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The Prognostic Significance of a Combined Determination of Cathepsin D and Estrogen Receptors in Breast Carcinomas with Positive Axillary Lymph Nodes

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Chinese Journal of Clinical Oncology 2006年第3期3卷 172-175,180页

作者： Yun Niu Xue yang Yu fan Ajuan lu Tieju Liu Xilin Fu Department of Breast Pathology and Research Tianjin Medical University Cancer Institute and Hospital Tianjin 30006China.

OBJECTIVE The aim of this study was to investigate the correlation between cathepsin D （Cath-D） and estrogen receptor （ER）expression in breast cancer tissue and to explore the prognostic significance of their combined determination in breast carcinoma patients with positive axillary lymph nodes. METHODS One hundred and thirty-eight cases of breast carcinoma were examined by immunohistochemistry （IHC） and the results relating to patient follow-up analyzed. RESULTS The overall 5-year disease-free survival rate （DFS） was 60.9% （84/138） in the series. The positive rate of Cath-D expression in the tumor cells was 55.07% and the positive ER staining was 51.4%. A definite significant negative correlation was found between the positive rates for Cath-D and ER （r=-0.294, P=0.001） The Cath-D expression for the cases in clinical Stage Ⅱ, ≥10 positive-node and recurrence or distant metastasis, was higher than that those cases in clinical Stage II with fewer node-metastasis and with 5 year DFS （X^2=13.926, P=0.000; X^2=13.070, P=0.001; X^2=10.545, P=0.001）. However, there was no significant difference of Cath-D expression between 2 groups of patients with different ages or among the different histopathologic types of the nonspecific invasive carcinoma. In the combined examination of Cath-D and ER, the cases that were ER （＋） and Cath-D （-） had the highest 5-year DFS compared to other situations. In contrast, the cases that were reversed in expression, ie, ER（-） and Cath-D（＋）, had a lower 5-year DFS. There was a significant difference between the 2 conditions （X2=18.675, P=0.000）. CONCluSION A combined determination and analysis of Cath-D and ER expression may be more useful to establish a prognosis than the biological characteristics of carcinomas with positive lymph nodes.

关键词： breast carcinoma cathepsin-D estrogen receptor combined determination prognosis.

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对铁路铺架机组过轨运输中存在问题的思考

铁道工程学报 2010年第5期27卷 95-98页

作者：杨路帆中国中铁股份有限公司北京100039

研究目的:铁路铺架机组是铁路新线建设的主要装备。我国行政许可制度实施后,铺架机组在维修和运输上存在诸多困难,无法转场运输,直接影响铁路建设的正常进行。本文针对这一问题进行分析,并提出相关解决的意见和建议。研究结论:该问题涉... 详细信息

研究目的:铁路铺架机组是铁路新线建设的主要装备。我国行政许可制度实施后,铺架机组在维修和运输上存在诸多困难,无法转场运输,直接影响铁路建设的正常进行。本文针对这一问题进行分析,并提出相关解决的意见和建议。研究结论:该问题涉及设备使用企业和政府管理部门,难以在短期内解决。因此,不仅需要施工企业自身加强设备管理和技术储备工作,同时主管部门应充分考虑铺架设备的实际情况,通过与施工单位一起完善技术管理、审批程序和管理机制创新来解决问题。

关键词：铺架机组运输管理

Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats

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World Journal of Gastroenterology 2003年第12期9卷 2742-2744页

作者： Tao-Tao Liu Department of Pharmacy,First Affiliated Hospital,Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China Ning-Sheng Liang Yan Li fan yang Yi lu Zi-Qing Meng Li-Sheng Zhang Department of Pharmacology,Guangxi Cancer Institute,Nanning 530021,Guangxi Zhuang Autonomous Region,China Department of Pharmacy First Affiliated Hospital Guangxi Medical University Nanning Guangxi Zhuang Autonomous Region China.

AIM: To investigate the effects of long-term tea polyphenols (TPs) consumption on hepatic microsomal drug-metabolizing enzymes and liver function in ***: TPs were administered intragastrically to rats at the doses of 833 ***-1.d-1 (n=20) and 83.3 ***-1@d-1 (n=20) respectively for six months. Controlled group (n=20)was given same volume of saline solution. Then the contents of cytochrome P450, bS, enzyme activities of aminopyrine N-demethylase (ADM), glutathione S-trasferase (GST) and the biochemical liver function of serum were ***: The contents of cytochrome P450 and b5 in the livers of male rats in high dose groups (respectively 2.66±0.55,10.43±2.78 *** MS pro-1) were significantly increased compared with the control group (1.08±1.04, 5.51±*** MS pro-1; P＜0.01, respectively). The enzymatic activities of ADM in the livers of female rats in high dose groups (0.91±0.08 mmol@mg MS pro-1min-1) were increased compared with the control group (0.82±0.08 *** MS ***-1; P＜0.05). The GST activity was unchanged in all treated groups, and the function of liver was not obviously ***: The antidotal capability of rats' livers can be significantly improved after long-term consumption of *** are differences in changes of drug-metabolizing enzymes between the sexes induced by TPs and normal condition.

关键词：茶叶酚肝微粒体药物代谢酶肝功能动物实验

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施工装备再制造的产业化探析

中国设备工程 2006年第8期 8-9页

作者：杨路帆中国铁路工程总公司北京100000

装备再制造是实现循环经济的重要途径之一。本文通过分析再制造产品供求方面的情况,认为目前我国的再制造技术已走出了一条具有自主知识产权的发展道路。但还存在一些问题。本文从价格机制、协会作用、技术研究及制度创新等方面对再制... 详细信息

装备再制造是实现循环经济的重要途径之一。本文通过分析再制造产品供求方面的情况,认为目前我国的再制造技术已走出了一条具有自主知识产权的发展道路。但还存在一些问题。本文从价格机制、协会作用、技术研究及制度创新等方面对再制造技术的产业化提出了建议。

关键词：再制造产业化

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国外施工机械管理特点探析

建筑机械化 2008年第6期29卷 47-48页

作者：杨路帆中国铁路工程总公司工业设备部北京000000

随着我国市场经济体制的逐步建立,以建筑施工企业工程项目管理为龙头改革的不断深入,原有计划体制下企业对管理模式已经不再适用,新的管理模式正在探索之中。对此,就国外市场经济发达国家施工机械管理的一些特点进行简介、思考、认识,... 详细信息

随着我国市场经济体制的逐步建立,以建筑施工企业工程项目管理为龙头改革的不断深入,原有计划体制下企业对管理模式已经不再适用,新的管理模式正在探索之中。对此,就国外市场经济发达国家施工机械管理的一些特点进行简介、思考、认识,供大家参考。

关键词：筑施施工施工机械管理企业工程项目管理管理模式

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关于完善我国盾构设备管理的思考

建筑机械化 2015年第10期36卷 73-76页

作者：杨路帆中国中铁股份有限公司北京100038

通过对比我国盾构设备与国外盾构设备使用的不同特点,指出我国盾构行业在行业监管、使用维修、经济管理等方面存在的不足,针对以上问题,从使用单位、行业协会及国家政策等三个层次提出相关意见和建议。

关键词：盾构设备管理存在问题建议

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试论影响设备购置的若干个因素

铁道工程学报 2000年第4期17卷 98-100页

作者：杨路帆中国铁路工程总公司北京100844

机械设备是建筑施工企业完成各项施工任务的重要物质基础 ,优化设备的购置工作具有重要的意义。本文分析了影响设备购置的若干个因素 ,认为施工产值是最主要的因素 ,并对施工产值用线形回归方法做了进一步分析。建立了分析模型 ,并对 2 0 0

关键词：机械设备设备购置施工产值线形回归分析建筑施工企业

Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng Zhang Menglei Wang Ruoxuan yang Shuai Feng Xuan Cao Yaping Zhang Zhongyuan lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Lithium-sulfur battery Universal synthesis 3D graphene-iron based promotor Electrocatalysis

Compressive elastic behavior of single-crystalline 4H-silicon carbide(SiC) nanopillars

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Science China(Technological Sciences) 2021年第1期64卷 37-43页

作者： fan SuFeng LI XiaoCui fan Rong lu yang Department of Mechanical Engineering City University of Hong KongHong Kong 999077China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Nanomanufacturing Laboratory(NML) Center for Advanced Structural Materials(CASM)City University of Hong Kong Shenzhen Research InstituteShenzhen 518057China

As a wide-bandgap semiconductor, 4H-SiC is an ideal material for high-power and high-frequency devices, and plays an increasingly important role in developing our country’s future electric vehicles and 5G techniques. Practical applications of SiCbased devices largely depend on their mechanical performance and reliability at the micro-and nanoscales. In this paper, singlecrystal [0001]-oriented 4H-SiC nanopillars with the diameter ranging from ~200 to 700 nm were microfabricated and then characterized by in situ nanomechanical testing under SEM/TEM at room temperature. Loading-unloading compression tests were performed, and large, fully reversible elastic strain up to ~6.2% was found in nanosized pillars. Brittle fracture still occurred when the max strain reached ~7%, with corresponding compressive strength above 30 GPa, while in situ TEM observation showed few dislocations activated during compression along the [0001] direction. Besides robust microelectromechanical system(MEMS), flexible device and nanocomposite applications, the obtained large elasticity in [0001]-oriented 4H-SiC nanopillars can offer a fertile opportunity to modulate their electron mobility and bandgap structure by nanomechanical straining,the so called "elastic strain engineering", for novel electronic and optoelectronic applications.

关键词： silicon carbide elastic deformation compressive behavior in situ SEM/TEM elastic strain engineering