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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu Yi-Sheng Chen Yu-chun xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Generation and Selection of the Immunized Fab Phage Display Library from Human B Cell Lymphoma

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Generation and Selection of the Immunized Fab Phage Display ...

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

江苏省遗传学会第七届代表大会暨学术研讨会

作者： SHEN Yong-mei, yang Xiao-chun, xie Xiao-fang, DONG Ning-zheng, SHI Yi-zhen (Second Affiliated Hospital of Soochow University, Suzhou 215004, China)

＜正＞Background The approval of monoclonal antibodies as antibody-targeted therapy in the management of patients with B cell lymphoma has led to new treatment options for this group of patients. But the traditional h... 详细信息

关键词： B cell lymphoma Fab Phage display library pComb3H-SS vector

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue Li Ziliang xie Wenjiao Zhou Huan Tong Dawen yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian yang Jiang Wu Xueshun xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Local-contrastive-learning machine with both generalization and adversarial robustness: A statistical physics analysis

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 109-123页

作者： Mingshan xie Yuchen Wang Haiping Huang PMI Lab School of Physics Sun Yat-sen University Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices Sun Yat-sen University

Distinct from human cognitive processing, deep neural networks trained by backpropagation can be easily fooled by adversarial examples. To design a semantically meaningful representation learning, we discard backpropagation, and instead, propose a local contrastive learning, where the representations for the inputs bearing the same label shrink(akin to boson) in hidden layers,while those of different labels repel(akin to fermion). This layer-wise learning is local in nature, being biologically plausible.A statistical mechanics analysis shows that the target fermion-pair-distance is a key parameter. Moreover, the application of this local contrastive learning to MNIST benchmark dataset demonstrates that the adversarial vulnerability of standard perceptron can be greatly mitigated by tuning the target distance, i.e., controlling the geometric separation of prototype manifolds.

关键词： machine learning statistical mechanics adversarial robustness neural networks

High-speed train positioning based on a combination of Beidou navigation, inertial navigation and an electronic map

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Science China(Information Sciences) 2023年第7期66卷 237-252页

作者： Hui yang Shuai-Qiang DONG chun-Hua xie School of Electrical and Automation Engineering East China Jiaotong University Key Laboratory of Advanced Control & Optimization of Jiangxi Province East China Jiaotong University State Key Laboratory of Performance Monitoring Protecting of Rail Transit Infrastructure East China Jiaotong University

To date, the studies on the combination positioning of high-speed trains have made great progress, but the positioning accuracy of these methods is relatively low. Map-matching positioning can improve positioning accuracy, but information transmission is time-consuming. Few studies incorporate it into combination positioning. To solve the problem, this paper proposes a high-speed train positioning method based on combining a Beidou navigation system, an inertial navigation system, and an electronic map. First, the combination positioning problem is transformed into a multi-objective optimization problem, which weights the direction similarity and distance error to form a fitness function and converts the railway line and the maximum error range of each positioning system into constraints. Second, an improved differential evolution algorithm is proposed to solve this problem. By referencing the gray wolf algorithm,the differential evolution algorithm updates individuals by varying toward the direction of multiple optimal values. Then, a new combination positioning algorithm for high-speed trains is proposed. In the simulation,the increase in positioning speed and accuracy is analyzed and validated. Compared to the current algorithms, the proposed algorithm performs better. The proposed method has practical value for improving the reliability and safety of train operations.

关键词： electronic map multi-objective optimization differential evolution algorithm Beidou navigation system high-speed train positioning

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灯盏花素治疗眼碱烧伤的疗效观察

国际眼科杂志 2014年第7期14卷 1275-1277页

作者：蔡玉莲谢杨春苏蓉钱道卫伍岚岳建军中国广东省深圳市坪山新区人民医院眼科 518118

目的:期望能找到更好治疗眼碱烧伤,减少病患痛苦,减轻社会负担的方法。方法:选择眼碱烧伤患者100例。根据化学烧伤程度分级分为4大组,每大组再随机分为对照组和治疗组各约一半。对照组行常规治疗,治疗组在观察组的基础上加用灯盏花素注... 详细信息

目的:期望能找到更好治疗眼碱烧伤,减少病患痛苦,减轻社会负担的方法。方法:选择眼碱烧伤患者100例。根据化学烧伤程度分级分为4大组,每大组再随机分为对照组和治疗组各约一半。对照组行常规治疗,治疗组在观察组的基础上加用灯盏花素注射液40mg静滴。观察两组角膜恢复时间、视力变化、角膜混浊程度、角膜新生血管数量、其它并发症等。统计分析其疗效。结果:治疗四大组患者中Ⅰ级的治疗组与对照组各项指标对比无显著性差异(P>0.05),Ⅱ,Ⅲ,Ⅳ级的各项指标对比均有显著性差异(P<0.05)。其角膜混浊程度与新生血管数量对比,治疗组明显优于对照组(P<0.05)。结论:灯盏花素治疗眼碱烧伤能缩短疗程,减少角膜瘢痕,提高视力。

关键词：灯盏花素碱烧伤角膜

Asymptotic state estimation for linear systems with sensor and actuator faults

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Science China(Information Sciences) 2019年第11期62卷 106-120页

作者： chun-Hua xie Hui yang Dianhui WANG Zhe LI School of Electrical and Automation Engineering East China Jiaotong University Key Laboratory of Advanced Control & Optimization of Jiangxi Province Department of Computer Science and Information Technology La Trobe University College of Electrical and Information Engineering Hunan University

This paper investigates the asymptotic state estimation problem for linear systems with sensor and actuator faults, where the faults are modeled via multiple modes. For the case of sensor faults, we first introduce a new notion of detectability, i.e., detectability of system against sensor faults. The notion helps to address the question of whether it is possible to asymptotically estimate the system state by using the control input and system output, irrespective of which mode the system is in and what values the fault signals are.A necessary and sufficient condition for the system to be detectable against sensor faults is given, and then two switched observers are proposed for asymptotic state estimation with the help of maximin strategy. For the system with ? fault modes, we provide the explicit form of the switched observer, which is based on a bank of ?(?+1)/2 Luenberger-like or sliding-mode observers. Furthermore, extensions to the case of sensor and actuator faults are further studied. Finally, a simulation example of a reduced-order aircraft system is provided to show the effectiveness of the proposed approaches.

关键词： asymptotic state estimation observer linear systems sensor faults actuator faults

Distributed Fault-Tolerant Consensus Tracking of Multi-Agent Systems Under Cyber-Attacks

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 1037-1048页

作者： chun Liu Bin Jiang Xiaofan Wang Huiliao yang Shaorong xie School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444 School of Artificial Intelligence Shanghai UniversityShanghai 200444China IEEE College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Energy and Electrical Engineering Hohai UniversityNanjing 210016China School of Computer Engineering and Science Shanghai UniversityShanghai 200444China

This paper investigates the distributed fault-tolerant consensus tracking problem of nonlinear multi-agent systems with general incipient and abrupt time-varying actuator faults under ***,a decentralized unknown input observer is established to estimate relative states and actuator ***,the estimated and output neighboring information is combined with distributed fault-tolerant consensus tracking *** of reaching leader-following exponential consensus tracking of multi-agent systems under both connectivity-maintained and connectivity-mixed attacks are derived with average dwelling time,attack frequency,and attack activation rate technique,*** example verifies the effectiveness of the fault-tolerant consensus tracking algorithm.

关键词： Cyberattacks fault-tolerant consensus tracking incipient and abrupt actuator faults nonlinear multi-agent systems unknown input observer