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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu yang-pu jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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BIRC3 induces the phosphoinositide 3-kinase-Akt pathway activation to promote trastuzumab resistance in human epidermal growth factor receptor 2-positive gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第11期16卷 4436-4455页

作者： Shu-Liang Li Pei-Yao Wang yang-pu jia Zhao-Xiong Zhang Hao-Yu He Peng-Yu Chen Xin Liu Bang Liu Li Lu Wei-Hua Fu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of Gastrointestinal Surgery The Second People’s Hospital of LiaochengLiaocheng 252600Shandong ProvinceChina Department of Gastrointestinal Surgery The Second Hospital of LiaochengAffiliated to Shandong First Medical UniversityLiaocheng 252600Shandong ProvinceChina

BACKGROUND Trastuzumab-targeted therapy is currently the standard of care for advanced human epidermal growth factor receptor 2(HER2)-positive gastric ***,the emergence of resistance to trastuzumab poses significant *** To identify the key genes associated with trastuzumab *** results provide a basis for the development of interventions to address drug resistance and improve patient *** High-throughput sequencing and bioinformatics were used to identify the differentially expressed pivotal gene BIRC3 and delineate its potential function and pathway *** samples were collected from patients with HER2-positive gastric cancer to evaluate the correlation between BIRC3 expression and trastuzumab *** established gastric cancer cell lines with both highly expressed and suppressed levels of BIRC3,followed by comprehensive in vitro and in vivo experiments to confirm the involvement of BIRC3 in trastuzumab resistance and to elucidate its underlying *** In patients with HER2-positive gastric cancer,there is a significant correlation between elevated BIRC3 expression in tumor tissues and higher T stage,tumor node metastasis stage,as well as poor overall survival and progressionfree ***3 is highly expressed in trastuzumab-resistant gastric cancer cell lines,where it inhibits tumor cell apoptosis and enhances trastuzumab resistance by promoting the phosphorylation and activation of the phosphoinositide 3-kinase-Akt(PI3K-AKT)pathway in HER2-positive gastric cancer cells,both in vivo and in *** This study revealed a robust association between high BIRC3 expression and an unfavorable prognosis in patients with HER2-positive gastric ***,the high expression of BIRC3 stimulated PI3K-AKT phosphorylation and activation,stimulating the proliferation of HER2-positive tumor cells and suppressing apoptosis,ultimately leading to trastuzumab resistance.

关键词： Gastric cancer Human epidermal growth factor receptor 2 Trastuzumab Drug-resistance BIRC3

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基于DEA模型的甘肃省林业投入产出效率研究

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西北林学院学报 2017年第2期32卷 315-320页

作者：李京轩陈秉谱杨璐嘉甘肃农业大学经济管理学院甘肃兰州730070 乐山职业技术学院财经管理系四川乐山614000

对于生态环境脆弱、绿色植被稀少的甘肃省来说,林业高效且持续的发展是实现可持续发展的重要举措之一。运用DEA评价模型,通过对1998-2014年甘肃省林业生产效率所选取的指标进行测算和分析。结果表明,甘肃省林业投入产出水平总体较高,但... 详细信息

对于生态环境脆弱、绿色植被稀少的甘肃省来说,林业高效且持续的发展是实现可持续发展的重要举措之一。运用DEA评价模型,通过对1998-2014年甘肃省林业生产效率所选取的指标进行测算和分析。结果表明,甘肃省林业投入产出水平总体较高,但还存在一定改进空间;导致林业DEA非有效的主要原因是规模效益较低,抵消了技术效率带来的正向影响;在DEA非有效年份中,可以发现存在一定程度的投入冗余,对其进行投影分析,得出营林固定投资是影响其主要原因。最后根据研究结果,针对甘肃省未来的林业发展指出可行的方向。

关键词： DEA模型林业投入产出率甘肃省

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公众理解科学视角下科学传播主体社会责任研究——基于《人民日报》、《南方周末》关于转基因报道的实证分析

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北京科技大学学报（社会科学版） 2016年第4期32卷 92-103页

作者：钱振华杨甲璞刘文霞北京科技大学马克思主义学院科技与社会研究所北京100083

文章以公众理解科学理论为研究基础,以文献收集法、典型抽样调查法和最小二乘回归计量模型(OLS)为主要研究方法,对《人民日报》和《南方周末》2003—2014共12年间关于转基因的相关报道进行实证分析,数据显示科学新闻的报道受到科学传播... 详细信息

文章以公众理解科学理论为研究基础,以文献收集法、典型抽样调查法和最小二乘回归计量模型(OLS)为主要研究方法,对《人民日报》和《南方周末》2003—2014共12年间关于转基因的相关报道进行实证分析,数据显示科学新闻的报道受到科学传播主体的影响较大,尤其政府对于科学传播内容的主导意见十分明显,科学家和媒体形成舆论倾向,另一方面由于自身职业素质和责任的不明确,导致科学传播未能落到实处,未能将科学技术知识通过合适的渠道传播到社会与公众之中,使得公众对于转基因的态度出现"反转"潮。由此分析科学传播主体未履行责任的原因,找出问题的症结,通过各个科学传播主体的协作配合来解决中国科学传播现今所面临的问题,实现科学传播的顺利进行和公众科学素质的整体提高。

关键词：公众理解科学科学传播主体社会责任

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The aliphatic hydrocarbon distributions of terrestrial plants around an alpine lake： a pilot study from Lake Ximencuo, Eastern Qinghai-Tibet Plateau

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Frontiers of Earth Science 2018年第3期12卷 600-610页

作者： yang pu Jihong jia Jicheng CAO School of Geographical Sciences Nanjing University of Information Science & Technology Nanjing 210044 China

As part of an investigation of the sources of aliphatic hydrocarbons to the sediments of alpine Lake Ximencuo, leaves of the eight dominant vascular plants were collected and their hydrocarbon contents were analyzed. A series of unsaturated aliphatic hydrocarbons were identified in the plant leaves; in particular, Festuca sp. contain a series of n-alkadienes that have rarely been reported in previous studies. The comparison of n-alkane proxies （ACL27 33, ACLT, Paq, and CPI） and δ13Corg among plant leaves, surface soils, and lake sediments suggests that organic proxies have been altered to varying degrees during the transport and burial process of organic materials. It is believed that microbial reworking and source changes have great impacts on organic proxies in the alpine lake system. In addition, the cluster analysis for plant leaves depending on n-alkane compositions and the ACLT proxy generates similar results. Accordingly, we postulate that the average chain length of plant waxes might be a potential indicator of plant classification in regions such as the Qinghai-Tibet Plateau.

关键词： plant leaves alpine lake n-alkanes n-alka-dienes Qinghai-Tibet Plateau (QTP)

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Prophenoloxidase from Pieris rapae:gene cloning,activity,and transcription in response to venom/calyx fluid from the endoparasitoid wasp Cotesia glomerata

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第2期12卷 103-115页

作者： jia-ying ZHU pu yang Guo-xing WU Key Laboratory of Forest Disaster Warning and Control of Yunnan Province and Key Laboratory of Southwest Mountain Forest Resources Conservation and Utilization of Ministry of Education Southwest Forestry University Kunming 650224 China Research Institute of Resource Insects Chinese Academy of Forestry Kunming 650224 China College of Plant Protection Yunnan Agricultural University Kunming 650201 China

Prophenoloxidase (PPO) plays an important role in melanization, necessary for defense against intruding parasitoids. Parasitoids have evolved to inject maternal virulence factors into the host hemocoel to suppress hemolymph melanization for the successful development of their progeny. In this study, the full-length complementary DNA (cDNA) of a Pieris rapae PPO was cloned. Its cDNA contained a 2 076-base pair (bp) open reading frame (ORF) encoding 691 amino acids (aa). Two putative copper-binding sites, a proteolytic activation site, three conserved hemocyanin domains, and a thiol ester motif were found in the deduced amino acid sequence. According to both multiple alignment and phylogenetic analysis, P. rapae PPO gene cloned here is a member of the lepidopteran PPO-2 family. Injection of Cotesia glomerata venom or calyx fluid resulted in reduction of P. rapae hemolymph phenoloxidase activity, demonstrating the ability to inhibit the host's melanization. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) showed that transcripts of P. rapae PPO-2 in the haemocytes from larvae had not significantly changed following venom injection, suggesting that the regulation of PPO messenger RNA (mRNA) expression by venom was not employed by C. glomerata to cause failure of melanization in parasitized host. While decreased P. rapae PPO-2 gene expression was observed in the haemocytes after calyx fluid injection, no detectable transcriptional change was induced by parasitization, indicating that transcriptional down-regulation of PPO by calyx fluid might play a minor role involved in inhibiting the host's melanization.

关键词： Prophenoloxidase Cloning Venom Calyx fluid Gene expression Parasitoid

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The primary use of artificial intelligence in cardiovascular diseases: what kind of potential role does artificial intelligence play in future medicine?

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Journal of Geriatric Cardiology 2019年第8期16卷 585-591页

作者： yang YAN jia-Wen ZHANG Guang-Yao ZANG Jun pu Department of Cardiology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Dermatology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina School of Medicine Jiangsu UniversityZhenjiangJiangsuChina

Cardiovascular diseases (CVD) is a major threat to human health and the leading cause of death worldwide.[1] The incidence of CVD caused 17.6 million deaths in 2016, an increase of 14.5% from 2006 to 2016.[2] Unfortunately, the mortality and morbidity rates of CVD are increasing year by year, especially in developing regions. Studies have shown that approximately 80% of CVD-related deaths occur in low- and middle-income countries. Besides, these deaths occur at a younger age than in high-income countries.[3]?

关键词： Artificial intelligence Cardiovascular diseases Machine learning

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Air-stable synaptic devices based on bismuth triiodide and carbon nanotubes

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Nano Research 2022年第6期15卷 5435-5442页

作者： Dandan Hao Junyao Zhang Li Li Ben yang pu Guo Shiqi Zhang jia Huang Interdisciplinary Materials Research Center School of Materials Science and EngineeringFrontiers Science Center for Intelligent Autonomous SystemsTongji UniversityShanghai 201804China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji UniversitySchool of Materials Science and EngineeringTongji UniversityShanghai 200434China

Artificial synaptic devices with the functions of emulating important biological synaptic behaviors are playing an increasingly important role in the development of neuromorphic computing ***-walled carbon nanotubes(SWCNTs)with excellent electrical properties and high stability have been studied as active materials for synaptic ***,the performance of optical synaptic devices(OSDs)based on pure SWCNTs is limited by the weak light absorption ***,bismuth triiodide(BiI_(3)),an environmentally stable and friendly optoelectronic material,is firstly combined with SWCNTs to fabricate OSDs with decent properties of perceiving and memorizing optical *** OSDs can exhibit typical synaptic behaviors including excitatory postsynaptic current,paired-pulse facilitation,and short/long-term ***,the photoresponse of the OSD is independent of pulse light wavelength in the range of 365 to 650 nm,different from most of the previously reported OSDs,which usually have wavelength-dependent ***-dependent photo-response behaviors of the devices are ***,the OSD without encapsulation holds good excitatory post-synaptic current(EPSC)behavior after being stored in the ambient environment for 170 days,indicating reliable environmental ***,an OSD array with nine synaptic devices is employed to mimic the human visual perception and memory *** results suggest the feasibility of BiI3/SWCNTs-based OSDs for the simulation of human visual memory.

关键词： semiconducting single-walled carbon nanotubes bismuth triiodide optical synaptic devices stability human visual memory

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Extension of a sharp-interface immersed-boundary method for simulating parachute inflation

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Advances in Aerodynamics 2024年第1期6卷 43-67页

作者： yang Zhang Tianmei pu He jia Shiqing Wu Chunhua Zhou College of Astronautics Nanjing University of Aeronautics and Astronautics Laboratory of Aerospace Entry Descent and Landing Technology CASC College of Electrical Energy and Power Engineering Yangzhou University College of Aeronautics Nanjing University of Aeronautics and Astronautics Beijing Institute of Space Mechanics and Electricity

In this work, the sharp-interface immersed boundary(IB) method proposed by Mittal et al.(J Comput Phys 227(10):4825–4852, 2008) is extended to fluid-structure-interaction(FSI) simulation of parachute inflation by utilizing several open-source *** method employs a Cartesian-grid ghost-cell methodology to accurately represent the immersed boundary, and it is suitable for solving moving-boundary flows with arbitrarily complex geometries. The finite-element code CalculiX is employed to solve the structural dynamics of the parachute system. The IB flow solver is coupled with CalculiX in a minimally-invasive manner using the multi-physics coupling library preCICE. The implicit fluid-structure coupling together with the Aitken adaptive under-relaxation scheme is considered to improve the numerical accuracy and stability. The developed approach is validated by a benchmark FSI case. Numerical experiments on the inflation process of several typical parachutes are further *** breathing process, flow structure, canopy displacement and drag coefficient are analyzed to demonstrate the applicability of the present approach for simulating parachute inflation.

关键词： CalculiX Fluid-structure interaction Immersed boundary method Parachute inflation preCICE

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Multilinear singular and fractional integrals on weighted Hardy spaces

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Applied Mathematics(A Journal of Chinese Universities) 2009年第2期24卷 214-220页

作者： ZHANG pu LAN jia-cheng Dept. of Math. Mudanjiang Teachers College Mudanjiang 157012 China Dept. of Math. Lishui College Lishui 323000 China

In this paper the boundedness properties of multilinear singular and fractional integrals on the weighted Hardy spaces are studied.

关键词： multilinear singular integral multilinear fractional integral Lipschitz function L^r-Dini condition weighted Hardy space

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