检索结果-南通市图书馆

Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway

引用

World Journal of Gastroenterology 2021年第26期27卷 4221-4235页

作者： Min Zhong Ling Zhou Zhi Fang yang-yang yao Jian-Ping Zou Jian-Ping Xiong Xiao-Jun Xiang Jun Deng Department of Jiangxi Key Laboratory for Individualized Cancer Therapy The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Cancer Center The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Ubiquitin-specific protease 15(USP15)is an important member of the ubiquitinspecific protease family,the largest deubiquitinase subfamily,whose expression is dysregulated in many types of ***,the biological function and the underlying mechanisms of USP15 in gastric cancer(GC)progression have not been *** To explore the biological role and underlying mechanisms of USP15 in GC *** Bioinformatics databases and western blot analysis were utilized to determine the expression of USP15 in *** was performed to evaluate the correlation between USP15 expression and clinicopathological characteristics of patients with GC.A loss-and gain-of-function experiment was used to investigate the biological effects of USP15 on GC *** sequencing,immunofluorescence,and western blotting were performed to explore the potential mechanism by which USP15 exerts its oncogenic *** USP15 was up-regulated in GC tissue and cell *** expression level of USP15 was positively correlated with clinical characteristics(tumor size,depth of invasion,lymph node involvement,tumor-node-metastasis stage,perineural invasion,and vascular invasion),and was related to poor ***15 knockdown significantly inhibited cell proliferation,invasion and epithelialmesenchymal transition(EMT)of GC in vitro,while overexpression of USP15 promoted these *** of USP15 inhibited tumor growth in ***,RNA sequencing analysis showed that USP15 regulated the Wnt signaling pathway in *** blotting confirmed that USP15 silencing led to significant down-regulation ofβ-catenin and Wnt/β-catenin downstream genes(c-myc and cyclin D1),while overexpression of USP15 yielded an opposite result and USP15 mutation had no *** indicated that USP15 promoted nuclear translocation ofβ-catenin,suggesting activation of the Wnt/β-catenin signaling pathway,which may be the critical mech

关键词： Ubiquitin-specific protease 15 Gastric cancer Wnt/β-catenin Cell proliferation Cell invasion Epithelial-mesenchymal transition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

引用

Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu Lijie yang Wanrong Jiang Xinyuan Zhang Zhaohui yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing yang Jinghui Chen Xingyue Xiao Xiayin yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Solid-State Batteries

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Bilevel Optimal Scheduling of Island Integrated Energy System Considering Multifactor Pricing

引用

Energy Engineering 2025年第1期122卷 349-378页

作者： Xin Zhang Mingming yao Daiwen He Jihong Zhang Peihong yang Xiaoming Zhang School of Automation and Electrical Engineering Inner Mongolia University of Science and TechnologyBaotou014010China

In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load *** to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption *** price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption *** benefits and win-win situations are achieved between the upper and lower ***,CPLEX is used to iteratively solve the bilevel optimization *** optimal solution is selected according to the joint optimal discrimination *** results indicate that the sourceload coordinate operation can reduce the upper and lower operation *** the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.

关键词： Bilevel optimal scheduling load aggregator integrated energy operator carbon emission dynamic pricing mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

引用

Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing yang Lilingxuan yao Xinyue Xu yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bammann-Chiesa-Johnson粘塑性本构模型的参数识别方法与验证

引用

材料导报 2017年第3期31卷 75-79,111页

作者：周婷婷王罡杨洋李遥帅茂兵表面物理与化学重点实验室江油621908 清华大学精密超精密制造装备及控制北京市重点实验室北京100084

Bammann-Chiesa-Johnson(BCJ)粘塑性本构模型对材料力学响应的再现和预测能力强烈依赖于其模型参数的确定,而模型参数的确定往往是通过反分析方法来进行。由于BCJ粘塑性模型包含了应变、应变率和温度耦合效应以及加载路径和温度历史,其... 详细信息

Bammann-Chiesa-Johnson(BCJ)粘塑性本构模型对材料力学响应的再现和预测能力强烈依赖于其模型参数的确定,而模型参数的确定往往是通过反分析方法来进行。由于BCJ粘塑性模型包含了应变、应变率和温度耦合效应以及加载路径和温度历史,其常数多达18个,所以寻找最佳的模型参数识别值十分繁琐。针对BCJ本构模型参数复杂、识别困难的问题,本文基于参数的物理意义,在准静态、蠕变及动态加载试验基础上,通过模型参数解耦分离、粒子群智能优化的方法分6步对18个材料常数进行识别,并用识别结果对1060纯铝动态加载试验力学响应进行模拟,模拟结果与试验结果符合良好。通过定量化误差分析,证明了BCJ粘塑性模型对实验数据的预测具有较高精度,该模型参数识别方法科学可行。

关键词： BCJ粘塑性模型参数识别参数解耦粒子群智能优化算法 1060纯铝

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

超临界压力锅炉螺旋水冷壁管传热特性的试验研究

引用

锅炉技术 2017年第1期48卷 19-22,37页

作者：杨杰杨耀杨勇华电莱州发电有限公司山东莱州261400 上海发电设备成套设计研究院上海200240

超临界压力直流锅炉炉膛水冷壁倾斜管内壁对工质的对流换热系数及对水冷壁管的安全运行尤为重要,为此对某1 000 MW超临界压力塔式直流锅炉螺旋水冷壁进行了实炉试验测量,计算出螺旋管圈水冷壁管内壁与工质间的对流换热系数,并以此为据,... 详细信息

超临界压力直流锅炉炉膛水冷壁倾斜管内壁对工质的对流换热系数及对水冷壁管的安全运行尤为重要,为此对某1 000 MW超临界压力塔式直流锅炉螺旋水冷壁进行了实炉试验测量,计算出螺旋管圈水冷壁管内壁与工质间的对流换热系数,并以此为据,拟合出计算超临界压力下螺旋水冷壁管对流换热系数的计算公式,并对该炉型水冷壁管超温现象进行了分析,为水冷壁的安全运行提供了参考依据。

关键词：超临界压力螺旋水冷壁对流换热系数计算公式

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

洞庭湖三口河系地区径流演变情势与农业用水面临的挑战

引用

中国农村水利水电 2016年第11期 86-92,100页

作者：李杨杨文尧湖南农业大学经济学院长沙410128 国防科技大学信息系统与管理学院长沙410073

基于1960-2012年实测径流及降水资料,利用M-K检验分析法得出三口河系年径流变化趋势及汛期径流变化趋势都显著减少,年径流量与年降水量变化过程中的突变年份为1973年与1982年;以1960-1968年为基准期,运用累积量斜率变化率比较方法,计算... 详细信息

基于1960-2012年实测径流及降水资料,利用M-K检验分析法得出三口河系年径流变化趋势及汛期径流变化趋势都显著减少,年径流量与年降水量变化过程中的突变年份为1973年与1982年;以1960-1968年为基准期,运用累积量斜率变化率比较方法,计算得到流域降水量变化和水利工程运行对洞庭湖三口径流量减小的影响贡献率在1974-1982年间分别为15.25%和84.75%,在1983-2012年间依次为11.01%及88.99%;随着本区农业生产规模的不断扩大,工程性缺水与季节性缺水问题日益凸现,到2020年洞庭湖三口河系地区90%保证率总缺水量为44 127万m3,其中农业生产缺水39 652万m3,农业供需水量的缺口对该区农业可持续发展将产生不同程度的约束性。

关键词：径流变化趋势影响贡献率农业水资源三口河系地区

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

引用

Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型高温合金718Plus的性能特点、航空应用和发展趋势

引用

材料导报 2017年第19期31卷 72-79页

作者：王妙全田成刚南洋徐瑶杨国宝童锦艳中国航发商用航空发动机有限责任公司上海201108

718Plus合金凭借其优异的力学性能、较高的耐温能力、良好的加工性和适宜的制造成本,有效填补了IN718和Waspaloy合金之间长期以来存在的合金空白,逐渐应用于高性能航空发动机零部件制造。详细阐述了新型高温合金718Plus的性能特点,包括... 详细信息

718Plus合金凭借其优异的力学性能、较高的耐温能力、良好的加工性和适宜的制造成本,有效填补了IN718和Waspaloy合金之间长期以来存在的合金空白,逐渐应用于高性能航空发动机零部件制造。详细阐述了新型高温合金718Plus的性能特点,包括化学成分、析出相、热处理制度和力学性能等。此外,还总结了718Plus合金的制造成本和航空应用情况。

关键词： 718Plus合金 γ′相力学性能制造成本航空应用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：