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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing gu Hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

Determination of haloacetic acids in hospital effuent after chlorination by ion chromatography

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Journal of Environmental Sciences 2007年第7期19卷 885-891页

作者： SUN Ying-xue gu Ping School of Environmental Science and Engineering Tianjin University Tianjin 300072 China.

The ion chromatography combined solid phase extraction （SPE） method was developed for the analysis of low concentration haloacetic acids （HAAs）, a class of disinfection by-products formed from chlorination of hospital wastewater. The monitored HAAs included monochloroacetic acid, monobromoacetic acid, dichloroacetic acid, dibromoacetic acid and trichloroacetic acid. The method employed a sodium hydroxide eluent at a flow rate of 0.8 ml/min, electrolytically generated gradients, and suppressed conductivity detection. To analyze the HAAs in real hospital wastewater samples, C18 pretreatment cartridge was utilized to reduce samples＇ turbidity. Preconcentration with SPE and matrix elimination with treatment cartridges were investigated and found to be able to obtain acceptable detection limits. Linearity, repeatability and detection limits of the above method were evaluated. The detection limits of monobromoacetic acid and dibromoacetic acid were 2.61 μg/L and 1.30 μg/L, respectively, and the other three acids are ranging from 0.48 to 0.82μg/L under 25-fold preconcentration. When the above optimization procedure was applied to three hospital wastewater samples with different treatment processes in Tianjin, it was found that the dichloroacetic acid was the major compound, and the growth ratios of the HAAs after disinfection by sodium hypochlorite were 91.28%, 63.61% and 79.50%, respectively.

关键词： hospital wastewater analysis ion chromatography (IC) sample pretreatment solid phase extraction (SPE) chlorination haloacetic acids (HAAs)

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超超临界锅炉受热面壁温测量技术研究

锅炉技术 2025年第1期56卷 55-59页

作者：鲍听楼玉民赵宁宁顾海林张光学严小华浙江浙能技术研究院有限公司浙江杭州310003 浙江省火力发电高效节能与污染物控制技术研究重点实验室浙江杭州311121 中国计量大学能源工程研究所浙江杭州310018

锅炉在高负荷运行时,往往会导致过热器管壁超温而发生爆管现象,因此,有必要对过热器管壁温进行监测。一般采用外壁安装集热块的方式,然而该温度不能反应真实的受热管温度。为准确测量高温下的受热管壁温,设计并加工了试验台,可实现受热... 详细信息

锅炉在高负荷运行时,往往会导致过热器管壁超温而发生爆管现象,因此,有必要对过热器管壁温进行监测。一般采用外壁安装集热块的方式,然而该温度不能反应真实的受热管温度。为准确测量高温下的受热管壁温,设计并加工了试验台,可实现受热管1/2壁厚处温度的测量。探究了不同烟气温度、安装角度和是否保温条件下管壁外表面温度和1/2壁厚处温度的变化规律。结果表明:同一角度时,温差随来流烟气温度和管内流速的增大而增大,其中最大可达到30 ℃。安装角度在迎风面(0°)和侧面(90°)时,温差相对较大,在背风面(180°)时,温差最小。添加保温层可以明显减小温差。

关键词：锅炉过热器管壁温度测量集热块

基于BDD的数控机床模具子系统组件重要度分析

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制造业自动化 2014年第6期36卷 71-73,78页

作者：古莹奎李晶承姿辛江西理工大学机电工程学院赣州341000

在对二状态系统结构重要度、概率重要度、关键重要度、F-V重要度和综合重要度分析的基础上,引入BDD分析技术,利用其路径搜索效率高和计算结果精确的优点,在BDD图上直接计算条件概率和可靠度,可以弥补传统重要度计算时计算量大和组合爆... 详细信息

在对二状态系统结构重要度、概率重要度、关键重要度、F-V重要度和综合重要度分析的基础上,引入BDD分析技术,利用其路径搜索效率高和计算结果精确的优点,在BDD图上直接计算条件概率和可靠度,可以弥补传统重要度计算时计算量大和组合爆炸等缺陷。对数控机床模具子系统组件的五种重要度进行分析,得到其重要组件和薄弱环节,有助于提高系统可靠性和进行故障诊断。

关键词： BDD 重要度可靠性数控机床

Effect of viscoelasticity on nonlinear vibration of single microbubble

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Journal of Southeast University(English Edition) 2011年第3期27卷 253-256页

作者：杨莉杨芳陈平顾宁东南大学生物电子学国家重点实验室南京210096 东南大学江苏省生物材料与器件重点实验室南京210096

Based on the Church-Hoff model, the nonlinear oscillations of a single encapsulated microbubble with a finite thickness shell are theoretically studied. The effects of viscoelasticity on radial oscillations and the fundamental and harmonic components are researched. The peaks of radial oscillations and magnitudes of power spectra of the fundamental and harmonic components all increase gradually with the shear modulus of shell varying from 0 to 10 MPa by an interval of 0. 1 MPa at the same shear viscosity, while they decrease as the shear viscosity increases from 0 to 1 Pa · s by an interval of 0. 01 Pa · s at the same shear modulus. The fluctuation ranges of subharmonic and ultraharmonic signals are much larger than both the fundamental and second harmonic components. It means that the effect of viscoelasticity on the subharmonic and ultraharmonic signals is greater than that on the fundamental and second harmonic components. So adjusting the viscoelasticity of the shell is a potential method to obtain a perfect microbubble contrast agent used for the subharmonic and ultraharmonic imaging. Four points with significant fundamental and harmonic components are chosen as an example： a shear viscosity of 0. 39 Pa · s with shear modulus of 3.9, 6. 6, and 8.6 MPa, respectively; a shear modulus of 6.6 MPa with a shear viscosity of 0.42 Pa · s.

关键词： microbubble viscoelasticity radial oscillation harmonic imaging

血栓弹力图联合凝血功能检测指导创伤患者输血治疗的效果

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中外医学研究 2025年第4期23卷 69-72页

作者：卢宁邓慧吴玲周林谷世娟麻城市人民医院湖北麻城438300

目的:探析血栓弹力图联合凝血功能检测指导创伤患者输血治疗的效果。方法:回顾性选取2022年9月—2023年12月麻城市人民医院收治的60例创伤患者。根据不同输血治疗指导将其分为对照组(2022年9月—2023年3月,30例)和试验组(2023年4—12月... 详细信息

目的:探析血栓弹力图联合凝血功能检测指导创伤患者输血治疗的效果。方法:回顾性选取2022年9月—2023年12月麻城市人民医院收治的60例创伤患者。根据不同输血治疗指导将其分为对照组(2022年9月—2023年3月,30例)和试验组(2023年4—12月,30例)。对照组在输血治疗中应用凝血功能检测,试验组在输血治疗中应用血栓弹力图联合凝血功能检测。比较两组输血前及输血24 h后(输血后)凝血功能,救治相关指标及血制品使用剂量。结果:试验组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)均短于对照组,FIB高于对照组,差异有统计学意义(P<0.05)。试验组凝血功能障碍诊断率高于对照组,诊断时间、住院时间均短于对照组,病死率低于对照组,差异有统计学意义(P<0.05)。试验组的新鲜冰冻血浆、冷沉淀凝血因子、红细胞、血小板的使用剂量均少于对照组,差异有统计学意义(P<0.05)。结论:在创伤患者的输血治疗中,应用血栓弹力图联合凝血功能检测指导,能取得较好的作用,不但能更好地恢复凝血功能,还可以减少各类血制品的用量,对提高救治的效果具有积极的意义。

关键词：血栓弹力图凝血功能创伤输血治疗

Dysregulation of mRNA profile in cisplatin-resistant gastric cancer cell line SGC7901

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World Journal of Gastroenterology 2017年第7期23卷 1189-1202页

作者： Xiao-Que Xie Qi-Hong Zhao Hua Wang Kang-Sheng gu Department of Oncology the First Affiliated Hospital of Anhui Medical University Department of Food and Nutrition Hygiene School of Public Health Anhui Medical University

AIM To explore novel therapeutic target of cisplatin resistance in human gastric *** The sensitivity of SGC7901 cells and cisplatin-resistant SGC7901 cells(SGC7901/DDP) for cisplatin were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. High-quality total RNA which isolated from SGC7901/DDP cells and SGC7901 cells were used for mR NA microarray analysis. Results were analyzed bioinformatically to predict their roles in the development of cisplatin resistance and the expression of 13 dysregulated mR NAs we selected were validated by quantitative real-time polymerase chain reaction(qR T-PCR). RESULTS SGC7901/DDP cells highly resistant to cisplatin demonstrated by MTT assay. A total of 1308 m RNAs(578 upregulated and 730 downregulated) were differentially expressed(fold change ≥ 2 and P-value < 0.05) in the SGC7901/DDP cells compared with SGC7901 cells. The expression of mR NAs detected by q RT-PCR were consistent with the microarray results. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway and protein-protein interaction analysis demonstrated that the differentially expressed mR NAs were enriched in PI3K-Akt, Notch, MAPK, ErbB, Jak-STAT, NF-kappa B signaling pathways which may be involved in cisplatin resistance. Several genes such as PDE3 B, VEGFC, IGFBP3, TLR4, HIPK2 and EGF may associated with drug resistance of gastric cancer cells to *** Exploration of those altered mR NAs may provide more promising strategy in diagnosis and therapy for gastric cancer with cisplatin resistance.

关键词： Gastric cancer Dysregulate Cisplatin resistance Microarray Biology

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液冷充电枪使用过程中可靠性影响分析

汽车电器 2025年第2期 42-45页

作者：李晓杜春雨薛子章古玉中汽研新能源汽车检验中心(天津)有限公司天津300300

液冷充电枪对大功率充电性能至关重要。文章主要分析并系统总结影响液冷充电枪性能的主要因素,旨在为大功率充电用充电枪提供技术支持,推动新能源汽车大功率充电健康、有序发展。研究发现,当前影响液冷充电枪性能的因素主要有温升可靠... 详细信息

液冷充电枪对大功率充电性能至关重要。文章主要分析并系统总结影响液冷充电枪性能的主要因素,旨在为大功率充电用充电枪提供技术支持,推动新能源汽车大功率充电健康、有序发展。研究发现,当前影响液冷充电枪性能的因素主要有温升可靠性、液冷管路可靠性、异常状态下的安全可靠性及其他问题。最后针对提升液冷充电枪性能提出若干建议。

关键词：液冷充电枪温升液冷系统可靠性热管理系统液冷介质

Secondary-Atom-Doping Enables Robust Fe-N-C Single-Atom Catalysts with Enhanced Oxygen Reduction Reaction

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Nano-Micro Letters 2020年第11期12卷 281-291页

作者： Xin Luo Xiaoqian Wei Hengjia Wang Wenling gu Takuma Kaneko Yusuke Yoshida Xiao Zhao Chengzhou Zhu Key Laboratory of Pesticide and Chemical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079People’s Republic of China Innovation Research Center for Fuel Cells The University of Electro-CommunicationsChofugaokaChofuTokyo 182‑8585Japan

Single-atom catalysts(SACs) with nitrogen-coordinated nonprecious metal sites have exhibited inimitable advantages in ***,a large room for improving their activity and durability ***,we construct atomically dispersed Fe sites in N-doped carbon supports by secondary-atom-doped *** the secondary doping,the density and coordination environment of active sites can be efficiently tuned,enabling the simultaneous improvement in the number and reactivity of the active ***,structure optimizations in terms of the enlarged surface area and improved hydrophilicity can be achieved *** to the beneficial microstructure and abundant highly active FeN_5 moieties resulting from the secondary doping,the resultant catalyst exhibits an admirable half-wave potential of 0.81 V versus 0.83 V for Pt/C and much better stability than Pt/C in acidic *** work would offer a general strategy for the design and preparation of highly active SACs for electrochemical energy devices.

关键词： Single-atom catalysts Fe-N-C catalysts Doping Porous nanostructures Oxygen reduction reaction

HCMV感染对糖尿病视网膜病变患者miR-155、TLR4/p38MAPK通路及微血管损伤的影响

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中华医院感染学杂志 2025年第1期35卷 50-54页

作者：邓雨谷朱萍高荔姗韩中舒李晓婷周嘉楠海宁市人民医院眼科浙江嘉兴314000

目的分析人巨细胞病毒(HCMV)感染对糖尿病视网膜病变(DR)患者微小核糖核酸(miR)-155、Toll样受体4(TLR4)/p38促分裂原活化的蛋白激酶(p38MAPK)通路及微血管损伤的影响。方法随机选取2022年2月-2024年2月海宁市人民医院诊治的DR合并HCMV... 详细信息

目的分析人巨细胞病毒(HCMV)感染对糖尿病视网膜病变(DR)患者微小核糖核酸(miR)-155、Toll样受体4(TLR4)/p38促分裂原活化的蛋白激酶(p38MAPK)通路及微血管损伤的影响。方法随机选取2022年2月-2024年2月海宁市人民医院诊治的DR合并HCMV感染患者100例为HCMV感染组,随机纳入同期未感染HCMV的DR患者100例为非HCMV感染组,检测两组患者外周血miR-155、TLR4、p38MAPK mRNA、微血管损伤相关因子[血管内皮生长因子(VEGF)、细胞间黏附分子(ICAM)-1)]水平,采用Pearson相关性分析miR-155、TLR4/p38MAPK通路与微血管损伤相关因子的关系。结果HCMV感染组患者外周血miR-155mRNA(1.93±0.54)、TLR4mRNA(3.26±0.71)、p38MAPK mRNA(2.68±0.46)及VEGF(222.63±20.57)pg/ml、ICAM-1(653.10±60.54)pg/ml水平均高于非HCMV感染组(P<0.05);Pearson相关性分析显示miR-155、TLR4、p38MAPK mRNA与VEGF、ICAM-1均呈正相关(均P<0.05)。结论HCMV感染可能会引起DR患者外周血miR-155上调,促进TLR4/p38MAPK通路激活,加重微血管损伤。

关键词：糖尿病视网膜病变人巨细胞病毒感染微小核糖核酸-155 Toll样受体4/p38促分裂原活化的蛋白激酶通路微血管损伤

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