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1例输入性类鼻疽的病原学诊断及溯源分析

中国人兽共患病学报 2024年第1期40卷 76-81页

作者：杨红霞王春雨王洋郝瑞娥赵启玉郑霄山西省疾病预防控制中心重点传染性疾病预防与诊治山西省重点实验室太原030012 山西省人民医院太原030012 太原市疾病预防控制中心太原030032 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206

目的对1例输入性类鼻疽患者进行病原学诊断及溯源分析,为山西省类鼻疽防控提供科学依据。方法患者血培养阳性,分离菌株鉴定为泰国伯克霍尔德菌。采用生化试验及微生物质谱仪进行菌株鉴定,核酸提取后进行全基因组测序,分析MLST型和耐药... 详细信息

目的对1例输入性类鼻疽患者进行病原学诊断及溯源分析,为山西省类鼻疽防控提供科学依据。方法患者血培养阳性,分离菌株鉴定为泰国伯克霍尔德菌。采用生化试验及微生物质谱仪进行菌株鉴定,核酸提取后进行全基因组测序,分析MLST型和耐药基因携带情况,同时构建系统进化树。结果此次分离株经生化试验及微生物质谱仪检测均鉴定为类鼻疽伯克霍尔德菌,MLST型为ST366,全基因测序分析与海南省3个分离株进化亲缘关系较近,同源性较高。结论此例类鼻疽病例经分子溯源分析及流行病学调查确定为海南省输入,提示医疗机构及疾控部门应加强对类鼻疽的认识,提高诊疗能力。

关键词：类鼻疽类鼻疽伯克霍尔德菌 MLST分型全基因测序分子溯源

景电灌区主要作物不同节水灌溉模式效益综合分析

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中国农村水利水电 2024年第1期 70-74页

作者：吴冠衡高雅玉杨红霞甘肃省景泰川电力提灌水资源利用中心甘肃白银730400 兰州理工大学甘肃兰州730000 甘肃农垦良种有限责任公司甘肃白银730400

景电灌区是以农业经济为主的高扬程跨流域灌区,干旱缺水成为制约农作物高产稳产的主要因素,节水灌溉技术在景电灌区得到大力推广,合理的节水灌溉方式可以节约用水,提高单方水效益,有利于推进水资源集约节约利用和建设节水型灌区。如何... 详细信息

景电灌区是以农业经济为主的高扬程跨流域灌区,干旱缺水成为制约农作物高产稳产的主要因素,节水灌溉技术在景电灌区得到大力推广,合理的节水灌溉方式可以节约用水,提高单方水效益,有利于推进水资源集约节约利用和建设节水型灌区。如何科学合理地选择节水灌溉模式是目前迫切需要研究的问题。基于熵值法,从社会经济效益、生态环境效益等方面构建节水灌溉效益评价体系,对灌区主要作物进行了不同节水灌溉模式的效益分析。结果表明,高效节水灌溉效益普遍高于其他灌溉方式,而滴灌模式则是该地区最优节水灌溉模式。评价结果与实际基本一致,说明这种方法应用到灌区中评价效益是可行的,对灌区的综合评价具有指导意义。

关键词：景电灌区熵值法节水灌溉效益分析

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Determination of Some Heavy-metal-ions Using a Sulfur Ion Modified BZ Oscillating System

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Chinese Chemical Letters 2006年第9期17卷 1221-1224页

作者： Hua CHEN Wu yang hong xia DAI xiao xia WEI Jie QU Jin Zhang GAO College of Chemistry ＆ Chemical Engineering Northwest Normal University Lanzhou 730070

A highly sensitive method is developed for the determination of trace amounts of some heavy metal ions in aqueous solution based on the classical Belousov-Zhabotinskii （BZ） oscillating chemical system. Introducing of S^2- ion makes the new oscillating system Ce（SO4）2 - KBrO3 - CH2（COOH）2 - Na2S - H2SO4 have to a high sensitivity for some heavy metal ions such as Ag^＋, Pb^2＋, Hg^2＋, Cd^2＋, Cu^2＋and Bi^3＋ with detection limits down to 10^-12 mol·L^- 1

关键词： BZ oscillating system kinetic determination heavy-metal-ion sulfur ion.

20~59岁山西籍个别正常(牙合)上前牙正面观美学指标分析

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口腔颌面修复学杂志 2024年第3期25卷 180-186页

作者：王景李风兰杨红霞李立美山西医科大学口腔医学院·口腔医院太原030001 山西医科大学第五临床医院口腔修复科太原030001

目的:分析山西籍个别正常(牙合)上前牙正面观美学指标,探讨性别、年龄、牙形、面形对牙齿美学指标的影响,为上前牙美学修复设计提供参考。方法:2022年10月~2023年6月于山西省人民医院体检中心选取20~59岁个别正常(牙合)受试者322例,以1... 详细信息

目的:分析山西籍个别正常(牙合)上前牙正面观美学指标,探讨性别、年龄、牙形、面形对牙齿美学指标的影响,为上前牙美学修复设计提供参考。方法:2022年10月~2023年6月于山西省人民医院体检中心选取20~59岁个别正常(牙合)受试者322例,以10岁为组距,按照年龄等距分为4个年龄组,拍摄其息止颌位正面像与前牙列正面咬合照,观测并记录面形分类与上中切牙形态分类,使用图像处理软件测量上前牙宽度、长度、上中切牙与侧切牙及尖牙间切缘台阶,并计算上中切牙宽长比、上前牙宽度比,分析各测量项目的性别差异与组间差异。结果:男性的W1/L1[0.83(0.10)]显著小于女性[0.86(0.10)](P0.05),不同形态天然上中切牙的宽长比不同[尖圆形、卵圆形、方圆形分别为0.78(0.07)、0.84(0.06)、0.90(0.08)](P<0.001)。40~49岁组的L1[(10.21±0.85) mm]显著大于20~29岁组[(9.84±0.76)mm]与30~39岁组[(9.87±1.01)mm](P<0.05)。女性的上中切牙与侧切牙间切缘台阶、上中切牙与尖牙间切缘台阶[分别为0.92(0.60)、1.32(1.00)mm]均显著大于男性[分别为0.80(0.60)、1.08(1.50)mm](P<0.05)。上中切牙与侧切牙间的切缘台阶从尖圆面形、卵圆面形到方圆面形逐渐减小[分别为1.33(0.38)、0.81(0.23)、0.43(0.95)mm](P<0.001)。关于上中切牙与尖牙间的切缘台阶,尖圆面形最大,其次是卵圆形和方圆形[分别为1.81(0.84)、1.17(0.87)、0.56(0.88)mm](P<0.001)。结论:前牙美学设计时需考虑性别差异的影响,但上中切牙宽长比的两性差异与牙齿形态无关;40~49岁个别正常上中切牙临床冠长度较20~29岁与30~39岁显著增加;前牙切缘台阶的设计应考虑性别差异及面形的影响。

关键词：牙齿美学美学比例切缘台阶牙齿形态牙修复体设计

Atomistic study of inverse size effect induced by interfacial plasticity in pearlitic multi-principal element alloy

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Rare Metals 2024年第7期43卷 3341-3355页

作者： Chen yang Qiao-Sheng xia Cun-hong Yin Dong-Peng Hua College of Mechanical Engineering Guizhou UniversityGuiyang 550025China Key Laboratory of Advanced Manufacturing Technology Ministry of EducationGuizhou UniversityGuiyang 550025China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi'an 710072China

Owing to the fine nano-laminated structure,the pearlitic multi-principal element alloy(PMPEA) exhibits excellent mechanical and tribological ***,the incomplete understanding of the size effect of its lamella thickness and the unclear understanding of the plasticity-interface interaction mechanism limit further optimization of *** this study,the FeCoNi/Ni_3Ti interface-mediated plastic deformation behavior in PMPEA and the variation of mechanical and tribological properties with lamella thickness within the nanoscale range using molecular dynamics(MD) simulation were *** results indicate that the mechanical and tribological properties of the PMPEA with lamella thicknesses below 10 nm have a significant inverse size effect,i.e.,the smaller the lamella thickness,the weaker the *** is because the plastic carrier-interface interaction mechanism changes from a strengthening mechanism that hinders dislocations to a weakening mechanism that promotes dislocations with the decreases in the lamella thickness,and the weakening effect becomes more pronounced as the lamella thickness decreases and the number of interfaces *** particular,the deformation behavior of Ni_3Ti lamellae changes from crystal-like to amorphous-like with decreasing ***,in the sample with larger lamella thickness,the occurrence of hierarchical slips in the body-centered cubic(BCC) phase due to the multiprincipal elements effect can better alleviate the stress concentration caused by the dislocation accumulation at the interface,so that the phase interface exhibits outstanding load-bearing *** the dislocation pattern in BCC phase shows a firm high-density cell,which makes the substrate exhibit a stable tribological response.

关键词： Multi-principal element alloy Nano-laminated structure Molecular dynamics simulation Nanoindentation and nanoscratch

Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

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Current Medical Science 2024年第1期44卷 223-231页

作者： hong-li ZHANG Na LI Lin DONG hong-xia MA Mo-chi yang Department of Ophthalmology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinoblastoma(RB)is a prevalent type of eye cancer in *** homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,hepatocyte,pancreatic,heart,lens,retinal,and cancer *** goal of this study was to investigate the role of Prox1 in RB cell proliferation and drug resistance,as well as to explore the underlying Notch1 *** Human RB cell lines(SO-RB50 and Y79)and a primary human retinal microvascular endothelial cell line(ACBRI-181)were used in this *** expression of Prox1 and Notch1 mRNA and protein in RB cells was detected using quantitative real time-polymerase chain reaction(RT-qPCR)and Western *** proliferation was assessed after Prox1 overexpression using the Cell Counting Kit-8 and the MTS ***-resistant cell lines(SO-RB50/vincristine)were generated and treated with Prox1 to investigate the role of Prox1 in drug *** employed pcDNA-Notch1 to overexpress Notch1 to confirm the role of Notch1 in the protective function of ***,a xenograft model was constructed to assess the effect of Prox1 on RB in *** Prox1 was significantly downregulated in RB *** of Prox1 effectively decreased RB cell growth while increasing the sensitivity of drug-resistant cells to ***1 was involved in Prox1’s regulatory ***1 was identified as a target gene of Prox1,which was found to be upregulated in RB cells and repressed by increased Prox1 *** pcDNA-Notch1 was transfected,the effect of Prox1 overexpression on RB was ***,by downregulating Notch1,Prox1 overexpression slowed tumor development and increased vincristine sensitivity in *** These data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1,implying that Prox1 could be a potential therapeutic target for RB.

关键词： Proxl Notch1 retinoblastoma cells proliferation drug resistance

Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer

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Genes & Diseases 2024年第3期11卷 400-416页

作者： Meijia Yu Yiming Wu Qingfang Li Weiqi hong yang yang xiaoyi Hu Yanfei yang Tianqi Lu xia Zhao xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Gynecology and Obstetrics Development and Related Disease of Women and Children Key Laboratory of Sichuan ProvinceKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationWest China Second HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology The First Affiliated HospitalArmy Medical UniversityChongqing 400038China

Ovarian cancer is the tumor with the highest mortality among gynecological *** have confirmed that paclitaxel chemoresistance is associated with increased infiltration of tumor-associated macrophages(TAMs)in the ***-stimu-lating factor 1(CSF-1)receptor(CSF-1R)plays a key role in regulating the number and differ-entiation of macrophages in certain solid *** are few reports on the effects of targeted inhibition of CSF-1R in combination with chemotherapy on ovarian cancer and the tu-mor ***,we explored the antitumor efficacy and possible mechanisms of the CSF-1R inhibitor pexidartinib(PLX3397)when combined with the first-line chemothera-peutic agent paclitaxel in the treatment of ovarian *** found that CSF-1R is highly ex-pressed in ovarian cancer cells and correlates with poor *** by PLX3397 in combination with paclitaxel significantly inhibited the growth of ovarian cancer both in vitro and in *** of CSF-1R altered the macrophage phenotype and reprogrammed the immunosuppressive cell population in the tumor microenvironment.

关键词： CSF-1R Ovariancancer Paclitaxel PLX3397 Targeted therapy Tumor-associated macrophages

Application of CFD and FEA Coupling to Predict Structural Dynamic Responses of A Trimaran in Uni-and Bi-Directional Waves

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China Ocean Engineering 2024年第1期38卷 81-92页

作者： LIAO Xi-yu xia Jin-song CHEN Zhan-yang TANG Qin ZHAO Nan ZHAO Wei-dong GUI hong-bin Marine Design&Research Institute of China Shanghai 200011China Ship Structure Division China Ship Scientific Research CenterWuxi 214082China College of Ocean Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China School of Foreign Studies Jiangnan UniversityWuxi 214122China

To predict the wave loads of a flexible trimaran in different wave fields,a one-way interaction numerical simulation method is proposed by integrating the fluid solver(Star-CCM+)and structural solver(Abaqus).Differing from the existing coupled CFD-FEA method for monohull ships in head waves,the presented method equates the mass and stiffness of the whole ship to the hull shell so that any transverse and longitudinal section stress of the hull in oblique waves can be ***,verification study and sensitivity analysis are carried out by comparing the trimaran motions using different mesh sizes and time step *** on the wave elevation of uni-and bi-directional waves is also carried *** a comprehensive analysis on the structural responses of the trimaran in different uni-directional regular wave and bi-directional cross sea conditions is carried out,***,the differences in structural response characteristics of trimaran in different wave fields are *** results show that the present method can reduce the computational burden of the two-way fluid-structure interaction simulations.

关键词： CFD-FEA fluid-structure coupling structural responses trimaran bi-directional cross sea

A Scoping Review of Real-World Study in Vaccine Evaluation

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China CDC weekly 2024年第16期6卷 357-362页

作者： Lei Wang hong yang Lanfang xia Quanwei Song Na Liu Guomin Zhang Fuzhen Wang Huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st Century Cures Act in 2016,emphasizing RWS(2).The FDA’s Real-world Evidence Program establishes real-world data(RWD)as“data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).The proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facilitating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical trials(RCTs)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse populations and are adept at identifying rare events not easily discernible in RCTs due to their infrequency.

关键词： routine gained traditionally