附壁生长成分浸润性腺癌的VDT为(520±285)d,完全浸润性腺癌的VDT为(371±183)d,3类进展性早期肺腺癌的VDT有统计学差异(P=0.044)。结论在早期肺腺癌中,约有35%的肿瘤处于进展阶段,是否含有附壁生长成分是影响肿瘤进展速度的重要因素。

关键词：附壁生长型肺腺癌肿瘤进展倍增时间

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同时性多原发肺癌的预后及生存相关因素研究

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中国肺癌杂志 2017年第1期20卷 21-27页

作者：郭海法毛锋张辉裘杨波申屠阳上海交通大学附属胸科医院/上海市肺部肿瘤临床医学中心上海200039

背景与目的同时性多原发肺癌(synchronous multiple primary lung cancer,sMPLC)既往属少见疾病,近年发病率呈持续上升趋势,但缺乏对其大样本的研究报道。本研究对357例s MPLC的临床病理资料进行分析总结,籍以为临床诊断、治疗及预后提... 详细信息

背景与目的同时性多原发肺癌(synchronous multiple primary lung cancer,sMPLC)既往属少见疾病,近年发病率呈持续上升趋势,但缺乏对其大样本的研究报道。本研究对357例s MPLC的临床病理资料进行分析总结,籍以为临床诊断、治疗及预后提供理论依据。方法参考Martini-Melamed诊断标准和国际肺癌研究协会(International Association for the Study of Lung Cancer,IASLC)第8版肿瘤-淋巴结-转移(tumor-node-metastasis,TNM)分期标准,对357例sMPLC的临床病理资料进行分析。结果 357例患者中,双原发病灶269例(75.35%),三原发病灶65例(18.21%),四原发病灶及以上者23例(6.44%),最多者为8个病灶。病灶好发于上叶,特别是右上叶(35.77%,298/833),病理类型以腺癌为主(95.56%,796/833),鳞癌次之(2.40%,20/833),腺癌亚型中以腺泡样为主的比例较高(70.81%,313/442),分期以Ib期及以下为主(68.35%,244/357)。病理类型相同者发病率(92.72%,331/357)远高于不同病理类型(7.28%,26/357),其中腺癌-腺癌比例较高(99.40%,329/331)。sMPLC的3年总生存率(overall survival,OS)为91.93%,5年总生存率为84.37%,多因素生存分析显示,有吸烟史(P=0.012)、最大病灶直径大于2 cm(P=0.027)、淋巴结转移(P=0.015)和胸膜受累(P<0.001)为影响sMPLC预后生存的独立危险因素。结论 sMPLC好发于右上叶,以腺癌最常见,腺泡样为主的亚型多见。吸烟史、最大结节直径、淋巴结转移和胸膜侵犯是影响sMPLC预后生存的独立危险因素。早期发现和积极的手术可以使sMPLC患者获得较好的预后。

关键词：同时性多原发肺癌外科手术危险因素生存分析

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半导体含氟废水“结晶-沉淀结合超滤-反渗透”的零排放工艺研究

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水处理技术 2023年第4期49卷 95-100页

作者：施锡栋裘洋波任龙飞邵嘉慧上海交通大学环境科学与工程学院上海200240

采用结晶-沉淀结合超滤-反渗透组合工艺对半导体产业含氟废水进行零排放处理。研究不同钙氟(Ca/F)摩尔比和晶种投加量对结晶-沉淀预处理影响效果;选择合适的超滤和反渗透膜,研究不同操作压力、进水流速、进水温度以及pH对产水通量和水... 详细信息

采用结晶-沉淀结合超滤-反渗透组合工艺对半导体产业含氟废水进行零排放处理。研究不同钙氟(Ca/F)摩尔比和晶种投加量对结晶-沉淀预处理影响效果;选择合适的超滤和反渗透膜,研究不同操作压力、进水流速、进水温度以及pH对产水通量和水质的动态影响。结果表明,利用同离子效应和晶种异相成核的原理,结晶-沉淀法不仅可以去除99.5%的氟化物,而且能降低32%的污泥含水率,便于污泥循环利用;通过超滤-反渗透膜选择性分离的原理进一步强化了除氟能力。根据产水量动态变化分析确定了组合工艺中超滤-反渗透最佳操作条件。经过双膜处理的产水,其氟化物浓度稳定在0.5 mg/L左右,低于1.5 mg/L(WHO饮用水氟化物标准),其余指标也满足工业用水水质要求,可全部回用。

关键词：结晶-沉淀超滤反渗透含氟废水零排放

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing qiu Mengting Yang Danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing Shen qiu-Wan Wei Yi-Ren Tian Yun-Zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

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Electric modulation of conduction in MAPbBr_(3) single crystals

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Journal of Advanced Ceramics 2021年第2期10卷 320-327页

作者： Shanming Ke Shangyu Luo Jinhui Gong Liwen qiu Renhong Liang yangbo Zhou Bingcheng Luo Baochang Cheng Li Wang Longlong Shu School of Materials Science and Engineering Nanchang UniversityNanchang330031China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China

The resistive switching(RS)mechanism of hybrid organic–inorganic perovskites has not been clearly understood until now.A switchable diode-like RS behavior in MAPbBr3 single crystals using Au(or Pt)symmetric electrodes is *** the high resistance state(HRS)and low resistance state(LRS)are electrode-area dependent and light *** propose an electric-fielddriven inner p–n junction accompanied by a trap-controlled space-charge-limited conduction(SCLC)conduction mechanism to explain this switchable diode-like RS behavior in MAPbBr_(3) single crystals.

关键词： resistive switching(RS) rectifying behavior hybrid organic–inorganic perovskites p–n structure

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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

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