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Effects of mild hypothermia on the expression of microtubule-associated protein 2 in neurons of the hippocampal dentate gyrus in a rat model of cerebral ischemia/reperfusion

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Neural Regeneration Research 2008年第12期3卷 1352-1355页

作者： Qian yang feng Zheng Jiami wu Department of Neurology Yijishan Hospital Wannan Medical College Wuhu 241000 Anhui Province China

BACKGROUND： It is widely accepted that mild hypothermia can protect against injury to cerebral ischemia/reperfusion. OBJECTIVE： To observe the effects of mild hypothermia on microtubule-associated protein 2 （MAP2） expression in the hippocampal dentate gyms in rats following cerebral ischemia/reperfusion. Also, to study neuronal ultrastmctural changes in the dentate gyms to investigate the mechanism of the protection against injury to cerebral ischemia/reperfusion conferred by mild hypothermia. DESIGN, TIME AND SETTING： This randomized grouping, neural cell morphology trial was performed at the Laboratory Animal Center of Yijishan Hospital between March and June 2007. MATERIALS： Eighty-five healthy male Sprague Dawley rats were randomly allocated to three groups： mild hypothermia （n = 40）, normothermia （n = 40）, and sham-operated （n = 5）. METHODS： Cerebral ischemia/reperfusion injury was induced by the suture method in the mild hypothermia and normothermia groups, with a threading depth of 180.5 mm. In the sham-operated group, the suture was inserted 15 mm, with no vascular ligafion, and was followed by reperfusion 2 hours later. In the sham-operated and normothermia groups, the rat rectal temperature was maintained at 36-37 ℃ ; in the mild hypothermia group, it was controlled at 32-33 ℃. MAIN OUTCOME MEASURES： The hippocampal dentate gyms was serially sectioned for hematoxylin-eosin staining and MAP2 immunohistochemistry. Ultrastructural changes and the MAP2 absorbance value of the hippocampal dentate gyms were examined by transmission electron microscopy. RESULTS： The sham-operated group exhibited approximately normal ultrastructure of neurons in the bilateral hippocampal dentate gyms. In the normothermia group, ischemic hippocampal dentate gyms neurons were found with markedly fewer normal mitochondria, greatly proliferated rough endoplasmic reticulum, and a swollen and dysmorphic Golgi. In the mild hypothermia group, at each corresponding time point, these abnorm

关键词： cerebral ischemia/reperfusion mild hypothermia rats

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Resilient sliding mode control for 2D CPSs under denial-of-service attacks

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Science China(Information Sciences) 2024年第6期67卷 262-278页

作者： Lingling LI Rongni yang Zhiguang feng Ligang wu College of Intelligent Systems Science and Engineering Harbin Engineering University School of Control Science and Engineering Shandong University School of Astronautics Harbin Institute of Technology

This study addresses the resilient sliding mode control(SMC) problem for two-dimensional cyber-physical systems(2D CPSs) characterized by the Roesser model under denial-of-service attack(DoSA), which can interfere with signal transmission over the communication network. First, the DoS-A model is established by introducing constraints on the Do S frequency and duration. Then, based on active or silent attack situations, the considered system is described as a switched mode. Furthermore, together with Lyapunov theory, the average dwell time technique is employed to deduce sufficient criteria that assure the existence of the desired sliding mode controller. Finally, verification examples are provided to show the validity of the established SMC scheme.

关键词： two-dimensional systems cyber-physical systems denial-of-service attack resilient sliding mode control

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On the Probability of Generating a Primitive Matrix

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Journal of Systems Science & Complexity 2024年第4期37卷 1755-1771页

作者： CHEN Jingwei feng Yong LIU yang wu Wenyuan Chongqing Key Laboratory of Automated Reasoning and Cognition Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Chongqing College University of Chinese Academy of SciencesChongqing 400714China Key Laboratory of Advanced Manufacturing Technology of Ministry of Education Guizhou UniversityyGuiyang 550025China Information Science and Engineering Chongqing Jiaotong UniversityChongqing 400074China

Given a k×n integer primitive matrix A(i.e.,a matrix can be extended to an n×n unimodular matrix over the integers)with the maximal absolute value of entries‖A‖bounded by an integer λ from above,the authors study the probability that the m×n matrix extended from A by appending other m-k row vectors of dimension n with entries chosen randomly and independently from the uniform distribution over{0,1,…,λ-1}is still *** authors present a complete and rigorous proof of a lower bound on the probability,which is at least a constant for fixed m in the range[k+1,n-4].As an application,the authors prove that there exists a fast Las Vegas algorithm that completes a k×n primitive matrix A to an n×n unimodular matrix within expected O(n^(ω)log‖A‖)bit operations,where O is big-O but without log factors,ω is the exponent on the arithmetic operations of matrix multiplication.

关键词： Integer matrix matrix completion probabilistic algorithm unimodular matrix

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Plasma-etching on monolithic MOFs-based MIM filter boosted chemical sensing

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Nano Research 2024年第4期17卷 2800-2807页

作者： Jianxi Liu Li feng Zhihuan Li yang wu feng Zhou Yadong Xu Research&Development Institute Northwestern Polytechnical University in ShenzhenShenzhen 518057China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Shandong Laboratory of Advanced Materials and Green Manufacturing at YantaiYantai 264006China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Metal-insulator-metal(MIM)cavity as a lithography-free structure to control light transmission and reflection has great potential in the field of optical ***,the dense top metal layer of the MIM prohibits any external medium from entering the dielectric insulation layer,which limits the application of the cavity in the sensing ***,we demonstrate a series of monolithic metal-organic frameworks(MOFs)based MIM cavities,which are treated by plasma etching to provide channels for chemical diffusion and to advance *** modulate the bandwidth of the MIM filters by controlling the MOF thickness as insulator *** plasma-etching is applied to build channels on the top metal layer without altering their saturation and brightness for chemical sensing *** etching time regulates the number and size of channels on the top metal *** behavior is demonstrated on the plasma-etched MOFs-based MIM cavity when external chemicals diffuse in the *** addition,we generate patterned structure of the MOFs-based MIM cavity via plasma-mask method,which can transfer to different substrates and produce a controllable structure color change for chemical *** MIM cavity may promote the advancement and applications of structural color in security imaging,color display,information anticounterfeiting,and color printing.

关键词： metal-organic frameworks(MOFs) spin-coating metal-insulator-metal filter patterns sensing

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Quantitative Investigation on Structural Evolution of Co-continuous Phase under Shear Flow

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Chinese Journal of Polymer Science 2022年第6期40卷 593-601页

作者： Jin Yin Qing-feng Ouyang Zhao-Bo Sun feng-yang wu Qian Liu Xi-Xi Zhang Ling Xu Hao Lin Gan-Ji Zhong Zhong-Ming Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Components of co-continuous phase can form an interpenetrating network structure,which has great potential to synergistically improve the mechanical properties of the blends,and to impart the functional blends superior electrical conductivity and *** this work,the effects of shear rates(50-5000 s^(-1))at different temperatures on the phase morphology,phase size and lamellar crystallites of biodegradable co-continuous polybutylene terephthalate(PBAT)/polybutylene succinate(PBS)blend are quantitatively *** results show that the above features of the PBAT/PBS have a strong dependence on the shear flow and thermal *** co-continuous phase of the blend is well maintained at 130℃.Interestingly,this phase structure transforms into a“sea-island”structure at 160℃,which gradually recovers to a co-continuous phase when the shear rate increases from 1000 s^(-1) to 5000 s^(-1).The phase size decreases with the increase of shear rate both at 130℃ and 160℃ due to the refinement and deformation of phase structures caused by strong shear ***,a unique phenomenon is observed that the shear-induced lamellar crystallites are oriented perpendicular to shear direction in the range of 500-5000 s^(-1) at 130℃,while the orientation of lamellar crystallites at 160℃ is along the shear direction within the whole range of shear *** degree of orientation for the PBAT/PBS blend crystals increases first and then decreases at both temperatures *** addition,the range of shear rate has reached the level in the industrial ***,this work has important guiding significance for the regulation of the co-continuous phase structure and the performance for the blend in the practical processing.

关键词： Co-continuous phase Shear rate Phase size Crystal orientation

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Enhancing the mechanical properties of casting eutectic high -entropy alloys via W addition

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1364-1372页

作者： Xu yang Dezhi Chen Li feng Gang Qin Shiping wu Ruirun Chen National Key Laboratory for Precision Hot Processing of Metals School of Material Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

The effect of W element on the microstructure evolution and mechanical properties of Al_(1.25)CoCrFeNi3 eutectic high-entropy alloy and Al_(1.25)CoCrFeNi_(3-x)W_(x)(x=0,0.05,0.1,0.3,and 0.5;atomic ratio)high-entropy alloys(HEAs)were *** show that the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs are composed of face-centered cubic and body-centered cubic(BCC)*** W content increases,the microstructure changes from eutectic to *** addition of W lowers the nucleation barrier of the BCC phase,decreases the valence electron concentration of the HEAs,and replaces Al in the BCC phase,thus facilitating the nucleation of the BCC *** results show that the addition of W greatly improves the mechanical properties,and solid-solution,heterogeneous-interface,and second-phase strengthening are the main strengthening *** yield strength,tensile strength,and elongation of the Al_(1.25)CoCrFeNi2.95W0.05 HEA are 601.44 MPa,1132.26 MPa,and 15.94%,respectively,realizing a balance between strength and *** fracture mode of the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs is ductile–brittle mixed fracture,and the crack propagates and initiates in the BCC *** eutectic lamellar structure impedes crack propagation and maintains plasticity.

关键词： high-entropy alloy microstructure mechanical property fracture behavior

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Mixed Integer Robust Programming Model for Multimodal Fresh Agricultural Products Terminal Distribution Network Design

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工程与科学中的计算机建模(英文) 2024年第1期138卷 719-738页

作者： feng yang Zhong wu Xiaoyan Teng Business School University of Shanghai for Science and TechnologyShanghai200093China School of Management Shanghai University of International Business and EconomicsShanghai201620China

The low efficiency and high cost of fresh agricultural product terminal distribution directly restrict the operation of the entire supply *** reduce costs and optimize the distribution network,we construct a mixed integer programmingmodel that comprehensively considers tominimize fixed,transportation,fresh-keeping,time,carbon emissions,and performance incentive *** analyzed the performance of traditional rider distribution and robot distribution modes in *** addition,the uncertainty of the actual market demand poses a huge threat to the stability of the terminal distribution *** order to resist uncertain interference,we further extend the model to a robust counterpart *** results of the simulation show that the instability of random parameters will lead to an increase in the *** with the traditional rider distribution mode,the robot distribution mode can save 12.7%on logistics costs,and the distribution efficiency is *** research can provide support for the design of planning schemes for transportation enterprise managers.

关键词： Fresh agricultural product terminal distribution network rider delivery robot delivery uncertainty

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Network Pharmacology Based Elucidation of Molecular Mechanisms of Laoke Formula for Treatment of Advanced Non-Small Cell Lung Cancer

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Chinese Journal of Integrative Medicine 2024年第11期30卷 984-992页

作者： feng Yu-yu LIU Jin-feng XUE yang LIU Dan wu Xiong-zhi Department of Nursing Tangshan Vocational and Technical College School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Department of Oncology Tianjin Medical University General Hospital Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for China Tianjin Nankai Hospital Tianjin Medical University

Objective: To explore the specific pharmacological molecular mechanisms of Laoke Formula(LK)on treating advanced non-small cell lung cancer(NSCLC) based on clinical application, network pharmacology and experimental validation. Methods: Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of Chinese medicine(CM) treatment in 296 patients with NSCLC in Tianjin Medical University Cancer Institute and Hospital from January 2011 to December 2015. The compounds of LK were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and the corresponding targets were performed from Swiss Target Prediction. NSCLC-related targets were obtained from Therapeutic Target Database and Comparative Toxicogenomics Database. Key compounds and targets were identified from the compound-target-disease network and protein-protein interaction(PPI) network analysis, respectively. Kyoto Encyclopedia of Genes and Genomes(KEGG) and Gene Ontology(GO) enrichment analysis were used to predict the potential signaling pathways involved in the treatment of advanced NSCLC with LK. The binding affinities between key ingredients and targets were further verified using molecular docking. Finally, A549 cell proliferation and migration assay were used to evaluate the antitumor activity of LK. Western blot was used to further verify the expression of key target proteins related to the predicted pathways. Results: Kaplan-Meier survival analysis showed that the overall survival of the CM group was longer than that of the non-CM group(36 months vs.26 months), and COX regression analysis showed that LK treatment was an independent favorable prognostic factor(P=0.027). Next, 97 components and 86 potential targets were included in the network pharmacology, KEGG and GO analyses, and the results indicated that LK was associated with proliferation and apoptosis. Moreover,molecular docking revealed a good binding affinity between the key

关键词： Chinese medicine LaoKe Formula anti-tumor network pharmacology non-small cell lung cancer

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Association between coronary artery calcification and cognitive function in a Chinese community-based population

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Journal of Geriatric Cardiology 2021年第7期18卷 514-522页

作者： Ya-Nan MA wu-Xiang XIE Zhi-Hui HOU Yun-Qiang AN Xin-Shuang REN Yan-Jun MA Cheng-Long LI yang-feng wu Bin LU Department of Radiology Fuwai HospitalPeking Union Medical College&Chinese Academy of Medical SciencesState Key Lab and National Center for Cardiovascular DiseasesBeijingChina Peking University Clinical Research Institute Peking University First HospitalBeijingChina

Background Coronary atherosclerosis and cognitive impairment are both age-related diseases,with similar risk *** artery calcium(CAC),a marker of coronary atherosclerosis,may play a role in early detection of individuals prone to cognitive *** study aimed to investigate the relationship between CAC and cognitive function,and the capability of CAC to identify participants with a high risk of dementia in a Chinese community-based *** A total of 1332 participants,aged 40-80 years and free of dementia from a community located in Beijing were *** participants completed neurocognitive questionnaires and noncontrast CT *** performance tests(including verbal memory,semantic fluency,executive function,and global cognitive function tests),the Cardiovascular Risk Factors,Aging,and Incidence of Dementia(CIDE)risk score,and the CAC score(CACS)were evaluated by questionnaires and CT.A CAIDE score≥10 was considered to indicate a high risk of dementia in *** were divided into three groups according to CACS(0,1-399,≥400).Results After adjusting for risk factors,CACS was significantly associated with verbal memory(r=-0.083,P=0.003)and global cognitive function(r=-0.070,P=0.012).The prevalence of a high risk of dementia in the subgroups of CACS=0,1-399,and≥400 was 4.67%,13.66%,and 24.79%,respectively(P<0.001).Individuals with CACS≥400 had a higher risk of CAIDE score≥10[OR=2.30(1.56,4.56),P=0.014]than those with CACS=*** receiver-operating characteristic curves showed that the capability of CACS to identify participants with a high risk of dementia was moderate(AUC=0.70,95%CI:0.67-0.72,P<0.001).Conclusions CAC,a marker of subclinical atherosclerosis,was significantly associated with cognitive performance in verbal memory and global cognitive *** had a moderate capability to identify participants with a high risk of dementia,independent of age,education,and other risk factors.

关键词： coronary function cognitive

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Photodegradation of Bisphenol A Induced by Metal Ions in Aqueous Solution in the Presence of Ascorbic Acid

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wuhan University Journal of Natural Sciences 2008年第1期13卷 107-112页

作者： PENG Zhang＇e ZHANG Xu yang Liu wu feng DENG Nansheng School of Resources and Environmental Sciences Wuhan University Wuhan 430079 Hubei China

The photodegradation of bisphenol A （BPA） in aqueous solution containing metal ions and ascorbic acid （AsA） was investigated. After strong irradiation, the aqueous solution containing AsA and Cu^2＋ could produce hydroxyl radicals that induced the photodegradation of BPA. The photodegradation efficiency of BPA in the solution containing 70 μmol·L^1 Cu^2＋ and 15 mg·L^1 AsA reached 59% at pH 6.0 after 4 hours irradiation with high pressure mercury lamp. The photodegradation efficiency of BPA reached 10% after 4 hours irradiation with daylight lamp in the presence of 70 μmol·L^1 Cu^2＋ and 15 mg·L^1 ascorbic acid. BPA was not degraded in the aqueous solution only containing AsA or Cu^2＋. The BPA photodegradation in aqueous solution containing AsA and Fe^3＋ was weaker than in aqueous solution that containing AsA and Cu^2＋ at the same concentration. This work showed a new route of the BPA photodegradation in aqueous environment.

关键词： bisphenol A photodegradation metal ions hydroxyl radicals

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