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清热化瘀中药治疗肝胆湿热型急性肝内胆汁淤积症疗效及对炎性细胞因子、SOD、MDA水平的影响

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现代中西医结合杂志 2017年第12期26卷 1272-1275页

作者：李恒飞杨帆陆定波湖北省中医院湖北武汉430074

目的探讨清热化瘀中药治疗肝胆湿热型急性肝内胆汁淤积症疗效及对炎性细胞因子、SOD、MDA水平的影响。方法将100例肝胆湿热型急性肝内胆汁淤积症患者随机分为2组,对照组60例给予西药治疗,观察组60例在此基础上加用清热化瘀中药治疗,观察... 详细信息

目的探讨清热化瘀中药治疗肝胆湿热型急性肝内胆汁淤积症疗效及对炎性细胞因子、SOD、MDA水平的影响。方法将100例肝胆湿热型急性肝内胆汁淤积症患者随机分为2组,对照组60例给予西药治疗,观察组60例在此基础上加用清热化瘀中药治疗,观察2组治疗前后中医证候积分、肝脏功能指标、炎症细胞因子、SOD及MDA水平变化情况,统计2组近期疗效和不良反应发生情况。结果治疗后2组目俱黄、胁肋疼痛、脘闷腹胀、烦热、口干而苦、小便黄赤积分及肝脏功能指标、炎症细胞因子水平均显著低于治疗前(P均0.05)。结论清热化瘀中药治疗肝胆湿热型急性肝内胆汁淤积症可有效缓解全身症状体征,改善肝脏功能,调节炎性细胞因子及SOD、MDA水平,且未增加不良反应发生风险。

关键词：清热化瘀中药急性肝内胆汁淤积症肝胆湿热

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人胸腺肽β4基因的克隆表达及活性检测

生物化学与生物物理学报 2002年第4期34卷 502-505页

作者：陈妍柯杨辉路凡蒲勤李仁德赵忠良兰州大学生命科学学院第四军医大学生物化学与分子生物学教研室第四军医大学生物化学与分子生物学教研室兰州730000 西安710032

采用化学与酶促合成技术 ,将胸腺肽 β4基因拆分为两个末端互补的片段进行化学合成 ,经变性、退火以及T4DNA聚合酶延伸过程 ,获得完整编码的基因片段。通过一平一粘末端连接 ,将胸腺肽 β4基因片段克隆入pLDH4 (一种大肠杆菌温度诱导表... 详细信息

采用化学与酶促合成技术 ,将胸腺肽 β4基因拆分为两个末端互补的片段进行化学合成 ,经变性、退火以及T4DNA聚合酶延伸过程 ,获得完整编码的基因片段。通过一平一粘末端连接 ,将胸腺肽 β4基因片段克隆入pLDH4 (一种大肠杆菌温度诱导表达载体 )的EcoRV和HindIII位点之间。经克隆筛选和DNA序列测定 ,获得目的基因表达工程菌 ,且表达量占细菌总蛋白质的 30 %。利用盐析和多种层析技术联合纯化该表达多肽 ,纯度达95 % ;活性测定表明纯化的人胸腺肽 β4能够促进淋巴细胞的增殖和分化

关键词：人胸腺肽β4 基因表达 E玫瑰花结 MTT

Natural and human-induced decline and spatio-temporal differentiation of terrestrial water storage over the Lancang-Mekong River Basin

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Journal of Geographical Sciences 2025年第1期 112-138页

作者： CHEN Junxu WANG Yuan ZHAO Zhifang fan Yunjiang luO Xiaochuan YI lu FENG Siqi yang Liang Emlyn Yunnan Key Laboratory of Soil Erosion Prevention and Green Development Yunnan University International Joint Research Center for Karstology Yunnan University School of Engineering Westlake University Department of Geography Ludwig Maximilian University of Munich (LMU)

Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB), the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified. This work investigated LMRB's terrestrial water storage anomaly(TWSA) and its spatio-temporal dynamics during 2002–2020. Considering the effects of natural factors and human activities, the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC) were separated. Results showed that:(1) LMRB's TWSA decreased by 0.3158 cm/a.(2) TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB. TWSA positively changed in Myanmar while slightly changed in Laos and China. It negatively changed in Vietnam, Thailand and Cambodia.(3) TWSA components decreased in a descending order of soil moisture, groundwater and precipitation.(4) Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5) Climate variability contributed 79% of TWSC in the LMRB while human activities contributed 21% with an increasing impact after 2008. The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.

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抗CD3单抗促进肿瘤细胞凋亡的研究

上海医学 2003年第S1期26卷 37-39页

作者：杨凡施伟民陆震宇孙向华于德华同济大学同济医院医学科研所上海200065

目的　研究抗CD 3单抗活化T细胞后促进肿瘤细胞发生凋亡的作用。方法　应用流式细胞术并结合AnnexinⅤ FITC/PI双染色法检测细胞凋亡情况并对凋亡因子Fas抗原 (CD 95 )和Apo 2 .7进行定量分析。结果　加入抗CD 3单抗后可明显诱导肿瘤细... 详细信息

目的　研究抗CD 3单抗活化T细胞后促进肿瘤细胞发生凋亡的作用。方法　应用流式细胞术并结合AnnexinⅤ FITC/PI双染色法检测细胞凋亡情况并对凋亡因子Fas抗原 (CD 95 )和Apo 2 .7进行定量分析。结果　加入抗CD 3单抗后可明显诱导肿瘤细胞的凋亡产生 (AnnexinⅤ FITC/PI染色 ) (P 0 .0 5 )。结论　加入抗CD 3单抗活化的T细胞可明显促进肿瘤细胞发生凋亡 ;介导凋亡发生主要通过Fas抗原 (CD 95 )

关键词：抗CD_3单抗流式细胞术 Annexin Ⅴ-FITC/PI Fas抗原(CD95)

Frustrated superconductivity and sextetting order

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 168-176页

作者： Zhiming Pan Chen lu fan yang Congjun Wu Institute for Theoretical Sciences Westlake UniversityHangzhou 310024China New Cornerstone Science Laboratory Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310024China School of Physics Beijing Institute of TechnologyBeijing 100081China Key Laboratory for Quantum Materials of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

The superconducting state typically favors a uniform spatial distribution akin to ***,the pair-densitywave state exhibits sign changes in the pairing order,leading to potential frustrations in phase *** propose a mechanism to the sextetting order stemming from the frustrations in the phase coherence of a pair-density-wave state,whose spatial modulation manifests a vortex-antivortex honeycomb *** classical ground state configurations are mapped to Baxter's three-coloring model,revealing a macroscopic degeneracy accompanied by extensive *** phase coherence problem intertwines the U(1)phases and the vorticity *** the resultant color and phase fluctuations suppress the pair-densitywave order,they maintain the sextetting order above the superconducting transition temperature(T_(c)).The 1/3-fractional vortex emerges as the fundamental topological defect in the sextetting *** novel mechanism of frustrated superconductivity provides an alternative explanation for the experimental observed fractional oscillations in CsV_(3)Sb_(5).

关键词： frustrated superconductivity pair density wave charge-6e order

Surface effects on mechanical behavior of elastic nanoporous materials under high strain

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Applied Mathematics and Mechanics(English Edition) 2015年第7期36卷 927-938页

作者： Zixing lu fan XIE Qiang LIU Zhenyu yang School of Aeronautics Science and Engineering Beihang University

This paper studies surface effects on the mechanical behavior of nanoporous materials under high strains with an improved anisotropic Kelvin model. The stress-strain relations are derived by the theories of Euler-Bernoulli beam and surface elasticity. Mean- while, the influence of strut （or ligament） size on the mechanical properties of nanoporous materials is discussed, which becomes a key factor with consideration of the residual sur- face stress and the surface elasticity. The results show that the decrease in the strut diameter and the increase in the residual surface stress or the surface elasticity can both lead to an increase in the carrying capacity of nanoporous materials. F^lrthermore, me- chanical behaviors of anisotropic nanoporous materials in different directions （the rise direction and the transverse direction） are investigated. The results indicate that the sur- face effects in the transverse direction are more obvious than those in the rise direction for anisotropic nanoporous materials. In addition, the present results can be reduced to the cases of conventional foams as the strut size increases to micron-scale, which confirms validity of the model to a certain extent.

关键词： surface effect nanoporous anisotropy high strain

Improved time-optimal B-spline feedrate scheduling for NURBS tool paths in CNC machining

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Advances in Manufacturing 2023年第1期11卷 111-129页

作者： yang Li Fu-Sheng Liang Lei lu Cheng fan School of Mechanic Engineering Northeast Electric Power UniversityJilin132012JilinPeople’s Republic of China Jiangsu Provincial Key Laboratory of Advanced Robotics and Collaborative Innovation Center of Suzhou Nano Science and Technology College of Mechanical and Electrical EngineeringSoochow UniversitySuzhou215021JiangsuPeople’s Republic of China

Feedrate scheduling in computer numerical control(CNC)machining is of great importance to fully develop the capabilities of machine tools while maintaining the motion stability of each *** and time-optimal feedrate scheduling plays a critical role in improving the machining efficiency and precision of complex surfaces considering the irregular curvature characteristics of tool paths and the limited drive capacities of machine *** study develops a general feedrate scheduling method for non-uniform rational B-splines(NURBS)tool paths in CNC machining aiming at minimizing the total machining time without sacrificing the smoothness of feed *** feedrate profile is represented by a B-spline curve to flexibly adapt to the frequent acceleration and deceleration requirements of machining along complex tool *** time-optimal B-spline feedrate is produced by continuously increasing the control points sequentially from zero positions in the bidirectional scanning and sampling *** required number of knots for the time-optimal B-spline feedrate can be determined using a progressive knot insertion *** improve the computational efficiency,the B-spline feedrate profile is divided into a series of independent segments and the computation in each segment can be performed *** proposed feedrate scheduling method is capable of dealing with not only the geometry constraints but also high-order drive constraints for any complex tool path with little computational *** and machining experiments are conducted to verify the effectiveness and superiorities of the proposed method.

关键词： B-spline feedrate Non-uniform rational B-splines(NURBS)tool path Knot insertion Bidirectional scanning Computer numerical control(CNC)machining

All-inorganic TiO_(2)/Cs_(2)AgBiBr_(6) composite as highly efficient photocatalyst under visible light irradiation

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Frontiers of Chemical Science and Engineering 2023年第12期17卷 1925-1936页

作者： Jianzhong Ma lu Wen Qianqian fan Siying Wei Xueyun Hu fan yang College of Bioresources Chemical and Materials Engineering Shaanxi University of Science and TechnologyXi’an 710021China College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi’an 710021China Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry(Ministry of Education) Shaanxi University of Science and TechnologyXi’an 710021China Xi’an Key Laboratory of Green Chemicals and Functional Materials Shaanxi University of Science and TechnologyXi’an 710021China College of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China

In recent years, limited photocatalysis efficiency and wide band gap have hindered the application of TiO_(2) in the field of photocatalysis. A leading star in photocatalysis has been revealed as lead-free Cs_(2)AgBiBr_(6) double halide perovskite nanocrystals, owing to its strong visible light absorption and tunable band gap. In this work, this photocatalytic process was facilitated by a unique TiO_(2)/Cs_(2)AgBiBr_(6) composite, which was identified as an S-cheme heterojunction. TiO_(2)/Cs_(2)AgBiBr_(6) composite was investigated for its structure and photocatalytic behavior. The results showed that when the perovskite dosage is 40%, the photocatalytic rate of TiO_(2) could be boosted to 0.1369 min^(-1). This paper discusses and proposes the band gap matching, carrier separation, and photocatalytic mechanism of TiO_(2)/Cs_(2)AgBiBr_(6) composites, which will facilitate the generation of new ideas for improving TiO_(2)’s photocatalytic performance.

关键词： Cs_(2)AgBiBr_(6)nanocrystals visible-light photocatalyst Cs_(2)AgBiBr_(6) TiO_(2)heterojunction

An In-Situ Variable-Temperature Surface-Enhanced Raman Spectroscopic Study of the Plasmon-Mediated Selective Oxidation of p-Aminothiophenol

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Chinese Journal of Structural Chemistry 2022年第10期41卷 77-81页

作者： Wumei Cao yang lu Yi-fan Huang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

The roles of temperature change in surface-enhanced Raman scattering(SERS)hotspots are important for understanding the plasmon-mediated selective oxidation of p-aminothiophenol in a SERS measurement. Here, we demonstrate that the temperature change in hotspots seriously influences the conversion of p-aminothiophenol on Au by employing variable-temperature SERS measurements. The conversion steadily and irreversibly increased when the temperature increased from 100 to 360 K. But the conversion decreased above 360 K, because this conversion was exothermic. This temperature-dependence conversion suggests that the temperature change in hotspots originated from the photothermal effect should be coupled to the hot-electron effect in promoting the selective oxidation of p-aminothiophenol.

关键词： surface-enhanced Raman spectroscopy p-aminothiophenol temperature plasmon-mediated chemical reaction